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Vacation rentals in Santa Clara, Panama City

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Clara, Panama City

Guests agree: these stays are highly rated for location, cleanliness, and more.

Guest favorite

Apartment in Panamá

5.0 out of 5 average rating, 53 reviews

Cozy n Comfy con balcón in the heart of Casco

Remodelado, cómodo y céntrico alojamiento en el corazón de Casco Viejo, pintoresco lugar declarado Patrimonio de la Humanidad por la UNESCO. Cerca de restaurantes, Bares, Impresionantes Iglesias y Museos. Podrás explorar la zona a pie, el apartamento esta completamente remodelado, un balcón espectacular, cocina full equipada, camas cómodas, te sentirás como en casa, rodeado de las famosas paredes de calicanto. -Amplia sala de estar-Smart tv -Cocina full equipada -1.5 baños -Balcón con vistas

Sep 9 – 16

G$23,654 GYD per night
Guest favorite

Condo in Panama City

4.89 out of 5 average rating, 195 reviews

Park View Luxury Apartment

This apartment provides the perfect comfort while travelling in Panama for business or pleasure. Enjoy a wonderful stay in this beautiful apartment in a great location, the building is new, it features gym, pool, hot tub and beautiful views of the city, pacific ocean. It is 2 blocks away from a giant recreational park called Parque Omar which happens to be the First Lady's Office so it is very well guarded, featuring free dance zumba and yoga classes everyday. Make this place your HOME.

Jan 23 – 30

G$31,241 GYD per night
Guest favorite

Condo in Panama City

4.8 out of 5 average rating, 25 reviews

Cozy 2-Bedroom Getaway. 15min from Airport!

Welcome to your perfect getaway! Our cozy apartment is conveniently located just 15-20 minutes from the airport and 30 minutes from Casco Viejo. Enjoy easy access to supermarkets, malls, restaurants and more, all within a short drive. With two bedrooms, including a master bedroom with a TV and a large bed, and a second bedroom with a twin bed and a desk, you can comfortably mix business with pleasure. Book now and make yourself at home! You have the entire place to yourself. Message me!

Apr 30 – May 7

G$4,560 GYD per night

Popular amenities for Santa Clara, Panama City vacation rentals

Other great vacation rentals in Santa Clara, Panama City

Guest favorite

Guest suite in Distrito San Miguelito, Brisas del Golf, Panama City

5.0 out of 5 average rating, 18 reviews

Apartment in a safe residential area

Oct 23 – 30

G$8,919 GYD per night
Guest favorite

Apartment in Panamá

5.0 out of 5 average rating, 33 reviews

Full apartment in Panama

Jan 28 – Feb 4

G$16,260 GYD per night
Guest favorite

Apartment in Panamá

5.0 out of 5 average rating, 35 reviews

Spacious and cozy with panoramic view

Jun 13 – 20

G$20,918 GYD per night
Superhost

Condo in Panamá

5.0 out of 5 average rating, 12 reviews

Nice apartment with amazing sea views!

May 28 – Jun 4

G$27,346 GYD per night
Guest favorite

Home in Panama City

4.86 out of 5 average rating, 22 reviews

Beautiful house with private pool

Jul 27 – Aug 3

G$32,415 GYD per night
Guest favorite

Villa in Panamá

5.0 out of 5 average rating, 27 reviews

Breathtaking Views Mansion w/King Beds

Feb 17 – 24

G$124,771 GYD per night
Guest favorite

Vacation home in Panama City

5.0 out of 5 average rating, 28 reviews

Luxury Apartment With Private Beach And Sea View

Apr 21 – 28

G$27,358 GYD per night
Guest favorite

Condo in Panamá

4.94 out of 5 average rating, 72 reviews

CASA SAEMA -PRESTIGIOSO PENTHOUSE DUPLEX WITH TERRACES

Aug 31 – Sep 7

G$111,473 GYD per night
Guest favorite

Apartment in Panama City

5.0 out of 5 average rating, 16 reviews

Luxury Mid-Century Apartment In Casco Viejo

Sep 24 – Oct 1

G$28,851 GYD per night
Superhost

Apartment in Panama

4.94 out of 5 average rating, 99 reviews

Tropical Paradise at Playa Bonita

Jul 12 – 19

G$29,768 GYD per night
Guest favorite

Condo in Panamá

5.0 out of 5 average rating, 5 reviews

Ocean view apartment

Oct 29 – Nov 5

G$49,730 GYD per night
Guest favorite

Villa in Panamá

4.98 out of 5 average rating, 45 reviews

Beautiful House in Panama w/ King Beds + Pool

Jul 2 – 9

G$114,555 GYD per night
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