Vacation rentals in Muscatine

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Top-rated vacation rentals in Muscatine

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
A historic four-bedroom home is captured with tall trees framing the exterior, set against a clear blue sky. The architectural features include a prominent turret and multiple windows, reflecting the home's charm. A snow-dusted yard leads to a view of the nearby Mississippi River.
Home in Muscatine
4.96 out of 5 average rating, 135 reviews

Historic West Hill Retreat

Beautiful historic 4 bedroom, 4 bath home within walking distance to shopping, bars/restaurants and all that downtown Muscatine has to offer. Enjoy sweeping views of the Mississippi River from several vantage points in and outside this home. The 3000 sf interior offers many places to gather and relax. Two of the bedrooms have on suite full baths. The other two bedrooms share a full bath. Additional amenities include, fully equipped kitchen, laundry, games, grill, outdoor entertainment area.

Top guest favorite
Two horseback riders are positioned on a grassy hill overlooking a tranquil pond. The clear water reflects the surrounding greenery, enhancing the serene rural setting. The landscape features rolling hills, contributing to a peaceful country experience.
Farm stay in Riverside
4.92 out of 5 average rating, 356 reviews

Farm stay close to Iowa City, IA

15 min.-Iowa City, 5 min- Riverside Casino, & 35 min-Eastern Iowa Airport, Cedar Rapids, IA. Comfy beds, living room sectional pulls out to queen hide a bed, 32 acres of rolling hills, horseback riding (sm. fee)*, winter fun, & fishing pond. First 2 guests pay base price, then 3rd thru 10th guests pay an extra 30.00 EACH. NO PARTIES on our farm. We live on property in a separate home. Dogs welcomed (must be kenneled when you leave property)NOTE: NO OVEN in kitchenette. *contact for details.

Top guest favorite
The cottage's exterior features a welcoming facade adorned with colorful flowers and greenery. A spacious deck is bordered by stone pathways, while large windows allow natural light to flood the living spaces. Mature trees provide shade in the surrounding area.
Cottage in Le Claire
4.97 out of 5 average rating, 517 reviews

The Cottage. River views, event & dog friendly!

Make yourself at home in a fully renovated cottage built in 1910. This cottage sits on a steep hill above the original Homestead of Buffalo Bill Cody. Enjoy a beautiful Park directly behind you, full river views in front of you. BEFORE BOOKING PLEASE NOTE: *The cottage is on a steep hill. *You will hear trains. LeClaire is a river & train town. 🚂🌊 *This is a wooded property, There will be sticks, leaves and bugs. 🌿🐞 *There are MANY steps inside and outside, as it's built into a hill.

Top guest favorite
A modern cabin is set on a landscaped lot with a gravel path leading to the entrance. The structure features a mix of dark siding and wood accents, surrounded by open fields and distant tree lines, offering a serene rural setting.
Cabin in Princeton
4.96 out of 5 average rating, 135 reviews

Private & Modern. Near river and wildlife refuge!

Experience the outdoors in comfort from this modern cabin, situated next to the 2200 acre Princeton Wildlife Management Area, and the nearby Mississippi River. It is ranked as the most “Favorited” Iowa listing of 2025 on Airbnb. Are you into hiking, biking, fishing, hunting, boating, or other water, winter, and summer sports? This cabin can support it all! Sit back and relax on the large deck while enjoying a coffee & the local wildlife, flora, & fauna of the Mississippi Valley Region.

Guest favorite
A spacious home is visible with a combination of brick and siding exterior, featuring multiple gables and a large covered porch. A manicured lawn extends toward a serene pond, enhancing the natural surroundings. Clear blue skies contribute to the relaxing outdoor atmosphere.
Home in Morning Sun
4.91 out of 5 average rating, 244 reviews

Buckman's Guesthouse BnB (5 Bedrooms+)

Enjoy the comfort and welcoming atmosphere of a home built to entertain family & friends. There are 5 guest bedrooms rooms: Room 1-King bed, sofa bed & recliner Room 2-Queen & sofa bed Room 3-Twin beds & convertible sofa Room 4-Queen & sofa bed Room 5-King & recliner Rooms 1,2 &5 have in suite bathrooms. Bathroom for room 4 is next door. Rooms 2 &3 share an inner door; ideal for parents with children. Breakfast is included. To book a room instead of the house, see separate listings.

Guest favorite
A cozy living area features a blue sofa and two wicker chairs, complemented by tropical-patterned pillows. A wooden coffee table sits atop a textured rug, with a television mounted on the wall. A potted plant adds a touch of greenery to the space.
Home in Davenport
4.91 out of 5 average rating, 157 reviews

Hidden Gem In The Quad Cities

Space is the upstairs of a duplex. Self check-in. Safe and friendly neighborhood. This special place is close to everything, making it easy to plan your visit. Note: Access requires steep stairs, so it may not suit guests with mobility concerns. Friendly owners live downstairs and are happy to assist. The place is close to St. Ambrose, Genesis West, Restaurants, 5 min from Palmer, Downtown and Mississippi Valley Fair grounds, 12 min from Augustana and 14 min from the Vibrant Arena.

