Vacation rentals with a patio in Cape Girardeau County

The White House, Centrally Located Historical Gem

Great for family or group vacations and holiday gatherings. Historic charm with large rooms and high ceilings with all the comfort and amenities of a brand new home. Plenty of off street parking. This spacious and unique historic home is completely renovated; like new inside and out. 2 minute drive to SEMO University and the Cape Catfish. Within walking distance to Mercy Hospital and The Pickleball Factory. Centrally located to most of Cape Girardeau. Close to downtown dining and entertainment.

Cape Charm: 3 BR Close to SEMO & Mercy! CLEAN!

Cape Charm is a "charming" 3 BR home in a safe, quiet neighborhood perfectly located next to SEMO, Mercy Hospital, Capaha Park & the historic district - all less than a 7 minute walk! Feel at home in a magnificently cute 3 bedroom home (w/king bed), fully equipped kitchen, living room, dining room, bathroom, & sun room. Free, fast WIFI, a smart TV in the living room & bedroom. It's centrally located to everything! We are experienced hosts with highly rated listings in Florida and Missouri.

Ace Of Hearts- 1 Bed 1 Bath

Directly across the street from Century Casino, this 1 Bed- 1 Bath home sleeps 2. Perfect for a weekend away or an elevated stay when traveling for work. Completely remodeled, be one of the first to stay in this iconic home that was built in the 1930's to house factory workers from the historical red star shoe company. Stylish interior and an exterior view like no other, sip your coffee in style. Enjoy cooking in a full kitchen or take a walk downtown to enjoy beautiful shops and restaurants.

Lorimier Loft Gallery next to SEMO River Campus

Directly across from Southeast Missouri State University’s River Campus, Lorimier Loft Gallery features luxury accommodations, purchasable gallery artwork and easy access to historic downtown Cape Girardeau. Every inch of this space delivers an aesthetic experience from the artwork to the tile-work to the location: Cross the street for performing art at the River Campus. Sit on the porch and listen to the marching band practice. Curl up by the fire and soak in a rich gallery during your stay.

Herman's Corner Cottage.

Tucked in historic Cape Girardeau, this charming cottage offers comfort and convenience. Enjoy the cozy back deck with a privacy fence—perfect for relaxing or grilling. With ample off-street parking, your stay is stress-free. The home is equipped with essentials for a smooth, hassle-free visit. Book the entire house for added privacy, providing a peaceful retreat for you and your guests. Experience the perfect blend of comfort, affordability, and convenience during your Cape Girardeau getaway.

Brand new 2 bedroom unit right in downtown Cape.

This special place is close to everything, making it easy to plan your visit. Walking distance to restaurants, the river and nightlife. Property includes wifi, full kitchen, laundry, deck and private parking for one. One king bed room and a twin bed room in addition to a roll out twin bed along with a 60 inch smart television. Dog bed and bowls included along with board games! Property is conveniently located across the street from "The Bar" the famous spot from the movie "Gone Girl" .

A-Frame tiny home in tiny home village

Enjoy nature as you stay in our unique tiny home village. Nestled between Boutin Creek and lovely natural rock formations, we are proud to share our beautiful property. The Mermaid is our bright yellow A-frame with a porch enveloped in nature featuring our Mermaid benches. With two bedrooms (both w/ queen beds), one bathroom and a futon in the living area, the Mermaid sleeps up to 5 people. The unit has a small kitchenette with a larger mini fridge, microwave, hotplate complete with dishes.

Twisted Sassafras Treehouse

A custom-built treehouse located on 10 acres with a water view that you can take in from the hot tub on the deck! It is nestled high in the trees and is the perfect romantic getaway for two! Feel like you are away from it all without being away from it all! This treehouse is located on a county road just minutes from Cape Girardeau. Enjoy catch and release fishing on site, local wineries, shopping in historic downtown Cape Girardeau, local restaurants, gambling, historical sites & more!

5 Bed Home in Great Neighborhood - Sleeps 10

Looking for a comfortable and spacious Airbnb in Cape Girardeau? 🏡✨ This 3 bedroom, 2 bathroom home in a great neighborhood is the perfect spot for your next group stay. This home features great living areas to relax and unwind including a living room with a large sectional and 70 inch TV. The game room features an air hockey table, dart board, and other board games. It will sleep 10 comfortably. Make this your destination for your next girls trip, sports tournament, or SEMO event.

Guesthouse w/ pool, outdoor fireplace, game room

Bring the whole family to this great place with lots of room for fun and located in a quiet country subdivision with beautiful sunsets and Missouri wildlife. Enjoy a fire and s’mores in the outdoor fireplace or sit by the propane fire feature in the high-top table. All S’more essentials are provided. Amenities are numerous, including full-sized washer and dryer for guest use. Game room has Pac-man arcade, ping pong, pool table and air hockey. No parties, no smoking, no pets allowed.

Downtown Penthouse w/ Amazing River View!

AMAZING RIVERVIEW Plus Close to Downtown Cape? Our Airbnb is the best place to be! Relax in our Roof Deck after going around downtown and ENJOY THE VIEW. Located in a safe and quiet neighborhood plus it is WALKING DISTANCE from everything! It features a roof deck with (by far) the best view in Cape, enough space for six to sleep (two queen beds and two couches), one off street parking spot and a building with secure entry. Plus we just live across the street if you need anything.

Cottage Near Casino

Welcome to your cozy cottage with a delightful retro feel, conveniently located near the Casino, Downtown, and SEMO University. You'll be greeted by the inviting sight of a white fence that surrounds the property, adding a touch of quaint charm to home away from home. This home features 2 bedrooms, 1 full bathroom and the convenience of main floor laundry. This is the perfect haven for traveling nurses or professionals seeking a comfortable and stylish residence.