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Vacation rentals in Isthmus of Panama

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Top-rated vacation rentals in Isthmus of Panama

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
A scenic view of rolling hills under a colorful sky at sunset. Shades of orange, pink, and purple blend, creating a vibrant horizon. Lush trees are scattered across the landscape, adding a touch of greenery to the terrain.
Cottage in Olá
4.95 out of 5 average rating, 19 reviews

Casa de Campo en Olá, ríos, cascadas, Los Picachos

Finca La Terapia hace honor a su nombre, se encuentra entre las montañas del pintoresco pueblo de Olá de Penonomé, en la cual podrás desconectarte del ajetreado día a día de la ciudad. Cuenta con 42 Hectáreas privadas para explorar la naturaleza. El distrito de Olá, se caracteriza por tener lo mas hermosos paisajes Naturales entre los que podemos mencionar, Los Chorros de Olá, Chorros las Mesitas, Cerros los Picachos, Rio San Antonio, Balneario Brujas, entre otros a muy poco minutos de la Finca.

Top guest favorite
An inviting infinity pool overlooks a stunning coastal view. A spacious seating area, featuring colorful cushions, complements the serene atmosphere. Natural light fills the space, enhancing the connection to the outdoors, while the blue waters of the pool blend seamlessly with the distant ocean.
Villa in Cacique
4.98 out of 5 average rating, 47 reviews

CARA AL MAR Cacique (Parque de Portobello)

Une maison ! véritable îlot de verre au cœur de la jungle ! Au beau milieu du Parque National de Portobello (accès uniquement en 4x4 AWD) blotti au sommet de la colline, entre ciel/mer, à l'abri de tout regard, une maison transparente où le verre épouse la nature de tous côtés créant une connexion unique entre l'intérieur et l'extérieur, ideal pour se reposer, se déconnecter, confortable, spacieuse, fraîche (clim centrale), exclusive. Elle est le témoin d'un spectacle grandiose qui vous attend !

Top guest favorite
An aerial view of the property showcases a spacious layout surrounded by lush greenery. A large saltwater pool and a hot tub are visible alongside a well-maintained outdoor area with red umbrellas providing shade. The roof of the main structure features a brown tone, blending with the natural surroundings.
Home in Costa Esmeralda
4.98 out of 5 average rating, 190 reviews

Beach House-Amazing Pool & Jacuzzi & Pet Friendly

Majestic Sands! Come relax with the whole family at this piece of paradise.located in a private beach community in Costa Esmeralda, San Carlos. Few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool and hot tub with hammocks with views of amazing palm trees.Uninterruptible power with Smart Home Energy Management Systems.

Guest favorite
An aerial view captures the layout of Tubasenik, showcasing a triangular island adorned with numerous palm trees and traditional cabins. A sandy beach gently curves around the island's edge, while boats are visible along the shoreline, complementing the clear turquoise waters surrounding the paradise.
Hut in San Blas Islands
4.91 out of 5 average rating, 118 reviews

San Blas islands, Tubasenik cultural getaway

Immerse yourself in the stunning beauty of Guna Yala, a paradise of crystal-clear waters and white-sand beaches. Explore secluded islands, relax under swaying palms, or snorkel vibrant coral reefs teeming with marine life. This experience goes beyond typical tourism—it’s a journey into the heart of the Guna culture, an indigenous community that cherishes its ancient traditions and deep connection to nature. Discover exclusive gems of the archipelago and make your adventure truly unforgettable

Superhost
Home in Playa Venao
5 out of 5 average rating, 4 reviews

Jungle Tiny House w/ Oceanview – Playa Venao

Live Tiny. Connect Big. Welcome to Tiny Samambaia — a modern tiny house located in Playa Venao, just 5 minutes from the beach. Enjoy ocean views, a fully equipped kitchen, a romantic outdoor hot tub, and the sounds of birds and monkeys in the surrounding jungle. Sustainably built is the perfect escape for surfing, relaxing, or remote work w' reliable Starlink Wi-Fi. Note: Occasional power outages may occur due to the remote location. No generator is available. Thank you for understanding.

Guest favorite
A shaded patio area features comfortable seating arrangements with dark wicker chairs and a matching table. An oceanfront saltwater pool is visible with loungers arranged beside it. Lush palm trees sway gently in the background against a clear blue sky.
Villa in Cambutal
4.88 out of 5 average rating, 8 reviews

Casa Almendra

A 3-bedroom luxury villa located on the pristine beaches of Cambutal, Panama. This beachfront paradise offers everything you need for a truly unforgettable stay... A spacious and elegantly designed living area, an open-concept kitchen, fully equipped with top-of-the-line appliances and breathtaking ocean views, and an oceanfront saltwater pool surrounded by comfortable loungers. Entirely off-grid with a state-of-the-art solar power system, your stay is not only luxurious but eco-friendly.

