
House vacation rentals in Santee
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Top-rated house rentals in Santee
Guests agree: these houses are highly rated for location, cleanliness, and more.

SDSU Beach Cottage
Welcome to our stunning SDSU Beach Cottage. Our home is 10 minutes away from everything amazing in San Diego! Our home is Centrally located in San Diego and in a desirable neighborhood. We are steps away from a Local favorite Eatery, Wine Bar, Beer Pub, Natural-Holistic Market, Pizza shop, Liquor Store, Nail shop, and Einstein's Bagels. Play in San Diego or stay and relax in our tropical yard that is set up to entertain you and your family with outside games and Ping Pong. 25 Yr's of age req'd

2 Bed Hidden Oasis | Garden, Laundry, Parking
Capture the essence of San Diego in our Hidden King Suite with Garden hosted by Ethos Vacation Homes. The peaceful property features elite comfort for up to 4 guests with beautiful outdoors and garden, off-street parking, A/C and heating, FREE laundry, comfortable king and queen size beds, plenty of sheets and towels, a large HDTV, Netflix, Max, Hulu, Showtime, Disney+, Apple+, and ESPN+. This spacious San Diego vacation rental home has everything you need for your California Dreaming Vacation!

San Diego Casita for 6 Morey de Prieto Surf Ranch
The Morey de Prieto Surf Ranch is truly awesome! Reserve your stay in this 2 Bed/1 Bath 650 sq. ft. casita for six. Home includes a kitchen with a GE electric cooktop, refrigerator, microwave/air fryer, rice cooker, mixer for drinks, sink with prep trays, Moen faucet fixtures, gorgeous shower, Krups coffee maker, 50" smart TV equipped with WiFi and NetFlix, mountain views, workspace and a sofa bed. Relax on the large 240 sq. ft. private deck featuring a fire pit, adirondack chairs and BBQ.

The Glass House - A Nature Retreat
Enjoy a unique retreat; 180 degrees of views from inside the home. Nestled at the end of a private road, our place is nearby great hiking and countryside wineries. The Glass House provides a magical space and nature retreat where individuals, couples, families and friends can gather together to re-connect with nature, each other, and themselves. The breathtaking mountain top views, the huge deck, hot tub, fireplace, and the open concept living space is unbeatable for the perfect getaway.

Classic Mid-Century Mount Helix Home with Views
Located in the exclusive Mount Helix neighborhood of La Mesa, this property is conveniently located near the 8 and 94 freeways for easy access to explore the greater San Diego area. Attractions like the historic Balboa Park with the San Diego Zoo or Sea World are a 15-25 minute drive away. With spacious interior and exterior spaces at the property, though, you may not want to leave. The property includes 4 bedrooms and 2.5 bathrooms with furnished living room, family room and kitchen.

Bright and spacious home with views, pool & spa.
This beautiful and recently remodeled, open-floor plan home is conveniently located directly across from Cowles Mountain, one of San Diego's most visited hiking trails. Each bedroom has its own full bathroom. Perfectly located for the outdoorsy family. Tons of hiking and mountain bike trails are just across the street. Only 15 min. away from beaches, zoo, & Sea World. Gaslamp/Downtown is only 20 min. by car. After a day of exploring, come home to a newly-built, salt-water pool and spa.

Mid-Century Style Family House with Spa
This home is the epitome of 1950’s luxury. A perfect family oasis, you won’t even want to leave the property. Beautiful Mt. Helix mid-century modern family home with incredible views, designed by architect of original Las Vegas Desert Inn situated on nearly an acre. Less than 20 minute drive to beaches/Zoo/Sea World/Downtown. With a swimming pool, jacuzzi, and AC. Surrounded by orange, lemon, pomegranate trees and herb garden. No loud parties please, this is a quiet community.

Spacious home with incredible backyard views
This beautifully appointed home is located in a quiet neighborhood & is central to all San Diego attractions - 5 min to hiking, 15 min to beaches/Zoo/Sea World, 20 min to downtown & 35 min to Legoland. But should you chose to stay in to relax there's plenty to enjoy - Bocce Ball, hot tub, BBQ & gas fire pit. Perfect for families or small groups looking to enjoy San Diego. Please note, if you’re looking to have a party or gathering this is NOT the property for you.

