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Vacation rentals in San Lorenzo District

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Top-rated vacation rentals in San Lorenzo District

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
A spacious living area offers a direct view of the ocean, framed by large openings. A private pool sits in the foreground, with the horizon and distant islands visible beyond. Natural light fills the space, and outdoor lounging areas are positioned alongside.
Villa in Boca Chica
5 out of 5 average rating, 23 reviews

On the Beach Villa in Boca Chica!

Contemporary on the beach Villa with 180° Panoramic Ocean & island views of the Gulf of Chiriqui National Park. Open concept, indoor/outdoor living with private pool & spacious terraces for lounging, sunsets & stargazing. Perched on a cliff with direct beach access. Ocean breezes, tropical birds, exotic monkeys, iguanas & dolphins in the Bay. Private gated community. Large sand beach, perfect for swimming, boogie boarding, long walks, bocce ball or just relaxing & enjoying the sounds of nature.

Top guest favorite
A spacious living area features a comfortable sofa and two accent chairs surrounding a striped area rug. Floor-to-ceiling windows offer panoramic views of the ocean and surrounding islands, while a flat-screen TV is positioned on a low console for easy viewing.
Villa in Boca Chica
4.96 out of 5 average rating, 102 reviews

Sand Dollar Villa by the sea at Boca Chica Panama

Sand Dollar Villa by the sea This beautiful, very private retreat boasts panoramic views and direct access to a beautiful beach and sheltered bay. Located in Boca Chica, it is only 45 minutes from Panama’s second largest city, David. From your doorstep, you can enjoy island hopping in an archipelago of unexplored islands, or you can choose to soak in the sun on your very own private beach. Sand Dollar Villa offers the perfect décor for gracious living and entertaining in a magical setting!

Top guest favorite
A private outdoor area features a pool surrounded by stone tiles and a covered seating area. Sun loungers are positioned under an umbrella, with views of green landscape and water in the background. The setting provides a serene atmosphere for relaxation.
Home in Playa Hermosa
5 out of 5 average rating, 44 reviews

Entire house with private pool facing beach !

Astonishing views, bird sounds & howler monkeys, Our region is designated by Panama as a Natural Water Preserve with 23 islands, lots of snorkeling, whale watching and beachcombing! One of the top best sport fishing destinations in the world! Casa Tanamera has a large garden set amidst the jungle. it boasts a plunging view on the beach and its entire bay area. the house is large enough for 4 persons, has large bedrooms and bathroom, a large patio with its dining, BBQ and lounge area.

Top guest favorite
A spacious room is visible through an open door, featuring a double bed with clean linens and a simple design. Natural light illuminates the area. A handcrafted wooden bench is placed in front of the bed. A potted palm adds a touch of greenery to the setting.
Guest suite in David
4.97 out of 5 average rating, 505 reviews

CasaMonèt

Suite con entrada independiente: estacionamiento techado, cama doble, baño sanitario, cocineta y escritorio. Tu espacio personal en el corazón de David. Cuenta con aire acondicionado tipo split, abanico de techo, TV con acceso a netflix, internet wifi gratis, cortinas black out, tanque de reserva de agua, agua caliente, cocineta equipada con estufa eléctrica, refrigerador, cafetera, microondas y utensilios básicos. No cuenta con lavandería, generador eléctrico y aislamiento acústico.

Top guest favorite
A serene pool area features a clear blue pool surrounded by tiled landscaping. Two white lounge chairs and a small table are positioned by the poolside, offering a relaxing spot. Lush greenery and a residential building are visible in the background under a bright blue sky.
Guesthouse in David
5 out of 5 average rating, 73 reviews

Pool House with Shared Pool Access

Pool House is a fully private space on a shared gated property. NOTE: We, the owners of the property, live in the Main House full time. If you have questions/need recommendations, we are available! Shared spaces on property: Pool, front yard, back walk way Local suburb, with bus and taxi access into town and plenty of parking if you choose to drive. 45 minutes from Boquete, 1 hour from Boca Chica and 2 hours and 1 hour boat ride to Bocas Del Toro, this location is a day-tripper's dream!

Superhost
Apartment in David
5 out of 5 average rating, 5 reviews

Elegante y acogedora Suite

A menos de 2 minutos en auto del Centro comercial/Mall Terronal. Elegante y acogedor. Cerca de supermercados, restaurantes, almacenes cafeterías, farmacias y más. Relájate en una hamaca al aire libre, rodeada de un jardín con bellas flores. A sólo unos metros de la vía interamericana y a 2 minutos de la vía Boquete. Esta suite cuenta con una cama matrimonial, aire acondicionado, TV Smart, wifi, ducha con agua caliente, closet, nevera, cafetera, microondas y utensilios de cocina.

