Vacation rentals in Santa Isabel District

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Top-rated vacation rentals in Santa Isabel District

Guests agree: these stays are highly rated for location, cleanliness, and more.

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A spacious terrace features various hammocks in vibrant colors, providing a comfortable resting area. The area is shaded by an overhead roof and surrounded by green grass and tropical plants, creating an inviting outdoor space for relaxation and leisure.

Home in La Guaira

4.56 out of 5 average rating, 9 reviews

Villa Frente al Mar Isla Grande

Disfruta de una Villa frente al Mar. Nada de ir en carro o caminar kms hasta la playa. Villa Espe está a solo a unos pasos de una espectacular y tranquila playa caribeña de arena blanca y aguas cristalinas. La casa está rodeada por un gran patio donde los niños puede jugar y correr con sus mascotas y la amplia terraza frente al mar tiene hamacas para relajarse y descansar. Toda la propiedad cuenta con cerca perimetral, cámaras de vigilancia y estacionamiento privado para mayor seguridad.

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A bright sleeping area features a spacious bed covered with a patterned blanket. Two windows allow natural light and offer views of the lush greenery outside. A ceiling fan adds comfort, while sliding glass doors lead to a covered patio.

Home in Garrote, Colón

4.67 out of 5 average rating, 9 reviews

Cozy Cottage with garden AC/WIFI in Puerto Lindo

Discover the tropical charm of Casa Mariposa, nestled in the heart of Portobelo National Park. This enchanting retreat offers you the opportunity to explore the wonders of the Caribbean just minutes from the idyllic islands of Mamey and Isla Grande. You can also visit the historic ruins in the center of Portobelo and Nombre de Dios, both UNESCO World Heritage sites. Casa Mariposa is the ideal base to experience the magic of Panama's Costa Arriba. Perfect for a unique blend of nature and history!

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Top guest favorite

Two wooden lounge chairs are positioned on a well-maintained grassy area facing the water, allowing for peaceful views of the surrounding landscape. Palm trees are visible in the background, contributing to a serene outdoor setting.

Home in La Guaira

5.0 out of 5 average rating, 15 reviews

Apt near sea+Parking+TV+AC+Kitchen+WiFi@IslaGrande

✔️ SuperAnfitrión Verificado ¡Tu estadía estará en las mejores manos! 🚨Envíanos un mensaje con la palabra DESCUENTO y pregunta por promociones especiales 📍 Apartamento en Provincia de Colon, Panamá 🇵🇦 🏡 Espacio limpio, cómodo y seguro, con excelente ubicación 🧼 Dotado con insumos y productos de limpieza Durante tu reserva, tu Airbnb cuenta con: 🌐 Wifi 📺 TV 🍳 Cocina ❄️ A/C 🌊 Cercano a la playa 🚗 Parqueo 👉Envíanos un mensaje con la palabra DESCUENTO y pregunta por promociones

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An aerial view shows a property situated by the water, featuring red-roofed cottages and a grassy yard. Kayaks are visible in the water, along with seating areas under palm trees. A smooth pathway leads down to the water's edge, offering direct access for guests.

Home in Viento Frio

5.0 out of 5 average rating, 8 reviews

Casa Canalú

Disfruta de los sonidos del mar cuando te quedes en este lugar único. El mar frente a la propiedad es como una piscina natural. La propiedad está ubicada a seis metros del mar por lo que siempre podras disfrutaras de la brisa marina desde una hamaca. A los que les gusta cocinar contaran con una cocina totalmente equipada. Las 3 confortables habitaciones, que son separadas una de otra, cuentan con Aire Acondicionado, abanicos y wifi. Estacionamiento para varios carros. Bote pedal,Kayak,Canoa

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Superhost

An aerial view showcases a rustic cottage surrounded by lush palm trees, located near a sandy beach. The gentle waves of the ocean are visible, along with several red-roofed structures nestled within the greenery, creating a serene coastal atmosphere.

Cottage in Palenque

4.88 out of 5 average rating, 96 reviews

Beachfront House in Caribbean sandy beach

Enjoy this rustic and cozy cottage with its almost private beach surrounded by beautiful palm trees along the whole area. With 2 oceanview bedrooms, 2 full bathrooms and a third bedroom in a mezzanine. Has a patio with a built in uruguayan parrilla, ideal for BBQs. Step in beautiful white sand and bath in crystal clear water. Coconut breakfasts watching the sunrise become a routine in this paradise. - This is a rural setting. Not a 5 star hotel. Insects and small animals can be around.

