Colleton County vacation rentals

4.95 out of 5 average rating, 274 reviews

A tranquil hammock is suspended between two sturdy trees near the water, offering a relaxing spot overlooking the Whale Branch River. Lush green grass surrounds the area, with wooden decking leading toward the nearby dock, enhancing the serene atmosphere of the setting.

Guesthouse in Beaufort

Sunset River Cottage

Our quaint little River House rests on the beautifully natural marsh grass banks of the Whale Branch River in a quiet rural neighborhood. It is located only 9 miles from Historic Downtown Beaufort and 15 miles from Parris Island Marine Corps Recruit Depot. Hunting Island State Park's sandy beaches, nature tails, and lighthouse tours are a scenic 40 minute drive away. You can swim, fish, kayak or go boating right from the dock in our own back yard. When you arrive; you won't want to leave!

5 out of 5 average rating, 34 reviews

A tree house elevated among lush green branches features white railings and a staircase leading to the entrance. The structure is surrounded by dense foliage, creating a natural canopy, while soft sunlight filters through the leaves, highlighting the inviting pathways.

Treehouse in Adams Run

Tree House Close to Beach

Nestled high among the branches this enchanting tree house offers a unique escape into nature. With panoramic views and the soothing sounds of rustling leaves, it’s the perfect retreat for adventurers and relaxation seekers alike. Featuring cozy interiors, modern amenities, and a rustic charm, this elevated hideaway invites you to unwind, explore, and reconnect with the great outdoors. Experience the magic of treetop living and create unforgettable memories in this serene woodland sanctuary.

A modern kitchen features sleek white cabinetry and stainless steel appliances. A kitchen island is accompanied by three metal stools, while a small potted plant rests on a round wooden table. Natural light fills the space through a nearby window.

4.99 out of 5 average rating, 122 reviews

Location & Charm-Close to Bay, Parris Island/MCAS

Come relax at our sweet cottage in the heart of Beaufort, SC! This charming space is designed to make your stay as comfortable and convenient as possible. Located in the quiet Hundred Pines/Hermitage neighborhood and just two minutes to downtown Beaufort, it is the perfect relaxing destination for your beach weekends or when visiting your Marine for graduation! 🔅Downtown Beaufort – 2 min 🔅Spanish Moss Trail – 1 min 🔅Waterfront Park – 2 min 🔅Parris Island – 15 min 🔅MCAS – 15 min

5 out of 5 average rating, 131 reviews

A modern kitchen area is displayed, featuring sleek gray cabinetry and a rich wooden countertop. A stainless steel sink and a glass cooktop are positioned under a contemporary hood. Textured white tiles provide a clean backdrop, complemented by a small potted plant.

Cottage in Beaufort

Private cottage in the pines

This cottage has a unique combination of being close to everything, while still maintaining a very private feel. The cottage is accessible by its private, dedicated drive. This new guest cottage has a King sized bed, as well as a pullout xl twin. The home boasts a large screen tv viewable from every angle, a full sized bath, full kitchen, exquisite outdoor shower, fire pit, full laundry, and all the amenities of home. 10 minutes to Beaufort/Parris isl. Boat parking available on site.

4.98 out of 5 average rating, 178 reviews

A spacious porch features a wooden floor with rocking chairs and a small table. Large columns support the covered area, allowing for unobstructed views of the surrounding trees and waterway beyond. Natural light floods the space, creating a serene and open atmosphere.

Cottage in Beaufort

Private Island Cottage

Beautiful key west inspired cottage set on a private Island with dock access To the intercoastal water way. Minutes firm downtown Beaufort, 35 miles from Hilton Head Island, 45 miles from Savannah, GA, 60 miles from Charelston. only minutes from great restaurantes and attractionss like: Hunting Island state park and3 public golf coures. Swimming, fishing, kayaking or canoeing (equipment provided), or just relax on one of the docks or porches. You can do as much or little as you desire.

4.93 out of 5 average rating, 109 reviews

The entrance features a sleek black door framed by large windows, allowing natural light to illuminate the space. A small potted plant adorned with colorful flowers is placed near the door, surrounded by greenery which adds a touch of nature to the entrance.

Home in Summerville

Guest House/Villa

Enjoy your stay at this immaculately designed new build Villa. Located on a family property surrounded by 2 acres of trees, in a quiet rural neighborhood. Lots of privacy, peace and quiet, yet only 5 minutes from restaurants and stores. 15 minutes from Downtown Summerville, 40 minutes from Charleston and various coastal attractions. The villa is separate from main house and has no shared space other than the driveway. NO smoking, No pets. Laundry service available for long stays.

