Apartment vacation rentals in Hannibal

Main Street Haven: King Suite

Welcome to our luxurious Main Street Haven, nestled in the heart of a picturesque small town only minutes away from Historic Hannibal (12min) and Quincy IL (18min). This charming ground level unit features a luxurious king size bed that will give you the restful sleep you deserve. The new bathroom is furnished with modern amenities, and the large living room provides ample space to relax and unwind. The full kitchen is perfect for preparing meals, and is equipped with everything you may need.

Lewis Street Cottage

Beautifully restored apartment in an historic home. Property features exposed brick walls, high ceilings with fans, and stylish decor. This charming apartment is a two bedroom, one bath single level unit that sleeps four comfortably and is located across the street from the city park and within walking distance to the Mississippi Riverwalk, restaurants, bars and shops in downtown Canton. Canton is home to Culver-Stockton College and is conveniently located near Quincy, IL and Hannibal, MO.

Bear Creek Hideaway

Beer Creek Hideaway is a three minute drive or 10 minute walk to downtown Historic Hannibal including unique shopping & eateries, and access to the Mighty Mississippi River. Walk, hike, or bike along Bear Creek to Sodalis Park Trailhead . Brand new unit with double security door access from the street (no steps), open concept including full kitchen with center island, Queen bed, and full bathroom with walk in shower. Washer & dryer included. Complete seperation from other (apartment) units.

Burton’s Hideaway

This relaxing getaway is welcoming to individuals and families. You can golf into the lake, feed the fish, just sit and relax listening to the fountain or play games inside. This walkout basement has a patio for you to enjoy. The kitchen is loaded with many amenities for those who want to cook or bake. Warm and welcoming place to stay! Disclosure- This is a commercial space. Very rarely are people there after 5:00 on weekdays or weekends. You'll have your own parking and private entry.

Main Street Suite w River & Main St Views!

Located in the heart of Historic Downtown Hannibal. Bring back the nostalgia or start memories of your own by staying in this charming antique building, built in 1879. Newly renovated suite allows for modern amenities while still enjoying the Hallmark charm of the Main street and the birthplace of Mark Twain. Short walks to the Big Muddy Mississippi River, Lighthouse, Riverboat, shopping and restaurants. Take a short drive to the caves for the full Tom Sawyer experience.

Eaton's Airbnb D

Enjoy a warm, pristine, and inviting atmosphere at our Airbnb, ideally situated in the heart of Quincy, IL. Located in a safe, family-friendly neighborhood, our Airbnb is operated by a local family and is just a four-block stroll from QU Stadium, with Quincy University also within close proximity. Blessing Hospital is a brief 5-minute drive away. Take advantage of our convenient off-street parking, featuring a dedicated spot for your vehicle. Let us host you!

Farmhouse

Enjoy nostalgic downtown Hannibal in this unique apartment located on Main Street just steps from a movie theater, restaurants and bars, shopping, museums, the riverfront, and Mark Twain historic sites. With a private bedroom with flat screen television, living area with sleeper sofa and daybed, and a full kitchen the interior of this rental is sure to charm any visitor. Book for a weekend, a week, or longer.

Updated Ground Level West Facing 1-bed w/ Wi-Fi

Completely remodeled in 2025. Spacious 1 bed 1 bath ground level apartment with large rooms and covered patio. Eat-in kitchen. Two separate entrances. Less than two miles to Blessing/Downtown. Fiber Wi-Fi. Central heat and A/C. In unit washer/dryer. No dishwasher. Off street parking. No pets. No smoking or vaping inside the unit. Owner is an IL and MO real estate agent.

Location! 2 Bedroom Apt w/ private parking & Wi-Fi

Centrally located in Quincy Illinois just 1 block to Blessing Hospital, 4 blocks to Quincy University and super close to Quincy Medical Center. This private 2 bedroom apartment will be a great fit for students, traveling medical professionals, visiting university families or just folks looking for a get a way. Equipped with 55" Smart TV and High Speed Fiber Internet.