Vacation rentals in South Carolina

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in South Carolina

Guests agree: these stays are highly rated for location, cleanliness, and more.

1 of 1 pages1 / 1
Top guest favorite
An outdoor space features a round inground pool with a water feature. Surrounding the pool, lounge chairs and colorful seating areas offer relaxation options. A covered outdoor kitchen is seen in the background against a backdrop of palm trees, enhancing the serene setting.
Home in Myrtle Beach
4.96 out of 5 average rating, 165 reviews

Southern Comfort

Vacation in the heart of Myrtle Beach! Situated in a quiet neighborhood just .5 miles to Broadway at the Beach and .75 miles to the ocean. Fully renovated home features 4 bedrooms, 4 bathrooms, comfortably sleeps 8 and boasts a brand-new billiards room perfect for evening entertainment. The private, secluded backyard offers an inground pool, outdoor kitchen, TV, and firepit, with plenty of sun and a covered patio for shade. Several golf courses within 10 minutes. Location...Location...Location!

LocationValueQuiet

Top guest favorite
Cabin in Tamassee
4.97 out of 5 average rating, 186 reviews

A Lakefront Tiny Cabin • Hot Tub • Kayaks • Canoe

Whitewater Cabin is where you wake up to peaceful lake views, sip coffee on the porch, and spend the day kayaking or swimming from your private dock. This lakefront cabin is tucked away on a private Lake in the South Carolina mountains, minutes from Lake Jocassee, and sleeps 6. It’s the perfect getaway for couples, families, or friends looking to escape into nature. After a day exploring waterfalls, hiking, or boating on Lake Jocassee, come back and unwind in the hot tub overlooking the water.

LocationFamilyAmenities

Top guest favorite
The entrance features large, rustic double doors opening to reveal a stylishly decorated bedroom. A crystal chandelier hangs above a beautifully crafted bed with an intricate headboard. Two decorative topiary plants frame the doorway, adding a touch of greenery to the warm wooden floor.
Treehouse in Waterloo
4.99 out of 5 average rating, 258 reviews

#1 most loved AirBnB in SC! *Old Soul Treehouse*

The Old Soul Treehouse is a fabulous destination for couples looking to have a unique getaway! This is a waterfront treehouse on Lake Greenwood with a private dock, heat/AC, hot tub, king size bed, & a fully equipped kitchen & bathroom. Take a dip in the lake during the day or at night enjoy a soak in the hot tub on the peaceful porch under the stars. Book with us and you will soon be enjoying luxury by the water during this intimate experience with the one you love. We would love to have you!

FamilyValueCheck-in

Top guest favorite
An airy loft space features a suspended wooden swing, inviting relaxation under the high, timbered ceilings. Natural light streams through large windows, illuminating cozy furnishings including a bed and a dining area with a wooden table. Unique decor elements enhance the overall character.
Guesthouse in Summerville
4.98 out of 5 average rating, 775 reviews

★Delightful guest house near historic plantations★

Nestled in the Historic Plantation District between Summerville & Charleston, our timberframe "bunkhouse" offers privacy, comfort & convenience. This 850+ sq ft retreat includes full kitchen & bath, 2 dbl beds, twin bed & plenty of living space. There's a private entrance, so come & go as you please (we're right next door if you need us). Minutes from Middleton Place, Drayton Hall & Magnolia Gardens, an easy drive to dntn Charleston, historic S'ville, beaches & golf courses. *Now with WiFi*

FamilyValueIndoor spaces

Top guest favorite
A vibrant scene showcases two golden retrievers playing in a shallow stream, surrounded by lush green foliage. Behind them, a cascading waterfall flows over rocky tiers, creating a soothing sound and enhancing the natural beauty of the forested landscape.
Cabin in Oconee County
4.99 out of 5 average rating, 400 reviews

Secluded Waterfall Cabin.