4.98 out of 5 average rating, 313 reviews

A blue crab is displayed on a weathered wooden surface, showcasing its distinct blue claws and a partially green shell. Water droplets are visible on the surface, indicating recent handling. Bits of seaweed and other remnants are scattered nearby, highlighting the coastal environment.

Guesthouse in Beaufort

Buddy's Cottage near everything in Beaufort, SC

Who is Buddy? He was our black Labrador of 12 years. You'll see his photo as you enter. This well kept tiny home has a private bedroom, 1 full bathroom, a sleeper sofa , 2 TV's, a full kitchen and all the amenities of home. Downtown Beaufort is 2 miles away, Parris Island is less than 5 miles away. In a quiet neighborhood. Are coming for a fishing trip and bringing your boat? Come stay with us , we have room for your boat. You can flush your engine and rinse your boat down.

A shaded patio area is framed by a wooden pergola, featuring a sectional sofa and multiple armchairs. Soft cushions provide comfort, while potted greenery adds a touch of nature. Decorative tiles cover the flooring, and light filters through the pergola's slatted design.

4.92 out of 5 average rating, 204 reviews

Always Welcome-Downtown Beaufort

You're Always Welcome when you choose this cozy cottage located within the historic district of Downtown Beaufort. Take a short stroll to the Waterfront Park, shopping, and dining. This cottage is located within 10 minutes of Paris Island and MCAS. Special occasion? Let us know! We can help you with special requests. Bringing a boat? No problem! Ample parking will accommodate your needs. Your experience is our top priority! It’s our pleasure to have you stay at Always Welcome.

4.96 out of 5 average rating, 194 reviews

A serene pond is surrounded by lush greenery and blooming flowers. A vintage bench is positioned by the water, providing a spot to enjoy the colorful sunset sky. A black dog rests nearby, contributing to the tranquil outdoor setting.

Farm stay in Ehrhardt

Lazy Dog Acres ‘Mini Suite’

Relax by one of the 2 ponds with water features or on the patio. Take a walk around the pond with Isaac or Isabella (Great Danes)as your guide on our 13 acres. Sorry no pets allowed! There is a a micro, fridge & coffee mkr in ur suite. Cook your meal in our shared kitchen. All linens are sanitized w/ high temp sanitizing wash. You have your own private entrance so come and go as you please! Airbnb designated parking. I live on the 2nd floor should u need assistance !

5 out of 5 average rating, 145 reviews

Three dispensing bottles are neatly arranged on a bamboo tray in the bathroom. Each bottle is labeled for shampoo, conditioner, and body wash, providing essential toiletries for guest convenience. The clean, minimalist design enhances the overall aesthetic of the bathroom space.

Home in Walterboro

The Cozy Casa

Whether looking for a place to rest during your travels.. or staying in the area for a while, the Cozy Casa is the perfect choice! Stylish, clean, affordable, premium linens, very well stocked, 1.5 acre fully fenced yard, and located just a 2 minute drive off of Exit 53 of I- 95 in Walterboro, SC. Just a few minutes drive to everything! The Cozy Casa is a stand out Short Term Rental that truly takes hospitality seriously. Come and enjoy this very well appointed home.

5 out of 5 average rating, 51 reviews

A shaded outdoor seating area features a patterned chair positioned on a wooden deck. A serene pond is visible in the foreground, surrounded by lush greenery and trees. The space includes a caution sign, adding a layer of awareness to the tranquil setting.

Tiny home in Yemassee

Tiny house nestled on private farm

We are less than 1 mile off of I-95 in the Low Country of South Carolina. Our 62 acre farm is nestled in the “middle of nowhere, but close to every where”. We are located close Beaufort, Charleston and Savannah! Our Tiny House, which used to be our feed shed, offers beautiful scenery from the Red barn, Moss draped Live Oak trees, Pecan Grove, horses, goats, free range donkeys and more. We have a brand new Bathhouse with a full bath. Washer & Dryer too!

A screened-in lanai surrounds a clear, inviting pool, complemented by multiple lounge chairs and a dining table. Comfortable seating is arranged nearby for relaxation, while a sun umbrella provides shade over the pool area. Lush greenery is visible in the distance.

4.9 out of 5 average rating, 177 reviews

Estate Living on 5 acres with pool in Beaufort, SC

Welcome Home! This spacious home is located on 5 beautiful acres that include a large pond, where you can sit on the dock and feed the fish under one of the oldest and most majestic live oaks in the Lowcountry. Swim laps in the 40-foot pool or just lounge poolside in the screened-in lanai with premium lounge chairs. Enjoy the gorgeous view through expansive picture windows overlooking the 200-acre nature preserve.

