Vacation rentals in Isthmus of Panama

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Isthmus of Panama

Guests agree: these stays are highly rated for location, cleanliness, and more.

0 of 0 items showing

1 of 3 pages

Top guest favorite

A private plunge pool is surrounded by vibrant tropical plants and lush garden foliage. Two sun loungers are positioned near the pool, creating a tranquil space for relaxation. Large glass doors offer a view into the indoor area, enhancing the connection with nature.

Tiny home in El Higo

5 out of 5 average rating, 27 reviews

Private Pool Oasis in a Tropical Boutique Villa

Eden Ubedi: Your own private sanctuary Enjoy 150m² of exclusive space featuring a private plunge pool, lush garden, jacuzzi, and a cinema screen—all conveniently located just 90 mins from Panama City and minutes from the main highway. Discover a destination beyond the usual tourist spots—immerse yourself in Panama by staying close to local communities Our boutique villa for 2-3 people ensures privacy with no shops or restaurants nearby, beaches and dining options are a short 5–10 minute drive

Top guest favorite

The living area features large glass doors that invite natural light and views of the garden. Indoor plants enhance the space, and a cozy seating arrangement includes a sofa and eclectic chairs. A workspace with a desk and lamp is positioned to the side.

Guesthouse in El Valle de Antón

4.99 out of 5 average rating, 99 reviews

Spacious Casita with Bamboo View

Walk 20 minutes to the artisan mercado and restaurants on Ruta 71. Cerro Cara Iguana trailhead is walking distance from the casita. High insulated ceilings and 2 ceiling fans for comfort. Private hammock patio for an afternoon nap. Washer/dryer in the casita. Hot water throughout. Kitchen has a 2 burner cooktop, countertop oven, microwave, instant pot, electric skillet, blender and coffee maker. 2 Internet providers and a small workspace available. * No television set * Non smoking property

Top guest favorite

A modern living area features a light-colored sofa adorned with colorful cushions. A round coffee table sits on a textured rug, while a dining table for six is visible in the background. Large windows present striking views of the city skyline.

Apartment in Panama City

5 out of 5 average rating, 32 reviews

Luxury apt in Panama City 2 Rooms 3 Baths

El edificio Wanders by yoo esta ubicado en el corazón de la ciudad, es un proyecto fuera de serie donde cada rincón tiene una historia que contar. Recepción 24/7, muchas areas de esparcimiento, estación de hidratación. En las afueras del lobby tenemos la Cafetería cafe con teclas y un restaurante de Carnes Popino. En el area social servicio de barra en la piscinas, parque de niños, sala de juegos con pantallas en e l techo baños, salon de eventos, cocina para eventos, gym full equipado y más

Top guest favorite

Lush greenery surrounds the charming casitas, with vibrant tropical plants in various colors dotting the landscaped garden. Mountains rise in the background under a partly cloudy sky, creating a serene backdrop for this tranquil retreat.

Guesthouse in El Valle de Antón

5 out of 5 average rating, 39 reviews

The Retreat in El Valle - Mountain House

Welcome to your serene retreat in El Valle, Panama! Nestled amid lush nature, our two-bedroom casitas offer a peaceful escape with breathtaking views, exotic wildlife, and flora. Each casita features a queen bed, choice of king or twin beds in the second room, a small fridge, coffee station, Wi-Fi, and large terrace. Enjoy the shared pool, meditation and healing sessions by appointment, and explore world-class hiking nearby. Just a short walk to restaurants and El Valle’s famous artisan market!

Top guest favorite

An aerial view of the property showcases a spacious layout surrounded by lush greenery. A large saltwater pool and a hot tub are visible alongside a well-maintained outdoor area with red umbrellas providing shade. The roof of the main structure features a brown tone, blending with the natural surroundings.

Home in Costa Esmeralda

4.98 out of 5 average rating, 175 reviews

Beach House-Amazing Pool, Surf & Pet Friendly

Majestic Sands! Come relax with the whole family at this piece of paradise.located in a private beach community in Costa Esmeralda, San Carlos. Few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool and hot tub with hammocks with views of amazing palm trees.Uninterruptible power with solar and battery backup systems.

Top guest favorite

A spacious living area features a combination of modern and vintage furnishings. A large turquoise sofa and a floral chaise lounge are complemented by a round coffee table and a green wooden chair. Exposed stone walls and large windows with blue accents create a warm ambiance.

