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Vacation rentals in La Mesa District

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Top-rated vacation rentals in La Mesa District

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
A view of the tranquil beachfront area reveals two boats anchored near the shore. The lush green jungle surrounds a rustic property featuring a cozy outdoor seating area under a canopy of palm trees. The calm waters reflect the greenery, creating a serene atmosphere.
Cabin in Sona
4.92 out of 5 average rating, 12 reviews

Beachfront Family EcoParadise to Coiba lsl BunkBed

Experience authentic Panama in our family-owned 30-hectare private tropical beachfront paradise. Accessible only by boat (30-min ride from Pixvae or 1:30hr from Santa Catalina). Gateway to Coiba Island, our remote bay offers pristine jungle, diverse wildlife, and breathtaking views. Enjoy kayaking, fishing, and guided eco-tours. Spot howler monkeys, sloths, and rare birds. Savor fresh tropical fruits and local cuisine. Perfect for nature lovers, photographers, and digital nomads (WiFi available)

Superhost
A scenic view of rolling hills under a colorful sky at sunset. Shades of orange, pink, and purple blend, creating a vibrant horizon. Lush trees are scattered across the landscape, adding a touch of greenery to the terrain.
Cottage in Olá
4.85 out of 5 average rating, 26 reviews

Casa de Campo en Olá, ríos, cascadas, Los Picachos

Finca La Terapia hace honor a su nombre, se encuentra entre las montañas del pintoresco pueblo de Olá de Penonomé, en la cual podrás desconectarte del ajetreado día a día de la ciudad. Cuenta con 42 Hectáreas privadas para explorar la naturaleza. El distrito de Olá, se caracteriza por tener lo mas hermosos paisajes Naturales entre los que podemos mencionar, Los Chorros de Olá, Chorros las Mesitas, Cerros los Picachos, Rio San Antonio, Balneario Brujas, entre otros a muy poco minutos de la Finca.

Superhost
Home in Santiago
4.82 out of 5 average rating, 22 reviews

Casa a minutos de Santiago, U Latina, HospChichoF.

Casa amplia, cómoda y totalmente equipada en una ubicación estratégica de Santiago.Perfecta para todo tipo de huéspedes: familias, viajeros de trabajo, estudiantes, personas que vienen a citas médicas o quienes buscan un espacio tranquilo y accesible. La casa está ubicada muy cerca del Hospital Dr. Chicho Fábrega, Clínica Norte, U.Latina, Oxford School, Comercios Supermercados, farmacia, ,restaurantes, y minutos de Santiago centro. Un lugar seguro para estadías cortas y de larga estancia.

Guest favorite
Home in Lagartero
4.9 out of 5 average rating, 20 reviews

Sunrise -Beach Front- king size, tour Coiba Island

Sunrise is a premiere beach house at Lago Bay. Nestled in a garden setting between the beach and lake with walking trails, the Sunrise experience is filled with nature. With a King-sized mahogany bed and spacious living area, it is very comfortable to unwind after Coiba. The kitchen and bathroom are fully equipped with granite counter tops. Sunrise also has a practical work station with Starlink internet. The screen-in porch is great for listening to the ocean or watching the stars.

Top guest favorite
An outdoor terrace is furnished with a sectional sofa in neutral tones and a low coffee table. A potted plant with green leaves and colorful flowers adds a vibrant touch. Large glass doors provide a view into the interior space, inviting natural light.
Villa in Lagartero
5 out of 5 average rating, 63 reviews

Private Villa & Pool, in Lago Bay, Santa Catalina

A beautiful stand-alone 60 sq mt villa, 1 King bed and 1 queen. King size bed in the master bedroom with black out drapes, Queen size bed and fold out couch in the loft area. Full kitchen, living and dining area, flat screen TV, Bathroom with soaps/shampoos, and rainfall showerhead. Large terrace with views as far as the eye can see, with BBQ, dining table and outdoor sectional sofa. Private swimming pool with seating area, pool lounge chairs, lighted gazebo and sun umbrellas.

