
House vacation rentals in Florence
Find and book unique houses on Airbnb
Quick stats about house rentals in Florence

Total vacation rentals
Explore 80 vacation rentals in Florence

Nightly prices starting at
Florence vacation rentals start at G$6,276 GYD per night before taxes and fees

Verified guest reviews
Over 2,450 verified reviews to help you choose

Family-friendly vacation rentals
60 properties offer extra space & kid-friendly amenities

Pet-friendly vacation rentals
Find 30 rentals that welcome pets

Rentals with dedicated workspaces
50 properties have a dedicated workspace

Wi-Fi availability
80 of Florence vacation rentals include wi-fi access

Popular amenities for guests
Guests love Kitchen, Wifi, and Pool across Florence rentals

4.9 Average rating
Florence stays are highly rated by guests—averaging 4.9 out of 5!
Top-rated house rentals in Florence
Guests agree: these houses are highly rated for location, cleanliness, and more.

Kuker Cottage Downtown Florence-Near I95 & I20
Kuker Cottage is a beautifully restored Florence home in the heart of downtown. Perfectly situated halfway between New York and Florida, it is an ideal overnight stopping point. Plenty of space to spread out, offering families room to unwind after a long day of traveling. This home has been beautifully updated and is ready to host you, whether for a short or an extended stay. 2 queen beds, one twin bed, full bath, kitchen, wifi and TV. Walkable to parks and restaurants. 4 miles from I95 and I20

Renovated 2 BR/2 B Townhouse Cozy & Clean
Keep it simple at this peaceful, centrally-located, and renovated townhouse close by I-95 and I-20 and within 15 mins. to the Florence Center, downtown Florence, many restaurants, and McLeod and MUSC Florence. House is located in a safe neighborhood with 2 queen beds and 1 sofa bed in the living room. Enjoy being outdoors? Relax outdoors on your own private patio, go on a walk around the neighborhood, or go on an adventure. The Rail Trail & Ebenezer Park are minutes away. Utilities included.

magical 1840s farm house getaway
Centuries old country estate with magical ambiance, art and antiques, beautiful views and wrap around porches. Relax in the hot tub in your own private oasis or gather with friends and family around the fire pit. Multiple bird feeders and grand live oaks, magnolias, fruit trees and a kitchen garden. Chefs kitchen will be stocked with fresh eggs, herbs and seasonal veggies. Sit and sip on the porch while enjoying the views of farmer's field and listing to the moos of the cows. Groups welcome!

Unique New Remodel Close to Beach and Golf
Fully remodeled, the little cabin on the marsh is a 1 BR house with a loft. Inside is almost all wood. The house sits on the marsh water of the Waccamaw river. The neighborhood is a dirt road with a mix of mobile homes and houses. The neighbors are great and have lived on the street for decades. The house is surrounded by live oaks, nature and tidal marsh water in the backyard. Litchfield and Pawleys Island beaches are 5 minutes away. World class golf, restaurants, and grocery stores are near.

Lakefront Retreat Nature Escape
Welcome to the Little Blue Heron! Relax and restore, or get your creative juices flowing at this nature sanctuary. Lake front cottage at Lake Waccamaw with canal views in the back. Great for wading, boating, or swimming in the summer and bird watching and soaking up the peaceful views in the winter. Watch the sun rise over the lake from the King bed in the master bedroom! Perfect for artists, those looking to reflect or re-connect, or short getaways. Up to 2 dogs allowed, woof! ($50 fee)

Manchester Place
Hartsville is a Charming Town with plenty of family activities, shops, and dining. Home is located in the quiet Fox Hollow subdivision which is just outside the city limits but still close to downtown. Robinson Nuclear Plant 10 min. Sonoco 7 min. Coker University 7 min. Downtown Hartsville 7 min. Carolina Pines Hospital 9 min. McLeod Hospital Florence 42 min. Byerly Park 9 min. Hartsville Center Theater 6 min. Governor's School for Science and Mathematics 9 min. Darlington Raceway 22 min.

Charming Home in Florence, SC
Welcome to Florence, South Carolina! This inviting 3-bedroom, 2-bathroom home is a haven of comfort and convenience. With four queen beds, it comfortably accommodates a group of friends or family. Step into the fully stocked kitchen, relax in the cozy living space, equipped with smart TVs for entertainment. The fenced backyard offers both privacy and a secure play area for your furry friends. Enjoy outdoor gatherings at the picnic table. Convenient amenities include a washer and dryer.