Apartment in Panamá

4.98 out of 5 average rating, 142 reviews

Escape to the Heart of Casco with a Private Balcony

Location is everything – just steps away from the city’s best restaurants, bars, stunning churches, and fascinating museums. Explore the historic district on foot while enjoying the comfort of a stylish apartment featuring: • A spectacular balcony with beautiful views • A fully equipped kitchen • 1.5 bathrooms • Cozy beds that make you feel right at home • Surrounded by iconic calicanto stone walls that reflect the charm of Panama’s colonial past.

Guest favorite

An aerial view captures the lush greenery surrounding the treehouse, which extends over tranquil waters. The vibrant blue and green hues of the lagoon contrast with the shoreline, showcasing the natural beauty of the area. Mangroves frame the water's edge, emphasizing the secluded environment.

Treehouse in Provincia de Bocas del Toro

4.93 out of 5 average rating, 233 reviews

Cocovivo Mangrove Treehouse

This secluded loft-style treehouse sits on stilts above the water, 30 feet from our colorful coral reef. Transparent and airy but bug proof walls let you enjoy the fresh ocean breeze and views while keeping you safe and cozy. When a sloth comes to visit, no need to leave the house to see him! Blend in with the surroundings of mangrove, lagoon and jungle, and enjoy water and reef access from your own deck. Bright and airy, 100% eco-conscious.

Guest favorite

An inviting infinity pool is positioned on a spacious patio, overlooking a sweeping mountain view. Two lounge chairs are arranged on the deck, facing the water, while lush greenery and colorful blooms enhance the serene environment surrounding the pool area.

Cottage in Altos del Maria

4.94 out of 5 average rating, 161 reviews

Mountain Cottage with Heated Pool and Amazing View

Mountain Cottage, with spectacular views of the Altos del María Mountains, perfect for relaxing or spending time with the family. It features a heated infinity pool, spacious outdoor spaces, Smart TV and A/C in all rooms and living room, Wi-Fi throughout the property, and is fully equipped. Includes Prime Video service. It also has a fire pit and a gas BBQ. Complimentary late checkout is available for rentals departing on Sundays.

Top guest favorite

An infinity pool blends seamlessly into the ocean view, with a person standing at the edge. A lounge chair is positioned nearby, providing a relaxing spot to enjoy the scenery under a clear blue sky.

Condo in San Carlos

4.96 out of 5 average rating, 126 reviews

New ocean apartment in beautiful beach complex

Modern new condo with breath taking views of the Pacific Ocean. We are in a beautiful new beach complex, Punta Caelo, with direct beach access, a beach club, and several large swimming pools. The Social Area is resort quality with deck chairs, infinity pools, billiards, children’s pools and pool beds. The apartment is open and spacious with a fully stocked kitchen and large terrace directly looking out over the ocean.

Top guest favorite

A covered patio area displays a mix of seating options, including two wicker chairs and a small glass-top table surrounded by greenery. A hammock hangs gracefully in the foreground, adding a touch of comfort to this relaxed outdoor setting.

Cottage in El Valle de Antón

4.99 out of 5 average rating, 137 reviews

Casa Campestre Los Macos, El Valle de Anton

🏡 Welcome to Casa Campestre Los Macos, a cozy retreat located in the green heart of El Valle de Antón, within an extinct volcanic crater, the largest inhabited in the world. It is an experience of total rest, in a safe and quiet area, ideal for lovers of nature, silence and fresh air. Wake up to the sound of birds singing, enjoy a cup of coffee in the garden, and spend family evenings in a fully equipped house.

Top guest favorite

A cozy living area features a light-colored sofa facing a wall-mounted television. A round table is set in front, and woven placemats add texture. Large windows showcase city views and provide natural light, while a bedroom is visible in the background, showcasing a spacious bed.

Apartment in Panamá

4.98 out of 5 average rating, 107 reviews

Full apartment in Panama

This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.

Top guest favorite

A modern beachfront building rises against a bright blue sky, with large windows reflecting the surroundings. Thatched-roof cabanas are visible on the sandy beach, bordered by lush greenery. The structure stands in a tranquil setting, inviting relaxation and enjoying ocean views.

Loft in Rio Hato

5 out of 5 average rating, 29 reviews

Beachfront Loft in Farallón

Wake up to the ocean in this beautiful beachfront loft in Farallón, located in the exclusive Miramar Loft next to the Decameron Hotel. Relax on the balcony with sea views, enjoy the pool, and walk to the beach with private cabanas on the sand. The apartment offers 2 bedrooms, a full kitchen, A/C throughout, and fast Wi-Fi. Just 2 hours from Panama City. Book now and live the beach experience you deserve!