House vacation rentals in Florence

Find and book unique houses on Airbnb

Top-rated house rentals in Florence

Guests agree: these houses are highly rated for location, cleanliness, and more.

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The charming facade of Kuker Cottage is framed by lush greenery and trees, featuring a covered porch with colorful seating. Large windows are positioned symmetrically, and the brick columns add character to the entrance, inviting guests to relax in a tranquil outdoor space.
Home in Florence
4.87 out of 5 average rating, 539 reviews

Kuker Cottage Downtown Florence-Near I95 & I20

Kuker Cottage is a beautifully restored Florence home in the heart of downtown. Perfectly situated halfway between New York and Florida, it is an ideal overnight stopping point. Plenty of space to spread out, offering families room to unwind after a long day of traveling. This home has been beautifully updated and is ready to host you, whether for a short or an extended stay. 2 queen beds, one twin bed, full bath, kitchen, wifi and TV. Walkable to parks and restaurants. 4 miles from I95 and I20

Top guest favorite
A comfortable living area features a dark gray sofa complemented by two accent pillows. A coffee table is positioned in front of the seating, and two standing lamps provide soft lighting. A simple wall art above the sofa adds a touch of elegance to the space.
Home in Florence
4.98 out of 5 average rating, 113 reviews

Renovated 2 BR/2 B Townhouse Cozy & Clean

Keep it simple at this peaceful, centrally-located, and renovated townhouse close by I-95 and I-20 and within 15 mins. to the Florence Center, downtown Florence, many restaurants, and McLeod and MUSC Florence. House is located in a safe neighborhood with 2 queen beds and 1 sofa bed in the living room. Enjoy being outdoors? Relax outdoors on your own private patio, go on a walk around the neighborhood, or go on an adventure. The Rail Trail & Ebenezer Park are minutes away. Utilities included.

Guest favorite
Home in Kingstree
4.94 out of 5 average rating, 123 reviews

magical 1840s farm house getaway

Centuries old country estate with magical ambiance, art and antiques, beautiful views and wrap around porches. Relax in the hot tub in your own private oasis or gather with friends and family around the fire pit. Multiple bird feeders and grand live oaks, magnolias, fruit trees and a kitchen garden. Chefs kitchen will be stocked with fresh eggs, herbs and seasonal veggies. Sit and sip on the porch while enjoying the views of farmer's field and listing to the moos of the cows. Groups welcome!

Top guest favorite
An aerial view of a home situated on a peninsula, surrounded by water and lush greenery. The property features a well-maintained lawn, with trees providing shade. A dock is visible, along with a boat ramp and areas for seating, creating a serene lakeside atmosphere.
Home in Camden
4.98 out of 5 average rating, 129 reviews

Wateree Sunsets, dock, family fun, w/ king bed!

Welcome to On The Rocks @ Lake Wateree, SC. Come and enjoy the best that South Carolina has to offer right here at the lake. This home is set out on its own peninsula with two coves. Perfect for boating, fishing, kayaking, and relaxing while watching the best sunsets by the fire pit. We offer so much with your stay, you will not want to leave. This is the perfect get away from the hustle and bustle of that nine to five life. We are minutes away from boat ramps, restaurants, and grocery stores.

Top guest favorite
A single-story home is shown with a welcoming front porch and bright red door. The exterior is accented by black shutters and a white facade, surrounded by a grassy lawn with small trees. A clear blue sky with soft clouds is visible in the background.
Home in Hartsville
4.99 out of 5 average rating, 140 reviews

Manchester Place

Hartsville is a Charming Town with plenty of family activities, shops, and dining. Home is located in the quiet Fox Hollow subdivision which is just outside the city limits but still close to downtown. Robinson Nuclear Plant 10 min. Sonoco 7 min. Coker University 7 min. Downtown Hartsville 7 min. Carolina Pines Hospital 9 min. McLeod Hospital Florence 42 min. Byerly Park 9 min. Hartsville Center Theater 6 min. Governor's School for Science and Mathematics 9 min. Darlington Raceway 22 min.

Top guest favorite
A spacious living area features a ceiling fan and multiple windows allowing natural light. Comfortable seating options include an armchair and a loveseat. A coffee table is centered on a wooden floor, and a television is mounted above a brick fireplace.
Home in Sumter
4.95 out of 5 average rating, 110 reviews

Charming 3 bedroom bungalow

You’ll be close to everything when you stay at this centrally-located bungalow. You’re a 1 minute walk from beautiful Swan Lake Iris Gardens. Drive to downtown Sumter in 4 mins & Shaw AFB in 15 mins. Enjoy the cozy porch or outdoor fire pit with seating & basketball goal. There's a fenced yard for kids/pets. 3 bedrooms/1 bath; extra room with loveseat, TV, games/books/toys. Spacious kitchen & laundry room for your convenience. Enjoy free Wifi & Smart TVs. I am a licensed real estate agent.

