Vacation rentals in Osborn Medical Center, Phoenix

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Top-rated vacation rentals in Osborn Medical Center, Phoenix

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite

Guesthouse in Encanto

4.97 out of 5 average rating, 119 reviews

Best Little Guesthouse in Melrose !

Historic guesthouse in the heart of the Melrose District! EV charger! Walking distance to restaurants, bars, coffee shops, the famous Melrose Vintage shops, grocery stores, LA Fitness and more! Want to head downtown to Chase Field, Talking Stick Arena for a game or a show? Campbell Street Light Rail station is only five short blocks away! No need for a car, you can take the Light Rail from Sky Harbor International Airport, save your money for entertainment! Off street parking if you have a car!

Dec 2 – 9

G$20,364 GYD per night

Guest favorite

Guesthouse in Encanto

4.96 out of 5 average rating, 117 reviews

Adorable Casita in Historic Central Phoenix.

Keep it simple at this peaceful and centrally-located place. This Willo casita is near downtown, unique restaurants, shopping and museums. 1/2 mile from the Light Rail and 10 min to Sky Harbor Airport. The Recently Updated Casita is off the main house but has its own fenced in yard. We have a fridge, microwave, induction cooktop, and Keurig for coffee. Washer/Dryer unit is outside and shared with main house but available if necessary. Sleeps 3 comfortably with pull out sofa. Street parking.

Jun 23 – 30

G$21,852 GYD per night

Guest favorite

Guesthouse in Encanto

4.98 out of 5 average rating, 1073 reviews

Private, Sparkling Clean Historic DTPHX Guesthouse

This charming studio guesthouse in the Campus Vista historic district is a fantastic find! Situated in a friendly neighborhood in the heart of Phoenix, this newly remodeled living space is cozy and practical, surpassing many of the similar properties in quality and character. A short ten-minute drive from the Sky Harbor Airport, and located within walking distance to two major bus lines and the light rail, the guests are sure to enjoy the easy access to all the popular downtown destinations.

Jul 4 – 11

G$13,705 GYD per night

Guest favorite

Guest suite in Encanto

5.0 out of 5 average rating, 214 reviews

Private, desert-chic casita in vibrant Midtown PHX

Welcome to Casita Amelia, a modern rustic retreat central to all the action Phoenix has to offer. Welcoming and cozy, this newly updated private guest suite has all the luxuries of a modern hotel suite while being quietly tucked away in a cute Midtown neighborhood. Walk to Melrose District. You're also just 5-10 mins by car to Uptown & Camelback Corridor, 10 mins to Downtown (Footprint Center, Chase Field, Arizona Financial), 15 mins to Sky Harbor Airport, and 20 mins to State Farm Stadium.

Sep 3 – 10

G$16,074 GYD per night

Guest favorite

Guesthouse in Encanto

5.0 out of 5 average rating, 293 reviews

Urban Green House

The Urban Green House brings farm life to the urban core. We offer fresh eggs from our backyard hens and gardens for guests to enjoy. We also live green-using solar panels, recycling, and composting. The hosts live on the property and are available to meet any needs that arise. We are located in a quiet and safe 1950s neighborhood, close to local restaurants, coffee shops, Encanto park, direct access to both the I-10 and I-17 freeways, and only 8 miles from Phoenix Sky Harbor Airport.

Sep 20 – 27

G$19,696 GYD per night

Guest favorite

Guesthouse in Encanto

4.88 out of 5 average rating, 165 reviews

Private Casita w/ Pool* & BBQ in Historic Melrose

*PLEASE READ HOUSE RULES IN "OTHER THINGS TO NOTE" AREA BEFORE BOOKING* Under no circumstance can one book the Airbnb for another guest . This violates our house rules as well as Airbnb policy. Read more under HOUSE RULES for more details. Our cozy casita is located in the Woodlawn Park neighborhood, a short car ride from the Melrose and Willo Districts. Located near some of the best restaurants in Phoenix, this is the perfect stay for visitors who want to explore the local food scene.

