Guesthouse vacation rentals in Colleton County

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in Colleton County

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

0 of 0 items showing

1 of 3 pages

Guest favorite

Guesthouse in Beaufort

4.96 out of 5 average rating, 210 reviews

Sunset River House

Our quaint little River House rests on the beautifully natural marsh grass banks of the Whale Branch River in a quiet rural neighborhood. It is located only 9 miles from Historic Downtown Beaufort and 15 miles from Parris Island Marine Corps Recruit Depot. Hunting Island State Park's sandy beaches, nature tails, and lighthouse tours are a scenic 40 minute drive away. You can swim, fish, kayak or go boating right from the dock in our own back yard. When you arrive; you won't want to leave!

Sep 25 – Oct 2

G$22,149 GYD per night

Guest favorite

Guesthouse in Ridgeville

4.82 out of 5 average rating, 213 reviews

Pond House Bungalow at Natural Gathering Grounds

Gathering Ground's Pond House bungalow sits on the edge of a pond surrounding three sides of the house for peaceful privacy. The Grounds offer 54 acres of hiking trails, fishing ponds, farm animals & Edisto river access with privatebeach. This is a great spot to unplug, enjoy nature, and cook outside with a provided propane camping stove! Guests are free to use our bathhouse with showers. If you are looking for a relaxing spot just outside of Historic Charleston, you have found your spot :)

Sep 3 – 10

G$22,896 GYD per night

Guest favorite

Guesthouse in Beaufort

4.96 out of 5 average rating, 200 reviews

Spacious Carriage House with Pool & King Bed

Forget your worries in this serene space. Located on 5-acres of secluded wooded land with extensive gardens. This quiet space is on the second floor above a detached garage. The spacious area has just been refurbished: includes a kitchenette and bathroom. Private entry through gated courtyard. Central HVAC; new King bed and TV; Private pool exclusively for guests. LGBTQ welcome. Driving times: 25 min. to Hunting Is. St. Park and Parris Island; 15 min. to historic downtown Beaufort.

Aug 11 – 18

G$27,284 GYD per night

Guest favorite

Guesthouse in Beaufort

4.94 out of 5 average rating, 396 reviews

Meridian Rd. Guest House Walk to Restaurants/Parks

1 Bedroom Guest House. GREAT location. 15 minute walk over bridge to downtown. Bedroom has queen bed, living room has full size futon. Small Fridge, Microwave & Toaster in kitchen (No Stove/Oven). Quick walk to Fishing dock and Dockside restaurant PLEASE! put the correct amount of people. It’s a maximum of 3 people. There is an additional fee for a third person. There is parking for 1 vehicle. If additional parking is needed please inquire as to availability prior to booking. Thanks!

Mar 25 – Apr 1

G$21,688 GYD per night

Superhost

Guesthouse in Beaufort

4.64 out of 5 average rating, 22 reviews

Cozy Pet Friendly 1/1 Guest House + Shared Yard

Welcome to our cozy, pet-friendly 1-bed, 1-bath guesthouse with a private entrance, ideal for solo travelers or budget-conscious couples. This simple yet comfortable space features a queen bed, bathroom with a stand-up shower, and convenient amenities including a mini-fridge, Keurig coffee maker, and microwave. Recently, we've added a bistro table and chairs set for your dining or planning needs. Shared spaces include the driveway, laundry room, and backyard. Only 10 mins to Parris Island.

Aug 24 – 31

G$22,809 GYD per night

Guest favorite

Guesthouse in Beaufort

4.98 out of 5 average rating, 203 reviews

Buddy's Cottage near everything in Beaufort, SC

Who is Buddy? He was our black Labrador of 12 years. You'll see his photo as you enter. This brand new guest cottage has a private bedroom, 1 full bathroom, a sleeper sofa , 2 TV's, a full kitchen and all the amenities of home. Downtown Beaufort is 2 miles away, Parris Island is less than 5 miles away. In a quiet neighborhood. Are coming for a fishing trip and bringing your boat? Come stay with us , we have room for your boat. You can flush your engine and rinse your boat down.

Sep 19 – 26

G$27,023 GYD per night

Guest favorite

Guesthouse in Saint George

4.96 out of 5 average rating, 55 reviews

Simmons Sweet Suite

Welcome to your home away from home! Whether it is for a one-night stop in between destinations or for an extended stay to enjoy the history and attractions of the Charleston area, Simmons Sweet Suite has everything you need to be comfortable on your trip. This peaceful place is 50 minutes from historic Charleston market, and 5 minutes from I- 95. It is a 1bedroom, 1 bathroom mother-in-law suite separate with tenants in the main house on the property.

Jul 30 – Aug 6

G$29,907 GYD per night

Guest favorite

Guesthouse in Summerville

4.98 out of 5 average rating, 52 reviews

Hearts & Dreams Peaceful Family Retreat w/ pool

Welcome to Hearts and Dreams Guesthouse. Our guesthouse sits on our 5 acre property behind our Main house. The property is fully fenced with electronic gate. -Large in-ground saltwater pool (not heated) shared -Screened in porch with outdoor seating -Patio outdoor eating area -Gazebo -Fire pit -Play area for children with large wooden playhouse, swingset and picnic table - Downtown Summerville 7 miles -30 miles to Charleston No parties allowed

Sep 6 – 13

G$39,382 GYD per night

Guest favorite

Guesthouse in Seabrook

5.0 out of 5 average rating, 45 reviews

Adorable guesthouse outside Beaufort

Kick back and relax in this calm, stylish guesthouse equipped with a coffee bar, office and cozy study nook. The neighborhood of Seabrook is just north of Beaufort on the Port Royal sound. You will be surrounded by trees and less than 5 minutes from a public fishing pier. The Spanish Moss bike trailhead and scrumptious breakfast spot Low Country Produce are less than 10 mins away. It is a 17 minute drive to Beaufort and 26 minutes to Parris Island.

May 25 – Jun 1

G$22,381 GYD per night

Guest favorite

Guesthouse in Summerville

5.0 out of 5 average rating, 57 reviews

Private Cottage on a Hobby Farm

Take a break and unwind at this peaceful oasis just 12 minutes from downtown Summerville. You'll get to meet our ever-evolving collection of animals, including our chatty chickens and adorable goats! You won't want to miss this experience and convenient location! The cottage features a full kitchen, living space, porch, and parking area. 1 BR/1BA. Your experienced hosts live on the property as well, so you have our full support should it be needed.

Jul 12 – 19

G$25,270 GYD per night

Guest favorite

Guesthouse in Ridgeville

4.9 out of 5 average rating, 30 reviews

Cute Frog

This unique place has a style all its own. This is a furnished room over detached garage 🐸. Open floor plan with queen-size bed, private bath and sitting area. Amenities include small refrigerator, kuerig coffee maker and microwave. A quaint deck with cafe table and chairs. No smoking inside. 45 minutes to downtown Charleston, 30 minutes to historical plantations and 10 minutes to historical downtown Summerville.

Jun 12 – 19

G$17,964 GYD per night

Guest favorite

Guesthouse in Summerville

4.87 out of 5 average rating, 30 reviews

1 Bed Detached Guest House, No Smokers, No Animals

We do not allow smoking/vaping on the property, even OUTSIDE. We appreciate your respect by not booking/requesting/inquiring our place if you or any other guests with you are smokers. Also, due to allergies, we cannot accommodate animals of any size or kind, including outside. This listing is for the detached guesthouse only, the main house is a separate rental.

Jun 10 – 17

G$19,076 GYD per night