Vacation rentals in Isthmus of Panama

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Top-rated vacation rentals in Isthmus of Panama

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Guest favorite

Cabin in Torio, Panama

4.97 out of 5 average rating, 99 reviews

Cozy open space, unique jungle views, river access

Casa Corotu is located in Torio Hills a 10 minute's walk to the beach with a a trail to access Torio river. Fiber Optic WiFi and two work spaces. The property surrounded by big trees that keep the house cool, which also provide shelter for birds and wildlife. The house is NOT childproof, minimal railing system. It's a great house to live the experience of #toriolife and all it has to offer. It is also an opportunity to experience the jungle in an open-style home with a mesmerizing treetop view.

Apr 15 – 22

G$24,338 GYD per night

Guest favorite

Apartment in Panamá

5.0 out of 5 average rating, 60 reviews

Cozy n Comfy con balcón in the heart of Casco

Remodelado, cómodo y céntrico alojamiento en el corazón de Casco Viejo, pintoresco lugar declarado Patrimonio de la Humanidad por la UNESCO. Cerca de restaurantes, Bares, Impresionantes Iglesias y Museos. Podrás explorar la zona a pie, el apartamento esta completamente remodelado, un balcón espectacular, cocina full equipada, camas cómodas, te sentirás como en casa, rodeado de las famosas paredes de calicanto. -Amplia sala de estar-Smart tv -Cocina full equipada -1.5 baños -Balcón con vistas

Jan 11 – 18

G$24,118 GYD per night

Guest favorite

Guesthouse in Torio

4.91 out of 5 average rating, 109 reviews

Torio guesthouse with panoramic view

Our private guesthouse is suspended over the Torio River, on the west coast of the Azuero Peninsula. It is a paradise for hikers, bird watchers, surfers and beach goers. Marked trails with posted maps begin at our place. Hike to a beautiful waterfall, mountain or beach. Photograph birds from the porch. Surf, body board and swim safely (no strong currents). Walk to good restaurants, and a small grocery. Experienced Surfers have Morrillo Beach and Playa Reina. Watch sun and moon rise.

Dec 12 – 19

G$16,114 GYD per night

Guest favorite

Villa in Río Hato, Panama

5.0 out of 5 average rating, 38 reviews

Luxury 4BR Villa + Guesthouse & Pool @Buenaventura

Welcome to one of the nicest villas in Buenaventura, Panama's most luxurious beach resort community. This meticulously kept, spacious, 4 bedroom vacation paradise with additional private guest house and pool will make for unforgettable getaways with family and loved ones. Private baths, multiple dining areas, Sonos indoor/outdoor sound system, gorgeous outdoor areas and high end finishes, furnishings, and appliances throughout make every moment spent in Las Portales one to treasure.

Jun 30 – Jul 7

G$102,055 GYD per night

Superhost

Earthen home in El Cope, Penonome

4.91 out of 5 average rating, 145 reviews

Beautiful Eco House in Panama

We are very pleased to offer our beautiful, modern, comfortable house designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and escape daily stress. It is in a beautiful part of Panama near a cloud forest national park. The house sits in 17 acres of forest and has 2 rivers for swimming. The house is very open allowing full enjoyment of nature. There are amazing hiking opportunities in the mountains with waterfalls and visits to local communities.

Jan 25 – Feb 1

G$53,504 GYD per night

Guest favorite

Townhouse in Panamá

4.97 out of 5 average rating, 161 reviews

Casa Casco Amigos - The Only House in Casco.

Located by the French Embassy in Casco Viejo in the absolute safest and most prestigious area of Panama City, Casa Casco Amigos is a 3 level, 3 bedroom 351 square meter house with a roof terrace and a garden terrace which can sleep 9. Despite the liveliness of the area, there is no noise whatsoever in the bedrooms. Perfect for 1 or 2 families, or a group of 6 to 9 friends who want to be in the heart of the old city, with a sea view and many areas to lounge and avoid the midday heat.

Mar 30 – Apr 6

G$75,130 GYD per night

Guest favorite

Earthen home in Punta Cocles, Costa Rica

4.98 out of 5 average rating, 116 reviews

Étnico Villas - Casa Cabécar / 3min from the beach

Located in a safe neighborhood, in one of the best beaches of the caribbean of Costa Rica. Étnico Villas offers exclusive cabins completely furnished, thought for couples or independant persons. Decorated with exotic ethnic touches, built with mostly natural materials like wood and clay localy sourced. Sourrended by beautiful and exuberant tropical gardens, with lush vegetation and wild animals. Only 3 minutes walking from the beach, close to supermarkets, restaurants and services.

Sep 3 – 10

G$24,225 GYD per night

Guest favorite

Loft in Panamá, Panama

4.92 out of 5 average rating, 177 reviews

Amazing Loft with the Best view of Casco viejo!

Hermoso loft ubicado en el centro de Casco Antiguo, la zona más turística de Panamá. Ven, disfruta y relájate en este impresionante loft, con una vista increíble de la Catedral de Panamá. Puedes visitar museos, bares, restaurantes e iglesias ubicados a tan solo unos cuantos metros de distancia. Beatiful Loft located in the center of Casco Antiguo, Panama´s most turistic location. Come, enjoy and relax at this amazing loft, with amazing view to Panama´s Cathedral.

Apr 10 – 17

G$23,617 GYD per night

Guest favorite

Hut in Cristóbal Island, Panama

4.94 out of 5 average rating, 120 reviews

Cocovivo Bioluminescent Coconut

Strategically placed to catch the sunset, this airy waterfront cabin is designed for ultimate relaxation. Perfect for sun bathing, sunset gazing and when night falls, strong bioluminescent waters makes this cabin seem like it's out of a fairy tale. A coral reef aligns the whole property for world-class snorkeling, kayak or SUP expeditions! Jetsons-meet-Flintstones" is the vibe here. Please read the “Other things to note” section so you know what to expect!

Aug 29 – Sep 5

G$16,671 GYD per night

Guest favorite

Home in Playa Mata Oscura

4.92 out of 5 average rating, 24 reviews

Casa De Ola, Jungle Beach Cabin

Welcome to Paradise: Your Pacific Jungle Oasis Nestled deep within the lush, untamed heart of Panama's wild Pacific coast, this remote jungle cabin isn't just a place to stay—it's an invitation to experience life at its most primal and extraordinary. It is a destination by itself. This is your passport to a world where nature reigns supreme, adventure lurks around every emerald-green corner, and artistry dances with the elements.

Apr 8 – 15

G$38,277 GYD per night

Superhost

Treehouse in Isla Colon

4.95 out of 5 average rating, 130 reviews

Secret Jungle Treehouse by the Sea

A 2 bedroom treehouse built around a huge tree overlooking the lush jungle in a hidden setting. Artistically designed & comfortable; welcoming romantic souls, nature lovers & the adventurous. Enjoy nature in the harmony of an eco environment; ocean breezes, sound of waves, birds & monkeys. Spectacular sandy beaches only steps away. Surf, swim, bike, explore & live the adventure!. YouTube « Jungle Treehouse by the sea »

Sep 27 – Oct 4

G$55,727 GYD per night

Guest favorite

Apartment in Panamá

5.0 out of 5 average rating, 39 reviews

Full apartment in Panama

This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a central place where you will find ample gastronomy, fun places, close to bus stations, and the most important shopping center in the city, Multiplaza. This central and quiet apartment is an opportunity that you will not want to let in. Offer the perfect combination of comfort, beauty, and convenient location.

Dec 3 – 10

G$16,186 GYD per night