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House vacation rentals in San Luis

Find and book unique houses on Airbnb

Top-rated house rentals in San Luis

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Guest favorite
Home in San Luis
4.96 out of 5 average rating, 52 reviews

Meraki Luxury" Home" 5 minutes from the border

This luxury home is designed thinking of our guest experience, cozy and comfortable . You will enjoy the indoor and outdoor areas great for a couples getaway asome for family time and lovely for having the house for yourself. Enjoy yourselves it’s an open layout well designed with unique charm a full kitchen super comfortable couch for movie night. outdoor is the perfect space to have a drink and relax its your home away from home Two private airbnbs with private entrance and private back yards

Top guest favorite
The main living room showcases two reclining sofas facing each other, with a coffee table situated in between. Natural light enters through the windows, adorned with wooden blinds. A piece of wall art depicts a desert landscape, enhancing the room's cozy vibe.
Home in Yuma
4.98 out of 5 average rating, 227 reviews

Cozy Foothills Retreat 3BD/2 Bath/Hot Tub/Cable TV

Perfect for families, couples, winter visitors, and traveling professionals, this home offers the ideal mix of comfort and relaxation. After a day of exploring or working unwind in the private hot tub and enjoy Arizona evenings on the patio. Relax comfortably indoors in reclining sofas in the main living room, big screen TV in the main living room. Play a game of pool or retire to a space all your in your private room or the second living room with a comfortable leather sofa and big screen TV.

Guest favorite
A contemporary home features a warm wooden front door, complimented by stone accents. A well-maintained lawn with tiered landscaping leads up to the entrance. Large windows allow natural light to illuminate the interior, while a two-car garage is visible on one side.
Home in San Luis
5 out of 5 average rating, 33 reviews

Mi Bonita Coquette

This new home is welcoming the minute you walk in. Our home offers the opportunity for short or long term stays with all the essentials to make you feel right at home. The home offers a cozy environment in which you will be able to enjoy outdoor grilling and it is perfect for enjoying your favorite wine at the outdoor bar. Half bathroom at the backyard. This home is only 20 minutes away from Yuma, AZ. and 5 minutes away from our neighboring country, Mexico. Free parking space for 2- 3 cars.

Guest favorite
The outdoor area features a private solar heated pool with a unique shape, surrounded by a spacious patio. Comfortable seating areas, including lounge chairs and a dining set, are arranged under a covered patio, complemented by well-maintained landscaping.
Home in Yuma East
4.94 out of 5 average rating, 119 reviews

Private Desert Retreat | Pool, Arcade & RV Parking

Experience elevated comfort in this spacious, serene retreat. Thoughtfully crafted for business and leisure travelers, the home features brand-new Samsung smart appliances, a pool, an arcade game, and a grill/smoker. Enjoy refined indoor comfort, stylish gathering spaces, ample parking for up to 5 vehicles (including RVs and desert vehicles), and step-free entry for wheelchairs, power chairs & walkers. Whether lounging poolside or unwinding indoors, this property offers a truly exceptional stay

Guest favorite
Home in Yuma
4.95 out of 5 average rating, 133 reviews

Yuma’s Best | Pet Friendly | Snowbirds Welcome

Modern desert retreat in the clean, quiet Lynwood neighborhood of Yuma. Open layout with high ceilings and dome skylights that bring in natural light without added desert heat. Ideal for snowbirds, families, traveling professionals, and guests visiting Algodones for dental care (18 mins). Pet-friendly with private backyard patio—perfect for relaxing mornings and evening grilling. High-speed reliable WiFi, Spectrum cable TV + streaming. Close to shopping, golf, dunes, and Los Algodones, MX.

Superhost
The front view of a single-story home showcases a welcoming entrance with a covered porch. Two chairs are positioned beside the door, flanked by potted plants. A spacious gravel area is visible in front, providing ample parking space.
Home in Yuma
4.91 out of 5 average rating, 108 reviews

Bright 4 bedroom home in the heart of town.

This 4 bedroom getaway brings all the comforts of home to your vacation. With the ability to comfortably sleep 10 people there’s plenty of room for you and your friends or family. Enjoy an evening of dinner under the lit gazebo and s’mores around the fire pit or hit the town and check out all the Yuma has to offer. This home is centrally located so you’re never far from food and drinks. Just a 20 minute drive to the dunes, a 15 minute drive to Mexico and a one minute walk down to the park.

Guest favorite
A spacious living area features a large sectional sofa adorned with decorative pillows in soft colors. Framed artwork of tropical leaves complements the neutral wall, and light curtains frame the window. A textured area rug adds warmth to the floor.
Home in San Luis
4.93 out of 5 average rating, 46 reviews

San Luis,Arizona- Centrally located-7min to border

Casa Arizona is located in the heart of San luis Az, easy access to everything from this centrally located place. Less than 7 min from the San Luis Rio Colorado border. 25 min from Yuma. Our place is perfect to host comfortably up to 5 people. Washer and Dryer for your convenience. Short and long stays are welcome. Note: You are renting the main house. We also have an studio on the property with its own private entrance and patio. Both spaces are designed for a relaxing experience.

