House vacation rentals in Lake City

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Top-rated house rentals in Lake City

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Guest favorite
The charming facade of Kuker Cottage is framed by lush greenery and trees, featuring a covered porch with colorful seating. Large windows are positioned symmetrically, and the brick columns add character to the entrance, inviting guests to relax in a tranquil outdoor space.
Home in Florence
4.87 out of 5 average rating, 558 reviews

Kuker Cottage Downtown Florence-Near I95 & I20

Kuker Cottage is a beautifully restored Florence home in the heart of downtown. Perfectly situated halfway between New York and Florida, it is an ideal overnight stopping point. Plenty of space to spread out, offering families room to unwind after a long day of traveling. This home has been beautifully updated and is ready to host you, whether for a short or an extended stay. 2 queen beds, one twin bed, full bath, kitchen, wifi and TV. Walkable to parks and restaurants. 4 miles from I95 and I20

Superhost
An aerial view captures the chalet by the lake during twilight, showcasing a well-maintained yard that includes a small pier, in-ground pool, and fire pit. The house features large windows reflecting the colorful sky, with cozy neighboring homes visible in the background.
Home in Manning
4.89 out of 5 average rating, 118 reviews

Luxury Lakefront Chalet W/Pool, Hot Tub & Beach

Bring the whole family to this gorgeous lakefront chalet with tons of guest amenities in a quiet neighborhood on Wyboo Creek. Sleeps 2 families comfortably w/ 4 large BR, 2 bathrooms, a game room, a fully equipped kitchen, living area, & screened porch. Enjoy the in ground pool w/ tanning ledge, hot tub, built-in fire pit, outdoor grilling & dining area, private sandy beach, & pier on open water. Launch your boat at the public ramp at the end of the street (.2 miles) & dock at the private pier.

Top guest favorite
A comfortable living area features a dark gray sofa complemented by two accent pillows. A coffee table is positioned in front of the seating, and two standing lamps provide soft lighting. A simple wall art above the sofa adds a touch of elegance to the space.
Home in Florence
4.98 out of 5 average rating, 119 reviews

Renovated 2 BR/2 B Townhouse Cozy & Clean

Keep it simple at this peaceful, centrally-located, and renovated townhouse close by I-95 and I-20 and within 15 mins. to the Florence Center, downtown Florence, many restaurants, and McLeod and MUSC Florence. House is located in a safe neighborhood with 2 queen beds and 1 sofa bed in the living room. Enjoy being outdoors? Relax outdoors on your own private patio, go on a walk around the neighborhood, or go on an adventure. The Rail Trail & Ebenezer Park are minutes away. Utilities included.

Guest favorite
A charming country estate is highlighted with a wrap-around porch surrounded by lush greenery. The architectural details feature brick and wood elements, with a tall chimney visible. Sunlight gently illuminates the exterior, showcasing the inviting atmosphere of the property.
Home in Kingstree
4.94 out of 5 average rating, 129 reviews

magical 1840s farm house getaway

Centuries old country estate with magical ambiance, art and antiques, beautiful views and wrap around porches. Relax in the hot tub in your own private oasis or gather with friends and family around the fire pit. Multiple bird feeders and grand live oaks, magnolias, fruit trees and a kitchen garden. Chefs kitchen will be stocked with fresh eggs, herbs and seasonal veggies. Sit and sip on the porch while enjoying the views of farmer's field and listing to the moos of the cows. Groups welcome!

Guest favorite
A covered porch features two Adirondack chairs, one painted blue and the other orange, positioned beside a small side table. A view of greenery is visible through a nearby window, contributing to a relaxed outdoor seating area.
Home in Georgetown
4.96 out of 5 average rating, 182 reviews

Carolina Wren Cottage: New, Relaxing, Dog-Friendly

Charming dog friendly cottage located minutes away from historic Georgetown only about an hour from Charleston. Whether you want to sit on the large porch and enjoy listening to the birds sing or watch them fly back and forth through the beautiful trees. Maybe have an adventure walking along the Harbor walk do a little shopping and enjoy the great selection of restaurants. If that wasn't enough there are several beautiful beaches to enjoy. You won't be disappointed. For pets see policies.

Top guest favorite
The exterior of a two-story house is nestled among tall trees, showcasing a deck with steps leading to the ground. Screened-in porches on both levels provide ample outdoor space and views of the surrounding greenery.
Home in Georgetown
4.99 out of 5 average rating, 172 reviews

Black River Refuge on the Water

The first guest comment I hear is "Wow - pictures don't do this place justice - the house is incredible and the views are spectacular! The next comment is "I thought we were way out in the country but it's only 20 minutes to the waterfront town of Georgetown, with shops, dining, museums and more. Looking to get away? This place is truly a retreat- a 3 bedroom house on the beautiful Black River in Georgetown. Four kayaks provided, swim or fish off the dock just a few steps from the house.

