Vacation rentals in Santa Clara, Panama City

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Top-rated vacation rentals in Santa Clara, Panama City

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite

A serene bedroom is presented, featuring a spacious bed with crisp white bedding. Nightstands with lamps provide gentle lighting beside the bed. A wooden accent wall adds warmth to the space, while an organized closet and shelving unit offer functional storage.

Apartment in Panamá

4.97 out of 5 average rating, 35 reviews

5MINUTOSCOSTADELESTEwifi6-tvstreaming

BIENVENID@! disfruta de la sencillez de este alojamiento tranquilo y céntrico. El apartaestudio es ideal para esas personas que quieren conocer la ciudad y también para el que viene por trabajo,ya que tiene su escritorio y su comodidad,esta cerca de plaza de comidas,supermercados,gym,etc. queda cerca a algunos lugares turísticos,como costa del este centro de negocios,malecón,Panamá Viejo.. te puedo horientar para sitios turísticos si necesitas carro en alquiler también tenemos esa opción 😇

Guest favorite

A contemporary studio layout is displayed, featuring a spacious bed with a light-colored duvet. Large windows adorned with sheer curtains allow natural light to fill the room. A plush sofa and strategically placed art pieces add to the modern aesthetic.

Apartment in Costa del Este

5 out of 5 average rating, 12 reviews

Coastal Chic Executive Studio in Panama City

Discover elevated living in Costa del Este with this modern studio at Arcadia Condo Suites—where comfort meets convenience. Designed to cater to business travelers, families, or couples, this spacious and contemporary home offers the perfect balance of comfort and sophistication for both work and leisure. - Bright and spacious 70 m² studio - Partial views of the Pacific Ocean and surrounding cityscape - Fully equipped, modern kitchen - Pet-friendly accommodations - 24/7 concierge service

Guest favorite

A cozy living area features a brown sectional sofa with a soft blanket draped over the arm. Two floral artworks adorn the walls, and a small dining table with two chairs is positioned near a window, allowing natural light to enter the space.

Condo in Panama City

4.81 out of 5 average rating, 32 reviews

Home Away From Home. 15min from Airport!

Welcome to your perfect getaway! Our apartment is conveniently located just 15-20 minutes from the airport and 30 minutes from Casco Viejo. Enjoy easy access to supermarkets, malls, restaurants and more, all within a short drive. With two bedrooms, including a master bedroom with a TV and a large bed, and a second bedroom with a twin bed and a desk, you can comfortably mix business with pleasure. Book now and make yourself at home! You have the ENTIRE place to yourself. Message me!

Guest favorite

A comfortable sleeping area is presented with a spacious bed covered in a soft, patterned blanket. Lively artwork featuring tulips adorns the wall above, while bedside tables with lamps provide gentle illumination. Dark curtains frame the window, and air conditioning is installed overhead.

Loft in Panama

4.94 out of 5 average rating, 52 reviews

Modern apartment 20 minutes from the airport

Comfortable and cozy apartment on Av. la Pulida, 8 minutes from the Cincuentenario metro station. For business travelers and couples, this apartment features a bedroom with a full bed, a TV in the room, a full bathroom with hot water, a fully equipped kitchen, a living-dining room, a Smart TV, air conditioning, a laundry room, and a closet. It's just 8 minutes from the metro station and offers easy access to any point in the city. Centrally located, yet quiet. Enjoy a perfect stay!

Guest favorite

Apartment in Panamá

4.99 out of 5 average rating, 136 reviews

Full apartment in Panama

This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.

Guest favorite

A modern living room is depicted, featuring a wall-mounted television above a black media console. Two light-colored armchairs are positioned beside a round coffee table, which is adorned with decorative items. A large window allows natural light and offers views of the surrounding area.

Apartment in Costa del Este

5 out of 5 average rating, 7 reviews

1bd/2Bthrm East Coast-Panama

What are you waiting for to get to know and enjoy Panama? Stay in our modern, furnished and quiet apartment in Costa del Este, where you can enjoy a spectacular view, fast Wi-Fi, a fully equipped kitchen, access to the pool on the top floor overlooking the city and an incredible sunset, gym and more. Surrounded by cafes, parks and everything you need to have the best experience in the city.

