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Vacation rentals in Santa Cruz County

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Cruz County

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
The large private deck overlooks expansive high desert mountain views. A grill sits ready for use, accompanied by a small potted plant on a metal cart. Lush greenery frames the view, providing a serene outdoor space.
Apartment in Sonoita
5 out of 5 average rating, 136 reviews

High Desert Wine Country

Take it easy at this tranquil getaway. Breathtaking views, 5000 feet altitude. See wineries or take a day's outing and visit local attractions. Second story apartment is a newly renovated space over hosts' garage (guests must be capable of climbing one flight of spiral stairs). It has a full kitchen (Including dishwasher), full bath (shower only - no tub), nice sized bedroom with queen bed and closet. Second story large private deck. NO DIRT ROADS TO PROPERTY! Adults only and (sorry!) no pets.

Guest favorite
A hammock is gently draped between two trees, with the fabric partially visible in the foreground. The background features a stunning sunset, casting soft hues across the sky. The landscape is open, with sparse vegetation and rolling hills creating a tranquil environment.
Guest suite in Nogales
4.94 out of 5 average rating, 130 reviews

Patagonia Lake Hideaway

PRIVATE SPACE! $105 p nite NO CLEANING FEES but airbnb charges its own fees. king bed, sofa, picture window,french doors, electric fireplace, Private courtyard, patios, gardens,sunrise over Patagonias,sunset behind the Atascosas. Birding paradise.Also great for hunters, hikers.Lake minutes away with boat rentals, swimming, fishing, hiking, small beach. Easy travel toTombstone, AZ Trail, Tubac, Golf Course, Kartchner caverns, Patagonia, Mexico, wine and spirit tasting .check in/check out flexible

Top guest favorite
A modern kitchen area features wooden cabinetry and stainless steel appliances, including a stove and refrigerator. Natural light fills the space through the window, and a cozy dining table is set nearby. Decorative elements, such as wall art, enhance the inviting design.
Home in Sonoita
4.99 out of 5 average rating, 324 reviews

Winemaker's Casita in the heart of Wine Country

The perfect casita for your wine tasting getaway! Our cozy space is full of local charm and minutes away from Elgin and Sonoita's many wineries. Centrally located near the Sonoita Crossroads, the Winemaker's Casita is walking distance from local restaurants, including Copper Brothel Brewery and Tia 'Nita's Cantina. Owned + operated by the proprietors of Rune Wines. Please note that the Winemaker's Casita is located next door to the Adobe House. There is plenty of room for privacy, or book both!

Top guest favorite
A spacious room features a comfortable king bed and a cozy seating area with a sofa. Natural light filters through windows, illuminating the neutral colors of the decor. A kitchenette with a coffee maker and a small fridge is also visible, enhancing convenience for guests.
Guest suite in Tubac
4.95 out of 5 average rating, 242 reviews

Private Tubac Retreat under The Milky Way

A tranquil, spacious, and beautiful Casita. Comfortable King bed with a gel memory foam mattress, additional pillows and blankets for your convenience, private bathroom, microwave, small fridge, toaster, coffee maker, and teas and coffee for a quick bite. Private entrance and a small patio with seating area, which leads to the staircase to the roof where you can enjoy the view during the day and the Milky Way at night. Large screen TV with Netflix and Hulu (bring your own passwords), and Wi-Fi.

Top guest favorite
A moderate-sized studio is focused on relaxation, featuring a spacious king bed with decorative pillows, a cozy seating area with a dark sofa, and a small dining table. A kitchenette with a mini fridge, microwave, and coffee maker is located adjacent, along with a decorative cabinet.
Guest suite in Patagonia
4.95 out of 5 average rating, 118 reviews

Box T Studio

The Studio is a moderate sized living quarters set up purposely for lounging, relaxing, personal entertainment and rest. Set within the compound of a historical property (The Box T Ranch built in 1902), the studio is the perfect home plate for all your Southern Arizona adventures. It includes an amazing king size bed, comfortable furnishings, a 57" Sony TV, mini fridge, microwave, Keurig, 2 person walk in shower and an AC unit. We are within 5 minute walking distance into town. Perfect getaway!

Guest favorite
A charming adobe-style guesthouse features a covered porch with seating areas. Natural stone pathways lead to the entrance, flanked by desert landscaping and potted plants. The exterior showcases warm earth tones with a tile roof, surrounded by open skies and a peaceful atmosphere.
Guesthouse in Tubac
4.86 out of 5 average rating, 104 reviews

Amazing Casita at the Tubac Resort-Self check-in*

Take it easy at this unique and tranquil getaway in the beautiful and historic Tubac Golf Resort. Located in a quiet neighborhood just a 5 minute walk to resort amenities including, spa, salon, resort shops, and Stables restaurant. Our Guesthouse includes a king bed, Sofa bed, personal driveway to park your car, private entrance, beautiful terrace, fireplace, Smart TV, internet, coffee maker, microwave, and mini refrigerator. Known as a center of art and history, is truly worth the visit.

