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Vacation rentals in Santa María

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa María

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
A single-story house is nestled beneath a large tree, featuring a tiled roof and a covered parking area. Surrounding greenery includes bushes and ornamental plants, enhancing the natural setting. The house is positioned to provide a sense of privacy and tranquility.
Home in Chitre
4.87 out of 5 average rating, 62 reviews

Country House Like in the City / La Casita

Casa fresca, con árboles y naturaleza. Áreas amplias para descansar. Ubicación céntrica, cerca de malls, restaurantes, estación de buses y ciclovía. Entrada privada, estacionamientos, cocina completa, mobiliario completo, baño, TV HD con cable, AC en recámara, agua caliente y Wi-Fi. ENG, PORT, FRAN and ITA Spoken! Ahora, Chitré, tiene un problema con el agua: no está potable; tenemos 50% de lo habitual, a veces estamos sin agua por algunas horas. Por favor, consulten antes de reserar.

Top guest favorite
The exterior of the cabin is showcased amidst lush greenery, featuring a sloped roof and large glass windows. A wooden staircase leads up to the entrance, while a stone pathway meanders through the garden, enhancing the natural surroundings.
Cabin in Penonome
4.97 out of 5 average rating, 116 reviews

Aqeel cabin in the nature

Relax at this unique and tranquil getaway surrounded by nature. If you're lucky, you may wake up to see white-faced capuchins from your bedroom window and spot an abundance of birds, such as the crested oropendola or a toucan. The property offers river access with a sandy, beach-like area, and there is a 1 km walking trail alongside the river. With satellite high-speed internet access, you'll stay connected, though the river and sandy area may not be accessible during rainy days.

Guest favorite
A scenic view of rolling hills under a colorful sky at sunset. Shades of orange, pink, and purple blend, creating a vibrant horizon. Lush trees are scattered across the landscape, adding a touch of greenery to the terrain.
Cottage in Olá
4.95 out of 5 average rating, 21 reviews

Casa de Campo in Olá, rivers, waterfalls, Los Picachos

Finca La Terapia honors its name, it is located among the mountains of the picturesque village of Olá de Penonomé, where you can disconnect from the busy day to day of the city. It has 42 private hectares to explore nature. The Olá district is characterized by having the most beautiful natural landscapes among which we can mention, Los Chorros de Olá, Chorros las Mesitas, Cerros los Picachos, Rio San Antonio, Balneario Brujas, among others, just a few minutes from the Farm.

Top guest favorite
A spacious outdoor deck features modern furniture arranged for relaxation, overlooking a lush mountainous landscape. Verdant hills and a colorful sky at dawn create a tranquil environment, inviting guests to enjoy the natural beauty and serenity of the surroundings.
Villa in El Copé
4.92 out of 5 average rating, 183 reviews

Mountain retreat

Our beautiful, modern, comfortable house is designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and also a base to explore the area which is in a beautiful part of Panama near a cloud forest national park with amazing hiking to waterfalls and local communities. The house is large, sleeping 12, within 17 acres of forest with rivers for swimming. We can arrange tours and hosted retreats for yoga, cooking and more.

Guest favorite
A refreshing swimming pool sits in the foreground, complementing the rustic building behind it. Lush greenery and potted plants surround the area, enhancing the natural setting. A shaded patio area with outdoor seating is visible, offering a serene environment for relaxation.
Guesthouse in La Enea
4.96 out of 5 average rating, 49 reviews

Country House with Pool in La Enea de Guararé

Far from the capital city, come and enjoy Panamanian folklore in a rustic but cozy space, living an indigenous experience. Lounge in the pool or lounge in a hammock, breathe fresh air, close to the ocean, surrounded by wide, natural gardens for a good walk. Close to the Port of Guararé where you can enjoy the best seafood and drinks or enjoy the heart of the best folklore event highlighting the traditions and the best Panamanian skirts.