Top guest favorite

The kitchen area features a black dining table with four chairs, complementing a modern microwave and refrigerator. Warm decorative elements, including wall art and a candle, add character to the space, which is equipped with essential appliances and a clean countertop.

Home in Panamá

4.94 out of 5 average rating, 395 reviews

Private Studio 10 Min from the Airport!

Entire apartment 10 minutes from the airport! The apartment is fully furnished including appliances and kitchen items, toiletries, dining room, work table and more. Just a few minutes walk from the SAN ANTONIO METRO Station, restaurants, shopping malls, laundries, supermarkets and pharmacies. We offer tours to San Blas to make the most of your trip. Our house is your house in Panama 🇵🇦

Top guest favorite

A spacious living area is highlighted by large windows that offer views of urban high-rises and the distant ocean. A soft, rounded sectional sofa and a plush armchair provide comfort, while a dark area rug anchors the space beneath a sleek coffee table.

Apartment in Costa del Este

5 out of 5 average rating, 23 reviews

Elegant Apt in Costa del Este. Premium Amenities

Enjoy a luxurious stay in our modern design apartment located in the exclusive Costa del Este area. It has a room with a private bathroom, a cozy living room, and a fully-equipped kitchen. Building facilities include a state-of-the-art gym, swimming pool, and co-working space ideal for remote work. Perfect for extended stays, combining comfort and convenience in the heart of Panama.

Guest favorite

A cozy living area is illustrated with a modern television positioned on a wooden console. A dining table with a simple setting is visible, accompanied by dark-colored chairs. Light-colored tiles cover the floor, and a clock is mounted on the wall, providing a functional accent.

Apartment in Panamá

5 out of 5 average rating, 16 reviews

Cozy, downtown and accessible

Enjoy the simplicity of this cozy and centrally located accommodation. Fully equipped and close to everything (transportation, supermarket, parks, restaurants). Rest at ease and in peace, after a day full of activity in the wonderful city of Panama. It has TV, Internet, air conditioning, 1 luxury bathroom, hot water, top-notch white goods with internal laundry and parking.

Guest favorite

An air conditioning unit is mounted on the wall above a wooden desk. A small lamp provides soft lighting beside a potted plant. A television is positioned on the desk, with a coffee maker and utensils visible in the foreground. The entrance can be seen to the left.

Guesthouse in Panama City

4.9 out of 5 average rating, 239 reviews

Boho Studio - Private Terrace 9 km from airport

Perfect for 1–2 guests, Wifi, quiet terrace, separate room, has A/C, and its small bathroom. Located near Tocumen International Airport, 10 to 13 minutes by car. The Studio is close to 2 Shopping Centers, Metromall and Los Pueblos OUTLET. The residential area is safe to walk, organized and clean streets. We have the Cerro Viento Metro station outside in Metromall.

Guest favorite

A small outdoor seating area is shown, featuring a blue two-seater sofa positioned against a green wall. Lush plants are visible nearby, and a covered terrace area offers shade. The flooring consists of tiled squares, creating a clean and inviting space.

Guest suite in Panamá

4.77 out of 5 average rating, 73 reviews

Nice and cozy studio apartment

Annex with private bathroom, kitchen and separate entrance, house in a very quiet residential development a few meters from the main road, close to supermarkets and shopping center. We have 1 dog and 1 turtle, the property has everything you need to have a pleasant stay, transportation service is offered if required.

Guest favorite

A modern living area features a sleek white entertainment center, accompanied by framed black-and-white photographs on the wall. A large window provides ample natural light, highlighting the glass coffee table with candles. A minimalist armchair and decorative plant add to the sophisticated ambiance.

Condo in Panamá

4.96 out of 5 average rating, 70 reviews

Cantabria Boutique Apt + WI-FI + AC

Kick back and relax in this calm, stylish space. Ideal for business trips, families, groups of friends, or small stopovers PH CANTABRIA V is located 10 minutes from Tocumen Airport, a 5-minute walk from the metro station. Enjoy a fully stocked kitchen and stay connected with high-speed WiFi.