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House vacation rentals in Lesbos Prefecture

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Top-rated house rentals in Lesbos Prefecture

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Top guest favorite
A dining table set on an outdoor terrace is arranged for a meal. Plates are placed beside crystal glasses, with a colorful spread of grapes, watermelon, and other fruits displayed on a platter. A glass pitcher and bottles, including a wine bottle, complete the inviting setting.
Home in Mitilini
4.98 out of 5 average rating, 85 reviews

Aegean View Resort # The House

Tranquillity, relax and comfort best describe this house set in absolute nature in a peaceful suburb, only a few minutes away from the heart of the Mitilini. The property featuring stunning architectural details that provides guests with a high level of comfort and style but it can also be your base for exploring the rest of the beautiful and big island.It is perfect for families, couples or a group of friends looking for spacious areas, large terraces, comfort and privacy.

Top guest favorite
A modern villa is set against a night sky, with soft illumination highlighting its sleek design. The stone exterior is contrasted by bright lighting, creating a welcoming entrance. Lush greenery frames the scene, providing a touch of nature to the contemporary architecture.
Home in Lesbos Prefecture
5 out of 5 average rating, 13 reviews

Pieres Blanches Recidences

Ανακαλύψτε την απόλυτη εμπειρία διαμονής 1,5 χιλιόμετρο απο το κέντρο της πόλης της Μυτιλήνη. Με κομψό σχεδιασμό και μοντέρνες ανέσεις, οι τρεις αυτόνομες μονοκατοικίες μας, των 120 τ.μ. η καθεμία, σας προσκαλούν να απολαύσετε την ηρεμία και την ομορφιά του νησιού. Κάθε βίλλα διαθέτε τρία άνετα υπνοδωμάτια, δύο μπάνια, ευρύχωρο σαλόνι, σοφίτα, πλήρως εξοπλισμένη κουζίνα και ιδιωτική πισίνα για να δροσιστείτε και να απολαύστε τον ήλιο στην άνεση της δικής σας πισίνας.

Top guest favorite
A two-story building with a light yellow facade is presented. The ground floor features a central white door framed by two windows with shutters. An ornate black balcony extends from the upper floor, adorned with decorative railings and additional windows, all framed by clear blue skies.
Home in Petra
5 out of 5 average rating, 16 reviews

The old tannery

Paleo Tsagariko is located in the center of Petra, in the traditional settlement, between the old mansions and the blooming gardens, opposite the picturesque church of Agioi Apostoloi, very close to the central square, 300 meters from the beach. Enjoy the view of the imposing rock of Panagia from the beautiful balcony. It was renovated in 2025 and has all modern amenities. Quality mattresses guarantee a restful sleep for 4 people. Each floor has a bathroom.

Guest favorite
A spacious dining area features a long wooden table surrounded by modern black chairs. Large windows on either side allow natural light to fill the room, revealing views of the surrounding landscape. A stone fireplace adds a touch of warmth.
Home in Plomari
4.97 out of 5 average rating, 32 reviews

Iris Home

Η μεζονέτα μας Iris Home δυο επιπέδων πρόσφατα ανακαινισμένη βρίσκεται στο κέντρο της πόλης .Διαθέτει πλήρως εξοπλισμένη κουζίνα και τραπεζαρία για να απολαύσετε το φαγητό σας με την οικογένεια και τους φίλους σας με θέα τη θάλασσα .Οι δυο κρεβατοκάμαρες και το μπάνιο βρίσκονται στο κάτω επίπεδο συνεχίζουν την θέα στο απέραντο γαλάζιο του Αιγαίου .Στα 2 λεπτά με τα πόδια η μαρίνα της πόλης ,εστιατόρια ,καφετέριες και αλλά καταστήματα.

Guest favorite
A spacious sleeping area features a wooden platform bed with light blue bedding, complemented by two decorative pillows. The stone walls add a rustic touch, while large windows provide natural light. A red area rug enhances the room’s warmth and comfort.
Home in Ayvacık
4.95 out of 5 average rating, 123 reviews

Babakale Cumbalı Ev-Entire Stone House w/ sea view

T.C. Kültür ve Turizm Bakanlığı, Turizm Amaçlı Kiralanan Konut İzin Belgesi No: 17-626 (3. Fotoğraf) Tüm bilgilerimiz mevcuttur Cumbalı taş evimiz 55 m2 kapalı alan 100 m2'den fazla kendine ait bahçesi ile iki kişinin konaklayabilmesi için tasarlanmıştır. Gün boyu evimizin hemen her yerinden Ege denizi manzarasının keyfini sürebilir; ve mangal eşliğinde ağaçlar altında enfes manzara ile akşam yemeğinin keyfini çıkarabilirsiniz

Top guest favorite
A logo for '4 Seasons Guest Room Mytilene' is displayed, featuring a stylized house silhouette against four colorful panels representing the seasons: green leaf, yellow sun, red maple leaf, and blue snowflake. The name is prominently presented in a bold font below.
Home in Mitilini
4.98 out of 5 average rating, 60 reviews

4 seasons

Fully furnished 38 sq.m. apartment, ideal for up to 2 guests — an ideal choice for couples or travelers seeking comfort and tranquility. The apartment is located in the traditional neighborhood of Synoikismos, very close to all local businesses (pharmacy, mini market, bakery, greengrocer, pastry shop, etc.) and just a few minutes away from the city center. It is an ideal choice for either a short getaway or a longer stay.

