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Vacation rentals in Melrose

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Top-rated vacation rentals in Melrose

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
A serene lake scene is captured at sunset, displaying colorful reflections of clouds and the vibrant sky on the water's surface. The landscape is framed by trees along the shoreline, creating a tranquil and picturesque backdrop.
Cottage in Hawthorne
4.84 out of 5 average rating, 209 reviews

Live Oak Oasis on Morris Lake

Unspoiled nature greets your every turn at this charming 650 SF lakefront retreat. A short distance from 10 of Florida's finest 1st magnitude springs, ranging from 30 - 90 minute drive, makes the location a perfect basecamp for adventure travel. Rest beneath the shade of Live oaks that pull the breeze ashore. Enjoy Sand hill cranes and hummingbirds from the cabana. Incredible sunsets from new dock. Paddle boat & paddle boards available for adventures. WiFi, Netflix, Laundry, HOT outdoor shower!

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Guest favorite
A collection of colorful kayaks and canoes rests along the shoreline of Lake Mable. A wooden dock extends into the calm water, surrounded by lush greenery in the background. The clear blue sky overhead reflects softly on the lake's surface.
Home in Melrose
4.93 out of 5 average rating, 148 reviews

Three Bedroom House on Private Scenic Lake Mable

Located on pristine (no gas engines) swimming and fishing Lake Mable, this cheerful home is the perfect spot for a fun filled family vacation or just a relaxing weekend getaway. Enjoy the peaceful sounds of nature as you sit and watch the sunset over the lake, roast some marshmallows over the firepit, or just relax by the lake with a fishing rod in hand. You may see Sandhill Cranes, Red-headed Woodpeckers, or even a few deer. Let your worries drift away and enjoy the tranquility around you.

LocationValueLong stay

Top guest favorite
A serene lakeside scene is depicted with a wooden dock extending into calm waters. Nearby, colorful Adirondack chairs surround a fire pit, creating a space for relaxation. The background features trees reflecting the hues of sunset, enhancing the tranquil atmosphere.
Home in Hawthorne
4.95 out of 5 average rating, 101 reviews

Serenity Escape lake house private beach

Serenity Escape at Hawthorne Lake Escape the hustle and unwind at Serenity Escape, a peaceful lakeside retreat nestled in the heart of Hawthorne, Florida. Whether you’re planning a family vacation, fishing trip, romantic getaway, or relaxing weekend with friends, this beautifully appointed home offers the perfect blend of comfort, privacy, and natural beauty .Wake up to breathtaking lake views, sip your morning coffee from the screened porch, and spend your days enjoying on our private beach🏖️

FamilyLocationLong stay

Guest favorite
Two comfortable chairs are positioned on a wooden deck overlooking a calm lake, surrounded by a serene landscape. The expansive water reflects a blue sky, creating a peaceful atmosphere for relaxation and enjoyment.
Home in Melrose
5 out of 5 average rating, 24 reviews

Modern LAKE HOUSE on Lake Santa Fe near Gville/UF

Have fun OR relax at this fully renovated LAKE HOUSE w/BOATHOUSE and raised sunset deck only 30 mins to Gainesville! Sit back and and enjoy the beautiful views of the lake as soon as you enter the home or up close from the hammock swings in the boat house! 3 BR/2 BA plus converted air conditioned garage used as a game room with Ping Pong Table and TV, easily sleeping 8. The backyard offers a large deck with privacy fencing and lush landscaping with direct access to step right into the lake.

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Top guest favorite
A charming log home is nestled among large trees draped in Spanish moss, with a well-kept grassy area leading to the lake. The porch is visible, and the peaceful water serves as a backdrop, enhancing the natural beauty of the surroundings.
Cabin in Hawthorne
4.97 out of 5 average rating, 179 reviews

Charming Lakefront Log Home

Welcome to your perfect lake retreat! Located on a no public access lake. This charming log home has a private dock and boat ramp suitable for launching your boat for fishing or skiing. There are kayaks on premises for use. This is an ideal location to enjoy North Florida’s lake life with family, friends, or work retreat. Includes a fully stocked kitchen, covered porch, fire pit, gas grill, and WiFi if you feel the need to plug in. NOT suitable for parties or events. NO loud noise, please.