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Popular amenities for Colleton County vacation rentals

Gym

BBQ grill

Laptop-friendly workspace

Wifi

Air conditioning

Other great vacation rentals in Colleton County

4.9 out of 5 average rating, 31 reviews

A spacious lawn stretches towards the Edisto River, featuring six blue Adirondack chairs arranged neatly. The river is bordered by lush greenery and trees, with hanging Spanish moss adding a natural touch. The home’s porch is visible, offering a perfect view of the serene water.

Home in Ridgeville

Red Dogs River House-Edisto River- *Boat Landing*

JuliaRating, 5 stars1 month ago

The cottage is in a great location by the river. The house had everything we needed, the beds were comfortable. We really enjoyed our stay in this great place. We will definitely come back.

4.9 out of 5 average rating, 21 reviews

A close-up portrait of a horse's eye is displayed on the wall, capturing the animal's expressive gaze. The rich colors of the horse's coat contrast with a textured, light-colored wall surface positioned to the left, adding depth to the decor.

Home in Walterboro

Beautiful Historic Home Downtown

KimRating, 5 stars1 week ago

Love the beautiful, big, spacious yet warm, and cozy surroundings of this home. Charming and an old world feel while being clean and comfortable. Artistic touches throughout the home add a feel of the whimsical. Wonderful backyard and patio are a delight. Lots of extras make this stay so enjoyable. All to be found in the quaint town of Walterboro. A perfect stop over on our way down to Florida. Who could ask for more?! I’ll be back!

Superhost

A modern kitchen displays a central island with seating for two. Black appliances, including a refrigerator and stove, create a sleek look. Natural light enters through multiple windows, illuminating the white cabinetry and light grey flooring, enhancing the kitchen's functional design.

Home in Yemassee

4.73 out of 5 average rating, 64 reviews

A Southern charm.

CareyRating, 5 stars1 week ago

We love this house! It was well supplied and easy to get to. The only issue we had is trucks driving really loud and using their air brakes on the road right in front, but that is not because of the house.

4.96 out of 5 average rating, 28 reviews

The kitchen area features a modern design with a large island and black appliances. A cozy dining table is surrounded by metal chairs, and a comfortable armchair is positioned nearby. Natural light pours in through multiple windows, illuminating the stylish decor.

Guesthouse in Meggett

77 Oaks on the River

MasonRating, 5 stars1 week ago

My Fiancé and I had a wonderful time here! We didn’t get to explore all of the available places on the property due to time constraints, but if giving the opportunity we would be more than excited to come back and stay here!

5 out of 5 average rating, 11 reviews

A modern bathroom features a glass shower enclosure with black framing, revealing a patterned tile floor. A compact white toilet and sink are visible, accompanied by two wooden stools. Shelves above hold neatly arranged white towels, contributing to a clean and organized appearance.

Home in Ridgeland

Sweet Cottage on the River

WendyRating, 5 stars1 week ago

We were blessed by our stay with Leslie! The view of the marsh was GORGEOUS!! In the midst of a cozy neighborhood with a low country feel and privacy of a personal cottage! We loved the calming and minimalistic beautiful decor that made for a relaxing and peaceful stay! Everything was perfect from the well stocked kitchen to the contemporary fixtures and luxurious shower in the bath! From the comfy bed to the cozy living space we felt right at home! The proximity of the cottage to lots of points of interest and activities made it a great place to spend our holiday ! Thanks to Leslie for her attentive and well thought out hosting, we can’t wait to return!

5 out of 5 average rating, 42 reviews

A floating dock is anchored on the river, featuring two bright red chairs for seating. A gentle slope leads to the dock from a grassy bank, lined by several trees. Nearby, a structure sits, partially obscured by the vegetation.

Home in Cottageville

The Cardinals Nest - On The Edisto River.

BarbaraRating, 5 stars1 month ago

We had a wonderful spring break enjoying their beautiful house. Sitting on the deck enjoying the river and wild life, especially the birds ❤️ the house had everything you could possibly need plus lots of activities for the children. I highly recommend their house.

4.99 out of 5 average rating, 77 reviews

A person holds a young duck close to their chest. The duck features soft yellow feathers and a small, rounded head, with its beak partially open. The background shows a hint of green grass and blurred surroundings, highlighting the connection with farm life.

Guesthouse in Hollywood

Farm Stay w Gardens, Cute Animals, Firepit + Porch

BrittanyRating, 5 stars2 weeks ago

we had a phenomenal stay at Britney's place and highly recommend it to anyone visiting the Charleston South Carolina area. the accommodations were clean comfortable and there is lots to see on this working farm. would highly recommend and would be happy to stay here again on a future trip.

A view of a garden area showcasing vibrant yellow flowers in a wooden planter. In the background, a lush landscape is visible, featuring tall trees and a clear blue sky with scattered clouds. The serene outdoor setting is surrounded by greenery, creating a tranquil atmosphere.