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Guest favorite

Villa in Palenque

5.0 out of 5 average rating, 30 reviews

All 5 Stars Reviews Caribbean Retreat Beach Front

If you are looking for a place to relax this is it. Located 2 and a half hours away from Panama City, this is a place to enjoy the beach while listening to the sound of the waves. In a luxurious villa. The place is ideal for families with kids. Very save with shallow waters as well with deeper areas. Our large gardens are also ideal for kids to play. Kayaks are included. We have high speed internet, which will allow you to work from here. We also have kayaks and paddle boards for our guest.

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Top guest favorite

An outdoor terrace features a table with seating for four, framed by colorful chairs in red and blue. A hammock is suspended nearby, with the serene view of the water and distant hills providing a tranquil backdrop. Natural light illuminates the space, highlighting the coastal setting.

Home in Juan Gallego

4.94 out of 5 average rating, 99 reviews

Beachfront · Large Sea View · Family Friendly

Welcome to Kasa Leilani, a charming beach house nestled between the jungle and the reef in the heart of a natural park. With stunning views of the nearby Caribbean islands, this peaceful retreat offers the perfect blend of nature and comfort. Surrounded by abundant wildlife, you can relax, explore the reef, or discover the island and crystal-clear waters. Kasa Leilani provides a serene escape for nature lovers and beach enthusiasts alike, offering an unforgettable tropical getaway.

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Home in La Guaira

4.71 out of 5 average rating, 38 reviews

Bella Casa, Mar Caribe, JuanGallego (waterfront)

Hermosa Casa de Playa, frente al mar caribe, para descansar y relajarse al 100%. La Casa cuenta con una ubicación privilegiada, mantiene 4 habitaciones (una de ellas cuenta con una mampara para dividir de la sala y ampliar esa área en caso que se desee), sala, comedor, terraza privada, frente a Isla Grande. 4 habitaciones. 3 tienen TV con cable y una TV extra en la sala. Todas con con Aire Acondicionado. Cuenta con 2 baños completos. Cocina equipada y lista para disfrutar y Wifi

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Superhost

Home in Palenque

4.5 out of 5 average rating, 4 reviews

Palenque Beach House · Pool & BBQ

Escape to this stunning beachfront home in Palenque! With 5 spacious bedrooms and 16 beds, it’s perfect for families, retreats, or group getaways. Enjoy a private pool, BBQ area, and direct beach access. The two-story layout offers ocean views, a full kitchen, and open living spaces for comfort and connection. Relax, recharge, and make unforgettable memories by the sea in this tropical gem!

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A serene outdoor area features a clear blue pool surrounded by well-maintained green grass. Tall palm trees are visible, creating a tropical atmosphere, with the ocean seen in the background under a bright sky dotted with clouds.

Home in Palenque

4.25 out of 5 average rating, 4 reviews

Casa de Playa Palenque

Crea recuerdos inolvidables en este alojamiento único ideal para familias. Disfruta de esta espectacular casa de playa. Cuenta con muchas habitaciones con sus baños privados y espacios comunes. Tendrás la playa justo enfrente al levantarte. Contamos con cuidador siempre a la disposición. También contamos con ayuda doméstica para la cocina y la limpieza en áreas comunes a solicitud.

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Chalet in Viento Frio

5.0 out of 5 average rating, 4 reviews

Chalet espacioso junto al mar

Vivienda dúplex. Ideal para eventos o grupos en estadías cortas. Acondicionada para familias en estadías largas. Playa sin erizos o piedras. Olas y brisa de mar de un lado; y del otro lado, el centro del pueblo, el parque y una iglesia centenaria. Pueblo con celebraciones anuales como "el día de la raza". Puedo darte oferta para 4 personas, para una sola noche o para menos.

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Superhost

Home in Palenque

4.64 out of 5 average rating, 11 reviews

Casa Palenque Panamá

Disfruta de una espectacular casa frente al mar, ideal para grupos y familias de hasta 14 personas. Relájate con vistas directas a la playa, amplios espacios interiores y exteriores, y todas las comodidades para una estancia inolvidable. Perfecta para descansar, convivir y crear recuerdos únicos con el sonido del mar como fondo. Somos pet friendly.

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