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Vacation rentals in Santa María

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Top-rated vacation rentals in Santa María

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Top guest favorite
The living area features large glass doors that invite natural light and views of the garden. Indoor plants enhance the space, and a cozy seating arrangement includes a sofa and eclectic chairs. A workspace with a desk and lamp is positioned to the side.
Guesthouse in El Valle de Antón
4.99 out of 5 average rating, 114 reviews

Spacious Casita with Bamboo View

Walk 20 minutes to the artisan mercado and restaurants on Ruta 71. Cerro Cara Iguana trailhead is walking distance from the casita. High insulated ceilings and 2 ceiling fans for comfort. Private hammock patio for an afternoon nap. Washer/dryer in the casita. Hot water throughout. Kitchen has a 2 burner cooktop, countertop oven, microwave, instant pot, electric skillet, blender and coffee maker. 2 Internet providers and a small workspace available. * No television set * Non smoking property

Top guest favorite
The living area features a spacious beige sofa adorned with patterned cushions, paired with a wooden coffee table. Natural light enters through large windows, illuminating the open layout that connects to a dining area and kitchen in the background.
Apartment in Provincia de Veraguas
4.94 out of 5 average rating, 125 reviews

Casa Melina Torio Cozy upscale 2b jungle apartment

Stylish jungle two bedroom apartment near all major Torio attractions: waterfall, jungle trails, Torio River, Playa Torio & Morrillo Surf break. The apartment is fully equipped with everything you need & want (Hot water, AC, WiFi & TV). Perfect for a couple/family seeking to blend work and play. Casa Melina was designed so our guests can fully experience our Torio culture. Cook with local fresh ingredients, discover Torio on foot & return to rest in the coziest rental you have ever experienced.

Top guest favorite
A serene evening scene features the bohío cottage with its thatched roof, surrounded by lush greenery and potted plants. The moon is visible in the sky above, casting a gentle glow on the outdoor area, near the tranquil pool reflecting the soft outdoor lighting.
Place to stay in Santa Clara
5 out of 5 average rating, 25 reviews

Paradise from ocean to jungle. Bohío cottage

Welcome to our beach house 850meters to beautiful pacific beach & 3 beach restaurants . Our house is gated and in a safe area .Many areas to visit nearby from surf areas to crater town in the mountains ! Hikes , Canyons , waterfalls ! Coronado is a 35 min drive with all conveniences .New mall is 10 min drive to grocery store , large drugstore. Fish market is 5 min . Seasonal riohato airport 5 min. . Our 1/4 acre property & house is on a country lane with some lovely estates surrounding it.

Guest favorite
A single-story villa is surrounded by lush greenery, featuring a light green exterior and large windows that allow ample natural light. A screened porch is visible, enhancing outdoor enjoyment while maintaining comfort. The well-maintained lawn provides a serene environment.
Home in Santa Catalina
5 out of 5 average rating, 6 reviews

Villa Coiba- Beach Front- king size - tour Coiba

Your king-sized villa is unique. It is the only one in the Santa Catalina area that offers shuttle service from the local airstrip. Coiba is the #1 dive tour in Panama (just search) Skip the 6+hour drive. A charter flight is 45 minutes. If planning an itinerary that includes Boquete and Bocas, we have a an effective logistical plan for you. Message us on the platform. Your 700ft2 villa is fully equipped (king bed). We can arrange all supplies for your stay as well as transportation.

Top guest favorite
A serene view from the guesthouse showcases a private balcony with two chairs and a small table, positioned before lush greenery and distant mountains. The inviting landscape is framed by the sliding glass doors, enhancing the connection to nature.
Guesthouse in Torio
4.92 out of 5 average rating, 149 reviews

Torio guesthouse with panoramic view; Kokomo

Our private guesthouse is suspended over the Torio River, on the west coast of the Azuero Peninsula. It is a paradise for hikers, bird watchers, surfers and beach goers. Marked trails with posted maps begin at our place. Hike to a beautiful waterfall, mountain or beach. Photograph birds from the porch. Surf, body board and swim safely (no strong currents). Walk to good restaurants, and a small grocery. Experienced Surfers have Morrillo Beach and Playa Reina. Watch sun and moon rise.

