Vacation rentals in Southeast Jacksonville

13 miles to Mayo Clinic!

Enjoy a stylish experience at this centrally located place in Jacksonville. Welcome to our beautiful townhouse in Jacksonville, Florida! Our home is the perfect place for your next vacation or business trip with modern and stylish decor, nestled in the heart of Jacksonville ( Baymeadows&Southside), close to all the best attractions, restaurants, beaches and shopping. Guests mayl be asked to sign rental agreement and provide ID. Welcome to your dream rental property in Jacksonville, Florida! This

Restful Studio Intercoastal West

Unwind in style within this peaceful retreat. A private entrance opens up to a fully furnished suite near Golf (Windsor Parke Golf and Country Club - 1 mile), Jacksonville Beach (6 miles), and Mayo Clinic (3 miles). The kitchenette features a microwave, refrigerator, stove, and dishwasher. A variety of dining options, including fast food, sandwich shops and upscale restaurants, as well as a supermarket and pharmacy, are situated within 1 to 2 miles. St. Johns Town Center is only 15 mts away.

Studio Suite in Beautiful Central Neighborhood

Studio guest suite with queen bed and kitchenette in beautiful Miramar neighborhood, just 5 minutes from historic San Marco. Close to restaurants, grocery, MD Anderson Cancer Center and Wolfson Children's Hospital. Owners live in main house on site but suite has its own private entrance and parking. You will have access to an outdoor dining space and fenced in backyard. Dogs live on premises but will not interfere, although you may hear barking. Sofa bed available if needed, please inquire.

XL family home, Pool, Pool table, Private 1 acre.

This well designed large home offers the perfect balance of luxury, comfort, and fun. Great for relaxing and reconnecting in style. Enjoy sun-filled living spaces : A family room with pool table, games, formal dining room, a fully stocked kitchen, coffee nook, pergola with an outdoor grill kitchen setup and an inviting inground pool which is shared with the cottage in the back on the same property. Conveniently located , this home offers space and amenities to make your stay truly memorable.

La Casita Chiquita Near Events & Entertainment!

Welcome to "La Casita Chiquita" our unique little guest cottage - in the heart of Jacksonville! This 250 square foot cottage, with a loft bed and comfortable amenities is nestled in a garden setting, underneath majestic trees. You can be away from it all - and just blocks to sports, entertainment & convention venues, craft breweries, sports bars, unique eateries, and museums. Are you here for business? Downtown is 5 minutes away and major medical facilities less than 10 minutes away.

The Jay

Nice little cozy camper with all the essentials. New super comfortable queen bed along with a nook that converts into a bed. Additionally, a 2 burner stove, fridge, freezer, microwave, sink, and an onboard shower with on-demand temperature control. There is a dedicated outside 1/2 bathroom for your use as well along with outdoor fireplace, grill, dining, and lounge area. I accommodate adults 18+ Pool rules: -Swim at your own risk -No diving -Please use outdoor shower before bathing

Blue Skies 1 Bedroom 1 Bath Apt

Stylish, centrally-located w/resort-like amenities. Just off of the main highwway minutes from the Mayo Clinic, UNF, & St. Johns Town Center. • pool & loungers • grills • club room /TVs & billiards • private offices & conf room • vehicle E charging stations • covered parking/elevator & wheelchair accessible ** upon confirmation, you will be required to complete a short form and to submit a copy of your ID. The complex requires this to secure the safety of residents and guests.

Sunset Retreat | 1BR | 1.5BA | Pool | Gym | Garage

Entire modern, luxurious, and spacious apartment. Stunning lake-front view with gorgeous sunsets. Large king bed and queen sleeper sofa provide a comfortable stay for 4. Whether your stay includes a day of shopping, a trip to golf, going to work, or to unwind at the beautiful Jacksonville beaches, you are never far from your destination. Less than 5 miles to the St. Johns Town Center, 7 miles to the nearest hospital, 11 miles to the beaches, and 6 miles to the nearest golf course.

Cosmic Serenity l 1BD Lux King in SE Jax

Perfect for long-term stays! Let go of the weight of daily life and step into a world of tranquility, where stress fades and serenity takes over. Experience the calming ambiance of a spa-like retreat, relaxing music, and soft lighting, all designed to create profound peace. This is more than a stay—it’s a curated experience designed to recharge your spirit, awaken your clarity, and inspire your dreams. Let go, unwind, and manifest your best self. Your escape begins here!

Mandarin 3BR + Flex + 3 Bath

Welcome to your fully furnished 3-bedroom, 3-bath home with a flex room in the heart of Mandarin, close to everything. Renovated in 2025, this home features modern fixtures, plush furnishings, and thoughtful amenities. Enjoy two queen bedrooms, a third bedroom with two twin beds, a full kitchen, and a cozy living area. Includes Wi-Fi, washer and dryer, and all utilities. Safe, clean, and quiet for your enjoyment in a peaceful Florida neighborhood.

Blue Bird Paradise

Welcome to “Bluebird Paradise”. Come visit our bright, beautiful, 400 sq. ft “Guest House”, detached from our home with a porch overlooking our beautiful Florida backyard with pool. The commute is very good; it is located less than 30 minutes from the city, 30 minutes from the beach and 30 minutes from the famous historical St Augustine. Peace and quiet await you. A guesthouse is a detached building that shares the property with the host.

Home Away From Home

Luxury Residence: Blending Style & Comfort Unwind in this stylish open space with great views and thoughtfully selected amenities to enhance your stay. This 2-bedroom, 2.5-bathroom home for up to four. Features include a gourmet kitchen, in-unit laundry, and Smart TVs throughout. Guests access exclusive amenities: resort-style pool, gym, outdoor grills, fire pit, game room, and theater room.