Vacation rentals in Brussels

Guest suite in Saint Charles

4.91 out of 5 average rating, 74 reviews

The Luxury Lodge in St. Charles

The Luxury Lodge is a Private Residence at Rear of Property with Private Keypad Door Entrance, Private Parking, Outdoor Deck, Dog Run Line and 1/2 acre Fenced Backyard. Kick back & relax in this serene, spotlessly clean, stylish luxury & country living in St. Charles, MO w/ Great Scenic View. Dog friendly, comfy Queen Size Bed, Love Seat, Queen Sleeper Sofa, Large Stone Fireplace, Huge Bathroom, Rain Shower, Private Powder Room, Large Screen TV, Cable & Streaming, Kitchenette, Fridge & Dresser.

4.98 out of 5 average rating, 617 reviews

301 Guesthouse- Historic Main street-Katy Trail

Our 301 Guest House is new and completely remodeled in 2018! It’s ideal for one or two people with beautiful furnishings, great queen bed, lots of amenities, full kitchen, with big back yard and patio to enjoy outdoors too! Cable and FAST WiFi! Enjoy light Breakfast! BEST location, Great events year round within walking distance, with being only about 2 blocks from S. Main St, where there are about 100 gift shops n restaurants! Katy Trail is so close, with Spring, Summer, Fall and Xmas events!

Guesthouse in Jerseyville

4.97 out of 5 average rating, 139 reviews

Cozy cabin on farm near Jerseyville and Grafton IL

No cleaning fees! Relax in this cozy cabin on a 30 acre farm w/beautiful views & peaceful surroundings. Near shopping, wineries, nightlife, hunting & fishing. Abundant wildlife & farm animals-horses, cows, chickens, goats, sheep, geese. Two bedrooms (one in a spacious loft) with a queen sofa sleeper in the living room. Full kitchen w/dish washer. Fireplace & cathedral ceilings in living room. Full bath w/shower. Covered front porch. Screen porch off living area w/outdoor seating. Fire pit.

4.85 out of 5 average rating, 171 reviews

Home in O'Fallon

The Gathering Home 3bdrm 2bath, finished basement

This Home is in a great location for visiting family, and for corporate stays, has a fully equiped kitchen, 2 full bathrooms, 3 bedrooms, laundry facility, comfortable beds, 2 Flat screen tv, WiFi, a fenced in yard, deck, lower level has a walk out basement to a patio. Central Heat and A/C., walking distance to Good News Brewery, Rendezvous wine Bar. , Banquet Center, Bowling Alley, Scooters Coffee, St. louis is 40 minutes, 1 minute from Hwy 70/Hwy K exit., 25 minutes to STL airport.

4.93 out of 5 average rating, 60 reviews

Home in Jerseyville

McClusky Trail Guesthouse

Close to town, but not in it - 5 min. away from grocery stores, restaurants, and mini marts. Just 15 min. away, Grafton is where you can tour wine country, hike Pere Marquette Park, or simply drive along the Great River Road, where hundreds of bald eagles migrate during the winter season. St. Louis Int'l Airport is 35 min. away. Downtown, you'll find attractions like the Gateway Arch and Saint Louis Zoo, or cheer on the St. Louis Cardinals, Blues Hockey, or take in a STL SC soccer game.

4.95 out of 5 average rating, 104 reviews

Cozy Mid-Century Modern Townhome

This comfy 2 bedroom, 1.5 bath townhome is perfect for up to 5 guests. Luxury King bed in bedroom 1 and luxury Queen bed in bedroom 2. A futon in the living room can be used for a 5th guest. A pack-n-play is available upon request. This dynamic location is 5 minutes from bars, restaurants, shopping, Lindenwood University, and Ameristar Casino. It's only 2 miles from St. Charles, historic, Main Street, and it's only 15 minutes from the airport, and about 30 minutes from downtown St. Louis.

4.95 out of 5 average rating, 309 reviews

*HotTub* The Jewel on 5th-2br2b-near Historic Main

A true gem only a 15 min drive from the STL Airport. Enjoy a well equipped, century home a short 12 min walk to Historic Main and a HOTTUB. The large stocked kitchen is great for entertaining. Master bedroom w/luxurious, king sized, 4 poster bed and ensuite bathroom awaits you. In the private, queen suite you’ll find its own bathroom and another door leading onto the deck. The chair off the kitchen folds out to a standard twin and bedding is provided for the sofa as well. Can sleep 6.

4.94 out of 5 average rating, 108 reviews

Home in O'Fallon

Beautiful 2 bedroom ranch home

The whole group will enjoy easy access to everything from this centrally located ranch home. This home has everything you will need for a cozy, relaxing stay. Our home is located in the middle of everything such as shopping, entertainment, restaurants, and hospital's. You can also enjoy staying in and cooking your own meals with a full kitchen. If this property isn't available for the dates you are needing I have another property listed under The Ladybug Inn in Wentzville Missouri.