Jun 5 – 12

G$14,945 GYD per night

Guest favorite

Guesthouse in Encanto

4.95 out of 5 average rating, 136 reviews

Midtown Casita | Heart of PHX w/ full kitchen

Escape to this newly finished modern casita in the heart of midtown PHX for business or pleasure. Located near local/ downtown coffee shops, restaurants, sports venues, and bars. Full kitchen, dining area, and workspace + WiFi for remote workdays. Perfect spot for a quick hangout, or longer term stay. We look forward to making your stay as enjoyable as possible. No smoking of any kind allowed on the premise. Property is cleaned & disinfected in accordance with Airbnb guidelines.

Mar 29 – Apr 5

G$18,441 GYD per night

Guest favorite

Guesthouse in Central City

4.95 out of 5 average rating, 908 reviews

Studio B industrial design

A contemporary industrial designed studio with cement floors and exposed pipes. A grey water system irrigates the lush southwest gardens. Be adventurous and choose the outdoor shower in the enclosed back patio to fully appreciate the warm weather! Tucked away in the historic F.Q. Story Neighborhood in downtown Phoenix. You are surrounded by charming historic homes as you walk the neighborhood. Close to local eats, parks, and museums. EVERYONE is welcome at Studio B!

Jun 21 – 28

G$18,329 GYD per night

Guest favorite

Home in Encanto

4.98 out of 5 average rating, 192 reviews

Central Phx-Great Outdoor Space-No Cleaning Fee!

Perfectly located, this Central Phoenix retreat is a remodeled, immaculately kept, Central Phoenix home built in 1944. It is beautifully furnished with everything you need for a comfortable stay. Included is a relaxing outdoor space to enjoy morning coffee or BBQ dinner. It is on a quiet street on the grand canal, walking distance to the light rail, restaurants, cafes, bars, museums, one of the largest parks in Phoenix, and all the attractions in downtown Phoenix.

Jun 28 – Jul 5

G$24,797 GYD per night

Guest favorite

Home in Encanto

5.0 out of 5 average rating, 251 reviews

Marta's Cozy Brick Home in Midtown PHX

Centrally located condo in a peaceful neighborhood with detached carport. Completely renovated and tastefully decorated. Cleaned following the guidelines recommendations from the CDC to prevent spread of COVID-19 and with HEPA air purifier. Cozy Tuft and Needle beds and fully equipped kitchen. Private patios. In walking distance to a variety of restaurants and The Valley Metro Light Rail. City of Phoenix Short-Term Rental Operating Permit # STR-2023-000407

Jun 11 – 18

G$31,809 GYD per night

Guest favorite

Guesthouse in Encanto

4.94 out of 5 average rating, 222 reviews

Charming Guesthouse w/ Full Kitchen & Pool

You'll love your private stay in our charming guesthouse, centrally located in Phoenix's historic Melrose District. It's perfect for folks staying several days: powerful air conditioning, a full kitchen, private laundry room, and access to our outdoor pool. You'll be a 10 minute drive from downtown Phoenix and a 15 minute drive from Sky Harbor Airport. With a personal entrance and a dedicated covered parking spot, your stay couldn't be more convenient!

Sep 27 – Oct 4

G$20,435 GYD per night

Guest favorite

Guesthouse in Encanto

4.99 out of 5 average rating, 165 reviews

Adorable Willo Cottage in Historic Central Phoenix

Peaceful one bedroom cottage in unbeatable location within Central Phoenix. Walking/ biking distance from light rail, restaurants, Heard Museum and Phoenix Art Museum. Enclosed backyard with a shared washer/dryer on property. The cottage has a queen bed, mini kitchen and private patio. Property is cleaned and sanitized according to the Airbnb cleaning procedures. 15 minutes from Sky Harbor Airport. 5 minutes from Encanto Park (Golf Course)

May 20 – 27

G$19,517 GYD per night