Vacation rentals in Midlands of South Carolina

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Midlands of South Carolina

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite

A charming cottage features a sloped roof and rustic brick exterior, surrounded by lush greenery. Natural light filters through the trees, enhancing the serene setting. A hammock and seating area are visible in the background, inviting relaxation in the natural surroundings.

Cottage in Gaston

4.96 out of 5 average rating, 760 reviews

Congaree Vines - Woodland Cottage by a Vineyard!

-Enjoy a Quiet Country Stay! This charming European style cottage is set by a Hobby Vineyard! Enjoy complimentary port wine from our vineyard, a fire pit and hammock under the stars! -Congaree Vines also has the Log Cabin Library for guest use & the Barn Bungalow to rent. Pets are welcome for a fee; service dog: bring paperwork. -We are near Congaree National Park (33 min), Columbia, USC, Ft. Jackson, Airport, I-26 & Hwy 77. -15% off Guided Kayak in CNP w/Carolina Outdoor Adventures.

ValueLocationBeach

Top guest favorite

A gazebo with a shingled roof is positioned near the water, featuring two Adirondack chairs. A private boat dock extends into the lake, with a canoe resting nearby. Lush green grass surrounds the area, providing a serene outdoor space for relaxation.

Home in Lake Murray

4.96 out of 5 average rating, 109 reviews

Lake House with amazing view

Lake front property located on Lake Murray across from Dreyer Island State Park-Create memories with families & friends-/spacious/4 large bedrooms, 3 full baths/Accommodates up to 8 guests with a large master suite and master shower/infant’s crib is available/Large flat screen TV/ Wi-Fi/Washer and dryer/Great space for any group size/Wrap-around balcony/Gazebo/Great outdoor space with amazing views/ enjoy morning ☕️ & evening 🍷 /private boat dock. Space for yoga and all. Let’s relax a little!

LocationValueKitchen

Top guest favorite

The cottage is surrounded by greenery, showcasing a welcoming front porch with white railings. Two planters are placed at the entrance, and a swing is visible on the side. The entrance is accessible from a paved pathway leading to the door.

Cottage in Sumter

4.97 out of 5 average rating, 539 reviews

Restful Lakeside Cottage -Dogs allowed

This pond-side cottage is a peaceful place to relax & unwind. Sit in the sunroom and enjoy watching the birds & the water or enjoy the front porch rockers where you can listen to the birds & frogs. We are 12 min. from downtown Sumter & 20 min from Shaw AFB. Local points of interest are Swan Lake Iris Gardens, Poinsett State Park & Congaree Nat. Park. It's only 2 hrs to Myrtle Beach or Charleston & 3 hrs to the mtns. While it's conveniently located, this cottage offers a quiet place to relax.

ValueFamilyBackyard

Top guest favorite

A cottage resides beside a serene pond, surrounded by lush trees. Its inviting exterior features large windows reflecting on the water's surface. A wooden deck extends over the pond, providing access to nearby fishing and kayaking equipment, creating a peaceful natural setting.

Cottage in Lexington

5.0 out of 5 average rating, 186 reviews

Relax and unplug at this private oasis!

Our beautiful cottage for adults only is set on a private spring fed pond with all amenities to unwind from the day-to-day hustle. A porch with rocking chairs, brick fire pit and outdoor lighting in the courtyard make this your destination for relaxation. Take a walk in the 20 acres of wooded trails, fish, kayak, paddleboat, read a book, write, listen to music or just take a nap. This property lets you unplug from the world, relax, and connect with nature without giving up modern conveniences.

LocationValueSleep quality

Superhost

Cabin in St. Matthews

4.76 out of 5 average rating, 206 reviews

A relaxing cabin on private pond. Old Bells Secret

Escape to our secluded cabin on 90 acres in St. Matthews, SC! This early 2000s style cabin features 2 cozy bedrooms, 1 bathroom, and a lovely porch. The large pond is perfect for swimming, fishing, or playing. It’s an endless adventure. The house can sleep up to 6 with the pull out couch. Accessible via a private road, it's perfect for weekend getaways with the family or housing for workers. Experience relaxation and adventure in nature at this wonderful cabin. Book now for a memorable stay!

LocationFamilyDecor

Top guest favorite

A light-filled living area includes a spacious sectional sofa adorned with decorative cushions. A wooden coffee table with a neutral finish sits centrally on a patterned rug. Glass doors offer access to a patio, while a ceiling fan provides airflow.

Home in Ridgeway

4.96 out of 5 average rating, 170 reviews

3000 sq ft lake house with views from every window

Lake Wateree 4 bedroom + bunk room with private dock and sleeps 12 comfortably. Our home has been completely renovated and is ready to enjoy! It is located in Ridgeway, SC and 20 minutes from Camden and Lugoff. Colonel Creek Landing is 4 miles away and the perfect location to launch your boat. You can dock your boat in 12 feet of water at our dock. Perfect location for fishing, kayaking and swimming. Two living spaces with smart tv's. Now you can enjoy the fire pit and outdoor shower.