Guest favorite
The entrance to the cottage features a decorative door framed by colorful trim. A wooden porch is accessed by a set of steps, and the house displays intricate architectural details, including a ceiling fan and house number on the door. Sunlight casts shadows across the entrance.
Cottage in Rock Island
4.94 out of 5 average rating, 311 reviews

Carla's Cottage

This little cottage is a Rock Island Historic house. Nestled among the large Victorians, it was built in 1879 and housed various workers, from a blacksmith, to a wallpaper hanger! Located just blocks from the Mississippi River you can walk along a paved bike path with gorgeous views. In the evening enjoy the vibrant nightlife, with music and a dinner playhouse! This tiny historic cottage is great for a quick night, but perfect for class reunions, weddings and the John Deer Classic!

Guest favorite
The exterior of a charming farmhouse is presented, featuring a white facade with a sloped roof. Lush green grass surrounds the front porch, which is shaded by large trees. A welcoming atmosphere is suggested by the open door and inviting entryway.
Home in Muscatine
4.97 out of 5 average rating, 113 reviews

Michelle's Place- The Farm House

Welcome to Michelle's Place- The Farm House. Where it's a farm feel, centrally located in town. It's a completely remodeled home with intentional planning and beautiful design for you to come rest at a home away from home. Close to parks, and walking trials while also only 4 minutes away from the historic downtown area! All aspects inside the home were uniquely picked by the host. With seasonal farm fresh varieties of berries, fruits, and vegetables to be enjoyed in your backyard!

Top guest favorite
The exterior of the Milk House features a red structure with gray siding, adorned with a triangular window and a decorative sun motif. A small porch with a welcome sign opens to a gravel path lined with flower planters. A chair and table are set for outdoor relaxation.
Farm stay in Iowa City
4.98 out of 5 average rating, 397 reviews

The Milk House at Lucky Star Farm

The Milk House is a unique space located in the countryside, between Iowa City and Kalona. This 700 square foot home has ample parking and room for four adults. The house is well appointed with a full kitchen, two luxurious queen beds, wifi and a Smart TV. Guests are invited to explore our 20-acre working farm with lots of livestock and two friendly dogs. It's a perfect blend of rural living with the perks of beautiful Iowa City 15 minutes away. Come unwind at Lucky Star Farm!

Top guest favorite
A view of the open-concept space highlights a kitchen area with a green countertop and a stove. The living area features light brown and tan upholstery on the seating, complemented by green carpet. A ceiling fan is visible along with warm lighting throughout the space.
Loft in Muscatine
4.95 out of 5 average rating, 238 reviews

The Emerald Loft Apartment

Stay in a Historic District Downtown loft! River views. Nearby park, playground, bike trails, boat ramps & marina. Shopping, live music, & restaurants. Private entry with 1,000 sqr ft of space, open concept, full kitchen, TV, laundry, private bath, literally right in middle of everything. Check in at Creations by Oz "Jewelry, Wine, & Unique Finds". Enjoy a glass of wine upon check-in. Come hungry. Photo comments provide dining options within steps of the Emerald Room.

Top guest favorite
Home in Davenport
4.92 out of 5 average rating, 101 reviews

Rieder Ranch 4 bdrm 2 bath house

You'll feel right at home in my comfy midwest ranch. It's nestled into a friendly subdivision known for great Christmas lights & it's own 4th of July fireworks show! Backyard is fenced with large firepit, patio, and deck to enjoy throughout the seasons. Five minutes to I-80 and under 15 minutes to TBK Sports Complex, Eldridge IA, downtown Davenport, East Village, and Tax Slayer Center. This has been my home for 18 years, so it's got everything you need to feel at home!!

Top guest favorite
A neatly landscaped home with a dark blue exterior is set amidst green grass and vibrant flower beds. The entryway features a welcoming red door framed by a decorative wreath. The walkway leads to a set of steps, enhancing the home's approachable charm.
Home in Bettendorf
4.92 out of 5 average rating, 159 reviews

Amazing updated 2 bedroom home 2 bath.

Your family will be close to everything when you stay at this centrally-located place. In the heart of Bettendorf. Close to interstates, shopping, Bettendorf Sports Complex, Village of East Davenport. Off street parking. Garage access if needed. Plenty of space two beds and bath on main level. Lower rec room has additional bath and sleeping accommodations. Quiet street. Fenced in back yard. Private deck. This house has everything for a short stay or long stay.

Popular amenities for Muscatine vacation rentals

When is the best time to visit Muscatine?

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Avg. priceG$28,872 GYDG$28,872 GYDG$28,872 GYDG$28,872 GYDG$29,291 GYDG$28,872 GYDG$30,546 GYDG$33,893 GYDG$37,450 GYDG$28,872 GYDG$28,872 GYDG$28,872 GYD
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Quick stats about vacation rentals in Muscatine

  • Total vacation rentals

    Explore 20 vacation rentals in Muscatine

  • Nightly prices starting at

    Muscatine vacation rentals start at G$14,645 GYD per night before taxes and fees

  • Verified guest reviews

    Over 790 verified reviews to help you choose

  • Family-friendly vacation rentals

    10 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 10 rentals that welcome pets

  • Wi-Fi availability

    20 of Muscatine vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Muscatine rentals

  • 4.8 Average rating

    Muscatine stays are highly rated by guests—averaging 4.8 out of 5!

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