Waterfront vacation rentals in Cape Girardeau County

4.96 out of 5 average rating, 142 reviews

The exterior of a charming brick farmhouse is displayed, featuring a symmetrical layout with two dormer windows. A well-maintained lawn surrounds the house, complemented by flower beds. A walkway leads to the welcoming entryway, which opens to a sunroom on the right.

Home in Cape Girardeau

River Run

BobRating, 5 stars1 month ago

Laura was an exceptional host! Her attention to detail was amazing—everything in the space was thoughtfully prepared and beautifully maintained. The place was spotless, well-stocked, and incredibly comfortable. She clearly goes above and beyond to make guests feel welcome. Highly recommend staying here!

Apartment in Old Appleton

A red steel bridge spans over a serene creek, with water cascading down a rocky ledge in the foreground. Lush greenery surrounds the area, enhancing the peaceful ambiance of the scene. The sky is partly cloudy, adding to the tranquil atmosphere.

5 out of 5 average rating, 33 reviews

Apple Creek Loft

TriciaRating, 5 stars3 days ago

Mark is a great host. He returns messages quickly and is helpful with questions. The loft is beautiful. It’s huge. Mark keeps it stocked with basic items in the fridge, shower and kitchen. Everything is in good condition. The waterfall is 3 minutes away from door to creek, just as he said. I highly recommend opening your windows at night so you can fall asleep to the waterfall (Mark’s suggestion). We will definitely be back. We will definitely

A private balcony offers outdoor seating with several chairs and a table. A clear view of the Mighty Mississippi River can be seen in the background, adding a scenic backdrop to the space. The balcony features a neutral-colored floor and walls.

4.83 out of 5 average rating, 35 reviews

The Outlook - Private Balcony

AndrayaRating, 5 stars1 month ago

This is the second time we have stayed at this place and it is the best place in town. We slept very well during the evening and enjoyed the amazing views during the day. Location is ideal and the parking garage guaranteed downtown parking in cape. Definitely recommend.

A modern living area features a sectional sofa and a recliner, providing comfortable seating. Light fixtures illuminate the space, and a ceiling fan enhances air circulation. A partition separates the entertainment area, which includes two televisions and decorative elements, contributing to a cozy atmosphere.

4.95 out of 5 average rating, 143 reviews

Private Downtown Apartment

AlexRating, 5 stars6 days ago

This is a cool, kind of funky, place to stay. It's right on street level and feels like it used to be a nail salon or hairdresser or some such. It's spacious and comfortable and right in the midst of the downtown area, a short walk - like, as close as next door and up to a few blocks - to bars and restaurants. We parked on the street, but there is parking in the garage available as well. One thing people might want to know is that because the apartment is on street level and the street side is all glass, it is kind of easy to see through. Privacy screens are provided to block the view, and we felt comfortable, but it is possible some might find it a bit off-putting. We would definitely rent again if we are in the area!

5 out of 5 average rating, 23 reviews

An open-concept living space is depicted with a mix of art pieces adorning the walls. Comfortable seating, including a sofa and armchair, is arranged around a wooden coffee table. Natural light filters in through a window, highlighting the warmth of the wooden flooring.

Loft in Cape Girardeau

Lorimier Loft Gallery next to SEMO River Campus

Directly across from Southeast Missouri State University’s River Campus, Lorimier Loft Gallery features luxury accommodations, purchasable gallery artwork and easy access to historic downtown Cape Girardeau. Every inch of this space delivers an aesthetic experience from the artwork to the tile-work to the location: Cross the street for performing art at the River Campus. Sit on the porch and listen to the marching band practice. Curl up by the fire and soak in a rich gallery during your stay.

A scenic view of the Mississippi River from a hillside, framed by lush green trees and foliage. The river is visible in the foreground, with a hint of a barge and distant hills creating a peaceful natural landscape.

Tiny home in Jackson

5 out of 5 average rating, 3 reviews

River View-Hines Landing Studio Cabin (Off-grid)

Overlooking the Mississippi River is a studio cabin on 200 acres of private property. The solar powered cabin has a back-up generator, indoor bathroom with shower and a gas stovetop (no oven). Excellent cell phone service, no Wifi/Internet-can use personal hotspot for Roku TV. Connect with nature outdoors as the cottage is not air conditioned. Unwind at this peaceful farm stay and experience green pastures, river views, beautiful sunrise/sunsets, bird watching, eagle and wildlife sightings.