Top guest favorite
A spacious bedroom features a comfortable bed dressed in neutral tones with decorative pillows. Two mirrors reflect natural light from a window framed by simple blinds. A textured rug complements the wood flooring, while a dresser and nightstands add functional decor.
Home in Yuma
4.98 out of 5 average rating, 237 reviews

Tuscany Style Casita

Discover a newly remodeled Tuscany-style casita that feels like a quiet Italian escape in the heart of Yuma. Thoughtfully furnished for up to four guests. This two bedroom casita is truly cozy and warm. The neighborhood is safe, quiet and well kept. We are centrally located with Onvida hospital 5 min away, 10 min to the airport, 10 min to Yuma Palms and downtown and just minutes from Sprouts, Starbucks, Bubba's 33, local restaurants and more. We offer gated private parking.

Guest favorite
A cozy living area features two brown sofas with accent pillows, positioned around a central coffee table. Natural light enters through large sliding doors, which are framed by floor-to-ceiling curtains. A green plant adds a touch of nature to the space.
Home in Yuma
4.93 out of 5 average rating, 128 reviews

Welcome To Our Cozy Home! Fully Equipped 3BR/2BA

Welcome to our cozy home! Enjoy this incredible clean and modern home. This home is ready for cooking, sleeping and enjoying the amazing Yuma sunshine. Our nearest shopping center is 2 miles away! We have a Walmart, Albertsons, Taco Bell…The marine base is 4 miles, the border of Algodones is 20 minutes drive. Locate in a safe and family neighborhood. Home is equipped with a fully accessible closet to ensure confort for longer stay.Just 4 miles to downtown Yuma and Hwy 8!

Guest favorite
A modern single-story home is showcased from the street, featuring a light-colored exterior and a gabled roof. The driveway leads to a three-car garage, with desert landscaping visible, including palm trees and various shrubs. Mountains are faintly visible in the background.
Home in Yuma
4.95 out of 5 average rating, 224 reviews

Beautiful Pool Home in Yuma Foothills!

Enjoy your stay at this modern pool home in Yuma! This property features 2 large master suites, each room has a king bed and sofa bed. Kitchen has high end built in cooktop and ovens, also all brand new appliances. Living room is extra spacious. 3 car garage. This house is near the foothills library, foothills golf courses, the sheriffs station, the I-8. Outside features fire-pit, pool, bbq grill, sitting areas, fruit trees, and more! Great home to kick back and relax.

Superhost
The exterior of the house is displayed, featuring a textured tile roof and light-colored walls. A spacious driveway leads to a closed garage, while neatly arranged palm trees and manicured grass flank the pathway, creating an inviting entrance.
Home in San Luis
4.87 out of 5 average rating, 68 reviews

Spacious house with a modern kitchen + 4 bedrooms

This Beautiful house is perfect to bring family , friends or for a couple . This house offers you comfort and is secure , with a spacious patio to relax and enjoy the outdoors . There's an emergency medical center just around the corner . Pleasant area to walk in the morning or just enjoy a delicious barbecue in the afternoon on the patio . It's a 10-minute drive to the Border Crossing and 5-minute drive to a supermarket , restaurants and gyms .

Top guest favorite
Home in San Luis Río Colorado
4.97 out of 5 average rating, 115 reviews

Casa Victoria, private and comfortable. We take payments.

Enjoy comfort, privacy, and a prime central location at Casa Victoria. A modern 2-story home (2 years old), perfect for families, couples, travelers, and pets. Sleeps up to 6 guests in a quiet, safe neighborhood—ideal for relaxing or exploring the city. Amenities: 🏡 2-story private home 🛏️Sleeps 6 guests 🚗 Covered parking for 2 cars 🔥 Gas BBQ grill ☕ Coffee station 🌅 Balcony 🐾 Pet-friendly 📍 Central location 🔒 Safe & peaceful area

Popular amenities for San Luis house rentals

When is the best time to visit San Luis?

MonthJanFebMarAprMayJunJulAugSepOctNovDec
Avg. priceG$21,975 GYDG$23,649 GYDG$23,021 GYDG$20,719 GYDG$21,975 GYDG$21,765 GYDG$21,138 GYDG$21,347 GYDG$20,928 GYDG$19,045 GYDG$20,928 GYDG$21,556 GYD
Avg. temp13°C15°C18°C21°C25°C30°C34°C34°C30°C24°C17°C12°C

Quick stats about house rentals in San Luis

  • Total vacation rentals

    Explore 100 vacation rentals in San Luis

  • Nightly prices starting at

    San Luis vacation rentals start at G$4,186 GYD per night before taxes and fees

  • Verified guest reviews

    Over 2,230 verified reviews to help you choose

  • Family-friendly vacation rentals

    90 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 30 rentals that welcome pets

  • Vacation rentals with a pool

    10 properties feature pools

  • Rentals with dedicated workspaces

    40 properties have a dedicated workspace

  • Wi-Fi availability

    100 of San Luis vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across San Luis rentals

  • 4.9 Average rating

    San Luis stays are highly rated by guests—averaging 4.9 out of 5!

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