
Vacation rentals in La Mesa District
Find and book unique accommodations on Airbnb
Top-rated vacation rentals in La Mesa District
Guests agree: these stays are highly rated for location, cleanliness, and more.

Beachfront Family EcoParadise to Coiba lsl BunkBed
Experience authentic Panama in our family-owned 30-hectare private tropical beachfront paradise. Accessible only by boat (30-min ride from Pixvae or 1:30hr from Santa Catalina). Gateway to Coiba Island, our remote bay offers pristine jungle, diverse wildlife, and breathtaking views. Enjoy kayaking, fishing, and guided eco-tours. Spot howler monkeys, sloths, and rare birds. Savor fresh tropical fruits and local cuisine. Perfect for nature lovers, photographers, and digital nomads (WiFi available)

Casa de Campo en Olá, ríos, cascadas, Los Picachos
Finca La Terapia hace honor a su nombre, se encuentra entre las montañas del pintoresco pueblo de Olá de Penonomé, en la cual podrás desconectarte del ajetreado día a día de la ciudad. Cuenta con 42 Hectáreas privadas para explorar la naturaleza. El distrito de Olá, se caracteriza por tener lo mas hermosos paisajes Naturales entre los que podemos mencionar, Los Chorros de Olá, Chorros las Mesitas, Cerros los Picachos, Rio San Antonio, Balneario Brujas, entre otros a muy poco minutos de la Finca.

Casa a minutos de Santiago, U Latina, HospChichoF.
Casa amplia, cómoda y totalmente equipada en una ubicación estratégica de Santiago.Perfecta para todo tipo de huéspedes: familias, viajeros de trabajo, estudiantes, personas que vienen a citas médicas o quienes buscan un espacio tranquilo y accesible. La casa está ubicada muy cerca del Hospital Dr. Chicho Fábrega, Clínica Norte, U.Latina, Oxford School, Comercios Supermercados, farmacia, ,restaurantes, y minutos de Santiago centro. Un lugar seguro para estadías cortas y de larga estancia.

Sunrise -Beach Front- king size, tour Coiba Island
Sunrise is a premiere beach house at Lago Bay. Nestled in a garden setting between the beach and lake with walking trails, the Sunrise experience is filled with nature. With a King-sized mahogany bed and spacious living area, it is very comfortable to unwind after Coiba. The kitchen and bathroom are fully equipped with granite counter tops. Sunrise also has a practical work station with Starlink internet. The screen-in porch is great for listening to the ocean or watching the stars.

Private Villa & Pool, in Lago Bay, Santa Catalina
A beautiful stand-alone 60 sq mt villa, 1 King bed and 1 queen. King size bed in the master bedroom with black out drapes, Queen size bed and fold out couch in the loft area. Full kitchen, living and dining area, flat screen TV, Bathroom with soaps/shampoos, and rainfall showerhead. Large terrace with views as far as the eye can see, with BBQ, dining table and outdoor sectional sofa. Private swimming pool with seating area, pool lounge chairs, lighted gazebo and sun umbrellas.

Peaceful home w/ spacious living & office area
Spacious and peaceful home in a safe area of Santiago. 4 bedrooms (ideal for families and groups), bright living-dining area and large kitchen to share with family or friends, plus a private office for working comfortably. High-speed Wi-Fi, air conditioning and fans in all rooms, fully equipped kitchen, washer/dryer, and safe for valuables. Self check-in with smart lock, parking for several cars, and a coffee station with board games and karaoke.

Amazing Cozy Villa Overlooking the Pacific Ocean
Disfruta de nuestra espectacular Villa, rodeada de tranquilidad con un hermoso paisaje, conectada con la naturaleza y perfecta para desconectar de la vida cotidiana; un lugar encantador para compartir con tu familia o amigos. Cuenta con todas las amenidades necesarias para que su estadía sea inolvidable y una piscina exclusiva para disfrutar de la hermosa vista al Océano Pacífico.

Cabaña del Sol en Finca Namuiki by the River
Spectacular contemporary style villa surrounded by local flowers and woods. The villas design enhances the relationship with the outside environment with panoramic windows which are found in the dining room and kitchen, this offers an awesome view of the mountains and green flora. The villa is located in a organic quiet farm, with abundant vegetation and great presence of birds.

k* Casa Matilde | 2BR Santa Fe Retreat by River
Escape to Casa Matilde, a renovated 100 m² home in Santa Fe de Veraguas. With 2 bedrooms and 3 beds (1 queen & 2 twins), it’s perfect for families or remote workers. Enjoy a bright living room, modern bath with hot water, A/C, and fast Starlink Wi-Fi. Relax by the private creek, explore the river just 200 m away, and take in mountain views—all with total privacy and comfort.

Cabane vue sur la riviere
Détendez-vous dans ce logement unique et tranquille. Goutez l'experience unique de la nature dans votre chambre et salon : -) Cabane confortable. (glamping). Acces a la riviere. Vue panoramique. tres calme, tres zen. Massages et osteophathie sur demande.

Cabana Vergara Santa Fe
Kick back and relax on this 2 acre ( 1 hectare) private mountain side property, on the Santa Maria River. Equipped with all the amenities you will need to make your stay a home away from home!

Casa de 3BD, 2BTHS, amoblada
Casa de 3 recámaras, 2 baños, céntrica, amoblada, garita de seguridad, cocina, lavadora Automática, A/A, Wi-fi, TV cable, construcción nueva en bonito residencial.
Popular amenities for La Mesa District vacation rentals
Other great vacation rentals in La Mesa District

Charming 1-Bedroom Beachfront Hotel With Pool

BLUE FROG Santa Fe Home with a View

Acogedora Cabaña en el Copé

Cómodas habitaciones en Santiago

Award winning Inn with National Park Tours

La Pinea Lodge

Cuarto principal-San Miguel Clean House, Santiago.

Casa de campo, La Mismísima
Destinations to explore
- Panama City Vacation rentals
- San José Vacation rentals
- Playa Santa Teresa Vacation rentals
- Puerto Viejo de Talamanca Vacation rentals
- Jaco Vacation rentals
- Uvita Vacation rentals
- Boquete Vacation rentals
- Quepos Vacation rentals
- Playa Blanca Vacation rentals
- Valle de Antón Vacation rentals
- Ancón Vacation rentals
- Bahía Ballena Vacation rentals




