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Vacation rentals in La Mesa District

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Top-rated vacation rentals in La Mesa District

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
An aerial view captures a charming retreat nestled in lush greenery. The red-tiled roof of the cabin stands prominently surrounded by colorful gardens and fruit trees. A winding path leads to the property, with a vehicle parked nearby, highlighting the spacious natural surroundings.
Tiny home in Cocle
4.93 out of 5 average rating, 136 reviews

Cozy 2 Bedrooms, el Cope/ Retreat at the Mountains

Hermosa cabaña de dos habitaciones y dos baños , den panorámico ubicada a unos 50 minutos de Penonome, Provincia de Cocle, en el Area del Parque Nacional Omar Torrijos Herrera , temperaturas entre 22 y 25 grados C a orillas del turístico Chorro de las Yayas en la comunidad de Barrigon del Cope, distrito de La Pintada. Agradable ambiente rodeado de árboles frutales y hermosas cascadas. Ideal para disfrutar de la naturaleza y relajarse. Cuenta con internet satelital de rápida velocidad .

Guest favorite
A spacious two-story villa is set amidst vibrant green grass and trees. The structure features a rooftop terrace and large windows, allowing for ample natural light. The clear blue sky provides a serene backdrop for the peaceful natural surroundings.
Townhouse in Santa Catalina
4.89 out of 5 average rating, 96 reviews

South Villa w Rooftop Fly- Drive- Coiba day tour

Fly in - charters. Rooftop w/great view! 1000ft2 Your rooftop lounge is perfect for star gazing and birdwatching. Your villa comes with a spacious bedrooms, a fully equipped kitchen (cookware, spices, blender, coffee maker etc), full living area, & your backyard grill. All surrounded by acres of gardens. Fly / drive / take a tour to Coiba Island. If you drive in, we have covered parking for you. If you fly - we have you covered as well! Message for additional information.

Superhost
A scenic view of rolling hills under a colorful sky at sunset. Shades of orange, pink, and purple blend, creating a vibrant horizon. Lush trees are scattered across the landscape, adding a touch of greenery to the terrain.
Cottage in Olá
4.79 out of 5 average rating, 29 reviews

Country House in Olá, rivers, waterfalls, Los Picachos

Finca La Terapia lives up to its name, it is located among the mountains of the picturesque village of Olá de Penonomé, where you can disconnect from the busy day to day of the city. It has 42 private hectares to explore nature. The Olá district is characterized by having the most beautiful natural landscapes, among which we can mention Los Chorros de Olá, Chorros las Mesitas, Cerros los Picachos, Rio San Antonio, Balneario Brujas, among others, just a few minutes from the property.

Top guest favorite
An outdoor terrace is furnished with a sectional sofa in neutral tones and a low coffee table. A potted plant with green leaves and colorful flowers adds a vibrant touch. Large glass doors provide a view into the interior space, inviting natural light.
Villa in Lagartero
5 out of 5 average rating, 73 reviews

Private Villa & Pool, in Lago Bay, Santa Catalina

A beautiful stand-alone 60 sq mt villa, 1 King bed and 1 queen. King size bed in the master bedroom with black out drapes, Queen size bed and fold out couch in the loft area. Full kitchen, living and dining area, flat screen TV, Bathroom with soaps/shampoos, and rainfall showerhead. Large terrace with views as far as the eye can see, with BBQ, dining table and outdoor sectional sofa. Private swimming pool with seating area, pool lounge chairs, lighted gazebo and sun umbrellas.

Top guest favorite
A spacious dining area features a large wooden table surrounded by chairs, with a well-equipped kitchenette visible in the background. Two hammocks are hung nearby, and large windows offer views of the greenery outside, enhancing the open-air concept.
Apartment in Santa Catalina
4.96 out of 5 average rating, 27 reviews

Eco-friendly apartment with treehouse feeling

Beautiful open-air 2BR/2BA apartment with large kitchen patio and wraparound terrace, located on the top floor of our cozy villa, tucked away in the treetops with a view of our tropical permaculture garden. This is a unique homestay, centrally located in Sta Catalina, walking distance from beaches, several surfspots, shops, restaurants and bars. Perfect for eco-minded and adventurous singles, couples, friends or families looking for a natural and authentic airbnb experience.