Top guest favorite
Lush tropical gardens filled with vibrant flowers lead towards a traditional structure. The backdrop features rolling mountains, partially shrouded in greenery, under a clear blue sky. A variety of plants create a peaceful natural setting, inviting exploration and observation.
Farm stay in Boquete
4.92 out of 5 average rating, 289 reviews

Casitas in Butterfly and Honey Farm

Romantic setting, immersed in nature and yet close to town. Fibre Optic Internet. Nestled in extensive tropical gardens on a traditional Boquete Coffee Estate. Abundance of birds, feeders and native bee hives. We are home to Panamas largest butterfly exhibit and specialty honey company. We offer a hearty breakfast. We can accommodate 4 px but booking price including breakfast is for 2px. We charge an additional $15 per person over 12 yrs, an additional $10 for children under 12 yrs

Top guest favorite
A spacious outdoor deck features modern furniture arranged for relaxation, overlooking a lush mountainous landscape. Verdant hills and a colorful sky at dawn create a tranquil environment, inviting guests to enjoy the natural beauty and serenity of the surroundings.
Villa in El Copé
4.92 out of 5 average rating, 183 reviews

Mountain retreat

Our beautiful, modern, comfortable house is designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and also a base to explore the area which is in a beautiful part of Panama near a cloud forest national park with amazing hiking to waterfalls and local communities. The house is large, sleeping 12, within 17 acres of forest with rivers for swimming. We can arrange tours and hosted retreats for yoga, cooking and more.

Top guest favorite
An aerial view captures the lush greenery surrounding the treehouse, which extends over tranquil waters. The vibrant blue and green hues of the lagoon contrast with the shoreline, showcasing the natural beauty of the area. Mangroves frame the water's edge, emphasizing the secluded environment.
Treehouse in Provincia de Bocas del Toro
4.93 out of 5 average rating, 237 reviews

Cocovivo Mangrove Treehouse

This secluded loft-style treehouse sits on stilts above the water, 30 feet from our colorful coral reef. Transparent and airy but bug proof walls let you enjoy the fresh ocean breeze and views while keeping you safe and cozy. When a sloth comes to visit, no need to leave the house to see him! Blend in with the surroundings of mangrove, lagoon and jungle, and enjoy water and reef access from your own deck. Bright and airy, 100% eco-conscious.

Guest favorite
The outdoor patio offers a panoramic view of the Pacific Ocean, framed by lush greenery. Comfortable lounge chairs are positioned on the tiled surface, inviting relaxation while enjoying the breathtaking sunset. The sky is painted in warm hues, enhancing the serene atmosphere of this coastal retreat.
Home in Playa Mata Oscura
4.94 out of 5 average rating, 71 reviews

Casa De Ola, Jungle Beach Cabin

Welcome to Paradise: Your Pacific Jungle Oasis Nestled deep within the lush, untamed heart of Panama's wild Pacific coast, this remote jungle cabin isn't just a place to stay—it's an invitation to experience life at its most primal and extraordinary. It is a destination by itself. This is your passport to a world where nature reigns supreme, adventure lurks around every emerald-green corner, and artistry dances with the elements.

Superhost
A tranquil garden scene is depicted, featuring a winding pathway of smooth stones and pebbles. Surrounding areas are adorned with various flowering plants and a small pond, enhancing the peaceful ambiance. Lush greenery is visible in the background, contributing to the serene atmosphere.
Farm stay in Santa Fe
4.89 out of 5 average rating, 301 reviews

Santa Fe villa with a espectacular view

Spectacular contemporary style villa surrounded by local flowers and woods. The villas design enhances the relationship with the outside environment with panoramic windows which are found in the dining room and kitchen, this offers an awesome view of the mountains and green flora. The villa is located in a organic quiet farm, with abundant vegetation and great presence of birds.

Guest favorite
The villa is nestled within a lush tropical garden, featuring a private pool with clear, inviting water. Lounge chairs are positioned beside the pool, surrounded by greenery. Large windows illuminate the house, which offers views of the serene outdoor environment.
Villa in Pedasí District
4.86 out of 5 average rating, 179 reviews

Charming beach villa Pedasi, Panama

Villa in the Destiladeros Beach Pedasi (3min walk), private garden and private pool only for the guests of the villa. Very quiet place, secure. For people who are looking for a hidden place, far from the crowd but with all the commodities around (markets in Pedasi village 10min driving, several beaches , little restaurants...). Just to enjoy nature with all the comfort.

Popular amenities for Isthmus of Panama vacation rentals