Superhost
Farm stay in Santa Fe
4.89 out of 5 average rating, 303 reviews

Sun Cabin at Finca Namuiki by the River

Spectacular contemporary style villa surrounded by local flowers and woods. The villas design enhances the relationship with the outside environment with panoramic windows which are found in the dining room and kitchen, this offers an awesome view of the mountains and green flora. The villa is located in a organic quiet farm, with abundant vegetation and great presence of birds.

Guest favorite
Cottage in Santa Fe
5 out of 5 average rating, 6 reviews

k* Casa Matilde | 2BR Santa Fe Retreat by River

Escape to Casa Matilde, a renovated 100 m² home in Santa Fe de Veraguas. With 2 bedrooms and 3 beds (1 queen & 2 twins), it’s perfect for families or remote workers. Enjoy a bright living room, modern bath with hot water, A/C, and fast Starlink Wi-Fi. Relax by the private creek, explore the river just 200 m away, and take in mountain views—all with total privacy and comfort.

Top guest favorite
A comfortable porch area features two colorful hammocks suspended from the walls. The polished tile flooring reflects soft light, and a pair of large wooden doors stands closed in the background. A vehicle is parked nearby, adding to the casual ambiance.
Home in Penonome
4.92 out of 5 average rating, 129 reviews

Comfortable, fenced and safe house.

Enjoy the simplicity of this spacious, quiet and centrally located place at Casa las Hamacas. You can enjoy the pleasant Penonomeño climate. A place close to everything, shopping malls, schools, hospital, mountains, rivers and beaches. Both rooms feature A/C to ensure your rest. A few minutes away from the Pan-American Highway.

Guest favorite
The two-story colonial house is showcased with a white facade and wooden accents. Decorative balconies with railings are present at the front, along with several potted plants adding color. The street is lined with other buildings, under a clear blue sky dotted with clouds.
Cottage in Parita District
4.8 out of 5 average rating, 44 reviews

Colonial House in Parita

Discover the charm of Parita from a comfortable and spacious home, perfect for large groups. Located in the picturesque and peaceful town of Parita, in the Herrera Province, just 12 minutes from Chitré, this spacious home is the ideal place to immerse yourself in the history and culture of a historic colonial-era town.

Guest favorite
A bright bedroom is displayed, featuring a spacious bed covered with a textured white blanket. A television is mounted on the wall opposite the bed. Natural light floods through large windows, accompanied by sheer curtains. A cozy orange chair and potted plant add a touch of warmth.
Tiny home in Playa El Jobo
4.95 out of 5 average rating, 20 reviews

Little home near to the beach -Las Tablas

10 min drive- Las Tablas Get away from it all when you stay under the stars. A room very close to the sea, with an open kitchen that will allow you to disconnect and enjoy the view and nature in Las Tablas. You can plan to visit nearby beaches or take a walk through Pedasí, 30 minutes from Las Tablas.

Guest favorite
Home in La Villa de los Santos
4.94 out of 5 average rating, 102 reviews

Spacious house in Villa de los Santos

Comfortable family accommodation in La Villa de Los Santos, with Wi-Fi, A/C, equipped kitchen, patio and parking. Located near supermarkets and plazas. Just 15 minutes from El Rompió y Monagre, 45 minutes from Isla Iguana and 1h 30 minutes from Playa Venao.

Guest favorite
A spacious living area is surrounded by large windows, offering panoramic views of the lush landscape. Comfortable seating is arranged in a circular layout, adorned with colorful cushions. A central coffee table is complemented by decorative plants and a warm wooden floor enhances the inviting ambiance.
Farm stay in Santa Fe
5 out of 5 average rating, 10 reviews

Mansion on Organic Farm with Heated Pool

Relax with the whole family and friends up to 30 people in this cozy house on an organic farm with animals, crops, tilapia fishing, coffee, rivers, we have a heated pool, a 120-meter roofed terrace for you to celebrate your special occasions.

Popular amenities for Santa María vacation rentals

  1. Airbnb
  2. Panama
  3. Herrera
  4. Santa María