Romantic, rustic cabin at the base of a 35-foot waterfall, nestled in the middle of 16 secluded acres surrounded by national forest that extends to the Chattooga River. This magical get-away caters to those with an adventurous spirit. Hike from the cabin to additional waterfalls, bike down Turkey Ridge Road to Opossum Creek Trail and the Five Falls or drive two miles to the Chattooga Belle Farm. The Waterfall Cabin is a joy to us all, and we hope you love it as much as we do. No cleaning fee.

FamilyLocationBiking

Top guest favorite
A treehouse surrounded by trees glows gently with warm lights in the evening. Two Adirondack chairs are positioned around a fire pit, with a small table nearby. The forest setting offers a calm and inviting atmosphere for outdoor relaxation.
Treehouse in Mountain Rest
5.0 out of 5 average rating, 490 reviews

THE BELLA LUNA Romantic Treehouse - Outdoor Shower

This is the perfect ROMANTIC ESCAPE! Located in the Sumter National Forest the Bella Luna is just 5 minutes from Stumphouse Tunnel, Issaqueena Falls, Yellow Branch Falls hiking trail, and Stumphouse Mountain Bike Park and within an hour of Clemson, Lake Jocassee and Clayton, GA. Our romantic retreat features carefully curated vintage furnishings, an outdoor shower, napping net, relaxing seating areas and an outdoor fire pit stocked with firewood and a S’mores kit! We can't wait to host you!

LocationValueKitchen

Guest favorite
Dome in Salem
4.88 out of 5 average rating, 403 reviews

Farm Geodome Near Lake Jocassee, Hot Tub, Zip Line

Glamping: where luxury meets the outdoors. This geodesic structure offers a rare opportunity to experience the outdoors without the elements. Complete with kitchen, AC & heat, dual control heated mattress pad, fully functioning bathroom, and sunrise views over the pasture. Whether you are looking to relax and enjoy feeding the farm animals, have an adventure riding the zip line, or indulge in a romantic evening sipping wine in the hot tub under the stars, you will leave with lasting memories.

FamilyLocationHeating

Superhost
Cabin in St. Matthews
4.76 out of 5 average rating, 206 reviews

A relaxing cabin on private pond. Old Bells Secret

Escape to our secluded cabin on 90 acres in St. Matthews, SC! This early 2000s style cabin features 2 cozy bedrooms, 1 bathroom, and a lovely porch. The large pond is perfect for swimming, fishing, or playing. It’s an endless adventure. The house can sleep up to 6 with the pull out couch. Accessible via a private road, it's perfect for weekend getaways with the family or housing for workers. Experience relaxation and adventure in nature at this wonderful cabin. Book now for a memorable stay!

FamilyValueGrill

Guest favorite
An outdoor game area features a pool table, with a set of colorful balls arranged on the surface. The scene includes a grassy lawn leading to the water, where a sunset illuminates the landscape. Two red chairs and a picnic-style setup are visible nearby.
Home in Prosperity
4.91 out of 5 average rating, 107 reviews

Sunset Cove-Beautiful Lake views

Your home away from home on Lake Murray! Spacious, modern clean, home with 3 levels of living -3 spacious decks, screen porch, and sunroom all with massive lake views! Plenty to do at Sunset Cove relaxing with family and friends and toys galore! "Wow just wow, best Airbnb ever..Sarah, June 2026. "..clean, beautiful view and so many fun games..Lisa, Oct 2025."Perfect setting for a quiet getaway. The house was amazing, clean, and had all the amenities we were looking for.."Jay, Sept 2025

FamilyValueIndoor spaces

Top guest favorite
Tiny home in Batesburg-Leesville
4.98 out of 5 average rating, 129 reviews

Private 75 acre farm with lake

Quiet getaway at Lake Tom-A-Shawna Farm. Fully furnished 2 queen bed, 1 full bath, mini cabin that offers accommodations for traveling professionals, equestrians, and vacationers. This gated private property spans 75 acres, including a 20-acre lake, and features a 4-person cabin with full appliances, granite countertops, high-speed internet, 2 TVs, an electric fireplace, heat/AC, deck. Fishing, shooting, hiking or just relaxing. We offer fresh eggs and meat for purchase.