The Parkside Retreat
Welcome to our beautiful Airbnb! Located next to a serene and picturesque park, our home is perfect for families or groups looking for a comfortable stay. With two king master suites and a cozy kids room, we can accommodate up to 6 guests, making it an ideal choice for a family or a group getaway. Each master suite features a comfortable king-sized bed, plush linens, and ample storage space providing a tranquil retreat after a day of exploring the local attractions. Book your stay today!

3 bd, 2ba, near ShawAFB, Game Rm
Welcome to our newly renovated 3 Bed, 2 Bath, home in Sumter. Our modern decor home has the following: - Master bdrm with King bed/ ensuite bath - Queen beds other rooms - Full equipped kitchen, coffee station - 65", 55", 43" TVs in rooms - Game Room, w/ pool table, table tennis, arcade games - Work area, wifi, 32" monitor, printer, adj height desk - Private backyard, BBQ grill ,gazebo, fire table, games. - Centrally located near Shaw AFB, Tuomey Hospital, food, parks and more

No Cleaning Fee 5 Min. to I95, 2QB 2BA
Home Halfway between Florida and New York, minutes from I-95 No Pets No Pets/ No Exception No Smoking in the Home No Pets/ No Exception Free Parking please park under Carport Do not drive in Back Yard Master Bedroom 1 Open closet, 32" TV with Roku, Bathroom with Standard Tub/Shower, his and hers vanity, Queen Size Bed and Linens Guest Room Queen Size Bed and Linens, 32" TV with Roku, 1 Closet, Living Room 50" Roku TV, Sofa, and Recliner Stocked Kitchen and Laundry Fast Wi-Fi

Big Water Sunset at Lake it Easy
Escape to Beautiful Lake Wateree for a relaxing weekend away with friends or family. This updated house features 2 bedrooms & 2 bathrooms. Enjoy the cozy vibes of a tastefully decorated space, perfect for unwinding after a day on the lake. Step outside to a serene screened in porch, a fire pit, and stunning big water sunsets that will take your breath away. Whether you're into fishing, kayaking, or simply relaxing by the water, this lakefront house has something for everyone!

Pet-Friendly Lake Marion Getaway - Just off I-95!
In the quaint lakefront town of Santee, There exists a special place. Past Main street and down a country road, nestled in a modest lakefront community, with views of the majestic Lake Marion, we've worked tirelessly to create the perfect family retreat. No matter who you call family, this home is perfect for boaters, golfers, and nature enthusiasts. Guests at the Kindred Spirits Retreat experience more than just a beautiful home, they experience the joys of purposeful travel.
Popular amenities for Florence house rentals
House rentals with a pool

Beach House with indoor pool!

Luxury Lakefront Chalet W/Pool, Hot Tub & Beach

Southern Comfort

Ocean Lakes Getaway | Golf Cart & Beach Access

Oceanfront Oasis: Private Pool, direct beach accss

Pear Tree Farm-pets welcome! Stables/paddocks too!

Berkeley - Private In-Ground Pool, Beach Pass Incl

Pawleys - Prvt Pool Hot Tub Fenced Dogs OK 5 BR
Weekly house rentals

Home on Broad

Farm Cottage in Laurinburg

Spacious, Historic Home for 12 - Near Myrtle Beach

Private Country Escape

Huddle House Farm

Cozy Retreat in Florence, SC

Florence 3Br Ranch

The Club House
Private house rentals

Tie One On! at 4 Bdr Waterfront Lake Marion

River House at Fork Retch

The Happy Sac

Cozy 3-Bedroom Retreat Florence

Lovely Cottage Close to Downtown w/EV chargers

WOW! The Purple Heart Cottage Whole House, Main St

Cozy 3 Bedroom Home! Located NEAR MUSC-Florence

* NEW * Cozy and Clean 3B/2Bath
When is the best time to visit Florence?
| Month | Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sep | Oct | Nov | Dec |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Avg. price | G$25,102 GYD | G$24,893 GYD | G$24,265 GYD | G$24,056 GYD | G$25,730 GYD | G$24,056 GYD | G$24,056 GYD | G$23,010 GYD | G$24,056 GYD | G$23,010 GYD | G$23,220 GYD | G$24,056 GYD |
| Avg. temp | 9°C | 11°C | 14°C | 18°C | 22°C | 25°C | 27°C | 26°C | 24°C | 19°C | 14°C | 11°C |
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- Pet-friendly rentals Florence
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- Rentals with pools Florence
- Family-friendly rentals Florence
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- Rentals with a patio Florence
- Apartment rentals Florence
- Rentals with a washer and dryer Florence
- Rentals with a fireplace Florence
- House rentals South Carolina
- House rentals United States




