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House vacation rentals in Santa Cruz County

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Top-rated house rentals in Santa Cruz County

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Guest favorite
A modern kitchen is equipped with stainless steel appliances, including a refrigerator and dishwasher. White cabinets provide ample storage, while a dining table for four sits beside a window, allowing natural light to pour in and offering views of the surrounding landscape.
Home in Elgin
4.96 out of 5 average rating, 114 reviews

Modern Elgin Home: Walk to Wineries + Pets Welcome

With its elegant design, secluded location, and 1-bedroom, 1-bath, ‘Starry Night Guest Retreat’ is the perfect cozy vacation rental! Start your days off by relaxing on the patio and admiring the views of the Mustang Mountains. When it’s time to explore, head to Deep Sky Winery for a glass of wine, try out some nearby birdwatching, or enjoy the farm animals grazing the meadow. Finish your stay with a visit to the old town of Tombstone and Kartchner Caverns State Park to see all that Elgin offers!

Guest favorite
A well-maintained yard features mature trees providing shading, with a spacious lawn that stretches towards the hacienda. The structure's exterior is characterized by a traditional design, complemented by a covered porch area. Clouds drift in the sky, hinting at a serene atmosphere.
Home in Arivaca
4.85 out of 5 average rating, 115 reviews

Private Getaway: Pandora Ranch House in Arivaca

Pandora is a private remote hacienda located on 20 acres in the high grasslands of the Sonoran Desert with 6 bedrooms, 6 bathrooms, a fully equipped kitchen, a dining room, living room. A well maintained yard with mature trees and charcoal BBQ grills invites to enjoy time outside. Minutes away from the quaint town of Arivaca, Buenos Aires Wildlife Refuge, Arivaca Lake and the Coronado National Forest Pandora offers easy access to hiking, boating,fishing, bird watching and off road exploration.

Guest favorite
The exterior features a welcoming entrance with a combination of rustic and vibrant elements. Adirondack chairs in turquoise and red are positioned in a small patio area, and a flag is displayed prominently. Native landscaping complements the porch area, creating a friendly ambiance.
Home in Patagonia
4.83 out of 5 average rating, 142 reviews

Javelina Corner

Our place is close to Patagonia Lake, 10 minute drive, Patton's hummingbird center, 2 minute drive or 8 minute walk. There is access to the Arizona trail at two locations within 10-20 minute drive and numerous other hikes! Tombstone, Bisbee, The Art haven of Tubac is close by and Nogales Mexico is 19 miles. You’ll love our place because of the neighborhood, the coziness, and the comfy beds. Our place is good for couples, solo adventurers, business travelers, families , and furry friends (pets).

Top guest favorite
A cozy living area features a large wooden coffee table with decorative items at its center. Two orange chairs and a dark sofa are arranged around the table. A television is positioned on a wooden console. Natural light filters in through a large window with blue curtains.
Home in Nogales
4.96 out of 5 average rating, 23 reviews

Tres Bellotas Ranch Guest House

14 miles south of Arivaca on a dirt road (will take about 45 minutes), almost to the border road. Located in the Coronado Nation Forest. Super peaceful and far from the outside world. Great spot for hunting, birdwatching, star gazing, horse back riding, and getting away. We're also a working cattle ranch. We're off the grid. Heat is wood burning stoves. We'll provide plenty of wood for you. For larger groups, we also have a studio and another small two bedroom that can be available.

Guest favorite
A southwestern-style ranch home is nestled on expansive land, surrounded by rolling plains. The structure features a white exterior with traditional architectural elements. Majestic mountains are visible in the distance under a clear sky, enhancing the serene rural landscape.
Home in Elgin
4.94 out of 5 average rating, 157 reviews

Peaceful SW-style ranch home in wine country

Welcome to our southwestern style ranch home in Sonoita/Elgin, Arizona wine country! Our home is 2,600 square feet and sits on 40 acres with unobstructed views of the beautiful Santa Rita Mountains. Our entire home is available for a wine country getaway. With three bedrooms, two full bathrooms with dual vanities, a half bath, an amazing kitchen, dining, two living spaces, and high-speed Internet, our home is ideal for two or three couples, or a family getaway (crib available for use).

Top guest favorite
A dining area features a long wooden table surrounded by six dark chairs. A large chandelier shaped like a star hangs above the table, casting intricate patterns on the walls. A decorative centerpiece of fresh fruits adds a touch of color.
Home in Tubac
5 out of 5 average rating, 133 reviews

A Tubac Getaway

Amazing luxury vacation rental in beautiful, historic Tubac, Arizona. Located in The Sanctuary neighborhood, this home is within walking distance of either The Village of Tubac or the Tubac Golf Resort. Plenty of nearby activities including hiking, golf, birdwatching, or day trips to southern Arizona. Visit unique shops in The Village of Tubac or the Resort for furnishings, jewelry, or great food at a variety of restaurants. Come see everything that southern Arizona has to offer!

