
Vacation rentals in Isthmus of Panama
Find and book unique accommodations on Airbnb
Top-rated vacation rentals in Isthmus of Panama
Guests agree: these stays are highly rated for location, cleanliness, and more.

Spacious Casita with Bamboo View
Walk 20 minutes to the artisan mercado and restaurants on Ruta 71. Cerro Cara Iguana trailhead is walking distance from the casita. High insulated ceilings and 2 ceiling fans for comfort. Private hammock patio for an afternoon nap. Washer/dryer in the casita. Hot water throughout. Kitchen has a 2 burner cooktop, countertop oven, microwave, instant pot, electric skillet, blender and coffee maker. 2 Internet providers and a small workspace available. * No television set * Non smoking property

Beach House-Amazing Pool & Jacuzzi - Pet Friendly
Majestic Sands! Come relax with the whole family at this piece of paradise.located in a private beach community in Costa Esmeralda, San Carlos. Few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool and hot tub with hammocks with views of amazing palm trees.Uninterruptible power with Smart Home Energy Management Systems.

Cozy open space, unique jungle views, river access
An open-style jungle home with mesmerizing treetop and mountain views. Located 10 minute walk to the beach, with a trail that leads to the River. The house is not childproof! It has three individual bedrooms, each with its own key. The price is based on the number of guests. The entire house is always yours. The house offers fiber optic WiFi and two dedicated workspaces. The property is surrounded by large trees, naturally keep the house cool and provide shelter for birds and wildlife.

FACING THE SEA Cacique (Portobello Park)
A house! A real glass island in the heart of the jungle! In the middle of the Portobello National Park (access only by 4x4 AWD) nestled at the top of the hill, between sky/sea, away from all eyes, a transparent house where glass embraces nature on all sides creating a unique connection between the inside and the outside, ideal for resting, disconnecting, comfortable, spacious, cool (central air conditioning), exclusive. It is the witness of a grandiose spectacle that awaits you!

Stylish & New, a short stroll away from the Beach
Welcome to your beachside escape at the Bambu Beach Haus! This brand-new modern duplex features a spacious king bed, stylish design, and all the comforts of home. Enjoy cooking in the fully equipped kitchen, relax on your private terrace or balcony, and take in the laid-back coastal vibe. Located in a resort-style community just a short stroll from the beach, you’ll also have access to a sparkling saltwater pool, jacuzzi, and cozy bohios—perfect for a relaxing getaway.

Experience Rio Mar Penthouse
Experience unparalleled luxury in Rio Mar, San Carlos’ premier beachfront community near Coronado. This top-floor penthouse offers breathtaking ocean and mountain views from every room. Enjoy world-class amenities, including a surfing beach, sparkling pools, a spa, gym, and on-site restaurant. Relax in the elegant, open-concept living space with high-end finishes. Perfectly located near shops and attractions, this is the ultimate getaway for relaxation and adventure.

Ocean View Marina Stay in Buenaventura | By Alura
Enjoy an exceptional stay in this elegant and modern apartment, located on the top floor in the marina in Buenaventura, Panama’s most exclusive beach resort. It offers panoramic views of the Pacific Ocean and the Marina. The apartment is fully equipped with high-quality furniture and finishes, thoughtfully designed to provide both comfort and style. You’ll also have access to beach clubs, restaurants, and more, for a truly unforgettable resort experience.

Amazing loft with an iconic view of Casco Viejo
Enjoy a unique experience, in this elegant and centrally-located loft. Fully remodeled 1 bedroom apartment, in a central location in Casco Viejo (the old city). You will be just steps away from many restaurants, cafes, museums, and the existing night life casco has to offer. Located in “Jeronimo,” this restored- colonial building was built in the year 1850, and features unique crafted wall décor, as well as some of the original "calicanto" walls.

Casco Viejo Dream Loft – Cozy & Central 1BR Apt
Enjoy a unique experience, in this elegant and centrally-located loft. Fully remodeled 1 bedroom apartment, in a central location in Casco Viejo (the old city). You will be just steps away from many restaurants, cafes, museums, and the existing night life casco has to offer. Located in “Casa Neuman",” this restored- colonial building and features unique crafted wall décor, as well as some of the original "calicanto" walls.

New ocean apartment in beautiful beach complex
Modern new condo with breath taking views of the Pacific Ocean. We are in a beautiful new beach complex, Punta Caelo, with direct beach access, a beach club, and several large swimming pools. The Social Area is resort quality with deck chairs, infinity pools, billiards, children’s pools and pool beds. The apartment is open and spacious with a fully stocked kitchen and large terrace directly looking out over the ocean.

Amazing! A paradise 5 minutes away from the sea
Discover our charming apartment just 5 minutes from the beach, where every morning will give you a spectacular view. Wake up to the beauty of a beautiful sunrise from the comfort of your room. Enjoy tranquility and serenity as you gaze at the warm colors painting the sky over the sea. Our apartment has been designed with you and your family in mind. Enjoy a cozy and functional space to create unforgettable memories.

Full apartment in Panama
This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.
Popular amenities for Isthmus of Panama vacation rentals
Other great vacation rentals in Isthmus of Panama

The Retreat in El Valle - Garden House

Luxury Centric 2BR Apartment in Casco Viejo

Luxury apartment in the heart of Panama

Lovely & Cozy central apartment in Casco Viejo

Wild Punta Uva Beach private house

The Don Quixote Loft by AcoModo (Ocean View)

Stunning loft in Buenaventura Golf&Beach Resort

Exclusive & luxury 1BR with balcony in Yoo Panama




