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Vacation rentals in Santa Cruz County

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Cruz County

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
A spacious room features a comfortable king bed and a cozy seating area with a sofa. Natural light filters through windows, illuminating the neutral colors of the decor. A kitchenette with a coffee maker and a small fridge is also visible, enhancing convenience for guests.
Guest suite in Tubac
4.95 out of 5 average rating, 262 reviews

Private Tubac Retreat under The Milky Way

A tranquil, spacious, and beautiful Casita. Comfortable King bed with a gel memory foam mattress, additional pillows and blankets for your convenience, private bathroom, microwave, small fridge, toaster, coffee maker, and teas and coffee for a quick bite. Private entrance and a small patio with seating area, which leads to the staircase to the roof where you can enjoy the view during the day and the Milky Way at night. Large screen TV with Netflix and Hulu (bring your own passwords), and Wi-Fi.

Top guest favorite
Guest suite in Patagonia
4.94 out of 5 average rating, 137 reviews

Box T Studio

The Studio is a moderate sized living quarters set up purposely for lounging, relaxing, personal entertainment and rest. Set within the compound of a historical property (The Box T Ranch built in 1902), the studio is the perfect home plate for all your Southern Arizona adventures. It includes an amazing king size bed, comfortable furnishings, a 57" Sony TV, mini fridge, microwave, Keurig, 2 person walk in shower and an AC unit. We are within 5 minute walking distance into town. Perfect getaway!

Top guest favorite
The spacious ranch house is situated on a gravel driveway, surrounded by green grass and gently rolling hills. A clear blue sky with wispy clouds serves as a backdrop, highlighting the peaceful rural setting and bringing attention to the home's exterior features.
Home in Sonoita
4.94 out of 5 average rating, 101 reviews

McFitz Guest Ranch

McFitz Ranch House is fully remodeled and available. Its a 3000 sqft 4 bedroom 3 bathroom w/ two master suites, and game room on 5 acres of beautiful horse property. Close to many attractions such as several wineries, brewery, the Sonoita rodeo grounds, Parker Canyon and Patagonia Lake, La Cienega Preserve and more. This location is ideal for Wedding Parties, Wine vacations, Rodeo, Kentucky Derby Fans, bird watching the Santa Cruz County Fair, hunting seasons or family weekends to the lake

Top guest favorite
A vibrant sunset casts a spectrum of purples and oranges across the sky, with silhouetted mountain peaks in the distance. The scene is set against a tranquil landscape dotted with sparse trees, showcasing the natural beauty of the surroundings.
Guesthouse in Elgin
4.97 out of 5 average rating, 258 reviews

Cozy Thunder Mountain Ranch bunkhouse experience

The perfect "getaway" that's still "near" it all! Our stand alone southwestern bunkhouse offers comfortable accommodations in a very unique setting, surrounded by thousands of acres of the Coronado National forest. Located in the desirable Sonoita/Elgin area of Southern Arizona. Near Parker Canyon Lake! From just soaking up the quiet serenity for a day or two, to an adventure filled longer stay, we can help tailor your experience to enjoy the many different things to see and do in the area.

Top guest favorite
The exterior of the casita features a welcoming entrance with wrought iron French doors, flanked by two adirondack chairs. Large windows allow natural light to enter, while the rustic structure is covered by a gabled roof, creating an inviting front porch space.
Guesthouse in Patagonia
4.99 out of 5 average rating, 101 reviews

Dream House

Replenish * Re-calibrate * Reconnect.. Welcome to our little house of dreams! You have found the perfect leaping off point to explore all this region has to offer. Nestled snugly between the Patagonia and Santa Rita mountains, our casita sits at just under 5,000 ft, making it temperature perfect almost year round. Enjoy our 38 acres and private hiking trails right out the front door with endless possibilities for adventure. Recharge, Rejuvenate, and Revel in our cozy, clean, quite space.

Top guest favorite
A dining area features a long wooden table surrounded by six dark chairs. A large chandelier shaped like a star hangs above the table, casting intricate patterns on the walls. A decorative centerpiece of fresh fruits adds a touch of color.
Home in Tubac
5 out of 5 average rating, 140 reviews

A Tubac Getaway

Amazing luxury vacation rental in beautiful, historic Tubac, Arizona. Located in The Sanctuary neighborhood, this home is within walking distance of either The Village of Tubac or the Tubac Golf Resort. Plenty of nearby activities including hiking, golf, birdwatching, or day trips to southern Arizona. Visit unique shops in The Village of Tubac or the Resort for furnishings, jewelry, or great food at a variety of restaurants. Come see everything that southern Arizona has to offer!

