Vacation rentals in Santa Fe

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Fe

Guests agree: these stays are highly rated for location, cleanliness, and more.

%{current} / %{total}1 / 1
Top guest favorite
The exterior features a two-story garage structure with a metal roof and two large doors made of wood, designed with a barn-style motif. Three well-proportioned windows adorn the upper level, providing natural light, while a small weather vane rests atop the building.
Guesthouse in Webster
4.93 out of 5 average rating, 160 reviews

Clear Creek Cabin: Cozy & Quaint Rental

Cabin on Clear Creek: Our cozy, quaint and clean above-garage apartment is perfect for your short or long term rental needs. Located on a quiet, dead end street with easy access to I-45. Easy access to Houston (20 miles) and Galveston (20 Miles.) Perfect stay for your visit to NASA or Beach! Features a secured separate entrance, gated parking with remote access, one full bedroom with queen bed and ample storage, loft with a queen bed, full bathroom, full kitchen and tons of natural light.

Top guest favorite
Guesthouse in Alvin
4.97 out of 5 average rating, 229 reviews

Comforts of Home Fully Equip WiFi W/D Spacious

Private, serene & clean guesthouse w/everything you need in a spacious 700 sq ft. • Thoughtfully cleaned by your SuperHost • Fast Wi‑Fi (532 Mbps) • In‑unit washer/dryer • Workspace • Full kitchen w/essentials • Excellent AC/Heat • Cozy couch & recliner • 55" Smart TV with Hulu & Disney+ included • Private bathroom & shower stocked with essentials • Outdoor lighted gardens w/ soothing water features Completely Detached from Main House Modern recessed LED lighting Midway Houston/Galveston

Guest favorite
Home in Texas City
4.82 out of 5 average rating, 112 reviews

Modern Comforts Cruisers Landing

Our cozy retreat offers luxurious amenities: a soaker tub, Brand new A/C, high-speed WiFi, a 70-inch Roku TV, a chef's dream kitchen and an office set off on its own. The home is perfectly situated, a short drive from I-45 so you can quickly and easily travel North to Houston or South to Galveston. The neighborhood offers parks, ponds, walking trails and a dog park. This is the perfect spot for cruisers departing from Galveston or travelers wanting to experience the Greater Houston area.

Guest favorite
An open living area features a dining table for four and a comfortable black sofa accented with decorative cushions. The space is illuminated by pendant lights, with wooden flooring and area rugs enhancing the warmth. A mirror reflects the room’s inviting design.
Home in Seabrook
4.91 out of 5 average rating, 108 reviews

Dog Friendly Cottage w/ pool, great for work/play!

This cute cottage is conveniently located in Seabrook - halfway between Houston & Galveston. This sits on a property that is a little over a 1/2 acre. The main house is next door. The cottage is completely detached & has its own small fenced backyard. Feel like you're in the country yet just a hop & a skip to the highway. Guests love being so close to amazing restaurants, bars, live music, shops & beaches! It's a great "homebase" for your vacation or if you're traveling for work!

Guest favorite
A wooden bench is positioned on a grassy area adjacent to a calm river. Lush greenery and trees line the opposite bank, reflecting the warm colors of the foliage in the water. The scene conveys a serene, natural setting ideal for relaxation.
Guest suite in Dickinson
4.81 out of 5 average rating, 139 reviews

Riverside getaway between Houston & Galveston

Riverside Manor is a peaceful retreat outside of Houston, just 15 min from NASA and Galveston island. This self enclosed Guest suite has a private entrance, bathroom and kitchenette (no full stove). Exit through the kitchenette straight down to the river, where you can relax around the fire pit, fish in the Bayou or paddle a kayak (or 3). Property is raised up amongst the trees, surrounded by nature and peace. Can sleep 4 but best suited for one couple, families or 3 close friends.

Guest favorite
The front porch is framed by green grass and decorative shrubs. A seating area with comfortable chairs is positioned under the covered section. A wooden swing set is visible in the yard, contributing to the family-friendly environment.
Home in Dickinson
4.9 out of 5 average rating, 141 reviews

Cheerful 3 bedroom home with loft

Make some memories at this unique and family-friendly place. 2 bedrooms and 2 bathrooms downstairs with a loft upstairs hosting two beds. Great for multiple families, or families with children. This updated home is cozy and bright. Great for business professionals or friends and family trying to get away. Just minutes from NASA Johnson Space Center, Clear Lake, one of the biggest yachting communities in the USA, and Galveston Island. Your home away from home awaits!

