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Vacation rentals in Rio Grande

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Rio Grande

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
Tiny home in El Copé, La Pintada
4.96 out of 5 average rating, 26 reviews

Serena Lodge & Camping - El Copé

Escape to Serena Lodge, a cozy mountain cabin tucked among pine trees in El Copé, Panama. Wake up to birdsong, stunning valley views, and total privacy—just minutes from waterfalls (Las Yayas, Tigrero, Santa Maria, El Harino river, Rio Grande, Chorro Grande) and the Omar Torrijos National Park. Perfect for couples, families, friends, remote workers and nature lovers seeking fresh air, and a true disconnect in the mountains. 🌧️ Rainy Season (May–November) ☀️ Summer Season (December–March) por

Guest favorite
A private pool is surrounded by a smooth concrete deck, with gentle steps leading into the water. The adjacent open-air area features large glass doors that highlight the indoor living space, while the softly lit evening sky adds a serene ambiance.
Home in El Higo
4.97 out of 5 average rating, 33 reviews

CasAna

Fantástico lugar con espacios abiertos, luz natural y aire puro, 2 habitaciones con baño interno, terraza para recibir el amanecer y el atardecer, piscina privada que hace sentir que vuelas, mientras puedes compartir con amigos y familiares en un área grupal proporcionada por un espacioso deck, disfrutar de tus asados en la terraza y cocina equipada con todo lo que necesitas Ubicada a 10 mtos de Playa La Ermita y 12 mtos de la entrada del Valle, y a un salto del Restaurante Los Camisones.

Guest favorite
An aerial view captures a charming retreat nestled in lush greenery. The red-tiled roof of the cabin stands prominently surrounded by colorful gardens and fruit trees. A winding path leads to the property, with a vehicle parked nearby, highlighting the spacious natural surroundings.
Tiny home in Cocle
4.94 out of 5 average rating, 140 reviews

Cozy 2 Bedrooms, el Cope/ Retreat at the Mountains

Hermosa cabaña de dos habitaciones y dos baños , den panorámico ubicada a unos 50 minutos de Penonome, Provincia de Cocle, en el Area del Parque Nacional Omar Torrijos Herrera , temperaturas entre 22 y 25 grados C a orillas del turístico Chorro de las Yayas en la comunidad de Barrigon del Cope, distrito de La Pintada. Agradable ambiente rodeado de árboles frutales y hermosas cascadas. Ideal para disfrutar de la naturaleza y relajarse. Cuenta con internet satelital de rápida velocidad .

Top guest favorite
The exterior of the cabin is showcased amidst lush greenery, featuring a sloped roof and large glass windows. A wooden staircase leads up to the entrance, while a stone pathway meanders through the garden, enhancing the natural surroundings.
Cabin in Penonome
4.98 out of 5 average rating, 138 reviews

Aqeel cabin in the nature

Relax at this unique and tranquil getaway surrounded by nature. If you're lucky, you may wake up to see white-faced capuchins from your bedroom window and spot an abundance of birds, such as the crested oropendola or a toucan. The property offers river access with a sandy, beach-like area, and there is a 1 km walking trail alongside the river. With satellite high-speed internet access, you'll stay connected, though the river and sandy area may not be accessible during rainy days.

Guest favorite
Home in San Carlos
4.89 out of 5 average rating, 171 reviews

El Palmar, playa a 50 metros

Escucha las olas desde la privacidad de nuestra terraza y crea recuerdos inolvidables en este alojamiento único y familiar a pocos paso de la playa con piscina privada. El palmar es una comunidad tranquila con varios restaurantes disponibles a unos pasos de la casa. La propiedad esta totalmente cercada para la tranquilidad y seguridad de hijos y sus mascotas adicional tienes wifi, TV cable en ambas habitaciones y aires acondicionados en la sala comedor y en todas las recamaras

Guest favorite
The modern house is set amidst lush greenery, featuring a sleek design with large glass windows. An infinity pool is positioned on a spacious patio that offers unobstructed views of the surrounding hills, creating an inviting outdoor space for relaxation.
Home in Altos del Maria
4.82 out of 5 average rating, 328 reviews

Modern House with Great Views and Heated Pool

Modern mountain house in Altos del Maria, Panama, a gated comunity at just 1 hour and 30 minutes away from Panama city. The comunity has rivers, bird watching trails, and is only 25 minutes away from the pacific beaches. Its a perfect place to take a break and relax. The house has a modern decor, infinity pool, 2 bedrooms with A/C, wifi, dishwashing machine, washer and dryer and great view of the mountains. Free late checkout is given for rentals checking out on Sundays.