Top guest favorite
The bedroom features a king-size bed with a light blue quilt and two accent pillows. Soft yellow curtains frame the window, allowing natural light to fill the space. Two bedside lamps with red shades illuminate the room, and a framed artwork hangs above the headboard.
Guest suite in Tubac
4.96 out of 5 average rating, 139 reviews

Tubac Golf Resort Casita - long stay discounts

The casita is centrally located between the Tubac Golf Course and Tubac village. The casita has a private bedroom and bathroom with outside entrance with dog door. The beautiful private yard has a covered porch, outdoor kitchen, and chiminea. Inside the casita is a king-size bed, table and chairs, refrigerator, microwave and coffee pot. Amenities include WIFI, local TV, Peacock. Weekly and long stay discounts. Early checkin and late checkout available upon request. Lockbox with code provided.

Top guest favorite
A brass bell is prominently displayed against a dark sky, capturing attention with its polished surface. It hangs from a metallic arm, showcasing detailed craftsmanship, while the surrounding structure is minimally visible in the foreground.
Apartment in Tubac
4.99 out of 5 average rating, 214 reviews

Coolest AirBnB in Tubac-Private Unique Free Charge

Located in the historic district of the village; a Tubac icon. Drive for free ... charge with my Level 2 solar while you're here; house is 100%, solar. Private, secure, best location, warm weather, fast Internet, new and comfy bed, complete kitchen, high quality AC, quaint, free easy parking, washer/dryer, walled courtyard with a fountain, walk-in shower, light blocking shades. Eight excellent restaurants within 1 mile. An exceptional value, best price, no deposit or cleaning fees

Guest favorite
A single-story building constructed with natural stone and warm-toned stucco is set against a backdrop of grassy landscaping. A covered outdoor area is visible, along with a clear sky, creating a serene and peaceful setting.
Cottage in Patagonia
4.95 out of 5 average rating, 118 reviews

Casa de campo con vistas espectaculares

Desconecta de tus preocupaciones en este espacio privado amplio y sereno, donde podrás disfrutar de luz natural, contacto con la naturaleza y bellas vistas naturales. Cuenta con cocina totalmente equipada, comedor, sala, estancia con tv y sillones reclinables, 3 amplios dormitorios, cuarto de juegos, lavandería y un bello porche donde podrás descansar en la sala o bien en el comedor exterior así como disfrutar de bellas puestas o atardeceres. también cuenta con una kiosco con iluminación.

Top guest favorite
A dining area features a long wooden table surrounded by six dark chairs. A large chandelier shaped like a star hangs above the table, casting intricate patterns on the walls. A decorative centerpiece of fresh fruits adds a touch of color.
Home in Tubac
5 out of 5 average rating, 125 reviews

Una Escapada en Tubac

Amazing luxury vacation rental in beautiful, historic Tubac, Arizona. Located in The Sanctuary neighborhood, this home is within walking distance of either The Village of Tubac or the Tubac Golf Resort. Plenty of nearby activities including hiking, golf, birdwatching, or day trips to southern Arizona. Visit unique shops in The Village of Tubac or the Resort for furnishings, jewelry, or great food at a variety of restaurants. Come see everything that southern Arizona has to offer!

Top guest favorite
A large agave plant is positioned in the foreground, surrounded by decorative gravel. The casita's exterior features a combination of earthy tones with a garage door visible on the right. A glimpse of landscaped greenery and desert plants is seen in the background under a clear blue sky.
Guesthouse in Tubac
4.97 out of 5 average rating, 108 reviews

Casita in the Barrio

Your own casita with queen size bed and adjoining bathroom located 45 minutes south of the Tucson International Airport, a short 10-minute walk from the center of the charming and historic village of Tubac and steps away from the Anza trail for hiking and birding. With adjacent patio for your exclusive use and a private entrance, your casita will be the perfect “headquarters” for your visit to Southern Arizona or a great place to house your "overflow" guests!

Top guest favorite
A refreshing saltwater pool is framed by a spacious deck, lined with comfortable lounge chairs. The surrounding landscape features native plants and offers expansive views of the desert terrain and distant mountains under a dramatic sky.
Cottage in Patagonia
4.96 out of 5 average rating, 113 reviews

Kestrel Cottage at Birdsong Retreat

ATTENTION SUMMER BOOKINGS: Swamp cooler and wall unit in queen bedroom. We provide fans. With monsoon rains, it’s too humid to use swamp cooler. Unit is priced to reflect the heat. Escape to serene high desert grasslands in Patagonia, AZ, offering 360-degree views at 4,058 feet offering respite from the Phoenix and Tucson heat. Nestled within BirdSong Retreat on 37 acres, the Kestrel Cottage promises luxurious accommodations and a focus on well-being.

Popular amenities for Santa Cruz County vacation rentals