ValueLocationBathroom

Top guest favorite
A spacious deck overlooks a serene cove, featuring a dining table surrounded by six chairs. Lounge seating is positioned nearby, inviting relaxation. Lush trees frame the area, with views of water and nearby boats visible, creating a calm retreat.
Home in Summerton
4.99 out of 5 average rating, 134 reviews

Cheerful 3 bedroom home on the lake

Great 3 bedroom home on the water. Perfect for family vacations, a weekend getaway or a stay for local fishing tournaments. This home is on a quiet cove that opens up to the larger lake. Get the best of both worlds. The cove is perfect for paddle boating, kayaking, fishing off the dock, grilling on the deck, or just relaxing on the screened porch enjoying the view. But, with the private dock you can bring your boats and jet skis to enjoy the entire lake.

FamilyLocationOutdoor spaces

Top guest favorite
The exterior showcases a striking multi-level mountain villa framed by lush trees. A spacious deck with loungers is visible, complemented by elegant outdoor lighting. The modern architecture features large windows that invite natural light, enhancing the connection with the scenic surroundings.
Home in Greenville
4.94 out of 5 average rating, 102 reviews

Mountain Villa 15min from Downtown Greenville

You'll love the unbelievable sunsets from this one-of-a-kind mountain villa that's just an easy 15 minute drive from downtown Greenville. With sweeping mountain views and luxurious finishes, this home will wow you from every room. The main level has a huge 8x12 accordion door that leads out to the soaring deck with glass rails, perfect for enjoying the sunsets. Elegantly designed, each room of this house is an experience and perfect for your stay.

FamilyValueWifi

Popular amenities for South Carolina vacation rentals

All about South Carolina

Weeping Spanish moss cloaks the cobblestone streets and historic homes of South Carolina’s oldest cities while its coast beckons travelers from near and far. South Carolina is one of the original 13 colonies of the United States, and it resisted British authority. Perched on the coast just north of Savannah, Charleston has been a major port city since the Spanish first settled the area in the 16th century, and was hotly contested territory in subsequent wars. Remnants of this history still stand in places like Fort Sumter and Fort Moultrie. South Carolina’s draws are heavily clustered around coastal areas like Hilton Head and Myrtle Beach — or on waterways that connect to the sea — but there’s plenty to do and see in its inland cities like the state capital of Columbia and the cultural hotbed of Greenville.

What are the top things to do in South Carolina?

Charleston

With its cobblestone streets and antebellum architecture, Charleston is one of the most charming cities in the American South. A peninsula town whose rivers empty into the Atlantic Ocean, it has a warm, welcoming vibe where visitors are treated like family, and just about anywhere you go somebody is eager to fill your cup with a heavy-handed pour of spiked sweet tea. If you want to combine urban travel with a beach getaway, Charleston is the place for you; its downtown core occupies a tight grid of streets and historic homes with thriving beach communities — Folly Island to the west and Isle of Palms and Sullivan’s Island to the east — on each side.

Congaree National Park

Wildlife enthusiasts, hikers, and paddlers will want to add South Carolina’s only national park, just south of Columbia, to their itinerary. The Congaree and Wateree rivers snake their way through the bottomland hardwood forest, part of the Congaree International Biosphere Reserve, making it a great place to observe the unique ecosystems by kayak via its waterways.

Greenville

In the northwestern corner of the Palmetto State near the Blue Ridge Mountains, Greenville is a melting pot of lifestyles: a city made for epicures and art lovers that also places heavy emphasis on outdoor living. While Falls Park on the Reedy is Greenville’s centerpiece, it’s not the only waterfall in town: Greenville boasts more than 30 breathtaking cascades, three state parks, and the 22-mile, multi-use Prisma Health Swamp Rabbit Trail.

Destinations to explore