Top guest favorite
A bright living area features a cozy seating arrangement with two plush armchairs and a sectional sofa. A modern coffee table sits in the center, while a large wall-mounted television is positioned above an elegant fireplace. Natural light filters through large windows adorned with light curtains.
Home in Rembert
4.98 out of 5 average rating, 225 reviews

New Home! Only 15 min to Shaw/Sumter. Dog friendly

Built in March 2022 single story home is full of amenities. High speed internet Upgraded cable 15 min to Shaw AFB Conveniently located between Sumter & Camden Premium mattresses Hotel like stay Backyard w/deck Iron/ironing board Vanity table 55 and 65 inch tv's Home office bedroom combo/printer, desk/ monitor and futon (can sleep 2 kids or 1 adult). Laundry room New appliances Kitchen is full of amenities Outdoor lighting Pet friendly! Dog toys, treats, indoor kennel Fenced in dog run

Top guest favorite
A bright living area features a light-colored sectional sofa arranged around a circular coffee table. Natural light enters through the windows, enhancing the warm ambiance. A simple desk with a chair is positioned nearby, complementing the overall spaciousness of the room.
Home in Florence
4.94 out of 5 average rating, 101 reviews

Charming Home in Florence, SC

Welcome to Florence, South Carolina! This inviting 3-bedroom, 2-bathroom home is a haven of comfort and convenience. With four queen beds, it comfortably accommodates a group of friends or family. Step into the fully stocked kitchen, relax in the cozy living space, equipped with smart TVs for entertainment. The fenced backyard offers both privacy and a secure play area for your furry friends. Enjoy outdoor gatherings at the picnic table. Convenient amenities include a washer and dryer.

Top guest favorite
A charming blue house showcases a welcoming front porch with white railings. Lush greenery surrounds the home, enhancing its inviting facade. The yellow door adds a pop of color, while well-maintained landscaping provides a pleasant entrance.
Home in Sumter
4.97 out of 5 average rating, 140 reviews

The Parkside Retreat

Welcome to our beautiful Airbnb! Located next to a serene and picturesque park, our home is perfect for families or groups looking for a comfortable stay. With two king master suites and a cozy kids room, we can accommodate up to 6 guests, making it an ideal choice for a family or a group getaway. Each master suite features a comfortable king-sized bed, plush linens, and ample storage space providing a tranquil retreat after a day of exploring the local attractions. Book your stay today!

Guest favorite
A stand-alone apartment building is shown, featuring a low brick exterior and a gabled roof. There are several windows framed with white shutters, allowing natural light to enter. The well-maintained lawn is bordered by neatly trimmed bushes, complementing the overall tidy appearance.
Home in Lake City
4.93 out of 5 average rating, 265 reviews

Home Away From Home Apt 3 - A Hidden Gem

Stand Alone (not a part of the main house) 1 Bed-Room Apt. with Full furnished Kitchen, Full Bath, Private Entrance, private bedroom with door, Private Parking. Living Room- Dining Combo. Fully Furnished. High-Speed WI-Fi, 2 ROKU TVs, 1 in BR & 1 in LR, 1/2 way from New York to Miami, Hablamos Espanol, Fresh Brewed In-Room Coffee. Easy 1-mile walk on Main St. to uptown. 23 miles from I-95, 60 miles to Myrtle Beach, 23 miles to Florence, 1&1/2 hours to Charleston and Columbia.

Guest favorite
The kitchen features modern appliances, including a stainless steel refrigerator and an electric stove. Natural light fills the space through multiple windows. A wooden dining table is visible, accompanied by a set of chairs. A doorway leads to the outside.
Home in Hartsville
4.84 out of 5 average rating, 135 reviews

Quaint 2BR home w access to Black Creek & downtown

Our freshly renovated home sits in a family-oriented neighborhood only a mile from downtown Hartsville and Kalmia Gardens and includes access to Black Creek. This 600 sf home features 2 bedrooms, 1 bath, a full kitchen, washer and dryer and an open living area. Digital antenna reception for smart-tv and high speed wi-fi internet. Small dogs will be considered for stays on a case-by-case basis. Pet stays require prior approval from the hosts and will involve additional fees.

Guest favorite
A charming bungalow exterior is displayed, featuring a light-colored wooden facade with dark shuttered windows. A small porch with a railing is visible at the front, surrounded by neatly trimmed landscaping and a grassy area leading to the street.
Home in Darlington
4.82 out of 5 average rating, 135 reviews

Located 100 feet from The Darlington Raceway!

This cute little bungalow is located across the street from The Darlington Raceway. Just a few steps puts you at the door of the famous Joe Weatherly Stock Car Museum. We are also within walking distance to Manheim Auto Auction. The Raceway Grill, a favorite of Dale Earnhardt, is located across the street ! If you are here during the week, South of Pearl, Darlington's finest eating establishment, is located in uptown Darlington. WE DO NOT HAVE A STOVE OR WASHER/DRYER

Popular amenities for Florence house rentals

When is the best time to visit Florence?

MonthJanFebMarAprMayJunJulAugSepOctNovDec
Avg. priceG$25,098 GYDG$24,889 GYDG$24,262 GYDG$24,053 GYDG$25,726 GYDG$24,053 GYDG$24,053 GYDG$23,007 GYDG$24,053 GYDG$20,915 GYDG$23,634 GYDG$23,216 GYD
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Quick stats about house rentals in Florence

  • Total vacation rentals

    Explore 80 vacation rentals in Florence

  • Nightly prices starting at

    Florence vacation rentals start at G$8,366 GYD per night before taxes and fees

  • Verified guest reviews

    Over 2,080 verified reviews to help you choose

  • Family-friendly vacation rentals

    60 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 30 rentals that welcome pets

  • Rentals with dedicated workspaces

    50 properties have a dedicated workspace

  • Wi-Fi availability

    70 of Florence vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Florence rentals

  • 4.9 Average rating

    Florence stays are highly rated by guests—averaging 4.9 out of 5!