Vacation rentals in De Soto

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Top-rated vacation rentals in De Soto

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Top guest favorite
A cabin with wooden exterior is surrounded by tall trees and shaded ground. A spacious porch is visible at the front entrance. A calm dog sits on the ground in the foreground, offering a glimpse of the natural tranquility of the setting.
Cabin in Alto Pass
4.99 out of 5 average rating, 319 reviews

Ma's Cabin, Alto Pass, IL. Fine country lodging.

Cute and country remodel done in 2019. Recent new appliances, furnishings, flooring, heat & A/C, washer & dryer. Cabin is secluded and quiet plus 1/2 mile from Alto Pass Lookout Point and right in the middle of many award-winning wineries. 15 miles from Carbondale 4 miles from Giant City 30 miles from Garden of the Gods 6 lakes within 10-mile radius Hundreds of miles of hiking trails in nearby Shawnee National Forest 6 miles from Bald Knob Cross Please, no dogs! No smoking in cabin!

Top guest favorite
The exterior of a charming cottage features a welcoming entrance with a light-colored door. Two blue chairs and a small table are positioned on a stone path, surrounded by well-maintained grass and flower pots. In the background, horses can be seen grazing in a fenced pasture.
Guesthouse in Carbondale
5 out of 5 average rating, 294 reviews

Homestead Cottage

Enjoy tiny farmhouse life in this adorable 375 sq. foot cottage. Loaded with everything you need this little cottage is nestled privately behind some trees on our 11 acre farm. You will soon forget how close you are to town with the beautiful view from your windows and the pasture fence just steps out the back door. Whether you’re here for the wineries, amazing hiking, an SIU event (3 miles) or to visit with family, the Homestead Cottage will provide a comfortable retreat from any adventure.

Superhost
The kitchen features white cabinetry and a central island with a wooden countertop. Dark metal stools are arranged around the island. Decorative items, including a floral centerpiece, are placed on the countertop, complemented by wall-mounted plants and a lemon-themed wreath.
Home in De Soto
4.97 out of 5 average rating, 34 reviews

Shady Lakes Escape

Our home offers a park-like setting, including a swing off of the pole barn, firepit, & Charcoal grill. The nicely decorated interior has stained concrete floors, 2 full-size bathrooms-one with a double-head shower and attached closet/laundry room. The master suite has a king size bed w/tv. The second bedroom has a queen size bed w/tv. The living/kitchen area is an open concept w/plenty of room for a queen blowup mattress (included). A perfect setting for watching the abundance of wildlife.

Top guest favorite
Home in De Soto
5 out of 5 average rating, 6 reviews

Awesome House in DeSoto

Welcome to this Awesome Home centrally located in Southern Illinois available for your enjoyment while in the area. Featuring a Large Furnished Kitchen, Livingroom, Laundry Room, Three Fully furnished Bedrooms, including TVs, Two Bathrooms, Large Driveway, Extended Wi-Fi Service, and Large Fenced in Backyard with Secure Gated Access for RV's, with 30-amp Electric Plugs and Water available for slight upcharge. I am personally available to ensure that your check-in and stay is enjoyable.

Top guest favorite
A spacious living area features a teal sectional sofa, complemented by soft throw pillows. A round coffee table rests in the center, surrounded by a neutral area rug. In the background, a dining table with seating for six is visible, enhancing the inviting ambience.
Home in Herrin
4.97 out of 5 average rating, 111 reviews

Charming 3 bedroom retreat

Four friends have joined forces to create this cozy space for you to feel right at home in. We've made the space fun, with each bedroom having a unique theme. Our coffee bar also offers a variety of mugs, so each person can pick their favorite. We had your comfort in mind when we selected new queen mattresses, soft bedding, and plush towels. The couch and extra seating are very comfy. For our likeminded germaphobe friends, we chose light bedding to ensure utmost cleanliness.

Top guest favorite
A comfortable living area features a stone fireplace beneath a mounted television. A wooden coffee table is surrounded by a brown leather sofa and a chair. Scenic wall art is displayed above the sofa, while natural light enters through a nearby window.
Cabin in Makanda
4.99 out of 5 average rating, 173 reviews

Hygge Log Cabin: HotTub & Hiking

Hi, hello, welcome! We are excited to have the opportunity to host you for your relaxing trip or jam packed adventure. Our local area has many hiking opportunities to explore, the Southern Illinois Wine Trail surrounds us, and the back roads have country views that are breathtaking. Our cabin will be waiting for your arrival or return, well equipped with a 55" TV above the gas fireplace, a comfortable King size bed, and an amazing back porch with a Weber Grill and huge hot tub.

