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Vacation rentals in Santa Isabel District

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Isabel District

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
Home in La Guaira
5 out of 5 average rating, 7 reviews

Apt near sea+Parking+TV+AC+Kitchen+WiFi@La Guaira

✔️ SuperAnfitrión Verificado ¡Tu estadía estará en las mejores manos! 🚨Envíanos un mensaje con la palabra DESCUENTO y pregunta por promociones especiales 📍 Apartamento en Provincia de Colon, Panamá 🇵🇦 🏡 Espacio limpio, cómodo y seguro, con excelente ubicación 🧼 Dotado con insumos y productos de limpieza Durante tu reserva, tu Airbnb cuenta con: 🌐 Wifi 📺 TV 🍳 Cocina ❄️ A/C 🌊 Cercano a la playa 🚗 Parqueo 👉Envíanos un mensaje con la palabra DESCUENTO y pregunta por promociones

An aerial view showcases a rustic cottage surrounded by lush palm trees, located near a sandy beach. The gentle waves of the ocean are visible, along with several red-roofed structures nestled within the greenery, creating a serene coastal atmosphere.
Cottage in Palenque
4.87 out of 5 average rating, 91 reviews

Beachfront House in Caribbean sandy beach

Enjoy this rustic and cozy cottage with its almost private beach surrounded by beautiful palm trees along the whole area. With 2 oceanview bedrooms, 2 full bathrooms and a third bedroom in a mezzanine. Has a patio with a built in uruguayan parrilla, ideal for BBQs. Step in beautiful white sand and bath in crystal clear water. Coconut breakfasts watching the sunrise become a routine in this paradise. - This is a rural setting. Not a 5 star hotel. Insects and small animals can be around.

Top guest favorite
Villa in Palenque
5 out of 5 average rating, 29 reviews

All 5 Stars Reviews Caribbean Retreat Beach Front

If you are looking for a place to relax this is it. Located 2 and a half hours away from Panama City, this is a place to enjoy the beach while listening to the sound of the waves. In a luxurious villa. The place is ideal for families with kids. Very save with shallow waters as well with deeper areas. Our large gardens are also ideal for kids to play. Kayaks are included. We have high speed internet, which will allow you to work from here. We also have kayaks and paddle boards for our guest.

Home in Playa Chiquita
5 out of 5 average rating, 7 reviews

Caribbean Jungle Beach House

Secluded loft beach house on 7 hectares of jungle with pristine beach. Enjoy the peaceful tranquility of coconut palm tree covered golden sand beach with shallow warm water great for swimming and body surfing. Lounge chairs, barbecue, kayaks, snorkel masks, boogie boards, hammocks and a fire pit for beach bonfires under the starry night sky all available. Great for families, couples or groups of friends. Delicious Panamanian food made to order on site. Tent camping (glamping) also available.

Guest favorite
Home in La Guaira
4.8 out of 5 average rating, 35 reviews

Bella Casa, Caribbean Sea, Juan Gallego (waterfront)

Hermosa Casa de Playa, frente al mar caribe, para descansar y relajarse al 100%. La Casa cuenta con una ubicación privilegiada, mantiene 4 habitaciones (una de ellas cuenta con una mampara para dividir de la sala y ampliar esa área en caso que se desee), sala, comedor, terraza privada, frente a Isla Grande. 4 habitaciones. 3 tienen TV con cable y una TV extra en la sala. Todas con con Aire Acondicionado. Cuenta con 2 baños completos. Cocina equipada y lista para disfrutar y Wifi

Guest favorite
A hammock sways gently between posts, overlooking calm waters that reflect a clear blue sky. In the distance, a lush island is visible, providing a picturesque backdrop. The green grass leads up to the water's edge, creating a serene outdoor space.
Apartment in Juan Gallego
4.87 out of 5 average rating, 150 reviews

Pebos Reef Apt 2 · Beachfront · Sea View Terrace

This spectacular beachfront property is ideally situated with an incredible view of neighboring islands, fishing friendly waters, and mesmerizing snorkeling spots for children and adults to enjoy. Monkey greetings from the jungle adjacent, octopus and colorful native fish inhabited waters, and lazy bear sloth sightings are all part of your daily experiences here at Pebos Reef! If you are lucky you will even see dolphins from the terrace ! A terrace on the sea is all you need.