Guest favorite
A spacious living area features a light-colored sofa with colorful accent pillows and a glass coffee table. Artwork adorns the walls, while natural light filters in through a window. A dining area with chairs and a modern workspace is visible in the background.
Home in Patagonia
4.93 out of 5 average rating, 107 reviews

Cottage on Santa Rita | Sundrenched 2 bd/1 bth

Nestled against the hill, this private, sun-filled home is located in the heart of Patagonia, a few quick steps to local businesses. Expansive patios and a cactus garden provide a hidden oasis behind the cottage - an ideal base for exploring the region's wineries, historic towns, gravel cycling, and forests. The home is fully updated, with a generously equipped kitchen, large master bedroom, washer/dryer, flexible second sleeping space, and tasteful minimalist southwest decor.

Guest favorite
A hammock is gently draped between two trees, with the fabric partially visible in the foreground. The background features a stunning sunset, casting soft hues across the sky. The landscape is open, with sparse vegetation and rolling hills creating a tranquil environment.
Guest suite in Nogales
4.94 out of 5 average rating, 142 reviews

Patagonia Lake Hideaway

PRIVATE SPACE! $105 p nite NO CLEANING FEES but airbnb charges its own fees. king bed, picture window, sofa, french doors,electric fireplace, Private courtyard, patios, gardens,sunrise over Patagonias,sunset behind the Atascosas. Birding paradise.part of Madrean sky Island.Lake minutes away with boat rentals, swimming, fishing, hiking, small beach. Easy travel toTombstone, AZ Trail, Tubac, Kartchner caverns, Patagonia, Mexico, wine and spirit tasting .check in/check out flexible

Top guest favorite
A green casita is situated in an open landscape, surrounded by a rustic fence. A gravel driveway leads towards the entrance, with an American flag waving gently overhead. Lush grass and a few scattered trees enhance the rural setting under a clear blue sky.
Home in Sonoita
4.98 out of 5 average rating, 283 reviews

Sky Island Retreat Sonoita, AZ.

Sky Island Retreat is a quiet and peaceful hilltop retreat in which you can relax and enjoy the natural beauty of this historic area. The casita is the original but updated ranch house built in the late 60’s. We have kept much of its original charm while upgrading to modern comfort and conveniences. We are located on a privately gated property just minutes from the heart of Sonoita and Southern AZ’s growing wine country.

Top guest favorite
A cozy sleeping area is presented with a spacious bed adorned in vibrant, patterned bedding. Framed landscape photography decorates the warm yellow walls, complementing the soft lighting from bedside lamps. A corner chair provides additional seating beside a window with light draping through soft curtains.
Barn in Sonoita
4.96 out of 5 average rating, 140 reviews

Cozy little Bunkhouse attached to the barn

If you love horses and dogs, that's your place. Our little Bunkhouse is directly attached to the private barn on our ranch. Horses and pets are welcome. Sleeps 3, cute bathroom, fully equipped kitchen, patio setting. 1 mile to the village of Sonoita with great dining options and vineyard tours. Our quiete place is nestled in the foothills of the Santa Rita Mountains at the Grasslands High Desert.

Top guest favorite
A modern kitchen area features wooden cabinetry and stainless steel appliances, including a stove and refrigerator. Natural light fills the space through the window, and a cozy dining table is set nearby. Decorative elements, such as wall art, enhance the inviting design.
Home in Sonoita
4.99 out of 5 average rating, 346 reviews

Winemaker's Casita in the heart of Wine Country

The perfect casita for your wine tasting getaway! Our cozy space is full of local charm and minutes away from Elgin and Sonoita's many wineries. Centrally located near the Sonoita Crossroads, the Winemaker's Casita is walking distance from local restaurants, including Copper Brothel Brewery and Tia 'Nita's Cantina. Owned + operated by the proprietors of Rune Wines.

Top guest favorite
The home is set under two large oak trees, providing a natural shaded environment. A spacious outdoor area is visible, featuring a patio with seating. Surrounding greenery enhances the serene landscape, while a fenced yard adds to the property's secluded feel.
Home in Sonoita
4.96 out of 5 average rating, 219 reviews

Under the Oaks

A beautiful setting with a very comfy and clean home. The house offers a screened in porch from which to watch beautiful sunsets and an outdoor Ramada from which to bird watch, grill or enjoy a glass of wine. Under the Oaks is located under 3 enormous oak trees; hence the name. These beautiful trees offer shade, scenery and homes to many varieties of birds.

Popular amenities for Santa Cruz County vacation rentals