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Vacation rentals in Isthmus of Panama

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Top-rated vacation rentals in Isthmus of Panama

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Top guest favorite
The living area features large glass doors that invite natural light and views of the garden. Indoor plants enhance the space, and a cozy seating arrangement includes a sofa and eclectic chairs. A workspace with a desk and lamp is positioned to the side.
Guesthouse in El Valle de Antón
4.99 out of 5 average rating, 114 reviews

Spacious Casita with Bamboo View

Walk 20 minutes to the artisan mercado and restaurants on Ruta 71. Cerro Cara Iguana trailhead is walking distance from the casita. High insulated ceilings and 2 ceiling fans for comfort. Private hammock patio for an afternoon nap. Washer/dryer in the casita. Hot water throughout. Kitchen has a 2 burner cooktop, countertop oven, microwave, instant pot, electric skillet, blender and coffee maker. 2 Internet providers and a small workspace available. * No television set * Non smoking property

Guest favorite
A charming beach house is surrounded by lush greenery and palm trees, elevated on sturdy pillars. The thatched roof complements the tropical setting, while large windows provide ample natural light. A spacious wooden deck with railing enhances the inviting outdoor space.
Home in Cambutal
4.92 out of 5 average rating, 25 reviews

Seaside Sanctuary • Steps to Surf • Fast Internet

Wake up to the rhythmic sounds of waves steps from your bed in this intimate beachfront paradise. Our charming one-bedroom home sits directly on Cambutal's pristine shoreline, offering ocean views and instant beach access. Relax on your private terrace with morning coffee as the sun rises, cook meals in the fully-equipped kitchen, and fall asleep to the soothing sounds of the surf. With Starlink internet, you can stay connected while experiencing the perfect blend of seclusion and convenience.

Top guest favorite
A serene evening scene features the bohío cottage with its thatched roof, surrounded by lush greenery and potted plants. The moon is visible in the sky above, casting a gentle glow on the outdoor area, near the tranquil pool reflecting the soft outdoor lighting.
Place to stay in Rio Hato
5 out of 5 average rating, 25 reviews

Paradise from ocean to jungle. Bohío cottage

Welcome to our beach house 850meters to beautiful pacific beach & 3 beach restaurants . Our house is gated and in a safe area .Many areas to visit nearby from surf areas to crater town in the mountains ! Hikes , Canyons , waterfalls ! Coronado is a 35 min drive with all conveniences .New mall is 10 min drive to grocery store , large drugstore. Fish market is 5 min . Seasonal riohato airport 5 min. . Our 1/4 acre property & house is on a country lane with some lovely estates surrounding it.

Top guest favorite
An aerial view showcases a serene saltwater pool framed by lush greenery. Red umbrellas provide shade for outdoor seating areas. The open kitchen and dining space are visible, along with comfortable hammocks situated nearby, offering a relaxed atmosphere for guests.
Home in Costa Esmeralda
4.98 out of 5 average rating, 203 reviews

Beach House-Amazing Pool & Jacuzzi - Pet Friendly

Majestic Sands! Come relax with the whole family at this piece of paradise.located in a private beach community in Costa Esmeralda, San Carlos. Few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool and hot tub with hammocks with views of amazing palm trees.Uninterruptible power with Smart Home Energy Management Systems.

Top guest favorite
An open living space features a wooden dining table surrounded by six wicker chairs. Two hanging hammocks are displayed on the covered terrace, offering views of the lush hills. Large glass doors reflect the greenery, blending indoor and outdoor spaces harmoniously.
Cabin in Torio
4.97 out of 5 average rating, 172 reviews

Cozy open space, unique jungle views, river access

An open-style jungle home with mesmerizing treetop and mountain views. Located 10 minute walk to the beach, with a trail that leads to the River. The house is not childproof! It has three individual bedrooms, each with its own key. The price is based on the number of guests. The entire house is always yours. The house offers fiber optic WiFi and two dedicated workspaces. The property is surrounded by large trees, naturally keep the house cool and provide shelter for birds and wildlife.

