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Vacation rentals in La Mesilla

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in La Mesilla

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
A cozy sleeping area features a spacious bed adorned with fluffy white pillows and a light duvet, surrounded by large windows allowing natural light to illuminate the space. Two soft, circular poufs rest on a rug, contributing to the inviting atmosphere.
Cottage in Santa Fe
4.97 out of 5 average rating, 373 reviews

Sky-filled “Studio Cielito” @ Rancho Los Sonadores

Welcome to Studio Cielito - a desert-inspired cottage designed with bath lovers in mind. Curated with vintage touches, luxury linens, and everything you need to relax and rejuvenate near the magical Sangre de Cristo Mountains. Just 8 mins from Meow Wolf and 14 mins from The Plaza, but surrounded by nature with a country feel. If your dates are not avail, click on our profile for our other rentals. **Due to COVID-19, we are asking that all guests be vaccinated to help keep our community safe.

Top guest favorite
An open living space features high ceilings with exposed wooden beams. A cozy seating area is arranged with a large couch, complemented by a coffee table and colorful rug. Natural light fills the room through multiple windows, enhancing the inviting atmosphere.
Apartment in Chimayo
4.89 out of 5 average rating, 177 reviews

Light Airy Spacious Retreat Between Santa Fe Taos

The Loft is a lovingly restored 300 year old adobe on the 2nd story of Rancho Manzana. Located on the historic Plaza del Cerro, in the world famous rural town of Chimayo. The main level features huge picture windows, soaring ceilings, a bedroom with a private claw foot soaking tub, a den with a double bed, & the sleeping loft with a double bed. There is a fully equipped kitchen, one bathroom with shower. Beautiful views and sunsets, overlooking the apple orchards and red cliffs in the distance.

Guest favorite
A series of images showcases the guest house and farm setting. The large bedroom features a king bed and natural light from a window. The farmhouse kitchen includes wooden cabinets and cooking utensils. The organic garden reveals rows of vegetables, while a chicken interacts with a simple nesting area.
Farm stay in Santa Fe
4.93 out of 5 average rating, 121 reviews

Nambé Farm Stay

Join us on our organic veggie farm, 20 minutes north of Santa Fe and 25 minutes from Los Alamos, in beautiful Nambé. Our guest house is a stand alone casita with a fenced-in yard for your dogs, on our 5 acre working-farm property. The space has a large bedroom with king bed and writing desk, a living room with a comfy leather couch, tv with streaming capacity, a large bathroom with a tub, shower, washer/dryer, and a farmhouse kitchen to cook in. There is WiFi through-out. Pop-up cot available.

Superhost
A glamping dome is nestled within a rugged, natural landscape, surrounded by canyons and desert terrain. The scene captures the dome's unique shape against a backdrop of rolling hills and distant mountains, set under a warm, golden sunset.
Dome in Santa Fe
4.83 out of 5 average rating, 503 reviews

Santa Fe Super Dome

*READ ALL property info BEFORE BOOKING* Stay in the coolest spot in the Santa Fe area. New deck! Glamping dome on 8 private acres of ancient canyons, just south of Santa Fe on Hwy 14. Enjoy 360 degree views of every mountain chain in the area - Sangre de Christos, Jemez, Sandias, Ortiz, Manzanos. You even get Mt. Taylor, silhoutted in exquisite sunsets. This is the ultimate high desert glamping experience. Indoor plumbing, heat, stone shower, king bed. Personal Chef services available.

Top guest favorite
A charming adobe casita is set against a serene backdrop, featuring warm lighting from windows. A shaded porch with wooden chairs overlooks the surrounding landscape. Natural desert plants frame the exterior, and a patio umbrella provides additional shade for outdoor relaxation.
Guesthouse in Abiquiu
4.97 out of 5 average rating, 116 reviews

Viento del Rio - Abiquiu Casita W/Private Hot Tub

Viento del Rio is a perfect place to absorb the serenity of the Abiquiu area. Located off the beaten path (but not too far) centrally located to many area wonders. There are numerous places to hike nearby. Views of mountains (including Pedernal) in all directions are stunning. Nearby attractions include Plaza Blanca, Georgia O'Keefe Welcome Center and Ghost Ranch. Easy drive to Taos and Santa Fe. A truly lovely place to rest, relax and take in all the nearby sites and activities.

Guest favorite
A two-story home is set against a dramatic sky colored in warm oranges and soft blues. Solar panels are positioned at the foreground, while juniper trees are visible nearby, contributing to the natural landscape of the Chama River Valley.
Home in Abiquiu
4.82 out of 5 average rating, 427 reviews

Hawk House

This cozy 2-story home sits on 10 acres in the Chama River Valley, with views of Cerro Pedernal and the mountains. Rustic, cozy, with all basic amenities. Ideal for the solo artist or couple. Hiking + hot springs nearby, including Ghost Ranch, Poshuouingue ruins & Ojo Caliente Springs! Most pets are welcome (for a pet fee). It's helpful to check in on it, however, due to our contained pups further back on the land. Open to longer stays at discounted price. Write about either to discuss!

