
Vacation rentals in La Mesilla
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Top-rated vacation rentals in La Mesilla
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Five Level Artist Retreat on Tano Road - Sleeps 8+
This five-level 4 bdrm 2 ba artist retreat has been freshly renovated to merge post modern style, easy comfort and traditional charm. Enjoy spectacular sunrises, sunsets and star gazing on the 5th level of the house while enjoying the warmth of a large fireplace. Special design touches include river rock lined showers, unique tile accents and the warmth of wood textures and finishes throughout. Only 15 minutes to the historic Santa Fe Plaza, this home has a lovely courtyard and plenty of parking
4.94 out of 5 average rating, 344 reviews
Desert Hideaway - Private Casita Suite
Brand new shower!! Experience the ultimate desert escape at our guest suite, nestled amidst majestic mountains. This charming oasis offers a serene retreat with a queen bed, full kitchen, bath, and dining room. Embrace the tranquility of the desert landscape as you relax in the cozy suite & savor panoramic mountain views. Immerse yourself in nature's beauty embarking on thrilling adventures. Discover the perfect balance between comfort & breathtaking surroundings in this idyllic desert haven.
4.81 out of 5 average rating, 129 reviews
Nambé Farm Stay
Join us on our organic veggie farm, 20 minutes north of Santa Fe and 25 minutes from Los Alamos, in beautiful Nambé. Our guest house is a stand alone casita with a fenced-in yard for your dogs, on our 5 acre working-farm property. The space has a large bedroom with king bed and writing desk, a living room with a comfy leather couch, tv with streaming capacity, a large bathroom with a tub, shower, washer/dryer, and a farmhouse kitchen to cook in. There is WiFi through-out. Pop-up cot available.
4.92 out of 5 average rating, 127 reviews
The Family Casita Santa Fe/ Pojoaque
The Family Casita is the guest wing to a family home with a private separate entrance. This is a large elegant adobe with thick walls that keep it cool in the summer and provide old world charm. A very spacious 900 square foot studio space, it has two original fireplaces, one in the eat-in kitchen, and one in the main room. There is a beautiful hand painted king sized bed and a Euro Lounger (that converts to a double bed), separated by a privacy wall. Dogs welcome. Sorry can't accept cats.
4.86 out of 5 average rating, 577 reviews
The Barn - Tiny Home near Santa Fe & Los Alamos
About 30 minutes from Santa Fe, experience this awesome tiny home themed "The Barn"! The custom bathroom features a stock tank bathtub and sink that you can tell all of your friends and family about! The kitchen is furnished with a refrigerator/freezer, oven/stove, microwave, toaster, coffee pot and more. With a queen bed in the main space and a twin bed in the loft, The Barn can sleep up to 3 people. The home also has a smart TV and Wifi so you can enjoy your stay or catch up on work.
4.94 out of 5 average rating, 216 reviews
Incredible Northern New Mexico Experience Awaits
Enjoy amazing vistas while you relax after a day hike, biking or rafting in the Rio Grande del Norte National Monument, or long day skiing. You'll love the memorable experience gained from this elegant adobe home. Prepare that savory dinner w/ amigos in the gourmet kitchen or enjoy a book during a soothing bath. The home kid friendly and centrally located w/ privacy you’ll cherish. Casa El Guiqueno provides the northern NM experience your looking for at a price that won’t break the bank.
4.93 out of 5 average rating, 122 reviews
River Oasis | Hot Springs Nearby
Nestled at the base of a majestic mountain, Casa del Rio offers sweeping views of the mesa and river, with the Jemez River flowing right through the property. Modern amenities meet natural beauty—enjoy sunsets from the deck, s’mores by the riverside firepit, and drift off to the soothing sounds of the water. Just five minutes from hot springs and scenic hikes, and only an hour from Santa Fe or Albuquerque, it’s the perfect place to relax, explore, and make unforgettable memories.
4.99 out of 5 average rating, 139 reviews
Charming Camper near Santa Fe
Newly renovated modern & spacious camper is located on a private gated 3.5 acre property in historic and beautiful Española River Valley, surrounded by 200 year old cottonwood trees and a running acequia. Located only 27 miles from Santa Fe, 24 miles from Abiquiu, 43 miles from Taos, 21 miles from Los Alamos, 12 miles from Chimayo, and 90 miles from Albuquerque, this relaxing & well-equipped camper provides the perfect getaway and home-base for your stay in Northern New Mexico.
4.94 out of 5 average rating, 217 reviews
Casa Encantada, Charming Northern New Mexico Adobe
Welcome to Casa Encantada! This charming historic adobe casa is the perfect getaway for those seeking an enchanting break from the bustle of city living. Nestled in the country, 20 miles north of downtown Santa Fe in the historic village of Nambe, this home is ideally situated for excursions to the many beautiful sites Northern New Mexico has to offer. Make Casa Encantada your base camp as you explore Santa Fe and beyond, then come home to a unique and comforting retreat.
4.89 out of 5 average rating, 227 reviews
Bonita Vista
Nambé, New Mexico in Santa Fe County quiet rural setting. It is located 20 minutes from Historic Santa Fe, surrounded by Ancient Anasazi hiking trails and ruins. On the High Road to Taos. Enjoy the peace of the country. Safe and friendly. Romantic, comfortable ,within a private compound. All the amenities of home. Star filled nights, quaint, beautiful accommodations and a charming shared garden to relax and enjoy the beauty of the view of the Sangre de Cristo Mountains.
4.97 out of 5 average rating, 707 reviews
Casita Viernes
A newly built casita in a convenient central location, provides easy access to Santa Fe, Los Alamos, Espanola, Abiquiu and Taos. Close to many special attractions such as Santuario de Chimayo, Puye Cliff dwellings, Bandelier National Monument, Los Alamos, Espanola Valley Fiber Arts Center and much more. We are only a few minutes drive off of route 285 in a quiet neighborhood situated behind the Dreamcatcher movie theater.
5.0 out of 5 average rating, 12 reviews
Guest House in Espanola
This unique place has a style all its own. It is an adorable adobe casita with its own full bath, King bed, mini fridge, microwave and coffee maker. Located in the beautiful Espanola Valley, just 45 miles away from Taos, 25 miles away from Santa Fe and 17 miles away from Los Alamos.The Casita is located near local restaurants and shopping areas but is hidden in its own private beautiful neighborhood.
4.91 out of 5 average rating, 114 reviewsPopular amenities for La Mesilla vacation rentals
Other great vacation rentals in La Mesilla

Finca del Sol - New Mexican Farm Casa
4.93 out of 5 average rating, 42 reviews
Modern Dome Home with Hot Tub near Santa Fe
4.63 out of 5 average rating, 8 reviews
6-Acre Sanctuary w/ Fireplaces•Hot Tub•Cowboy Pool
4.99 out of 5 average rating, 94 reviews
Cozy private apartment with private, gated parking
5.0 out of 5 average rating, 11 reviews
Kokopelli Suite
4.71 out of 5 average rating, 87 reviews
Centrally Located Southwest Oasis-Sage Casita
4.96 out of 5 average rating, 93 reviews
High Desert Home w/ SW Flare
4.94 out of 5 average rating, 64 reviews
Casa Chuparosa (The Hummingbird House)
5.0 out of 5 average rating, 21 reviewsDestinations to explore
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