FamilyLocationLong stay

Top guest favorite
A serene lakeside view features vibrant pink flowers and lush greenery framing a hammock. The calm, clear waters of the private lake are visible in the background, with two kayaks resting on the shore, creating an inviting space for relaxation.
Cottage in Hawthorne
4.97 out of 5 average rating, 209 reviews

Modern Cottage on Private Spring Fed Lake

Nestled on a gorgeous spring-fed private lake in the woods, our charming cottage is your ideal retreat. Whether you're dreaming of peace and quiet, a romantic getaway, or fun with your kids, this is the place to be! Kayak around the serene lake as you witness breathtaking sunsets, take a dip in the cool water or simply unwind amidst the beautiful surroundings. As night falls, gather around a fire and gaze up at the many stars lighting the sky. Come and create many cherished memories ☀️

ValueLocationQuiet

Guest favorite
Home in Melrose
4.91 out of 5 average rating, 68 reviews

Lakefront A-Frame · Hot Tub + Fire Pit · Dock

Our beautifully renovated A-frame sits on a quiet private lake in the heart of Melrose. Enjoy peaceful surroundings, modern finishes, and plenty of outdoor fun: relax in the hot tub, fish from the shore, paddle the lake with our pedal boat, or gather around two fire pits under the stars. Inside, you’ll find an open layout, lake views, and a fully equipped kitchen. Conveniently located near Gainesville, Ocala, St. Augustine, and natural springs—perfect for family and friends!

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Guest favorite
A figure glides across the water at sunset, creating ripples in the smooth lake surface. The sun casts a golden reflection, enhancing the serene ambiance. Soft clouds are visible in the sky, adding depth to the tranquil scene.
Cottage in Melrose
4.98 out of 5 average rating, 104 reviews

The Nest on Lake Santa Fe in Melrose, FL

The Nest is a beautiful two-story cottage on Lake Santa Fe. Enjoy some peace and serenity, catch monster bass, or bring your ski boat for high-speed fun. We are located just 20 minutes from Gainesville and UF. The Nest is great for a weekend getaway or a week of peaceful relaxation. We do not allow parties or events out of respect for our neighbors and we allow a maximum of 6 guests (max 4 adults). Absolutely no animals are allowed on the property at any time for any reason.

LocationFamilyLayout

Superhost
Guesthouse in Melrose
4.82 out of 5 average rating, 45 reviews

Gator Trail Guesthouse

Slow mornings, quiet evenings, and adventure whenever you crave it. This quaint lakeside hideaway is your home base for exploring North Florida — whether you’re here for a Gators game, a beach day, or a stroll through St. Augustine. Nestled in peaceful Swisher Lakes Estates, you’ll feel secluded and surrounded by nature, yet only a short drive to Gainesville, Jacksonville, Crescent Beach, and more. Kick back, breathe deep, and make memories by the water.

FamilyValueKitchen

Top guest favorite
A clean, functional kitchen area is visible, featuring a white tiled countertop and a stainless-steel sink. In the background, a cozy studio living space offers comfortable seating and colorful furniture. A doorway leads to a private bathroom, enhancing the apartment's practicality.
Apartment in Waldo
4.98 out of 5 average rating, 186 reviews

Fernbank on beautiful Lake Alto. Laketime Getaway

Visit this beautiful, tranquil lakeside spot for an amazing getaway. It's a six acre property, an inspiring place to study, write, or get work done with fun things to do while on a break. Swim, kayak, canoe, paddle board or enjoy sitting on the dock. Visit the barn for basketball, ping pong, and corn hole. It's a studio apartment with a private bathroom and beds for four, plus two couches and air beds available. Note: This is an upstairs apartment.

