Kid-friendly vacation rentals in Cape Girardeau County

Guesthouse in Cape Girardeau

A full-size bed is showcased with a light gray duvet and patterned pillows, positioned against a green headboard. Two bedside lamps are placed on either side of a small nightstand. A wall clock and storage bins add functional touches to the cozy living space.

4.92 out of 5 average rating, 111 reviews

Cozy 1-BR guest house w/free parking on premises

Enjoy a cozy experience at this centrally, located place. Literally, a 1-4 minute walk to Mercy Hospital(formerly Southeast Hospital), less than 1 mile to Southeast University Campus, along with downtown(river). A street over is Broadway with many restaurants. Walmart Market and Dollar General are also conveniently located nearby. The kitchen is fully furnished with cooking utensils, clean towels, pots and pans for those who prefer eating in. Please no animals and no smoking in the apartment.

Apartment in Cape Girardeau

A view from the front porch showcases a vibrant autumn scene, with trees covered in golden leaves. A cozy seating area is visible, framed by white railings, and a peaceful street with fallen leaves creates a calm atmosphere.

4.98 out of 5 average rating, 415 reviews

Beautiful Historic Boulevard District Apartment

This beautiful, private upstairs apartment is located on a favorite street in Cape Girardeau’s Historic Boulevard District. It is walking distance to SEMO University, Capaha Park, and the downtown riverfront. Recently remodeled for laundry, spacious rooms offer private bedroom spaces and a cozy den for watching movies or reading. The kitchen is fully equipped with amenities. This quiet neighborhood setting even has a front porch swing and sitting area where you can enjoy your morning coffee.

Superhost

The cottage exterior presents a single-story structure with light blue siding and a dark roof. A wooden deck is located at the front, featuring a railing. The yard is grassy, bordered by a privacy fence, with a driveway visible beside the house.

4.82 out of 5 average rating, 113 reviews

Herman’s Corner Cottage

Tucked in historic Cape Girardeau, this charming cottage offers comfort and convenience. Enjoy the cozy back deck with a privacy fence—perfect for relaxing or grilling. With ample off-street parking, your stay is stress-free. The home is equipped with essentials for a smooth, hassle-free visit. Book the entire house for added privacy, providing a peaceful retreat for you and your guests. Experience the perfect blend of comfort, affordability, and convenience during your Cape Girardeau getaway.

Guest suite in Cape Girardeau

An exterior view of the entrance features a welcoming white door framed by black accents. A small staircase leads up to the door, complemented by a light fixture. A vehicle is parked near the entrance, with a tree and a fenced area visible in the background.

4.97 out of 5 average rating, 151 reviews

MAINSTAY CAPE [downtown]

Nestled in the heart of the Downtown Historic District, this suite is centrally located as a prime destination for any and all travelers alike. With parking available, this space offers a unique & trendy “midwest boho” vibe. ~WALKABLE~ Our studio is 1 block from the bustling Southeast Missouri State University, 1 block from the gorgeous Capaha Park, and 2 blocks from Mercy Hospital. If you are interested in night life, this space is simply a 5-10 minute walk to all DT bars and restaurants.

Apartment in Cape Girardeau

A spacious living area features large windows allowing natural light to fill the space. A comfortable grey sofa is paired with a unique coffee table, while stylish dining chairs surround a white table. The kitchen area includes modern appliances and cabinetry.

4.95 out of 5 average rating, 245 reviews

Brand new 2 bedroom unit right in downtown Cape.

This special place is close to everything, making it easy to plan your visit. Walking distance to restaurants, the river and nightlife. Property includes wifi, full kitchen, laundry, deck and private parking for one. One king bed room and a twin bed room in addition to a roll out twin bed along with a 60 inch smart television. Dog bed and bowls included along with board games! Property is conveniently located across the street from "The Bar" the famous spot from the movie "Gone Girl" .

Superhost

A spacious dining area is seen with a glass table surrounded by light blue chairs. A stylish chandelier hangs overhead, illuminating the space. Decor includes a large area rug and decorative elements, while bicycles are parked nearby, hinting at an outdoor adventure option.

