Vacation rentals in Osborn Medical Center, Phoenix

4.95 out of 5 average rating, 661 reviews

Home in Encanto

Elegantly Renovated Bungalow in a Historic District

This home was renovated by a professional designer (@designxwoods) and showcases unique details and inspiring finishes around every corner! Soak in the natural light in the airy and open living space wrapped in white brick and even venture up the ladder to the loft for a meditate moment. From the retro furnishings and oak hardwood floors to the spa-like bathrooms, the home is warm and charming and filled with amenities to make your stay comfortable. It is perfect for larger groups or families wanting a cozy stay near the best restaurants and shops Phoenix has to offer. The brick paved back patio offers a great al fresco dining option with the beautiful Arizona sunsets. Disclaimer: For your safety of our property and our guests, one surveillance camera has been installed on the front porch. Guests have access to the entire home, including back patio. PLEASE NOTE: The loft is accessed via a steel ladder that is secured to the wall. We ask that guests use ladder carefully and at their own risk. We are always available via telephone or through the app. The house is in the Coronado Historic District, a quiet residential community of young families and artists. Several restaurants and coffee shops are within walking distance. Downtown Phoenix is a 5-minute drive away. Guests are welcome to park on the gravel driveway, two cars can fit tandem. We have a two car maximum at the property. PLEASE NOTE: The listing photos were taken before the window treatments were installed. The master bedroom currently has a blackout drapery panel. The guest bedrooms have blackout roller shades and the living room windows have privacy roller shades.

The exterior of the guesthouse is surrounded by greenery, featuring a manicured lawn and various trees. A stone pathway leads to the porch area, which includes comfortable outdoor seating under a wooden gazebo. The home is framed by lush plants and vibrant flowers.

4.96 out of 5 average rating, 180 reviews

Best Little Guesthouse in Melrose !

Historic guesthouse in the heart of the Melrose District! EV charger! Walking distance to restaurants, bars, coffee shops, the famous Melrose Vintage shops, grocery stores, LA Fitness and more! Want to head downtown to Chase Field, Talking Stick Arena for a game or a show? Campbell Street Light Rail station is only five short blocks away! No need for a car, you can take the Light Rail from Sky Harbor International Airport, save your money for entertainment! Off street parking if you have a car!

The bathroom features a spacious vanity with wood accents and dual sinks, complementing the modern design. A glass-enclosed shower is visible, alongside a toilet. The floor is adorned with light grey tiles and soft bath rugs, creating a clean and inviting environment.

4.98 out of 5 average rating, 105 reviews

Spacious Midtown guesthouse with full privacy

Welcome to your private casita (tiny home) in the heart of Midtown. Located right across the street from Starbucks, Buffalo Exchange, and the famous Taco Guild, relax comfortably with vaulted ceilings, a spacious layout, outdoor patio, and a quiet bedroom with a Queen-size bed — perfect for solo travelers or couples. Plus, the Light Rail station is walkable, which goes to Uptown, Downtown, the airport, Tempe, and Mesa. You are only: 7 mins to Downtown 9 mins to the Airport 15 mins to Scottsdale

4.9 out of 5 average rating, 164 reviews

The exterior of Chase Field is showcased, featuring the iconic tall baseball bats that mark the entrance. The vibrant signage and architectural elements reflect the stadium's unique design, with clear blue skies above emphasizing a spacious outdoor area.

Condo in Encanto

The Beverly Bungalow 1BR/BA in the 🖤 of Phoenix

Relax & unwind at our mid-century bungalow in the heart of Phoenix. This 1BR/1BA condo will comfortably sleep 2 (up to 4 using an air mattress). Our condo is complete with a full kitchen, cozy living room & dedicated work space for the WFH professional. Also included is a shared pool/hot tub to cool off on those hot summer days. Located in Midtown center to museums, unique bar & restaurant concepts, Chase Field, The Footprint Center - the list goes on. We hope you enjoy all AZ has to offer!

A clean bathroom sink area is highlighted by granite countertops and a modern faucet. White towels are neatly hung on a wall hook. To the side, toiletries are organized in a textured basket, offering easy access for guests.

4.97 out of 5 average rating, 1,233 reviews

Private, Sparkling Clean Historic DTPHX Guesthouse

This charming studio guesthouse in the Campus Vista historic district is a fantastic find! Situated in a friendly neighborhood in the heart of Phoenix, this newly remodeled living space is cozy and practical, surpassing many of the similar properties in quality and character. A short ten-minute drive from the Sky Harbor Airport, and located within walking distance to two major bus lines and the light rail, the guests are sure to enjoy the easy access to all the popular downtown destinations.