Top guest favorite
An open living space features a wooden dining table surrounded by six wicker chairs. Two hanging hammocks are displayed on the covered terrace, offering views of the lush hills. Large glass doors reflect the greenery, blending indoor and outdoor spaces harmoniously.
Cabin in Torio
4.97 out of 5 average rating, 172 reviews

Cozy open space, unique jungle views, river access

An open-style jungle home with mesmerizing treetop and mountain views. Located 10 minute walk to the beach, with a trail that leads to the River. The house is not childproof! It has three individual bedrooms, each with its own key. The price is based on the number of guests. The entire house is always yours. The house offers fiber optic WiFi and two dedicated workspaces. The property is surrounded by large trees, naturally keep the house cool and provide shelter for birds and wildlife.

Top guest favorite
A spacious terrace offers a view of the outdoors, featuring large glass sliding doors that provide access to the interior. Inside, a bright dining area is visible, accompanied by a compact kitchen. The decor is light and minimal, enhancing the overall sense of openness.
Shipping container in Torio
4.94 out of 5 average rating, 34 reviews

Casita Chill #1 | Ocean View + Starlink Wi-Fi

A tiny house with soul — the perfect place to disconnect and reconnect. Thoughtfully designed 15 m² with a breathtaking view of the Pacific Ocean, a comfy bed, private bathroom, kitchenette, A/C, fan, terrace, and Wi-Fi so you have everything you need. Whether you're here to unwind, work remotely, or explore nearby rivers, waterfalls, and beaches — this is your spot. Surf, unforgettable sunsets, total peace… and yes, your furry friend is welcome too! 🐾

Top guest favorite
A spacious living area is visible, adorned with natural light filtering through large glass doors that open to a lush outdoor setting. The seating arrangement includes a sofa and dining table surrounded by stylish chairs. A smart TV is mounted on the wall, complemented by decorative greenery.
Home in Santa Catalina
4.97 out of 5 average rating, 102 reviews

Casa Colibrí - modern house in the green

Casa Colibri is a beatiful, spacious home in the middle of nature and will make your stay in Santa Catalina perfect. It has a large terrace with a fantastic view into the green where you can relax and listen to the birds. The interior has a lot of natural light and stays cool during the day, in case you need to escape the tropical heat. It is the perfect place for a unique experience in this special town with your friends or family.

Guest favorite
An outdoor terrace features a cozy seating area with a brown sofa and a wooden table. A hammock is suspended nearby, surrounded by lush greenery. The space is covered by a roof, allowing for enjoyment of nature in comfort.
Home in Torio
4.89 out of 5 average rating, 38 reviews

Architectural Jungle Home | Torio Eco Retreat

Wake up to birdsong and soft jungle light in this architectural eco home nestled in the hills of Torio. Designed for slow living and connection to nature, the house blends open-air terrace living with comfortable enclosed bedrooms with AC, and a fully equipped kitchen. Just minutes from the beach yet surrounded by forest, it’s ideal for families, creatives, and remote workers seeking space, privacy, and tropical immersion.

Top guest favorite
A contemporary living space is highlighted, with natural light entering through large windows. An inviting sofa is paired with a wooden coffee table. The kitchenette, featuring modern appliances and a breakfast bar, is visible in the background, alongside a green door that adds a vibrant touch.
Bungalow in Santa Catalina
4.97 out of 5 average rating, 149 reviews

OCTOPUS studio

Disfruta de una experiencia con estilo en este alojamiento de encanto, ideal para pareja : acogedor, luminoso y actual . Ubicación fantastica en área privada y a unos paso del centro, playas y lugares de interés. Confortable para largas estadías y teletrabajo. Wifi gratuito, A/C. Kitchenette. Amplia terraza de madera rodeada de exuberante naturaleza, excelente para practicar Yoga y relajarse.

Guest favorite
Farm stay in Santa Fe
4.9 out of 5 average rating, 312 reviews

Sun Cabin at Finca Namuiki by the River

Spectacular contemporary style villa surrounded by local flowers and woods. The villas design enhances the relationship with the outside environment with panoramic windows which are found in the dining room and kitchen, this offers an awesome view of the mountains and green flora. The villa is located in a organic quiet farm, with abundant vegetation and great presence of birds.

Guest favorite
Cottage in Santa Fe
4.89 out of 5 average rating, 9 reviews

k* Casa Matilde | 2BR Santa Fe Retreat by River

Escape to Casa Matilde, a renovated 100 m² home in Santa Fe de Veraguas. With 2 bedrooms and 3 beds (1 queen & 2 twins), it’s perfect for families or remote workers. Enjoy a bright living room, modern bath with hot water, A/C, and fast Starlink Wi-Fi. Relax by the private creek, explore the river just 200 m away, and take in mountain views—all with total privacy and comfort.

Popular amenities for Santa María vacation rentals

  1. Airbnb
  2. Panama
  3. Herrera
  4. Santa María