Top guest favorite
A spacious bed is centered in a room with vibrant green walls. Decorative pillows are arranged neatly on the gray bedding, complemented by a bedside table with a lamp. Art featuring a flower and a hummingbird adorns the wall above the bed.
Bungalow in Boca Chica
4.94 out of 5 average rating, 78 reviews

Finca Colibri

Ein moderner Bungalow mit einmaligen Blick auf die Mangroven von der Bucht Bajia de Muerte, die im Herzen eines Naturschutzgebietes liegt. Der Bungalow ist sehr privat und ruhig gelegen. Zum nächsten Strand sind es nur wenige Autominuten. Es erwarten dich eine voll ausgestattete Küche, ein modern eingerichtestes Panorama Bad und ein sehr bequemes King Size Bett. Auf Anfrage können wir auch Bootsfahrten zu den Inseln, Yoga sowie Reit und Angelausflüge organisieren.

Superhost
A spacious living area features large windows allowing natural light to flood the space. A blue sofa is complemented by decorative pillows. Textile art in various shades of blue adorns the walls. A wooden table with chairs is positioned for dining or relaxation, with greenery visible outside.
Villa in San Lorenzo District
4.84 out of 5 average rating, 19 reviews

Villa Turquesa with sea view in Isla Boca Brava

Welcome to Villa Turquesa, a true hidden gem on the stunning Boca Brava Island. This tropical retreat blends luxury, comfort, and adventure—all with spectacular ocean views. It accommodates up to 8 guests, features a fully equipped kitchen, shared pool, free WiFi, and easy access to Playa Las Cocas, just a 25-minute walk from the villa, as well as trails where you can spot birds and howler monkeys. Book Villa Turquesa now and let the sea breeze do the rest!

Guest favorite
An open-plan dining and living area features a round table with four chairs, a beige couch, and a ceiling fan. A modern kitchen with new appliances and a breakfast bar can be seen in the background, complemented by natural light from nearby windows.
Condo in Los Anastacios
4.95 out of 5 average rating, 21 reviews

Lemongrass House Los Anastacios

Relax in this immaculate, pleasant, and excellent value accommodation, operated by Lemongrass House Rentals, ideally located between Boquete and David. The apartment has 2 bedrooms and 1 bathroom, with air conditioning in each bedroom and ceiling fans for your comfort. This well-furnished home features a full kitchen and laundry facilities for a comfortable stay. We’re happy to welcome dogs! We accept one per stay, with a weight limit of 25 lbs (11 kg).

Guest favorite
A small cottage is nestled among trees, featuring a simple white exterior and dark wood window shutters. Softly glowing string lights enhance the entryway, illuminating the path leading inside. The peaceful surroundings contribute to a calm ambiance, inviting relaxation.
Tiny home in Boquete
4.95 out of 5 average rating, 115 reviews

Cozy Sunrise Cottage

Very cozy small cottage but spacious tucked between the trees and only 7 minutes ride to downtown Boquete. The cottage has a washer and dryer and very nice finishes. A comfortable king size bed and kitchenette with all the utensils needed to prepare breakfast or a small meal. Public service transportation is available just as you open the gate and leave the premises. Wi-Fi service available and reliable. Hot water on the shower, sink and kitchen faucets.

Top guest favorite
A modern studio apartment features a well-appointed sleeping area with a spacious bed. A sleek television stands on a minimalist media unit. Large glass doors open to a private balcony, allowing natural light to fill the room. Contemporary furnishings are complemented by marble flooring.
Apartment in David
4.95 out of 5 average rating, 19 reviews

Fully equipped studio

Modern Studio with Kitchen and Laundry Enjoy this cozy, fully equipped studio. It features a full kitchen with a blender, toaster, coffee maker, utensils, and a washer and dryer for added convenience. The queen bed and sofa provide a comfortable space to rest. The bathroom is spacious and modern. Ideal for short or long stays, in an excellent location. Perfect for those looking for comfort and functionality. Book now and feel at home!

Guest favorite
The property features a spacious beachfront villa, framed by lush palm trees and open grass areas. A vibrant red roof contrasts with the white exterior, and the shimmering ocean is visible in the background, providing a serene coastal atmosphere.
Home in Playa Nanzal
4.89 out of 5 average rating, 35 reviews

Private Beachfront Getaway

Forget your worries in this spacious and serene space. Its seclusion is its charm. Escape from the busy city of David and kick back in our private beachfront property! There are little to no lights nearby, making for extraordinary sunsets/sunrises and star gazing. Whether you are a family looking to get away in the summer, a group of friends celebrating a birthday, or just looking for a break from life, this is the spot.

Popular amenities for San Lorenzo District vacation rentals