Vacation rentals with a patio in Cape Girardeau County

MCM Flashback

Flashback to a simpler time. This 1940’s gem has been styled with a Mid Century Modern vibe, complimenting the original features of the space. Modern updates have been splashed in to enhance the space while maintaining the original charm. Conveniently located in historic Uptown Jackson. * Bedroom 1: Queen * Bedroom 2: King with sitting area/designated workspace. * Bedroom 3: 2 twin, 1 Full and "Kid Zone" * 1 Full Bathroom * 3/4 Bath (shower and toilet) in the unfinished basement.

Beautiful Sunset Cottage with amazing views

Robinson Farms NxtGen – The Sunset Cottage Experience the charm of modern farmhouse living with a soulful twist. Nestled in the heart of nature, The Sunset Cottage is an exclusive Airbnb retreat that blends clean, stylish design with the peaceful essence of the outdoors. Whether you're planning a small family escape, a girls’ or guys’ weekend, or a romantic getaway, this serene space offers the perfect backdrop for rest, reconnection, and renewal. A timeless getaway with a fresh perspective.

Herman's Corner Cottage.

Tucked in historic Cape Girardeau, this charming cottage offers comfort and convenience. Enjoy the cozy back deck with a privacy fence—perfect for relaxing or grilling. With ample off-street parking, your stay is stress-free. The home is equipped with essentials for a smooth, hassle-free visit. Book the entire house for added privacy, providing a peaceful retreat for you and your guests. Experience the perfect blend of comfort, affordability, and convenience during your Cape Girardeau getaway.

Twisted Sassafras Treehouse

A custom-built treehouse located on 10 acres with a water view that you can take in from the hot tub on the deck! It is nestled high in the trees and is the perfect romantic getaway for two! Feel like you are away from it all without being away from it all! This treehouse is located on a county road just minutes from Cape Girardeau. Enjoy catch and release fishing on site, local wineries, shopping in historic downtown Cape Girardeau, local restaurants, gambling, historical sites & more!

5 Bed Home in Great Neighborhood - Sleeps 10

Looking for a comfortable and spacious Airbnb in Cape Girardeau? 🏡✨ This 3 bedroom, 2 bathroom home in a great neighborhood is the perfect spot for your next group stay. This home features great living areas to relax and unwind including a living room with a large sectional and 70 inch TV. The game room features an air hockey table, dart board, and other board games. It will sleep 10 comfortably. Make this your destination for your next girls trip, sports tournament, or SEMO event.

Guesthouse w/ pool, outdoor fireplace, game room

Bring the whole family to this great place with lots of room for fun and located in a quiet country subdivision with beautiful sunsets and Missouri wildlife. Enjoy a fire and s’mores in the outdoor fireplace or sit by the propane fire feature in the high-top table. All S’more essentials are provided. Amenities are numerous, including full-sized washer and dryer for guest use. Game room has Pac-man arcade, ping pong, pool table and air hockey. No parties, no smoking, no pets allowed.

The Outlook - Private Balcony

Welcome to 115 N Water, Unit 103 in Cape Girardeau, MO! This delightful property not only offers a cozy retreat but also boasts a private balcony with stunning, unobstructed views of the Mighty Mississippi River. Perfectly situated close to downtown, it's just steps away from a vibrant nightlife scene, with numerous bars and restaurants for an unforgettable date night experience. Enjoy the best of both worlds – scenic beauty and lively entertainment – right at your doorstep!

Cottage Near Casino

Welcome to your cozy cottage with a delightful retro feel, conveniently located near the Casino, Downtown, and SEMO University. You'll be greeted by the inviting sight of a white fence that surrounds the property, adding a touch of quaint charm to home away from home. This home features 2 bedrooms, 1 full bathroom and the convenience of main floor laundry. This is the perfect haven for traveling nurses or professionals seeking a comfortable and stylish residence.

Mid-Town Historic Like New Gem

This spacious and unique historic home is completely renovated; like new inside and out. Nice covered deck, overlooking a large back yard. 2 minute drive to SEMO University and the Cape Catfish. Within walking distance to Mercy Hospital, Muy Bueno, The Pickleball Factory, as well as Pacific Rim Market and Walmart Neighborhood Market for groceries. Centrally located within a 5 minute drive of most of Cape Girardeau. Close to downtown dining and entertainment.