Waterfront vacation rentals in Cape Girardeau County

Find and book unique waterfront rentals on Airbnb

Top-rated waterfront rentals in Cape Girardeau County

Guests agree: these waterfront rentals are highly rated for location, cleanliness, and more.

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Guest favorite

A stylish living area features a geometric black and white floor. A gray couch is paired with a bright red chair, while a modern chandelier hangs above. A television is mounted on the wall, and large windows provide a view of the outdoors.

Home in Cape Girardeau

4.88 out of 5 average rating, 43 reviews

Ace Of Hearts- 1 Bed 1 Bath

Directly across the street from Century Casino, this 1 Bed- 1 Bath home sleeps 2. Perfect for a weekend away or an elevated stay when traveling for work. Completely remodeled, be one of the first to stay in this iconic home that was built in the 1930's to house factory workers from the historical red star shoe company. Stylish interior and an exterior view like no other, sip your coffee in style. Enjoy cooking in a full kitchen or take a walk downtown to enjoy beautiful shops and restaurants.

Top guest favorite

An open-concept living space is depicted with a mix of art pieces adorning the walls. Comfortable seating, including a sofa and armchair, is arranged around a wooden coffee table. Natural light filters in through a window, highlighting the warmth of the wooden flooring.

Loft in Cape Girardeau

5 out of 5 average rating, 21 reviews

Lorimier Loft Gallery next to SEMO River Campus

Directly across from Southeast Missouri State University’s River Campus, Lorimier Loft Gallery features luxury accommodations, purchasable gallery artwork and easy access to historic downtown Cape Girardeau. Every inch of this space delivers an aesthetic experience from the artwork to the tile-work to the location: Cross the street for performing art at the River Campus. Sit on the porch and listen to the marching band practice. Curl up by the fire and soak in a rich gallery during your stay.

Guest favorite

Home in Cape Girardeau

4.96 out of 5 average rating, 138 reviews

River Run

Charming 1940s farmhouse. Updated 1 1/2 story house in a rural setting overlooking the Mighty Mississippi River, but close to the heart of Cape Girardeau. Our house has lots of room to relax with a large kitchen and sunroom. You can sit by a cozy fire pit and enjoy chilly evenings watching the beautiful sunsets. We look forward to you spending time in our neck of the woods (so to speak). We are located with in seven miles from the Isle casino, SEMO state university and a happening down town.

Superhost

A serene view of the Mississippi River is presented, highlighting the tranquil water and the pavilion that juts into the river. Lush green grass borders the water, and trees line the distant shore, creating a natural landscape under a clear sky.

Apartment in Scott City

4.95 out of 5 average rating, 42 reviews

RiverSide Barn Suite on the Mississippi River.

The barn suite is a beautiful 2 bedroom apartment overlooking the Mississippi River and housed in a unique barn with its own separate entrance. The deck views are spectacular and takes sitting and relaxing to a new level. Our wine place “The RiverHouse “ is within walking distance with the best worldwide wines and menu in the area. www.theriverhousewineplace.com We are 12 minutes from Cape Girardeau and serviced by Lyft & Car-Go. You May contact us by text or call and available at any time.

Top guest favorite

The custom-built treehouse is elevated on stilts, surrounded by greenery. A spacious deck features a railing, offering access to the entrance. Steps lead to the ground below, while large glass doors enhance the connection to nature.

Treehouse in Cape Girardeau

4.99 out of 5 average rating, 134 reviews

Twisted Sassafras Treehouse

A custom-built treehouse located on 10 acres with a water view that you can take in from the hot tub on the deck! It is nestled high in the trees and is the perfect romantic getaway for two! Feel like you are away from it all without being away from it all! This treehouse is located on a county road just minutes from Cape Girardeau. Enjoy catch and release fishing on site, local wineries, shopping in historic downtown Cape Girardeau, local restaurants, gambling, historical sites & more!

Guest favorite

A red steel bridge spans over a serene creek, with water cascading down a rocky ledge in the foreground. Lush greenery surrounds the area, enhancing the peaceful ambiance of the scene. The sky is partly cloudy, adding to the tranquil atmosphere.

Apartment in Old Appleton

5 out of 5 average rating, 26 reviews

Apple Creek Loft

Make some memories at this unique and family-friendly place. Enjoy what many remember to be the Old Store in Old Appleton. Have a peaceful experience near the Historic Bridge spanning the Apple Creek waterfall. Enjoy kayaking, fishing, and swimming in the creek right outside your door. This destination has beds to accommodate 6 people. Plus, there is a spacious living room and master bedroom where more guests could sleep if they would like to bring an air mattress/sleeping bag.

Guest favorite

A private balcony offers outdoor seating with several chairs and a table. A clear view of the Mighty Mississippi River can be seen in the background, adding a scenic backdrop to the space. The balcony features a neutral-colored floor and walls.

Apartment in Cape Girardeau

4.82 out of 5 average rating, 33 reviews

The Outlook - Private Balcony

Welcome to 115 N Water, Unit 103 in Cape Girardeau, MO! This delightful property not only offers a cozy retreat but also boasts a private balcony with stunning, unobstructed views of the Mighty Mississippi River. Perfectly situated close to downtown, it's just steps away from a vibrant nightlife scene, with numerous bars and restaurants for an unforgettable date night experience. Enjoy the best of both worlds – scenic beauty and lively entertainment – right at your doorstep!

Guest favorite

A rustic log cabin features a covered porch with wooden railings and chairs. The structure is surrounded by open grassy areas and a clear blue sky with scattered clouds. Natural landscaping completes the serene country setting.

Farm stay in Jackson

4.88 out of 5 average rating, 16 reviews

The Cabins 2

$135/cabin per night For Extended stays, please inquire about pricing. Make some memories at this unique and family-friendly place. Two log cabins each with 2 bedrooms and a full bath. Beautiful on the inside with plenty of space outside for relaxing and playing with family and friends. Enjoy fishing in the pond and a bonfire once the sun sets over the picturesque horizon. Enjoy!

Guest favorite

A private deck is highlighted, featuring a round glass table surrounded by six black metal chairs. The scenic view includes the Mississippi River and a colorful sunset, with the silhouette of the Emerson bridge visible in the background.

Apartment in Cape Girardeau

4.95 out of 5 average rating, 42 reviews

Downtown Condo on the River

Located in the heart of downtown Cape Girardeau, this furnished condo features a view of the Mississippi River & Emerson bridge from every window. A historic gem with all of today's modern amenities. This unique building has a private covered parking garage. A perfect place to get away and sit out on the deck overlooking the river while you BBQ, or just enjoy the river and relax.

Superhost

A modern living area is presented, featuring a light grey sofa adorned with dark and light cushions. A wooden coffee table sits on a patterned area rug. Artwork and decorative items are arranged on the dark wall, with indoor plants adding a touch of greenery.

Home in Cape Girardeau

4.85 out of 5 average rating, 112 reviews

Lucky Queen- 4-bedroom Steps away from the Casino

Directly across the street from Century Casino. This 4 Bedroom, 2 Bath home is PERFECT for larger groups staying together. Completely remodeled with design touches that highlight all of Cape Girardeau's wonderful history. Each Bedroom has a queen bed with a large closet. Master Bedroom offers its own private full bath. Plenty of parking and private fenced in back yard!