
Vacation rentals in Isthmus of Panama
Find and book unique accommodations on Airbnb
Top-rated vacation rentals in Isthmus of Panama
Guests agree: these stays are highly rated for location, cleanliness, and more.

Puntita Manzanillo, fantastic sea and jungle
Come visit one of the most unique and exclusive properties in the Panamanian Caribbean. A magical completely private 5 acre property nestled between the Caribbean Sea (500meters of ocean front) and the jungle. Surrounded by a garden of corals and visited by monkeys and macaws. Our energy is solar and we have our own aqueduct. Temperature oscillates between 72 and 84 degrees F. It is rented in its entirety. It has 3 one bedroom cabins with full baths. Satellite Internet (Starlink) is provided.

Beach House-Amazing Pool & Jacuzzi - Pet Friendly
Majestic Sands! Come relax with the whole family at this piece of paradise.located in a private beach community in Costa Esmeralda, San Carlos. Few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool and hot tub with hammocks with views of amazing palm trees.Uninterruptible power with Smart Home Energy Management Systems.

Casa Coco - Beautiful Mountain Villa With AC
Elegant and modern, our home strikes the perfect balance between luxury and warmth. With ample space to accommodate large groups and families, as well as cozy and inviting for smaller groups. The yard features a covered social area, ideal for relaxing or entertaining. A lush garden adorned with vibrant greenery includes a charming mango tree and mountain peak views. A 5 minute walk to restaurants and the open air market. If you have a group larger than 12- please reach out to us directly.

Modern House with Great Views and Heated Pool
Modern mountain house in Altos del Maria, Panama, a gated comunity at just 1 hour and 30 minutes away from Panama city. The comunity has rivers, bird watching trails, and is only 25 minutes away from the pacific beaches. Its a perfect place to take a break and relax. The house has a modern decor, infinity pool, 2 bedrooms with A/C, wifi, dishwashing machine, washer and dryer and great view of the mountains. Free late checkout is given for rentals checking out on Sundays.

El Palmar, beach 50 meters away
Listen to the waves from the privacy of our terrace and create unforgettable memories in this unique and family-friendly accommodation just steps from the beach with a private pool. El Palmar is a quiet community with several restaurants available a few steps from the house. The property is fully fenced for the tranquility and safety of children and their pets. In addition, you have wifi, cable TV in both rooms and air conditioning in the dining room and in all the bedrooms

Mountain retreat
Our beautiful, modern, comfortable house is designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and also a base to explore the area which is in a beautiful part of Panama near a cloud forest national park with amazing hiking to waterfalls and local communities. The house is large, sleeping 12, within 17 acres of forest with rivers for swimming. We can arrange tours and hosted retreats for yoga, cooking and more.

Paradise house in nature in Playa Coronado with pool
Enjoy relaxing days with the whole family or your friends in this peaceful place with lots of nature! The beach is a 5-minute walk away. Many different shops are a 8-minute drive away. Two small shops are also a 5-minute walk away. Everything is taken care of in the house: air conditioning in every room, large 75" TV, washing machine, dryer, hair dryer, towels... everything you need. The pool provides refreshment – a place to feel good!

Three Bedroom Luxury Mountain Home * Heated Pool *
Marte is a spacious, luxurious mountain home designed to accommodate up to 8 guests. It is an excellent choice for those seeking a quiet and relaxing stay while enjoying the comforts of a brand-new home. This two-story residence features three bedrooms, a large terrace overlooking the impressive Picacho Peak, and a private heated pool. With its serene setting and modern amenities, Marte is an outstanding choice in Altos del María.

Beachfront Loft in Farallón
Wake up to the ocean in this beautiful beachfront loft in Farallón, located in the exclusive Miramar Loft next to the Decameron Hotel. Relax on the balcony with sea views, enjoy the pool, and walk to the beach with private cabanas on the sand. The apartment offers 2 bedrooms, a full kitchen, A/C throughout, and fast Wi-Fi. Just 2 hours from Panama City. Book now and live the beach experience you deserve!

Casa Campestre Los Macos, El Valle de Anton
🏡 Welcome to Casa Campestre Los Macos, a cozy retreat located in the green heart of El Valle de Antón, inside an extinct volcanic crater, the largest inhabited in the world. It is an experience of total rest, in a safe and quiet area, ideal for lovers of nature, silence and fresh air. You'll wake up to birdsong, enjoy a cup of coffee in the garden, and spend family evenings in a fully equipped house.

Casa Namuiki by the Mountains
Casa Namuiki is a mountain house with two bedrooms, a private pool, a barbecue area, and a terrace with a pool table and outdoor TV. Large living-dining room, equipped kitchen and wifi. Located in Namuiki by the Mountains, it offers spectacular views and access to trails and streams. Ideal for families or couples.

Luxury villa with ocean view near Playa Venao
Villa Bambú is a private tropical retreat where modern design meets nature. Wake up to open ocean views, unwind by your private pool, and enjoy the peace of an exclusive setting just minutes from Playa Venao. Perfect for disconnecting, recharging, or working remotely in a calm and inspiring environment.
Popular amenities for Isthmus of Panama vacation rentals
Other great vacation rentals in Isthmus of Panama

La Florecita - Country house in Valle de Antón

CasAna

A peaceful retreat in the countryside

Playa Malibu Beach House.

Blue Sky Suites; cooler climate in Altos del María

beach house: Villa Pacifica

Buenaventura home directly on beach, private pool

Jungle Sky Loft | Mountain & Ocean Views