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Top guest favorite
A wooden dock extends over calm waters reflecting a vibrant sunset. Two Adirondack chairs are positioned atop the dock, offering a serene spot to relax and enjoy the view. The horizon showcases a blend of warm colors as the sun sets gently in the distance.
Apartment in Melrose
4.99 out of 5 average rating, 127 reviews

Lakefront Retreat Apartment Remodeled, Premium Bed

Private lake home on Big Lake Santa Fe is the perfect place to unwind and enjoy gorgeous sunset views. The rental unit is an upstairs separated apartment. It has a cedar interior with a cabin feel that has been renovated with new appliances, flooring and updated bathroom with walk in shower. Bring your boat to cruise the lake or fish and tie up at our dock. Enjoy swimming, water skiing, fishing or just relaxing on the deck.

LocationFamilyParking

Top guest favorite
Home in Melrose
4.96 out of 5 average rating, 54 reviews

Lake Getaway-2/2*UF*King BR*Hot tub*Firepit*Boats

Lake Retreat •Sandy Beach •Kayaks •Fire Pit •Hot Tub •Kayaks, canoe, peddle boat, stand-up paddle boards •Fishing • High Speed WIFI •Fully equipped kitchen •Fireplace •Laundry with washer and dryer •Close to many springs •Free parking for 2 vehicles •20 Minutes to Gainesville and UF •Perfect for couples, friends, snowbirds, traveling professionals, and small families looking for a peaceful lake getaway.

FamilyLocationBathroom

Popular amenities for Melrose vacation rentals

KitchenWifiPoolFree parking on premisesAir conditioning

Other great vacation rentals in Melrose

Superhost
A modern, elevated structure features a sleek exterior with large glass panels, providing expansive views of the surrounding landscape. The building is supported by a sturdy frame, with a pathway of white stones leading up to it, set against a backdrop of greenery and blue skies.
Cabin in Interlachen
4.78 out of 5 average rating, 68 reviews

Space Camp

LocationValueBackyard

Guest favorite
A spacious living area features comfortable maroon leather sofas and an artistic throw draped over one armrest. A vibrant woven rug covers the floor, complementing the soft lighting from standing lamps. In the background, a kitchen area is partially visible, showcasing wooden cabinetry.
Cottage in Melrose
4.87 out of 5 average rating, 45 reviews

The Maple Lake House

FamilyLocationLong stay

Top guest favorite
Home in Keystone Heights
4.98 out of 5 average rating, 53 reviews

Sweet Tea Cottage • Lakefront • Beach • Fire pit

LocationValueAccuracy

Top guest favorite
Four blue adirondack chairs are positioned on a sandy beach overlooking a calm lake. The water reflects soft pastel hues from the sunset, while trees line the opposite shore, creating a serene atmosphere.
Cottage in Keystone Heights
4.99 out of 5 average rating, 75 reviews

Crystal Lake Retreat

ValueFamilyHiking

Guest favorite
A comfortable living area contains a dark leather sofa and a wooden coffee table, accented by a decorative bowl. To the side, a colorful throw pillow adds a pop of color, while a small rug defines the space under the coffee table. Warm lighting brightens the room.
Apartment in Melrose
4.95 out of 5 average rating, 19 reviews

Melrose Bless

ValueFamilyLong stay

Top guest favorite
A wooden dock extends over the water towards a two-story house, featuring a spacious patio with seating. The grassy area around the house is shaded by trees draped in Spanish moss, contributing to a serene outdoor environment.
Home in Waldo
4.97 out of 5 average rating, 34 reviews

Lake Santa Fe House Amazing Views Sunrise Sunset

FamilyLocationAmenities

Guest favorite
A wooden deck features a picnic table, surrounded by natural scenery. Glowing string lights add a warm touch as they hang overhead. The view captures White Sands Lake, with lush greenery and trees framing the tranquil landscape under a partially cloudy sky.
Home in Keystone Heights
4.92 out of 5 average rating, 25 reviews

Sunset Lake Escape | Views From Every Room

FamilyValueKitchen

Top guest favorite
Farm stay in Melrose
5 out of 5 average rating, 14 reviews

Highlander Ranch Farmhouse Retreat

FamilyValuePets

Frequently Asked Questions

  • What are the best places to stay in Melrose?

    Lakeside neighborhoods in Melrose have vacation rentals that include cabins, cottages, and renovated historic homes. Many stays feature access to outdoor amenities, making it easy to enjoy nature and community spaces.

