Vacation rentals with a washer and dryer in Cape Girardeau County

The exterior of a charming one-story house is displayed, featuring a sloped roof with a pointed peak. Two planters with colorful flowers flank the steps leading to the entrance, surrounded by lush greenery and autumn foliage.

5 out of 5 average rating, 12 reviews

Urban Cape Downtown Escape-The Rivertown Nook

Welcome to The Rivertown Nook, your downtown escape into the heart of Cape Girardeau! Centrally located, this stylish one-story retreat is perfect for couples or small families. Walk to local eateries, breweries, coffee shops, and take in Broadway Street’s charm, or take a quick drive to Southeast Missouri State University. The cozy, modern home features a sleek kitchen, spa-like bathroom, and off-street parking. Whether for a weekend or vacation, it's the perfect base to explore Cape Girardeau!

A view from the front porch showcases a vibrant autumn scene, with trees covered in golden leaves. A cozy seating area is visible, framed by white railings, and a peaceful street with fallen leaves creates a calm atmosphere.

4.98 out of 5 average rating, 424 reviews

Beautiful Historic Boulevard District Apartment

This beautiful, private upstairs apartment is located on a favorite street in Cape Girardeau’s Historic Boulevard District. It is walking distance to SEMO University, Capaha Park, and the downtown riverfront. Recently remodeled for laundry, spacious rooms offer private bedroom spaces and a cozy den for watching movies or reading. The kitchen is fully equipped with amenities. This quiet neighborhood setting even has a front porch swing and sitting area where you can enjoy your morning coffee.

Superhost

The cottage exterior presents a single-story structure with light blue siding and a dark roof. A wooden deck is located at the front, featuring a railing. The yard is grassy, bordered by a privacy fence, with a driveway visible beside the house.

4.84 out of 5 average rating, 124 reviews

Herman's Corner Cottage.

Tucked in historic Cape Girardeau, this charming cottage offers comfort and convenience. Enjoy the cozy back deck with a privacy fence—perfect for relaxing or grilling. With ample off-street parking, your stay is stress-free. The home is equipped with essentials for a smooth, hassle-free visit. Book the entire house for added privacy, providing a peaceful retreat for you and your guests. Experience the perfect blend of comfort, affordability, and convenience during your Cape Girardeau getaway.

A spacious living area features large windows allowing natural light to fill the space. A comfortable grey sofa is paired with a unique coffee table, while stylish dining chairs surround a white table. The kitchen area includes modern appliances and cabinetry.

4.95 out of 5 average rating, 262 reviews

Brand new 2 bedroom unit right in downtown Cape.

This special place is close to everything, making it easy to plan your visit. Walking distance to restaurants, the river and nightlife. Property includes wifi, full kitchen, laundry, deck and private parking for one. One king bed room and a twin bed room in addition to a roll out twin bed along with a 60 inch smart television. Dog bed and bowls included along with board games! Property is conveniently located across the street from "The Bar" the famous spot from the movie "Gone Girl" .

The exterior of a charming brick farmhouse is displayed, featuring a symmetrical layout with two dormer windows. A well-maintained lawn surrounds the house, complemented by flower beds. A walkway leads to the welcoming entryway, which opens to a sunroom on the right.

4.97 out of 5 average rating, 144 reviews

River Run

Charming 1940s farmhouse. Updated 1 1/2 story house in a rural setting overlooking the Mighty Mississippi River, but close to the heart of Cape Girardeau. Our house has lots of room to relax with a large kitchen and sunroom. You can sit by a cozy fire pit and enjoy chilly evenings watching the beautiful sunsets. We look forward to you spending time in our neck of the woods (so to speak). We are located with in seven miles from the Isle casino, SEMO state university and a happening down town.

4.95 out of 5 average rating, 39 reviews

The spacious living area features a comfortable couch and a coffee table, while a set of three barstools accompanies a sleek dining table. Natural light streams through multiple windows, highlighting the wood flooring and modern kitchen appliances in the background.

Tiny home in Jackson

The Cottage, Rusted Route Farms

You won’t forget your time in this romantic, memorable place. The Cottage at Rusted Route Farms is a 1 bedroom beautiful suite on an old 10 acre farm history galore. A picturesque pond is settled next to The Market our onsite Restaurant that will be serving food and drinks to be ready on your arrival or for a certain time that you choose. The over 125 year old barn has been renovated to keep the history alive and is located here on site. This retreat is located right outside Cape Girardeau.