ValueFamilyBeach

Superhost

A vibrant sunset casts warm hues over the landscape, filling the sky with shades of orange and red. Silhouetted trees form a natural backdrop, while a rustic shelter stands nearby. The open field adds to the expansive view, inviting a sense of tranquility.

Home in Rembert

4.85 out of 5 average rating, 123 reviews

Pear Tree Farm-pets welcome! Stables/paddocks too!

Relax with the family at this peaceful place with GORGEOUS sunsets. When we say family, we mean pets & horses as well! We have 12 stables, 7 paddocks. Fenced yard & in ground pool. 5 fireplaces & heart pine floors. 3 living/family rooms. Once owned by the DuPont family (yes that DuPont family), the main part of the home is 96 yrs old and has many charming details. The 4 car garage was also the site of building race cars for the DuPonts. Pear Tree Farm offers the best in country quaintness.

FamilyValueIndoor spaces

Superhost

A dining area features a rustic wooden table surrounded by several chairs, illuminated by a modern pendant light. Large windows provide natural light, offering views of the outdoor scenery, while a cozy living space is seen in the background.

Home in Columbia

4.87 out of 5 average rating, 314 reviews

The Carolina Cottage: Near Ft Jackson, Zoo & 5pts!

Enjoy true Southern hospitality and charm at this 3-bed, 2-bath Columbia home! Whether you’re here to visit family at Fort Jackson or friends at USC, this vacation rental has ALL the essentials you need for a relaxing stay. *Special rates also provided for Military Families waiting on housing. The space: Central Location| Easy Access to Downtown, Five Points & Public Transit (5-10 min) Fort Jackson: 15 Min. Zoo 10 Min MAIN FEATURES: 1 Smart TV ( Master bedroom), 1 TV w/ Roku-living room.

FamilyValueAccuracy

Guest favorite

An outdoor game area features a pool table, with a set of colorful balls arranged on the surface. The scene includes a grassy lawn leading to the water, where a sunset illuminates the landscape. Two red chairs and a picnic-style setup are visible nearby.

Home in Prosperity

4.91 out of 5 average rating, 107 reviews

Sunset Cove-Beautiful Lake views

Your home away from home on Lake Murray! Spacious, modern clean, home with 3 levels of living -3 spacious decks, screen porch, and sunroom all with massive lake views! Plenty to do at Sunset Cove relaxing with family and friends and toys galore! "Wow just wow, best Airbnb ever..Sarah, June 2026. "..clean, beautiful view and so many fun games..Lisa, Oct 2025."Perfect setting for a quiet getaway. The house was amazing, clean, and had all the amenities we were looking for.."Jay, Sept 2025

ValueLocationAir conditioning

Top guest favorite

A spacious living area features an oversized orange sectional sofa, complemented by a wooden coffee table. A modern kitchen is visible in the background, equipped with stainless steel appliances and white cabinetry. Natural light filters through sheer curtains, creating an inviting atmosphere.

Home in Sumter

4.99 out of 5 average rating, 135 reviews

3 bd, 2ba, near ShawAFB, Game Rm

Welcome to our newly renovated 3 Bed, 2 Bath, home in Sumter. Our modern decor home has the following: - Master bdrm with King bed/ ensuite bath - Queen beds other rooms - Full equipped kitchen, coffee station - 65", 55", 43" TVs in rooms - Game Room, w/ pool table, table tennis, arcade games - Work area, wifi, 32" monitor, printer, adj height desk - Private backyard, BBQ grill ,gazebo, fire table, games. - Centrally located near Shaw AFB, Tuomey Hospital, food, parks and more

ValueLocationQuiet

Top guest favorite

A modern kitchen with sleek white cabinetry and granite countertops is highlighted. Four black bar stools are positioned at an island, and stainless steel appliances, including a stove and refrigerator, are visible. Natural light enters through multiple windows, creating a bright and functional space.

Home in West Columbia

4.99 out of 5 average rating, 163 reviews

Golden Reflections Getaway

Welcome to the Golden Reflection Getaway—a spacious, stylish retreat perfect for families and groups. Enjoy this 2,600+ sq. ft. spacious family area with three luxury themed bedrooms upstairs and extra sleeping options with a full bathroom on the main level. Tucked away in a peaceful neighborhood, just 7 minutes from the vibrant heart of Downtown Columbia and 18 minutes from Fort Jackson. Relax, recharge, and make lasting memories in this thoughtfully designed and comfortable home.

ValueFamilyTV

Top guest favorite

A tranquil lakeside scene features a circular stone fire pit surrounded by black Adirondack chairs. The vibrant sunset reflects on the calm water, with lush green trees framing the view, creating a serene outdoor space for relaxation.

Home in Camden

4.95 out of 5 average rating, 122 reviews

Big Water Sunset at Lake it Easy

Escape to Beautiful Lake Wateree for a relaxing weekend away with friends or family. This updated house features 2 bedrooms & 2 bathrooms. Enjoy the cozy vibes of a tastefully decorated space, perfect for unwinding after a day on the lake. Step outside to a serene screened in porch, a fire pit, and stunning big water sunsets that will take your breath away. Whether you're into fishing, kayaking, or simply relaxing by the water, this lakefront house has something for everyone!

ValueFamilyTV