
Vacation rentals in Santa María
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Top-rated vacation rentals in Santa María
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Pacific View | Jacuzzi, Pool, Views and Alexa
We are a country house for a maximum of 10 people on a fenced 1,000 m² plot at the top of Valle Los Lirios, Las Uvas de San Carlos, which maintains a feeling of seclusion. Located in a neighborhood with 24/7 video surveillance and a security gate. It offers views of the ocean, Valle de Antón, and forests. Relax in the Jacuzzi with hydro-massage and jets or swim in the pool. We have hammocks, a barbecue, a ping pong table, a fire pit and an Alexa voice assistant. There is parking for a maximum of 6 cars.

CasAna
Fantastic place with open spaces, natural light and fresh air, 2 bedrooms with internal bathroom, terrace to receive the sunrise and sunset, private pool that makes you feel like you are flying, while you can share with friends and family in a group area provided by a spacious deck, enjoy your barbecues on the terrace and kitchen equipped with everything you need Located 10 meters from Playa La Ermita and 12 meters from the entrance to the Valley, and a hop from the Los Camisones Restaurant.

Country House in Olá, rivers, waterfalls, Los Picachos
Finca La Terapia lives up to its name, it is located among the mountains of the picturesque village of Olá de Penonomé, where you can disconnect from the busy day to day of the city. It has 42 private hectares to explore nature. The Olá district is characterized by having the most beautiful natural landscapes, among which we can mention Los Chorros de Olá, Chorros las Mesitas, Cerros los Picachos, Rio San Antonio, Balneario Brujas, among others, just a few minutes from the property.

Private Oceanfront Villa | Sleeps 14 |Playa Blanca
Private beachfront estate in Farallón, Playa Blanca. This spacious oceanfront villa sits directly on the sand and comfortably sleeps up to 14 guests — perfect for large family gatherings, group getaways, retreats, or special celebrations. Enjoy true direct beach access from your private garden, with no roads to cross and no shared resort spaces. Relax in hammocks facing the ocean, host sunset dinners on the terrace, and wake up to uninterrupted panoramic sea views.

Private Beach Studio · Sunset & Nature Views
Designed for comfort, functionality, and a welcoming atmosphere: • Comfortable bed for a truly restful sleep • Air conditioning • Wi-Fi • Kitchen • 2 Bathrooms • Parking Perfect for short stays or longer breaks. Wake up at your leisure, enjoy a relaxing coffee, stroll to the beach, or simply unwind in this space. This place is ideal for: • Romantic getaways • Personal retreats • “Work from the beach” • Escaping the hustle and bustle of the city

Santiago city, home w/ spacious living & office
Spacious and peaceful home in a safe area of Santiago. 4 bedrooms (ideal for families and groups), bright living-dining area and large kitchen to share with family or friends, plus a private office for working comfortably. High-speed Wi-Fi, air conditioning and fans in all rooms, fully equipped kitchen, washer/dryer, and safe for valuables. Self check-in with smart lock, parking for several cars, and a coffee station with board games and karaoke.

Guacamaya’s Hill View|3BR Country Home In Penonomé
We want you to feel truly comfortable and at home. A home away from home. If you’re looking to spend quality time with family or friends, “Mi casa es su casa” at Villas de Santa María is the perfect place to relax, disconnect, and escape the noise of crowded cities. Enjoy our private garden and unwind on the terrace with stunning views of Guacamayas Hill, where you’ll experience peaceful surroundings and beautiful sunsets every afternoon.

Beachfront Loft in Farallón
Wake up to the ocean in this beautiful beachfront loft in Farallón, located in the exclusive Miramar Loft next to the Decameron Hotel. Relax on the balcony with sea views, enjoy the pool, and walk to the beach with private cabanas on the sand. The apartment offers 2 bedrooms, a full kitchen, A/C throughout, and fast Wi-Fi. Just 2 hours from Panama City. Book now and live the beach experience you deserve!

k* Casa Matilde | 3BR Santa Fe Retreat by River
Escape to Casa Matilde, a renovated 100 m² home in Santa Fe de Veraguas. With 3 bedrooms and 4 beds (1 queen, 1 full & 2 twins), it’s perfect for families or remote workers. Enjoy a bright living room, modern bath with hot water, A/C, and fast Starlink Wi-Fi. Relax by the private creek, explore the river just 200 m away, and take in mountain views—all with total privacy and comfort.

Cabaña del Sol en Finca Namuiki by the River
Spectacular contemporary style villa surrounded by local flowers and woods. The villas design enhances the relationship with the outside environment with panoramic windows which are found in the dining room and kitchen, this offers an awesome view of the mountains and green flora. The villa is located in a organic quiet farm, with abundant vegetation and great presence of birds.

Colonial House in Parita
Discover the charm of Parita from a comfortable and spacious home, perfect for large groups. Located in the picturesque and peaceful town of Parita, in the Herrera Province, just 12 minutes from Chitré, this spacious home is the ideal place to immerse yourself in the history and culture of a historic colonial-era town.

Spacious house in Villa de los Santos
Comfortable family accommodation in La Villa de Los Santos, with Wi-Fi, A/C, equipped kitchen, patio and parking. Located near supermarkets and plazas. Only 15 minutes from El Rompió and Monagre, 45 minutes from Isla Iguana and 1h 30 minutes from Playa Venao.
Popular amenities for Santa María vacation rentals
Other great vacation rentals in Santa María

Casa Blu Central Chitre| Sleeps 6| Private Parking

Luxury 4BR Villa + Guesthouse & Pool @Buenaventura

Penonomé - Comfortable house

Beachfront cottage with swimming pool

Country House with Pool in La Enea de Guararé

Farmhouse

Salamanca Loft

Family home for 8 | 3 bedrooms with A/C
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