Guest favorite
A bright living area features a light-colored sectional sofa arranged around a circular coffee table. Natural light enters through the windows, enhancing the warm ambiance. A simple desk with a chair is positioned nearby, complementing the overall spaciousness of the room.
Home in Florence
4.92 out of 5 average rating, 105 reviews

Charming Home in Florence, SC

Welcome to Florence, South Carolina! This inviting 3-bedroom, 2-bathroom home is a haven of comfort and convenience. With four queen beds, it comfortably accommodates a group of friends or family. Step into the fully stocked kitchen, relax in the cozy living space, equipped with smart TVs for entertainment. The fenced backyard offers both privacy and a secure play area for your furry friends. Enjoy outdoor gatherings at the picnic table. Convenient amenities include a washer and dryer.

Top guest favorite
The bedroom features a spacious bed with decorative pillows, flanked by two bedside tables with lamps. Soft lighting creates a calming ambiance. A door leads to an adjoining space, while light walls enhance the feeling of openness.
Home in Timmonsville
5 out of 5 average rating, 42 reviews

Comfy Suite Sleeps 4 Near I20&95

Suite Carolina is a newly renovated private guest suite located in a rural setting just minutes from Florence, South Carolina. This one-bedroom, one-bathroom suite offers comfort and simplicity with modern touches—perfect for an overnight stay or a longer visit. The space includes a queen bed, queen sleeper sofa, partial kitchenette, and a spacious master bath. Situated just 4 minutes off I-20, this spot is ideal for travelers or anyone seeking a home base with quick access to Florence.

Guest favorite
The kitchen features modern appliances, including a stainless steel refrigerator and an electric stove. Natural light fills the space through multiple windows. A wooden dining table is visible, accompanied by a set of chairs. A doorway leads to the outside.
Home in Hartsville
4.84 out of 5 average rating, 136 reviews

Quaint 2BR home w access to Black Creek & downtown

Our freshly renovated home sits in a family-oriented neighborhood only a mile from downtown Hartsville and Kalmia Gardens and includes access to Black Creek. This 600 sf home features 2 bedrooms, 1 bath, a full kitchen, washer and dryer and an open living area. Digital antenna reception for smart-tv and high speed wi-fi internet. Small dogs will be considered for stays on a case-by-case basis. Pet stays require prior approval from the hosts and will involve additional fees.

Superhost
A charming bungalow exterior is displayed, featuring a light-colored wooden facade with dark shuttered windows. A small porch with a railing is visible at the front, surrounded by neatly trimmed landscaping and a grassy area leading to the street.
Home in Darlington
4.82 out of 5 average rating, 136 reviews

Located 100 feet from The Darlington Raceway!

This cute little bungalow is located across the street from The Darlington Raceway. Just a few steps puts you at the door of the famous Joe Weatherly Stock Car Museum. We are also within walking distance to Manheim Auto Auction. The Raceway Grill, a favorite of Dale Earnhardt, is located across the street ! If you are here during the week, South of Pearl, Darlington's finest eating establishment, is located in uptown Darlington. WE DO NOT HAVE A STOVE OR WASHER/DRYER

Top guest favorite
A cozy living area features floral-patterned sofas, a wooden coffee table, and a rocking chair. Natural light filters through sheer curtains, highlighting decorative accents like a lamp and wall art. A ceiling fan provides comfort in this welcoming space.
Home in Sumter
4.98 out of 5 average rating, 124 reviews

Quiet Country Living w/private lot

Welcome to Quiet Country Living! Experience all that Sumter has to offer with this renovated home that has everything you will need for your stay. Located in a country neighborhood only 8.9 miles from downtown, local shops, Swan Lake Iris Gardens, and other parks and attractions. Also 19.4 miles to Shaw Air Force Base. Business friendly, military friendly, family friendly. Home available for temporary duty (TDY) . This location is perfect for any and all travelers.

Top guest favorite
The exterior of the home showcases a classic brick facade, highlighted by tall white columns and large windows with black shutters. A welcoming front porch features a decorative rug and a flower arrangement, framed by lush greenery and neatly manicured grass.
Home in Georgetown
4.98 out of 5 average rating, 126 reviews

Holiday Discount at Historic Georgetown

Lovingly restored 1908 Georgian home in historic district of "America's Best Coastal Small Town." Walk to waterfront restaurants, boutique shops & historic attractions. Guests rave about our exceptionally well-equipped kitchen! "Perfectly imperfect" authentic historic charm meets modern comfort & spotless cleanliness. Game room with air hockey, grand two-story portico, private fenced yard perfect for pets. Fresh local welcome treats await.

Popular amenities for Lake City house rentals

Quick stats about house rentals in Lake City

  • Nightly prices starting at

    Lake City vacation rentals start at G$6,266 GYD per night before taxes and fees

  • Verified guest reviews

    Over 930 verified reviews to help you choose

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Lake City rentals

  • 4.9 Average rating

    Lake City stays are highly rated by guests—averaging 4.9 out of 5!