A spacious living room is furnished with a large sectional couch, complemented by decorative pillows. A wooden coffee table sits center stage on an area rug. A ceiling fan is visible, and light enters through window treatments, creating a comfortable atmosphere.

4.84 out of 5 average rating, 130 reviews

5 Bed Home in Great Neighborhood - Sleeps 10

Looking for a comfortable and spacious Airbnb in Cape Girardeau? 🏡✨ This 3 bedroom, 2 bathroom home in a great neighborhood is the perfect spot for your next group stay. This home features great living areas to relax and unwind including a living room with a large sectional and 70 inch TV. The game room features an air hockey table, dart board, and other board games. It will sleep 10 comfortably. Make this your destination for your next girls trip, sports tournament, or SEMO event.

Cottage in Cape Girardeau

A charming brick house is presented, featuring a front porch supported by columns. Large windows allow natural light to brighten the interior. The lush green lawn is bordered by a stone pathway leading up to the entrance, surrounded by well-manicured shrubs and trees.

4.98 out of 5 average rating, 368 reviews

The Candle Cottage in downtown Cape.

All the best that downtown Cape Girardeau has to offer just steps away from your front door! Short distance from Isle Casino and just 2 1/2 blocks from the Mississippi River walk, downtown restaurants, shops and minutes from Southeast Missouri State River Campus. Completely renovated with loads of charm and coziness, high ceilings, comfy bed, fully stocked kitchen, and laundry. My place is ideal for couples, solo adventurers, and business travelers. Owner is licensed real estate agent.

A spacious roof deck is highlighted, featuring a wooden surface and metal railing. Two woven chairs and a small table are positioned to allow for relaxing moments while enjoying expansive views of the river and surrounding greenery.

4.97 out of 5 average rating, 151 reviews

Downtown Penthouse w/ Amazing River View!

AMAZING RIVERVIEW Plus Close to Downtown Cape? Our Airbnb is the best place to be! Relax in our Roof Deck after going around downtown and ENJOY THE VIEW. Located in a safe and quiet neighborhood plus it is WALKING DISTANCE from everything! It features a roof deck with (by far) the best view in Cape, enough space for six to sleep (two queen beds and two couches), one off street parking spot and a building with secure entry. Plus we just live across the street if you need anything.

4.94 out of 5 average rating, 215 reviews

A modern farmhouse is depicted at sunset, featuring a welcoming entrance with a covered porch. A stone pathway leads to the front door, bordered by a grassy lawn that extends to fields and trees in the background.

Barn in Cape Girardeau

Under the Stars - Farmhouse

Enjoy the tranquility of this modern farmhouse charmer! Custom built minutes from downtown Cape. Relax outside around the fire pit, roast marshmallows and watch the sunset. Finish the night with a long soak in the hot tub. Start the morning on the front porch rocking chairs and take in a sunrise. Open concept, fully equipped kitchen, 3 Bd. including King master/full bath, 2 Queens with full guest bath. Near Trail of Tears and walking distance to classic dive bar/burger joint

A cozy living area showcases a plush sofa paired with two armchairs. A modern workspace with a desk and chair is highlighted, along with a Smart HDTV displaying Netflix. The bedroom features a spacious bed, accented by natural light filtering through multiple windows.

4.92 out of 5 average rating, 24 reviews

Downtown Luxe Boho 2KBR Apt w/ Electric Fireplace

This luxury apartment offers a unique blend of modern elegance and cultural charm, nestled right above the beautifully revitalized Broadway Theatre. Enjoy a vibrant stay by being in walking distance to shopping, dining, and downtown entertainment! The apartment features a spacious, light-filled layout with high-end finishes and appliances. Enjoy cozy living spaces complete with an electric fireplace. Don't forget to visit the bourbon lounge below and bistro next door!

Superhost

A modern kitchen area is visible, showcasing stainless steel appliances and a blue kitchen island with seating. Decorative elements include artwork and a wall shelf with dishware. A cozy living space with a light-colored sofa adorned with patterned throw pillows is situated adjacent to the kitchen.