Top guest favorite
An inviting infinity pool overlooks a stunning coastal view. A spacious seating area, featuring colorful cushions, complements the serene atmosphere. Natural light fills the space, enhancing the connection to the outdoors, while the blue waters of the pool blend seamlessly with the distant ocean.
Villa in Cacique
4.98 out of 5 average rating, 52 reviews

FACING THE SEA Cacique (Portobello Park)

A house! A real glass island in the heart of the jungle! In the middle of the Portobello National Park (access only by 4x4 AWD) nestled at the top of the hill, between sky/sea, away from all eyes, a transparent house where glass embraces nature on all sides creating a unique connection between the inside and the outside, ideal for resting, disconnecting, comfortable, spacious, cool (central air conditioning), exclusive. It is the witness of a grandiose spectacle that awaits you!

Guest favorite
An open-concept living area features floor-to-ceiling windows that provide expansive ocean views. A light-colored sofa and an orange accent chair complement a minimalist coffee table, while a dining area with modern chairs is visible in the background, enhancing the spacious feel of the room.
Apartment in San Carlos
4.91 out of 5 average rating, 47 reviews

Experience Rio Mar Penthouse

Experience unparalleled luxury in Rio Mar, San Carlos’ premier beachfront community near Coronado. This top-floor penthouse offers breathtaking ocean and mountain views from every room. Enjoy world-class amenities, including a surfing beach, sparkling pools, a spa, gym, and on-site restaurant. Relax in the elegant, open-concept living space with high-end finishes. Perfectly located near shops and attractions, this is the ultimate getaway for relaxation and adventure.

Top guest favorite
Apartment in Panamá
4.97 out of 5 average rating, 31 reviews

Gorgeous Flat in the best location in Casco Viejo

This cute and stylish studio is perfectly located in the heart of Casco Viejo, Panama City’s most charming historic district. Recently renovated, it combines modern comfort with classic charm inside a beautiful colonial building—just steps from top restaurants, bars, monuments, and attractions. The space includes a comfortable sofa bed, making it ideal for a couple or a small family looking to enjoy the vibrant atmosphere of Casco right outside their door.

Top guest favorite
Loft in Panama City
5 out of 5 average rating, 17 reviews

Casco Viejo Dream Loft – Cozy & Central 1BR Apt

Enjoy a unique experience, in this elegant and centrally-located loft. Fully remodeled 1 bedroom apartment, in a central location in Casco Viejo (the old city). You will be just steps away from many restaurants, cafes, museums, and the existing night life casco has to offer. Located in “Casa Neuman",” this restored- colonial building and features unique crafted wall décor, as well as some of the original "calicanto" walls.

Top guest favorite
An expansive outdoor area showcases a large infinity pool bordered by deck chairs and shaded loungers. Palm trees and manicured grass areas provide greenery, with panoramic views of the Pacific Ocean in the background. The tranquil atmosphere invites relaxation under the clear blue sky.
Condo in San Carlos
4.96 out of 5 average rating, 142 reviews

New ocean apartment in beautiful beach complex

Modern new condo with breath taking views of the Pacific Ocean. We are in a beautiful new beach complex, Punta Caelo, with direct beach access, a beach club, and several large swimming pools. The Social Area is resort quality with deck chairs, infinity pools, billiards, children’s pools and pool beds. The apartment is open and spacious with a fully stocked kitchen and large terrace directly looking out over the ocean.

Guest favorite
Apartment in Panamá
4.99 out of 5 average rating, 138 reviews

Full apartment in Panama

This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.

Guest favorite
Apartment in San Carlos
5 out of 5 average rating, 6 reviews

Beautiful 1BR Condo Right on the Ocean

Sit back and relax in this newly furnished one-bedroom apartment, delivered in 2025, with a fully equipped kitchen and small family-friendly spaces, including a full bed perfect for children or an extra guest. It can accommodate up to 4 people. Located beachfront with direct access to the beach and several pools, this unit is perfect for a short or long stay and is situated on the 2nd floor.

Popular amenities for Isthmus of Panama vacation rentals