Palm Cottage, San Diego
Palm Cottage sits in the heart of La Mesa Village, San Diego. Enjoy the charm of a historic home with a fully remodeled and stylish interior featuring both Dutch & French doors letting in plenty of sunshine. A large private yard w/ covered outdoor living area creates the ultimate indoor/outdoor lifestyle. You're steps from the local grocery store, village shopping, coffee shops, restaurants, bars and the trolley. You could not ask for a better location!

Spacious & Fun | 5br, 4.5ba | Hot Tub | Views
Experience sunny San Diego from this 5 bedroom, 4.5 bathroom foothill home. Wake up to panoramic views of the surrounding hillsides and gather in the spacious living and dining rooms. The home is conveniently located just 15-20 minutes from San Diego's famous beaches and top attractions. After a day of exploration, unwind in the backyard area featuring a hot tub, fire pit, pool table, and life-sized chessboard.

Sunny & Spacious 3BR Retreat w/ Parking & A/C
Discover your La Mesa retreat! This newly refurbished home offers a perfect blend of comfort and convenience. Enjoy a gourmet kitchen, stylish dining, three bedrooms, two modern bathrooms, and an expansive yard. Explore nearby attractions like the Grossman Center (10-min walk) with shopping and dining, or venture to San Diego's heart (20-min drive). Perfect for families and groups seeking a relaxing getaway.

Quiet Country Home
Extremely clean home. Fenced private yard with BBQ & Tables. Outdoor smoking. 25 minutes to beach or downtown. Rural area with animals “talking”. Horses and carrots included. Seasonal Fruits & Vegetables. 1st bedroom: king/full bath. 2nd bedroom: queen/work desk. 3rd bedroom: full & 2 twin trundle. All dishes/appliances. Crib & Highchair available (Host lives in completely separate granny flat.)
Popular amenities for Santee house rentals
House rentals with a pool

Modern Central SD Home w/ Pool & Spa Near Beach

3 bedroom home with pool 15 minutes from beaches

The Agave House | Mountain Views & Pool

Views - Quiet Mt. Helix Home - Pool -Sleeps 11

Entertainers Dream Pool Home

San Diego Pool | Fire Pit | Sunshine | Sleeps 10

The Dell, a relaxing country estate in Ramona.

Modern Hilltop Home: Roomy, Views, Family-Friendly
Weekly house rentals

BIG Modern Mt Helix Home with Pool

Cozy SoCal Oasis

A Walk in the Clouds: Stunning Views & Game Room!

Luxury Private Suite w/ Kitchen & Patio

Hidden Gem! Amazing Resort Style Pool & Spa!

Private comfy studio; solo, couple, kids friendly

5BR Oasis | Pool, Hot Tub & Luxe Outdoor Retreat!

Cozy 4 BDR Family Home!
Private house rentals

Spacious Home with Large Yard and Mountain Views

Relax in Lakeside.

Discover La Mesa: Your Perfect Cozy Base

Helix Haven

Spacious 5BR Group Retreat w/ Backyard Lounge

Lakeside Haven | Mountain Views, Private Pool

Country Modern |5bdr w/ ADU | |Soaking Tub

Hilltop Hot Tub Retreat • Arcade • 12 Guests
When is the best time to visit Santee?
| Month | Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sep | Oct | Nov | Dec |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Avg. price | G$28,214 GYD | G$25,915 GYD | G$20,899 GYD | G$31,767 GYD | G$33,439 GYD | G$26,751 GYD | G$45,769 GYD | G$40,126 GYD | G$36,365 GYD | G$36,365 GYD | G$39,917 GYD | G$33,021 GYD |
| Avg. temp | 15°C | 15°C | 16°C | 17°C | 18°C | 20°C | 21°C | 22°C | 22°C | 20°C | 17°C | 14°C |
Quick stats about house rentals in Santee

Total vacation rentals
Explore 50 vacation rentals in Santee

Nightly prices starting at
Santee vacation rentals start at G$6,270 GYD per night before taxes and fees

Verified guest reviews
Over 1,270 verified reviews to help you choose

Family-friendly vacation rentals
30 properties offer extra space & kid-friendly amenities

Pet-friendly vacation rentals
Find 10 rentals that welcome pets

Vacation rentals with a pool
10 properties feature pools

Rentals with dedicated workspaces
20 properties have a dedicated workspace

Wi-Fi availability
50 of Santee vacation rentals include wi-fi access

Popular amenities for guests
Guests love Kitchen, Wifi, and Pool across Santee rentals

4.9 Average rating
Santee stays are highly rated by guests—averaging 4.9 out of 5!
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