Apartment in Cape Girardeau

4.86 out of 5 average rating, 609 reviews

Unique Design | Walk Downtown/River | .5 mile SEMO

At our Adventurous 2 Bedroom Suite you’ll first arrive at a Brightly decorated Space with Artsy Walls and Bold Decor. Designed with its History in mind & a twist of Creativity, you will Immerse Yourself within your Stay; from our Stocked Kitchen, Reading Area with Indoor Swing to Themed & Cozy Bedrooms. Enjoy being near Downtown/the River with a short Bike Ride or Walk and when you are ready to Tuck in at night, Sink into our 10” Memory Foam mattress with Plush Pillows and feel at Ease.

Treehouse in Cape Girardeau

The custom-built treehouse is elevated on stilts, surrounded by greenery. A spacious deck features a railing, offering access to the entrance. Steps lead to the ground below, while large glass doors enhance the connection to nature.

4.99 out of 5 average rating, 141 reviews

Twisted Sassafras Treehouse

A custom-built treehouse located on 10 acres with a water view that you can take in from the hot tub on the deck! It is nestled high in the trees and is the perfect romantic getaway for two! Feel like you are away from it all without being away from it all! This treehouse is located on a county road just minutes from Cape Girardeau. Enjoy catch and release fishing on site, local wineries, shopping in historic downtown Cape Girardeau, local restaurants, gambling, historical sites & more!

A spacious living room is furnished with a large sectional couch, complemented by decorative pillows. A wooden coffee table sits center stage on an area rug. A ceiling fan is visible, and light enters through window treatments, creating a comfortable atmosphere.

4.85 out of 5 average rating, 124 reviews

5 Bed Home in Great Neighborhood - Sleeps 10

Looking for a comfortable and spacious Airbnb in Cape Girardeau? 🏡✨ This 3 bedroom, 2 bathroom home in a great neighborhood is the perfect spot for your next group stay. This home features great living areas to relax and unwind including a living room with a large sectional and 70 inch TV. The game room features an air hockey table, dart board, and other board games. It will sleep 10 comfortably. Make this your destination for your next girls trip, sports tournament, or SEMO event.

A comfortable living room is presented with soft, beige seating adorned with red accent pillows. A dark trunk serves as a coffee table, while a lamp gently illuminates the space. The room features multiple windows, enhancing natural light alongside decorative curtains.

4.87 out of 5 average rating, 103 reviews

House Of Clubs- 2 Bed 1.5 Bath

The PERFECT hideway. The House of Clubs offers a quiet setting with a creek that wraps around the enitre property. Two bedrooms, each include a queen size bed. One Full bathroom. Full Laundry room that also offers a private cammode. The stylish living room offers a unique style that higlights Cape Girardeaus rich history. Enjoy your morning coffee in the four seasons room with breathtaking views of this hidden gem . Less than 5 minutes to downtown. Only 2 minutes to Cape Country Club.

4.96 out of 5 average rating, 196 reviews

A modern farmhouse is depicted at sunset, featuring a welcoming entrance with a covered porch. A stone pathway leads to the front door, bordered by a grassy lawn that extends to fields and trees in the background.

Barn in Cape Girardeau

Under the Stars - Farmhouse

Enjoy the tranquility of this modern farmhouse charmer! Custom built minutes from downtown Cape. Relax outside around the fire pit, roast marshmallows and watch the sunset. Finish the night with a long soak in the hot tub. Start the morning on the front porch rocking chairs and take in a sunrise. Open concept, fully equipped kitchen, 3 Bd. including King master/full bath, 2 Queens with full guest bath. Near Trail of Tears and walking distance to classic dive bar/burger joint

Guesthouse in Cape Girardeau

The exterior of the guesthouse features a charming brick facade with yellow shutters framing the windows. A sturdy front door painted in a vibrant hue complements the traditional architecture. Flower boxes add a touch of color, while a manicured garden enhances the welcoming appearance.

4.93 out of 5 average rating, 516 reviews

Downtown Guesthouse- Romantic Getaway

The guesthouse seamlessly blends modern amenities with historic charm in a cozy, compact space. The antique claw foot tub/shower combo offers a charming, yet snug, spot for a relaxing soak—true to its historic roots, the bathroom could be best described as a quaint water closet. After a day of exploring unwind in the patio. Play a favorite record, and savor your coffee while daydreaming about new experiences. Despite its small size, it provides all the modern comforts you need.

Superhost

A brightly lit bedroom features two beds with decorative headboards and comfortable bedding. Pillows are arranged neatly on each bed, complemented by window treatments that allow natural light to filter in. The hardwood floor adds a warm touch to the inviting space.