Guest favorite
An aerial view shows a property situated by the water, featuring red-roofed cottages and a grassy yard. Kayaks are visible in the water, along with seating areas under palm trees. A smooth pathway leads down to the water's edge, offering direct access for guests.
Home in Viento Frío
5 out of 5 average rating, 8 reviews

Casa Canalú

Enjoy the sounds of the sea when you stay at this unique place. The sea in front of the property is like a natural pool. The property is located six meters from the sea so you can always enjoy the sea breeze from a hammock. Those who like to cook will have a fully equipped kitchen. The 3 comfortable rooms, which are separated from each other, have air conditioning, fans and WiFi. Parking for several cars. Pedal boat, Kayak, Canoe

Home in Palenque
4.5 out of 5 average rating, 4 reviews

Palenque Beach House · Pool & BBQ

Escape to this stunning beachfront home in Palenque! With 5 spacious bedrooms and 16 beds, it’s perfect for families, retreats, or group getaways. Enjoy a private pool, BBQ area, and direct beach access. The two-story layout offers ocean views, a full kitchen, and open living spaces for comfort and connection. Relax, recharge, and make unforgettable memories by the sea in this tropical gem!

Guest favorite
An aerial view showcases the property nestled between two natural beaches, surrounded by lush greenery. Calm waters and rocky formations are visible nearby, alongside beachside features that highlight the area's tropical environment.
Villa in Palenque
5 out of 5 average rating, 10 reviews

Beach Front House Surrounded by 2 Private Beaches

La propiedad esta rodeada de dos playas naturales. Preserva una selva primaria con múltiples clases de arboles endémicos del área que sirven de alimento a los aulladores, titis, perezosos y muchas aves en especial tucanes que vienen a comer uvitas tropicales. Tenemos un camino interno para observar la selva. Entre Marzo-Mayo y Agosto-Oct se observa la migración de aves.

A welcoming entrance to Casa Guaymar is framed by lush greenery and vibrant plants. The structure features a spacious porch, highlighted by the colorful sign overhead. Large glass doors allow for a view of the inviting interior and surrounding landscape.
Home in Juan Gallego
4.57 out of 5 average rating, 21 reviews

House facing Isla Grande

Discover the Caribbean paradise at Casa Guaymar, an oceanfront house with a pool, bar, hammocks, and a spectacular view of Isla Grande. Perfect for groups of up to 16 people, with spacious spaces, 4 bedrooms with king beds and 8 single mattresses. Experience crossing to the island from the very shore of the house. Ideal to disconnect and enjoy.

Guest favorite
Home in Palenque
4.8 out of 5 average rating, 5 reviews

Casa Palenque Panama

Enjoy a spectacular oceanfront house, ideal for groups and families of up to 14 people. Relax with direct beach views, spacious indoor and outdoor spaces, and all the comforts for an unforgettable stay. Perfect for resting, living and creating unique memories with the sound of the sea in the background. We are pet friendly.

Superhost
The image captures a tranquil scene of the Caribbean Sea at sunset. Silhouetted palm trees dot the horizon, while gentle waves roll towards the shore. A soft orange and yellow sky reflects upon the water, creating a serene and calming atmosphere.
Home in Cuango
4.75 out of 5 average rating, 12 reviews

Beach house with an ocean view

Disconnect or homework? Enjoy this house away from the city but with everything you need for your stay right in front of the Panamanian Caribbean Sea. We have two rooms with air conditioning, TV and WiFi. Pets are allowed.

Popular amenities for Santa Isabel District vacation rentals