  • What are the best things to do in Melrose with kids?

    Kids in Melrose enjoy swimming or fishing at Santa Fe Lake, exploring playgrounds in local parks, and joining craft activities at community centers. Weekend market visits or nature walks offer extra ways to learn about the area.

  • What are some of the best things to do in Melrose?

    Explore Santa Fe Lake for swimming, paddling, or fishing, browse neighborhood art galleries, and stroll historic streets around the town center. Parks, seasonal markets, and community festivals invite visitors to experience Melrose's welcoming atmosphere.

  • How is the weather in Melrose?

    Melrose has mild winters around 43–69°F (6–21°C) and hot, humid summers reaching 91°F (33°C), with rainier months in summer. Packing both sun protection and a light jacket helps visitors stay comfortable year-round.

  • When is the best time to visit Melrose?

    Spring and fall are often recommended for visiting Melrose, with warm days, cooler nights, and fewer heavy summer rains. These seasons also bring outdoor community events and more opportunities to enjoy lakes and parks.

  • What are the best places to visit in Melrose?

    Visitors to Melrose often explore the Santa Fe Lake, local art galleries, and historic sites around the town center. Parks with playgrounds and natural views, as well as community gardens, are also frequently suggested.

  • What are some hiking trails in Melrose?

    The area around Melrose has several nature trails, including those in local parks and conservation lands. These paths offer opportunities to walk under tall trees, spot local birds, and enjoy waterfront views.

  • What are some family activities we can do in Melrose?

    Families in Melrose often explore lakes for swimming or paddling, visit parks with picnic areas and playgrounds, and browse local arts spaces. Community events, like outdoor markets and craft fairs, create a welcoming, family-friendly atmosphere.

  • What are some of the best day trip ideas from Melrose?

    Popular day trips from Melrose include exploring nearby state parks, visiting historic small towns, and discovering nature preserves. Outdoor enthusiasts often enjoy canoeing, birdwatching, or walking among gardens around the region.

  • Are there any pet friendly accommodations available in Melrose?

    Many vacation rentals in Melrose and the surrounding lakes area welcome pets, with convenient outdoor spaces for walks. It is common for homes and cottages near the water to provide pet-friendly amenities.

  • What are some local tips for visiting Melrose?

    Pack lightweight clothing for warm, humid days, and a light jacket for cooler evenings in winter. Exploring the lakes and local art scene, stopping by weekend markets, and enjoying a meal at a locally owned café are often recommended.

  • What is Melrose known for?

    Melrose is known for its lakefront scenery, local art scene, and community-focused events. Visitors often associate the town with outdoor activities, galleries, and historic buildings reflecting its roots as a rural lakeside community.

  • What are the best hidden gems to explore in Melrose?

    Explore tucked-away galleries showcasing regional artists, small local history museums, and serene spots along the area's lakes. Nature lovers often discover quiet trails, birdwatching sites, and charming farmers markets.

  • What are the best foods to try in Melrose?

    Melrose is known for Southern-inspired comfort food, fresh-caught fish, and seasonal produce from local farms. Travelers frequently suggest sampling homemade baked goods, smoked barbecue, and dishes that highlight regional vegetables.

  • What should I bring for a trip to Melrose?

    Bring lightweight clothing for humid weather, sturdy walking shoes for exploring trails, and sun protection for days near the lake. A light rain jacket can be useful during the wetter months.

  • What is the nightlife in Melrose like?

    Melrose has a relaxed, small-town nightlife experience, with local spots featuring laid-back bars, live music on select evenings, and casual eateries. Travelers enjoy gathering at neighborhood venues for conversation, community events, and occasional performances.

  • What are the most popular events or festivals in Melrose?

    Melrose hosts a range of community events through the year, such as arts festivals, farmers markets, and seasonal celebrations. The area is known for art walks and live music gatherings, especially in the spring and around holidays.

  • Are there family friendly vacation rentals in Melrose?

    Melrose has a mix of family-friendly vacation rentals, especially lakeside cottages and homes with spacious yards. Many accommodations include kitchens and outdoor amenities, adding flexibility for visitors traveling with children.

Destinations to explore