Guesthouse in Central City

A potted green plant sits on a wooden stand atop a marble countertop. The round mirror above reflects soft lighting, and the faucet features a warm metallic finish. Neatly rolled towels are placed nearby, adding to the clean aesthetic of the bathroom.

4.92 out of 5 average rating, 173 reviews

Amazing Casita with Minigolf & Corn-Hole

Cozy and fully renovated casita located in a Historic District of downtown Phoenix, with private lighted entrance and access code. Comfy queen sized bed. Smart TV with Netflix, Amazon Prime, Disney Plus, and more. Fully equipped kitchenette with refrigerator, microwave, double burner electric stove, coffee maker, and dishwasher. The eating area for two, can double as a work desk onlooking beautiful views of the semiprivate backyard. Note: Please book total occupancy for accurate pricing.

4.96 out of 5 average rating, 136 reviews

Home in Encanto

Paradise, Conferences, Dbacks, w/Guesthouse, Pool

Enjoy this completely renovated 3-bedroom house, together with a separate, self-contained Guesthouse. Located in the beautiful Willo District of Central Phoenix - just 10 minutes from Sky Harbor Airport, Downtown, Convention Center, & major freeways. it is ideally suited for large families or groups in town for either business or pleasure. The resort-like feel is enhanced with a beautiful backyard patio & pool (ask about heating) offering guests the ultimate in both relaxation and fun.

A communal living space features a comfortable sofa adorned with various textured cushions. A chalkboard wall displays creative messages, while a vibrant red kitchen cabinet adds visual interest. Sunlight enters through double French doors, enhancing the overall ambiance.

5 out of 5 average rating, 351 reviews

Urban Green House The Garden House

The Urban Green House brings farm life to the urban core. We offer fresh eggs from our backyard hens and gardens for guests to enjoy. We also live green-using solar panels, recycling, and composting. Sarah and Ryan live locally and are available to meet any needs that arise. We are located in a quiet and safe 1950s neighborhood, close to local restaurants, coffee shops, Encanto park, direct access to both the I-10 and I-17 freeways, and only 8 miles from Phoenix Sky Harbor Airport.

4.99 out of 5 average rating, 298 reviews

A private patio area is presented with two woven lounge chairs facing the street. A low hexagonal table is situated between them, and surrounding greenery adds a natural touch. Soft sunlight filters through the trees, enhancing the relaxing outdoor space.

Home in Encanto

Marta's Cozy Brick Home in Midtown PHX

Centrally located condo in a peaceful neighborhood with detached carport. Completely renovated and tastefully decorated. Cleaned following the guidelines recommendations from the CDC to prevent spread of COVID-19 and with HEPA air purifier. Cozy Tuft and Needle beds and fully equipped kitchen. Private patios. In walking distance to a variety of restaurants and The Valley Metro Light Rail. City of Phoenix Short-Term Rental Operating Permit # STR-2025-000722

4.99 out of 5 average rating, 151 reviews

DARK HOUSE | private, modern Spanish casita

Tucked into a charming enclave of Phoenix’s historic Coronado neighborhood, this private, 450 sq. ft. guest casita is an ode to form + function. Situated minutes from Sky Harbor Airport, Downtown Phoenix + a bevy of compelling cultural + culinary districts, Casa Oscura is your passport to life as a local. Casa Oscura’s aesthetic honors the home’s Spanish influences with a palette of earthy tones, woven textures + design moments evoking the modern Southwest.

A private patio is shown, featuring two outdoor chairs and a small table on a patterned rug. Soft string lights are illuminated overhead, and desert plants are arranged along the walls, adding a touch of greenery against the backdrop of a clear evening sky.

5 out of 5 average rating, 209 reviews

Adorable Willo Cottage in Historic Central Phoenix

Peaceful one bedroom cottage in unbeatable location within Central Phoenix. Walking/ biking distance from light rail, restaurants, Heard Museum and Phoenix Art Museum. Enclosed backyard with a shared washer/dryer on property. The cottage has a queen bed, mini kitchen and private patio. Property is cleaned and sanitized according to the Airbnb cleaning procedures. 15 minutes from Sky Harbor Airport. 5 minutes from Encanto Park (Golf Course)