Guest favorite
A spacious outdoor deck features modern furniture arranged for relaxation, overlooking a lush mountainous landscape. Verdant hills and a colorful sky at dawn create a tranquil environment, inviting guests to enjoy the natural beauty and serenity of the surroundings.
Villa in El Copé
4.92 out of 5 average rating, 190 reviews

Mountain retreat

Our beautiful, modern, comfortable house is designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and also a base to explore the area which is in a beautiful part of Panama near a cloud forest national park with amazing hiking to waterfalls and local communities. The house is large, sleeping 12, within 17 acres of forest with rivers for swimming. We can arrange tours and hosted retreats for yoga, cooking and more.

Guest favorite
Home in Canto del Llano
4.9 out of 5 average rating, 42 reviews

Santiago city, home w/ spacious living & office

Spacious and peaceful home in a safe area of Santiago. 4 bedrooms (ideal for families and groups), bright living-dining area and large kitchen to share with family or friends, plus a private office for working comfortably. High-speed Wi-Fi, air conditioning and fans in all rooms, fully equipped kitchen, washer/dryer, and safe for valuables. Self check-in with smart lock, parking for several cars, and a coffee station with board games and karaoke.

Top guest favorite
A spacious living area is visible, adorned with natural light filtering through large glass doors that open to a lush outdoor setting. The seating arrangement includes a sofa and dining table surrounded by stylish chairs. A smart TV is mounted on the wall, complemented by decorative greenery.
Home in Santa Catalina
4.97 out of 5 average rating, 112 reviews

Casa Colibrí - modern house in the green

Casa Colibri is a beatiful, spacious home in the middle of nature and will make your stay in Santa Catalina perfect. It has a large terrace with a fantastic view into the green where you can relax and listen to the birds. The interior has a lot of natural light and stays cool during the day, in case you need to escape the tropical heat. It is the perfect place for a unique experience in this special town with your friends or family.

Guest favorite
A contemporary living space is highlighted, with natural light entering through large windows. An inviting sofa is paired with a wooden coffee table. The kitchenette, featuring modern appliances and a breakfast bar, is visible in the background, alongside a green door that adds a vibrant touch.
Bungalow in Santa Catalina
4.96 out of 5 average rating, 163 reviews

OCTOPUS studio

Disfruta de una experiencia con estilo en este alojamiento de encanto, ideal para pareja : acogedor, luminoso y actual . Ubicación fantastica en área privada y a unos paso del centro, playas y lugares de interés. Confortable para largas estadías y teletrabajo. Wifi gratuito, A/C. Kitchenette. Amplia terraza de madera rodeada de exuberante naturaleza, excelente para practicar Yoga y relajarse.

Guest favorite
Farm stay in Santa Fe
4.9 out of 5 average rating, 322 reviews

Sun Cabin at Finca Namuiki by the River

Spectacular contemporary style villa surrounded by local flowers and woods. The villas design enhances the relationship with the outside environment with panoramic windows which are found in the dining room and kitchen, this offers an awesome view of the mountains and green flora. The villa is located in a organic quiet farm, with abundant vegetation and great presence of birds.

Guest favorite
Cottage in Santa Fe
4.88 out of 5 average rating, 17 reviews

k* Casa Matilde | 2BR Santa Fe Retreat by River

Escape to Casa Matilde, a renovated 100 m² home in Santa Fe de Veraguas. With 2 bedrooms and 3 beds (1 queen & 2 twins), it’s perfect for families or remote workers. Enjoy a bright living room, modern bath with hot water, A/C, and fast Starlink Wi-Fi. Relax by the private creek, explore the river just 200 m away, and take in mountain views—all with total privacy and comfort.

Top guest favorite
Bungalow in Sona
5 out of 5 average rating, 16 reviews

Nukumi Club-Only Adults Stay-Santa Catalina (3)

Nukumi Club est un boutique eco-retreat adults-only (+18) situé à Santa Catalina, Panama. Le lieu se compose de six casitas privées de luxe, nichées dans un jardin tropical avec piscine partagée, à seulement 200 m du célèbre surf break de La Punta. Un sanctuaire balnéaire au luxe discret, pensé pour une expérience de calme, de nature et de beach life raffinée.

Popular amenities for La Mesa District vacation rentals