Top guest favorite
A hot tub is situated on a wooden deck, surrounded by tall trees and a clear blue sky. The water's surface reflects the sunlight, creating a serene setting for relaxation amidst a forest backdrop.
Cabin in Jemez Springs
4.94 out of 5 average rating, 218 reviews

Cozy Forest Escape with Private Hot Tub

Escape to a Peaceful Forest Retreat Nestled on a 1.5-acre wooded lot, this relaxing cabin offers the perfect retreat for nature lovers and adventure seekers. Located adjacent to the Valles Caldera National Preserve, our property boasts: - Relaxing Hot Tub: Unwind among the pines - Wildlife watching opportunities - Short drive to Fenton Lake for top-notch fishing - Modern comforts for a peaceful stay - Proximity to outdoor activities for all seasons: hiking, biking, fishing, and skiing

Guest favorite
The interior of the camper features a modern design with a spacious island in the center. Soft lighting is provided by decorative hanging lamps. A cozy seating area with a leather couch and two chairs is visible, complemented by natural light from large windows.
Camper/RV in Española
4.94 out of 5 average rating, 209 reviews

Charming Camper near Santa Fe

Newly renovated modern & spacious camper is located on a private gated 3.5 acre property in historic and beautiful Española River Valley, surrounded by 200 year old cottonwood trees and a running acequia. Located only 27 miles from Santa Fe, 24 miles from Abiquiu, 43 miles from Taos, 21 miles from Los Alamos, 12 miles from Chimayo, and 90 miles from Albuquerque, this relaxing & well-equipped camper provides the perfect getaway and home-base for your stay in Northern New Mexico.

Top guest favorite
The entrance of a rustic casita is framed by a tree, featuring a shaded porch with a small table and two chairs. A potted plant adds a touch of greenery. The door is flanked by wall sconces, and a welcoming bell hangs above.
Guesthouse in Santa Fe
4.97 out of 5 average rating, 688 reviews

Bonita Vista

Nambé, New Mexico in Santa Fe County quiet rural setting. It is located 20 minutes from Historic Santa Fe, surrounded by Ancient Anasazi hiking trails and ruins. On the High Road to Taos. Enjoy the peace of the country. Safe and friendly. Romantic, comfortable ,within a private compound. All the amenities of home. Star filled nights, quaint, beautiful accommodations and a charming shared garden to relax and enjoy the beauty of the view of the Sangre de Cristo Mountains.

Top guest favorite
The interior space features natural wooden beams and a stone wall that enhances the rustic charm. A large opening provides views of the outdoor landscape, including distant mountains and trees. A stone hot tub is situated indoors, inviting relaxation.
Earthen home in Santa Fe
4.97 out of 5 average rating, 358 reviews

Infinite Views | Ridgetop Retreat | 2 Hot Tubs

There's nothing quite like this in Santa Fe — a genuine Earthship eco-home on a secluded ridgetop, with two hot tubs and views that stretch to the Jemez Mountains. 🛁 2 hot tubs — indoor jetted spa with waterfall & rooftop infinity tub 🌄 Sweeping views of Santa Fe, the Jemez Mountains & National Forest 🌿 Rare Earthship design with living indoor gardens 🧘 Dedicated spa & yoga retreat 🏡 Spacious 2BR entire earth-home, secluded ridgetop setting

Top guest favorite
The cabin exterior presents a wooden structure with large windows framed in white, allowing for abundant natural light. A green metal roof contrasts with the wood finish. A gravel pathway leads to the front door, surrounded by a simple outdoor landscape.
Tiny home in Española
4.95 out of 5 average rating, 225 reviews

The Cabin - Tiny Home near Santa Fe & Los Alamos

Plan your vacation at this cute little cabin! The kitchen is furnished with a refrigerator/freezer, oven/stove, microwave, toaster, coffee pot and more. There is A/C and heating as well as a smart TV and Wifi so you can have a comfortable, relaxing, and productive stay! On top of all that, we are centrally located between Los Alamos, Santa Fe, Pojoaque and Taos so you can easily visit some of our most amazing tourist spots!

Top guest favorite
The interior of the casita features a king-sized bed with stylish bedding and a large artwork of a horse mounted above it. Two brown lounge chairs are positioned in the foreground, accompanied by a small table. Earthy tones and wooden beams contribute to a cozy atmosphere.
Home in Ojo Caliente
4.95 out of 5 average rating, 101 reviews

Luxury Desert Casita • Chiminea Nights • Views

Stay in a serene casita surrounded by the inspiring landscapes that shaped Georgia O’Keeffe’s art. Located just south of Ojo Caliente and a short drive from Ghost Ranch, this retreat offers effortless access to the area’s best hiking, hot springs, and high-desert beauty. With Ojo Mineral Springs only 14 miles away and dining within walking distance, it’s the perfect base for couples seeking both exploration and relaxation.

Popular amenities for La Mesilla vacation rentals