Guest favorite
Home in Canto del Llano
4.9 out of 5 average rating, 21 reviews

Peaceful home w/ spacious living & office area

Spacious and peaceful home in a safe area of Santiago. 4 bedrooms (ideal for families and groups), bright living-dining area and large kitchen to share with family or friends, plus a private office for working comfortably. High-speed Wi-Fi, air conditioning and fans in all rooms, fully equipped kitchen, washer/dryer, and safe for valuables. Self check-in with smart lock, parking for several cars, and a coffee station with board games and karaoke.

Superhost
An inviting swimming pool is framed by natural stone, surrounded by lush greenery and flowering plants. The expansive view reveals a tranquil body of water and rolling hills under a clear blue sky, creating a serene outdoor setting.
Villa in Quebrada de Piedra
4.92 out of 5 average rating, 13 reviews

Amazing Cozy Villa Overlooking the Pacific Ocean

Disfruta de nuestra espectacular Villa, rodeada de tranquilidad con un hermoso paisaje, conectada con la naturaleza y perfecta para desconectar de la vida cotidiana; un lugar encantador para compartir con tu familia o amigos. Cuenta con todas las amenidades necesarias para que su estadía sea inolvidable y una piscina exclusiva para disfrutar de la hermosa vista al Océano Pacífico.

Guest favorite
Farm stay in Santa Fe
4.9 out of 5 average rating, 311 reviews

Cabaña del Sol en Finca Namuiki by the River

Spectacular contemporary style villa surrounded by local flowers and woods. The villas design enhances the relationship with the outside environment with panoramic windows which are found in the dining room and kitchen, this offers an awesome view of the mountains and green flora. The villa is located in a organic quiet farm, with abundant vegetation and great presence of birds.

Guest favorite
Cottage in Santa Fe
4.88 out of 5 average rating, 8 reviews

k* Casa Matilde | 2BR Santa Fe Retreat by River

Escape to Casa Matilde, a renovated 100 m² home in Santa Fe de Veraguas. With 2 bedrooms and 3 beds (1 queen & 2 twins), it’s perfect for families or remote workers. Enjoy a bright living room, modern bath with hot water, A/C, and fast Starlink Wi-Fi. Relax by the private creek, explore the river just 200 m away, and take in mountain views—all with total privacy and comfort.

A cozy sleeping area features a spacious bed, surrounded by natural wooden walls made from woven materials. A wooden dresser holds neatly arranged towels, with soft lighting creating a serene ambiance. A textured area rug complements the wooden floor.
Cabin in Santa Fe
4.74 out of 5 average rating, 61 reviews

Cabane vue sur la riviere

Détendez-vous dans ce logement unique et tranquille. Goutez l'experience unique de la nature dans votre chambre et salon : -) Cabane confortable. (glamping). Acces a la riviere. Vue panoramique. tres calme, tres zen. Massages et osteophathie sur demande.

Guest favorite
A contemporary cabana is nestled among lush greenery, showcasing a unique stone accent wall. Large windows offer expansive views of the natural surroundings, complemented by a covered terrace that invites outdoor relaxation.
Home in Las Trancas
4.92 out of 5 average rating, 26 reviews

Cabana Vergara Santa Fe

Kick back and relax on this 2 acre ( 1 hectare) private mountain side property, on the Santa Maria River. Equipped with all the amenities you will need to make your stay a home away from home!

A modern one-story home with a flat roof features large windows framed by wooden slats. A well-manicured lawn surrounds the entrance, while a concrete pathway leads to the front door. The exterior is painted in neutral tones, contributing to its contemporary design.
Home in Santiago
4.78 out of 5 average rating, 112 reviews

Casa de 3BD, 2BTHS, amoblada

Casa de 3 recámaras, 2 baños, céntrica, amoblada, garita de seguridad, cocina, lavadora Automática, A/A, Wi-fi, TV cable, construcción nueva en bonito residencial.

Popular amenities for La Mesa District vacation rentals