4.99 out of 5 average rating, 134 reviews

Little House By Main St -5 4K TV's- 1-75 Inch -1GB

Little House By Main St -5 4K TV's- 1-75 Inch -1GB Internet- No location has better access to so much. All the best amenities on both sides of Main Street St Charles! Walking distance from the Ameristar Casino, Texas Road House, Main Street (Honky Tonk, Big A's, Q, Thirstys), Starbucks, Taco Bell, Buffalo Wild Wings, McDonald's and the Bars / Restaurants on Main. An Awesome Location for all of the Festivals in St Charles! And secured parking in the 1 car garage!

5 out of 5 average rating, 26 reviews

Home in Grafton

Charming Escape in Grafton!

Welcome to this charming 2-bedroom, 2-bathroom home in Grafton, Illinois, offering stunning river views for a relaxing getaway. Perfect for families and friends, this spacious retreat combines comfort and scenic beauty. The inviting living spaces are designed for relaxation, with ample room to unwind after a day of exploration. Enjoy meals with loved ones in the fully equipped kitchen and dining area. Step outside to take in the picturesque views of the river.

5 out of 5 average rating, 17 reviews

Home in Dow

Grafton Getaway @ The Studio

The Studio joins our sister Grafton Getaway locations and is located on 3 acres just 7 minutes from town. Bring the kids for pond fishing and rock play pit or have a couples retreat in this cozy studio home. Walk the property which has fruit trees and a dry creek bed, or enjoy our hammocks, rocking chairs, record player etc that Grafton Getaway Guesthouses are known for. Our Towering Pines rental home is on the other side of driveway.

Guest suite in Dardenne Prairie

4.9 out of 5 average rating, 271 reviews

Treehouse Spa Suite

Treehouse Day Spa is nestled on 3 wooded acres in St.Charles County. Get away from it all while being close to it all at the same time. Augusta wineries, Main Street St. Charles and the Streets of Cottleville are all within minutes of the location! There are two rental units in the treehouse: The spa suite and the penthouse. They each have a separate entrance and are private spaces. Recharge your battery! Regroup Relax Refresh

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Other great vacation rentals in Brussels

Townhouse in O'Fallon

4.85 out of 5 average rating, 13 reviews

Spacious Townhome Retreat by StayLage

RichardRating, 5 stars3 weeks ago

second time we have stayed here. Good clean place. Very responsive host. Discovered A/X was not working first night and they came out next morning and fixed. It was just turned off at outside disconnect 😂. Will stay here again.

Private room in Hazelwood

4.93 out of 5 average rating, 14 reviews

My humble abode by the airport.

FaithRating, 5 stars2 weeks ago

William's place was perfect for our stay.. Easy to find, check- in was hassle free, room/shared spaces were quiet, and clean.

4.96 out of 5 average rating, 27 reviews

Home in Edwardsville

Cozy Chicken Cottage

BillRating, 5 starstoday

Emma's cottage was beautiful and exactly as described. We found it to be charming and felt like "home" She provided some soda/pop, water and light snacks. The outside area was amazing, lovely seating areas. The chickens are are pretty cool and the pigs Corona and Modelo are adorable. Emma stopped outside while we were walking around and let us know that if you say their names they come out of the barn. Truly enjoyed our 1 night stay and already looking forward to a future visit.

5 out of 5 average rating, 10 reviews

Loft in Moscow Mills

Studio Apartment 2nd Floor

HowardRating, 5 stars1 month ago

We had to find a place to crash on a road trip and this was the perfect spot. Roomy and clean. The bed was comfortable and the coffee maker was well stocked. By only complaint was that the WiFi signal is not strong enough (the apt is located above a separate garage, which is maybe the reason for the signal issues). Otherwise would recommend for a stop off I70.

4.98 out of 5 average rating, 53 reviews

Loft in Saint Charles

Lovely Couples Escape on Mississippi River!

PattiRating, 5 stars2 months ago

Our 4th stay and as always such a delight. We love the peacefulness of this getaway. The location is close enough to drive to St. Charles for a delicious dinner. Cozy is the best description for this property. Hosts are always in touch prior to arrival and instructions are clear. Well maintained and very clean. We will return again!

4.95 out of 5 average rating, 43 reviews

Private room in Winfield

Shalom Acres Bedroom #3

JakeRating, 5 stars2 weeks ago

Teresa is a great host and wonderful person. Her home is very cozy and a great place to relax, especially in the gazebo and deck outside.

Private room in St. Peters

4.94 out of 5 average rating, 821 reviews

Private Suite in Nice Home with a view! Near I-70

KatelynRating, 5 stars2 weeks ago

This was our first time staying in a shared-space Airbnb, and it completely exceeded our expectations. We chose it for the unbeatable price, but I had my doubts—thought it was too good to be true. Turns out, it was just that good. The space was bigger than expected, super clean, and the temperature was absolutely perfect. My fiancé and I couldn’t stop talking about how comfortable it was. The family gave us total privacy, but I’m chatty and was lucky enough to briefly meet Brandon, his sweet family, and their adorable dog, Aspen. They were warm, kind, and truly the sweetest—honestly, the only thing I regret is not having more time to talk with them! We were in town for a wedding in Cottlesville and likely won’t have another reason to visit again, but if we ever do, this would be our first choice without hesitation. Whoever stays here next is in for a real treat. Thank you for such a wonderful stay!