Guest favorite
Home in Altos del Maria
4.76 out of 5 average rating, 158 reviews

Villa Acuario

Relaxation is guaranteed in this one-of-a-kind glass house nestled in the lush mountains of Altos del María. Surrounded by nature and designed with floor-to-ceiling glass walls on all sides— as if you’re living inside a crystal ball. With no direct neighbors, panoramic forest views, it is perfect for a family getaway, a quiet reset, or an extended stay. The home offers light-filled interiors during the day and unforgettable stargazing nights from the rooftop.

Top guest favorite
A spacious outdoor deck features modern furniture arranged for relaxation, overlooking a lush mountainous landscape. Verdant hills and a colorful sky at dawn create a tranquil environment, inviting guests to enjoy the natural beauty and serenity of the surroundings.
Villa in El Copé
4.92 out of 5 average rating, 194 reviews

Mountain retreat

Our beautiful, modern, comfortable house is designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and also a base to explore the area which is in a beautiful part of Panama near a cloud forest national park with amazing hiking to waterfalls and local communities. The house is large, sleeping 12, within 17 acres of forest with rivers for swimming. We can arrange tours and hosted retreats for yoga, cooking and more.

Top guest favorite
Home in Cañaveral
5 out of 5 average rating, 17 reviews

Peaceful Garden Home |3BR| Fast WiFi|Near Penonomé

We want you to feel truly comfortable and at home. A home away from home. If you’re looking to spend quality time with family or friends, “Mi casa es su casa” at Villas de Santa María is the perfect place to relax, disconnect, and escape the noise of crowded cities. Enjoy our private garden and unwind on the terrace with stunning views of Guacamayas Hill, where you’ll experience peaceful surroundings and beautiful sunsets every afternoon.

Superhost
A welcoming porch area is furnished with comfortable seating and vibrant hammocks, surrounded by lush greenery and flowering plants. The structure is set against a backdrop of a clear blue sky, with sunlit grass creating an inviting outdoor space.
Home in El Valle de Antón
4.89 out of 5 average rating, 79 reviews

La Florecita - Casa de campo en Valle de Antón

Escapada acogedora en el corazón del Valle de Antón Disfruta de una estancia inolvidable en nuestra cálida y acogedora casa, ideal para familias y grupos de amigos. Ubicada en el centro del Valle de Antón, estarás a pocos minutos de mercados, restaurantes y las principales atracciones naturales. Nuestra casa combina comodidad y encanto, con espacios amplios perfectos para relajarse y disfrutar del fresco clima de la montaña.

Guest favorite
A cozy sleeping area features a spacious bed with neutral bedding. Soft lighting is provided by bedside lamps, and a ceiling fixture adds warmth. Two framed art pieces adorn the walls, offering a subtle contrast to the light decor.
Tiny home in Penonome
4.85 out of 5 average rating, 78 reviews

Fenced and Pet-Friendly Cottage in Penonomé

Cozy private cottage, fully fenced — perfect for relaxing, remote work, or traveling with your pet. Enjoy the garden surrounded by greenery, rest in the covered hammocks, or do some birdwatching. Equipped kitchen, air conditioning, high-speed WiFi, and secure on-site parking. Just minutes from the Interamerican Highway, with easy access to cafés, shops, and more. Ideal for a peaceful getaway or productive stay.

Top guest favorite
A comfortable porch area features two colorful hammocks suspended from the walls. The polished tile flooring reflects soft light, and a pair of large wooden doors stands closed in the background. A vehicle is parked nearby, adding to the casual ambiance.
Home in Penonome
4.92 out of 5 average rating, 153 reviews

Casa cómoda, cercada y segura.

En Casa las Hamacas, disfruta de la sencillez de este alojamiento espacioso, tranquilo y céntrico. Podrás disfrutar del agradable clima penonomeño. Un lugar cerca de todo, centros comerciales, escuelas, hospital, montaña ríos y playas. Ambas habitaciones cuentan con aire acondicionado para garantizar tu descanso. A pocos minutos de la vía interamericana.

Popular amenities for Rio Grande vacation rentals