Treehouse in Cape Girardeau

The custom-built treehouse is elevated on stilts, surrounded by greenery. A spacious deck features a railing, offering access to the entrance. Steps lead to the ground below, while large glass doors enhance the connection to nature.

4.99 out of 5 average rating, 142 reviews

Twisted Sassafras Treehouse

A custom-built treehouse located on 10 acres with a water view that you can take in from the hot tub on the deck! It is nestled high in the trees and is the perfect romantic getaway for two! Feel like you are away from it all without being away from it all! This treehouse is located on a county road just minutes from Cape Girardeau. Enjoy catch and release fishing on site, local wineries, shopping in historic downtown Cape Girardeau, local restaurants, gambling, historical sites & more!

Vacation rentals for every style

Get the amount of space that is right for you

Apartments

Convenient locations with everyday essentials

Hotels

Stylish accommodations and amenities

Unique stays

Spaces that are more than just a place to sleep

Popular amenities for Cape Girardeau County waterfront rentals

Kitchen

Wifi

Pool

Free parking on premises

Air conditioning

Waterfront apartment rentals

4.95 out of 5 average rating, 44 reviews

A serene view of the Mississippi River is presented, highlighting the tranquil water and the pavilion that juts into the river. Lush green grass borders the water, and trees line the distant shore, creating a natural landscape under a clear sky.

Apartment in Scott City

RiverSide Barn Suite on the Mississippi River.

ChrisRating, 5 stars3 days ago

Loved it! The view is gorgeous! Perfect Airbnb!

A private deck is highlighted, featuring a round glass table surrounded by six black metal chairs. The scenic view includes the Mississippi River and a colorful sunset, with the silhouette of the Emerson bridge visible in the background.

4.96 out of 5 average rating, 45 reviews

Downtown Condo on the River

RogerRating, 5 stars6 days ago

Place was very nice very clean. Definitely say there again.

Apartment in Old Appleton

5 out of 5 average rating, 33 reviews

Apple Creek Loft

TriciaRating, 5 stars3 days ago

Mark is a great host. He returns messages quickly and is helpful with questions. The loft is beautiful. It’s huge. Mark keeps it stocked with basic items in the fridge, shower and kitchen. Everything is in good condition. The waterfall is 3 minutes away from door to creek, just as he said. I highly recommend opening your windows at night so you can fall asleep to the waterfall (Mark’s suggestion). We will definitely be back. We will definitely

4.83 out of 5 average rating, 35 reviews

The Outlook - Private Balcony

AndrayaRating, 5 stars1 month ago

This is the second time we have stayed at this place and it is the best place in town. We slept very well during the evening and enjoyed the amazing views during the day. Location is ideal and the parking garage guaranteed downtown parking in cape. Definitely recommend.

4.95 out of 5 average rating, 143 reviews

Private Downtown Apartment

AlexRating, 5 stars6 days ago

This is a cool, kind of funky, place to stay. It's right on street level and feels like it used to be a nail salon or hairdresser or some such. It's spacious and comfortable and right in the midst of the downtown area, a short walk - like, as close as next door and up to a few blocks - to bars and restaurants. We parked on the street, but there is parking in the garage available as well. One thing people might want to know is that because the apartment is on street level and the street side is all glass, it is kind of easy to see through. Privacy screens are provided to block the view, and we felt comfortable, but it is possible some might find it a bit off-putting. We would definitely rent again if we are in the area!

Show all

Waterfront house rentals

4.96 out of 5 average rating, 142 reviews

Home in Cape Girardeau

River Run

BobRating, 5 stars1 month ago

Laura was an exceptional host! Her attention to detail was amazing—everything in the space was thoughtfully prepared and beautifully maintained. The place was spotless, well-stocked, and incredibly comfortable. She clearly goes above and beyond to make guests feel welcome. Highly recommend staying here!

The exterior of Rivercrest Castle is displayed, showcasing a historic three-story structure painted in a warm yellow tone. A well-maintained yard features grass and a pathway leading to the entrance. Views of the Mississippi River are visible in the background, contributing to the property's appeal.

Home in Cape Girardeau

4.59 out of 5 average rating, 22 reviews

Rivercrest Castle

CalebRating, 5 stars1 week ago

Place was great for my friends and I to come and relax for a short weekend trip, loved the view of the river and felt cozy at home! Great place to stay and very spacious!