Top guest favorite
A cozy bedroom is presented with wooden walls, featuring a spacious bed adorned with a patterned quilt. Small sitting area includes a table with two chairs. A window allows natural light, complemented by decorative elements on the walls.
Apartment in Murphysboro
4.88 out of 5 average rating, 76 reviews

The Windbreak

Forget your worries in this spacious apartment, the lower/first level of a 3-level house, a peaceful place at the woodsy end of a country lane, not far from two state parks, five lakes, wine trail, Southern Illinois University and other interesting features of this area. The 1st level apartment is large, has a kitchen, dining room, 2 bedrooms, living room/bedroom, a full bath, and a utility room, 2 exterior doors, one to a patio with a fire pit and charcoal cooker.

Top guest favorite
The exterior of the cabin is surrounded by tall trees displaying vibrant autumn foliage. A porch extends from the front, offering a view of the yard blanketed in fallen leaves. Sunlight filters through the branches, enhancing the serene woodland setting.
Place to stay in Makanda
4.95 out of 5 average rating, 296 reviews

Secluded Cabin*Blue Sky & Shawnee*Pet-Friendly

Secluded, yet convenient. Within 5 min of two wineries, ziplining, trail heads, & I-57. Your unforgettable romantic wine country retreat or comfortable rest after hiking or travel. No TV or Wi-Fi (good cell signal though) but that is not why you’re here! Explore the vineyards, walk the trails, and drink complementary on-farm roasted coffee! Pets welcome when you add them to the reservation. We have them too! Maple Ridge Cabin : Gateway to Shawnee Wine Country

Top guest favorite
The treehouse is elevated on wooden stilts, surrounded by lush greenery. A wooden deck with a railing extends from the entrance, creating a welcoming outdoor space. Large windows brighten the upper level, while a sun art piece adorns the side of the structure.
Treehouse in Makanda
4.96 out of 5 average rating, 439 reviews

Panthers Inn Treehouse

Come nestle amongst the leaves at Panthers Inn Treehouse. This secluded, well equipped, elevated cabin has the perfect combination of natural beauty and artful luxury. Isolated yet conveniently located 2 minutes from Blue Sky and Feather Hill wineries, within 5 minutes of Panthers Den hiking trail and the Shawnee Hills canopy tour and only 10 min from I-57 exit 40. Panthers Inn is the perfect starting and ending point to your Shawnee Hills Wine Country vacation!

Guest favorite
A cozy living area is furnished with a large sectional sofa and a matching armchair, complemented by decorative cushions. Light filters through window blinds, and a soft area rug covers the hardwood floor. A small table is positioned nearby.
Home in Carbondale
4.86 out of 5 average rating, 318 reviews

Relaxing 3 Bedroom Cottage in Quiet Neighborhood

This happy 3 bedroom duplex will be a family favorite on your next trip to Southern Illinois. You'll enjoy 3 cozy bedrooms each equipped with a TV, 1 bathroom, ample deck space and firepit. We are located on a quiet street within walking distance of all Carbondale has to offer – Downtown Carbondale, restaurants and pubs (.8 miles), the Memorial Hospital of Carbondale (.5 miles), Carbondale Civic Center (.8 miles), Amtrak Station (.9 miles), and SIU (1.1 miles).

Top guest favorite
The bedroom features a spacious bed with a textured tan coverlet, flanked by two bedside lamps. A large window offers views of the outdoors, while an armchair adds a cozy seating option. A decorative area rug enhances the room's comfort and style.
Cabin in Carbondale
4.99 out of 5 average rating, 107 reviews

Wooded Cabin · Hot Tub, Firepit & Giant City

Nestled under a grand elm tree on 35 private wooded acres — just 5 minutes from Giant City State Park. This single-level modern cabin sleeps 4 with a king bed, private hot tub on the forest deck, fire pit with Adirondack chairs, and complimentary firewood. Full kitchen, washer/dryer, and dedicated workspace. Dogs welcome (max 2). One of four well-spaced cabins on the property — each private, other guests may be present on the grounds.

Top guest favorite
A serene cabin sits amidst lush greenery, surrounded by trees that reflect in a tranquil pond. A well-kept lawn leads up to the entrance, enhancing the peaceful setting. Blossoming branches frame the scene, adding a touch of nature’s elegance.
Cabin in Cobden
4.96 out of 5 average rating, 137 reviews

Unique luxury cabin with fireplace and pond view

Shawnee Pond Retreat is a two-bedroom countryside haven that sits on a ridge in the Shawnee National Forest. Located just outside Alto Pass near numerous vineyards, lakes and hiking trails, it is a perfect destination for friends, couples, or families. Shawnee Hills Wine Trail has 11 wineries nearby. With its impressive bluffs and spectacular trailways, Giant City State Park is just a 15-minute drive.

Popular amenities for De Soto vacation rentals

  1. Airbnb
  2. United States
  3. Illinois
  4. Jackson County
  5. De Soto