Guest favorite
A spacious living area features a light-colored sofa with colorful accent pillows and a glass coffee table. Artwork adorns the walls, while natural light filters in through a window. A dining area with chairs and a modern workspace is visible in the background.
Home in Patagonia
4.93 out of 5 average rating, 102 reviews

Cottage on Santa Rita | Sundrenched 2 bd/1 bth

Nestled against the hill, this private, sun-filled home is located in the heart of Patagonia, a few quick steps to local businesses. Expansive patios and a cactus garden provide a hidden oasis behind the cottage - an ideal base for exploring the region's wineries, historic towns, gravel cycling, and forests. The home is fully updated, with a generously equipped kitchen, large master bedroom, washer/dryer, flexible second sleeping space, and tasteful minimalist southwest decor.

Top guest favorite
A green casita is situated in an open landscape, surrounded by a rustic fence. A gravel driveway leads towards the entrance, with an American flag waving gently overhead. Lush grass and a few scattered trees enhance the rural setting under a clear blue sky.
Home in Sonoita
4.98 out of 5 average rating, 278 reviews

Sky Island Retreat Sonoita, AZ.

Sky Island Retreat is a quiet and peaceful hilltop retreat in which you can relax and enjoy the natural beauty of this historic area. The casita is the original but updated ranch house built in the late 60’s. We have kept much of its original charm while upgrading to modern comfort and conveniences. We are located on a privately gated property just minutes from the heart of Sonoita and Southern AZ’s growing wine country.

Guest favorite
A comfortable living area features a dark brown leather sofa set and a wooden coffee table. A flat-screen television is positioned on a dark wood console against a grey wall. Two framed artworks add visual interest, and a ceiling fan provides ventilation.
Home in Nogales
4.81 out of 5 average rating, 21 reviews

Nikki's Townhome

Stylish 3-Bedroom Stay—Steps from Dining, Shopping & More Enjoy the comfort of a well-equipped home with three cozy bedrooms—two with queen beds and one with twin beds—plus a dedicated desk for remote work, a relaxing living area, and in-unit washer/dryer. Located just minutes from popular restaurants, shopping centers, movie theaters, and a nearby medical clinic, this spot offers convenience for every kind of traveler.

Top guest favorite
A clear blue pool is visible, reflecting sunlight under a vast sky adorned with fluffy white clouds. The surrounding landscape features rolling hills and mountains in the distance, highlighting the serene nature of the location.
Home in Patagonia
4.95 out of 5 average rating, 56 reviews

Poolside Escape Near Patagonia

Unwind at this scenic hilltop retreat just a mile south of Patagonia, AZ. Enjoy a private pool with stunning Red Mountain views, 3 spacious bedrooms, and a dedicated office space. Close to hiking, biking, and town. Relax in modern comfort, soak up breathtaking sunsets, and explore the best of Southern Arizona. Pet-friendly for making memories with the whole family!

Top guest favorite
A modern kitchen area features wooden cabinetry and stainless steel appliances, including a stove and refrigerator. Natural light fills the space through the window, and a cozy dining table is set nearby. Decorative elements, such as wall art, enhance the inviting design.
Home in Sonoita
4.99 out of 5 average rating, 339 reviews

Winemaker's Casita in the heart of Wine Country

The perfect casita for your wine tasting getaway! Our cozy space is full of local charm and minutes away from Elgin and Sonoita's many wineries. Centrally located near the Sonoita Crossroads, the Winemaker's Casita is walking distance from local restaurants, including Copper Brothel Brewery and Tia 'Nita's Cantina. Owned + operated by the proprietors of Rune Wines.

Top guest favorite
The home is set under two large oak trees, providing a natural shaded environment. A spacious outdoor area is visible, featuring a patio with seating. Surrounding greenery enhances the serene landscape, while a fenced yard adds to the property's secluded feel.
Home in Sonoita
4.96 out of 5 average rating, 213 reviews

Under the Oaks

A beautiful setting with a very comfy and clean home. The house offers a screened in porch from which to watch beautiful sunsets and an outdoor Ramada from which to bird watch, grill or enjoy a glass of wine. Under the Oaks is located under 3 enormous oak trees; hence the name. These beautiful trees offer shade, scenery and homes to many varieties of birds.

Popular amenities for Santa Cruz County house rentals