Guest favorite
A scenic outdoor space showcases a pathway leading to a pool area, framed by olive trees and vibrant greenery. The blue waters of the bay are visible in the background, with hills rising gently along the shoreline under a partly cloudy sky.
Home in Mitilini
4.98 out of 5 average rating, 57 reviews

Twostorey house with amazing view (Aqua)

Πολυτελές διώροφο σπίτι 120 τ.μ. με ιδιωτική πισίνα και με θέα στον κόλπο της Γέρας,100 μ. από τη θάλασσα. Διαθέτει δύο υπνοδωμάτια, μπάνιο με υδρομασάζ,wc, σύστημα κεντρικου κλιματισμού, ενδοδαπέδια θέρμανση και wi-fi. Είναι κτισμένο μέσα σε ελαιώνα, έχει χώρο parking και είναι 5km από την πόλη της Μυτιλήνης το αεροδρόμιο και το λιμάνι. Σε απόσταση 5 km βρίσκονται οι γνωστές παραλίες Χαραμίδα και Άγιο Ερμογένη.

Guest favorite
The exterior showcases a two-story traditional building with maroon shutters framing the windows, which are adorned with white lace curtains. A small outdoor seating area features a patterned tablecloth, complemented by light-colored chairs, inviting relaxation in a serene setting.
Home in Taxiarches
4.81 out of 5 average rating, 108 reviews

PanDesSia

"PanDesSia" is a traditional house in Mytilene, with Lesbian architecture. It is located in "Kayani", close by the famous "Antonis" Ouzeri. Offers a veranda with a fantastic view of the Aegean Sea, the town and the harbor of Mytilene and the Turkish coasts. It is only 6km from the town of Mytilene and 4km from the airport. It has two bedrooms overlooking the sea and can accommodate at least 4 people.

Guest favorite
A double bed is positioned in a softly lit room, adorned with floral patterned bedding. A piece of wall art depicting a sunset is displayed above the bed, while decorative flowers frame the image. A warm ambiance is created by the light entering through a nearby window.
Home in Mitilini
4.81 out of 5 average rating, 36 reviews

Gina 's Cozy nest in Mytilene

Welcome to our apartment in the heart of Mytilene! Just steps away from restaurants and bars, we offer a comfortable double bed, personal care essentials, a fully equipped kitchen, a washing machine, and an iron. Enjoy free high-speed WiFi, a smart TV with Netflix, and air conditioning. We invite you to experience a unique stay filled with comfort, authentic hospitality, and unforgettable moments.

Guest favorite
A cozy seating area is positioned near large windows overlooking the sea. The stone wall adds a rustic touch, while two tall chairs with green cushions invite relaxation. Natural light floods the space, highlighting the nearby decorative items and the calm waters outside.
Home in Nifida
4.9 out of 5 average rating, 21 reviews

Pelagia's House

Pelagia's house is a seaside house that has been recently renovated while keeping its traditional character along with the memories of many carefree summers. The house has 2 bedrooms with one double and two single beds, a fully equipped kitchen, a very comfortable bathroom, air conditioning and wifi in all areas This seaside house is ideal for a quiet and relaxing vacation.

Guest favorite
A rooftop terrace is visible, featuring black chairs and a table arranged on a patterned rug. The skyline is dominated by a church clock tower, adding architectural interest. A woven blanket is draped nearby, complementing the outdoor space against a bright blue sky.
Home in Mitilini
4.86 out of 5 average rating, 21 reviews

Casa De Pera Ermou

Casa de pera Ermou is an accommodation in the heart of the historical center of Mytilene. In our accommodation you will find a beautiful and elegant space with all the necessary amenities. Finally, the terrace of the house offers a view of the central market of Ermou with the highlight being the amazing bell tower with the clock of the cathedral church.

Guest favorite
Home in Perama
5 out of 5 average rating, 15 reviews

Villa Caroline

Villa Caroline Welcome to your own private retreat, an authentic traditional house in a lush paradise within a well-kept vineyard. The property is in a great location, just a few steps from the sea, ideal for those seeking peace, authenticity and contact with nature.

Popular amenities for Lesbos Prefecture house rentals

When is the best time to visit Lesbos Prefecture?

MonthFebMar
Avg. priceG$19,659 GYDG$19,241 GYD
Avg. temp9°C11°C

Quick stats about house rentals in Lesbos Prefecture

  • Total vacation rentals

    Explore 440 vacation rentals in Lesbos Prefecture

  • Nightly prices starting at

    Lesbos Prefecture vacation rentals start at G$2,091 GYD per night before taxes and fees

  • Verified guest reviews

    Over 5,410 verified reviews to help you choose

  • Family-friendly vacation rentals

    240 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 130 rentals that welcome pets

  • Vacation rentals with a pool

    20 properties feature pools

  • Rentals with dedicated workspaces

    110 properties have a dedicated workspace

  • Wi-Fi availability

    390 of Lesbos Prefecture vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Lesbos Prefecture rentals

  • 4.8 Average rating

    Lesbos Prefecture stays are highly rated by guests—averaging 4.8 out of 5!