Top guest favorite
A cozy living area is furnished with comfortable gray sofas and a glass coffee table. Soft gray curtains frame the window, providing a gentle backdrop. A flat-screen TV is positioned on a sleek stand, while a light ceiling fan circulates air overhead.
Home in Santa Fe
4.91 out of 5 average rating, 66 reviews

Comfortable 3 Bedroom Home with Garage

3 bedroom 2 bath home with large fenced back yard, 2 car attached garage, and driveway parking. Family friendly and pet friendly! Make this your home base for day trips to Moody Gardens in Galveston, Great Wolf Lodge and NASA Space Center in Clear Lake, the Boardwalk in Kemah, and the Houston Zoo and Museums. My home has all the necessary amenities for a comfortable stay: 4 comfortable beds, a well stocked kitchen, central AC, laundry, dishwasher, and disposal

Guest favorite
A light-colored horse stands in a grassy area beside a winding creek, with a scenic barn and a white farmhouse visible in the background. Tall trees provide a natural border, enhancing the serene rural landscape.
Barn in Santa Fe
4.89 out of 5 average rating, 505 reviews

The Loft at Green Gables

Cozy barn apartment on a lovely small farm, secluded and quiet in the country. Located halfway between downtown Houston and the Galveston beaches, it's just a few minutes to lots of shopping and restaurants, with Kemah Boardwalk and Nasa Space Center a short drive away. Winding creek through the property, with chickens and two horses grazing in the pasture. Lots of sheep, pigs, and donkeys next door. Property has private swimming pool for your enjoyment.

Guest favorite
An open-concept living area features a light-colored sectional sofa and a matching ottoman, complemented by a wooden coffee table. The modern kitchen is equipped with stainless-steel appliances and white cabinetry. Soft lighting is provided by pendant fixtures above a dining table for four, surrounded by large windows.
Home in La Marque
4.96 out of 5 average rating, 133 reviews

Fully remodeled home just minutes from Galveston

Fully remodeled and newly furnished home on a quiet street just minutes from Galveston, NASA, Kemah, the Texas City Dike, and Houston. Play on the beach, tour historic sites, or visit the Space Center. Shop the Tanger Outlets just down the road, or The Strand in Galveston. Fisherman will love the Texas City Dike close by. It's all super accessible and convenient from this location. ...or, just tuck away in this clean, cozy, and cute getaway!

Top guest favorite
A three-story villa is displayed, featuring a modern exterior with white walls and a dark shingled roof. A landscaped yard with a stone border surrounds the entryway. A serene bayou lies adjacent to the property, with a private dock visible along the water's edge.
Villa in Dickinson
4.91 out of 5 average rating, 186 reviews

Waterfront Retreat Getaway Gameroom FirepitFishing

Enjoy a relaxing stay at the beautiful villa. It has a breathtaking view of the bayou. It is only 2 minutes away from I-45 highway, which is an easy commute to Nasa, Galveston, or Houston. As well as an outlet mall 5 minutes away. The house is equiped with a ton of amenties like fast wifi, a huge tv, a large backyard, a fire pit, a private dock, and even a kayak is provided. This unique place has a style all of its own.

Guest favorite
The living area features a spacious sectional sofa adorned with decorative pillows. A vibrant area rug displays a mix of colors under a modern coffee table. Natural light flows in through the window, complemented by light pink curtains, with a decorative shelving unit positioned in the corner.
Home in League City
4.92 out of 5 average rating, 146 reviews

The Flamingo House

Have fun with the whole family at this stylish place! 5 minutes from the great wolf lodge! Completely updated home, tv in every room with a set of board games for the entire family to enjoy. Nestled only 25 miles to Galveston and Downtown Houston. Close to shopping and dining at Baybrook mall and Top Golf is 5 minutes away. If you enjoy pickleball, the all new Chicken and Pickle is 5 minutes away also!

Top guest favorite
A serene sunset illuminates the water, reflecting hues of orange and pink. Silhouettes of wooden piers extend into the calm bay, surrounded by tree branches that frame the scene, offering a peaceful view of the natural beauty.
Guest suite in San Leon
4.92 out of 5 average rating, 267 reviews

Me and the Sea-cozy waterfront apartment

Make some memories at this unique and family-friendly place. Near fantastic restaurants, Pier 6 and Top Water Grill. You'll never run out of fun in this cute apartment on the Bay. Great for boating, fishing, a romantic get-away, or just listening to the ocean waves. Want more to do? We are less than 10 miles from Kemah Boardwalk and 20 miles from Galveston Seawall.

Popular amenities for Santa Fe vacation rentals

  1. Airbnb
  2. United States
  3. Texas
  4. Galveston County
  5. Santa Fe