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Vacation rentals in Isthmus of Panama

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Top-rated vacation rentals in Isthmus of Panama

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Top guest favorite
The living area features large glass doors that invite natural light and views of the garden. Indoor plants enhance the space, and a cozy seating arrangement includes a sofa and eclectic chairs. A workspace with a desk and lamp is positioned to the side.
Guesthouse in El Valle de Antón
4.99 out of 5 average rating, 114 reviews

Spacious Casita with Bamboo View

Walk 20 minutes to the artisan mercado and restaurants on Ruta 71. Cerro Cara Iguana trailhead is walking distance from the casita. High insulated ceilings and 2 ceiling fans for comfort. Private hammock patio for an afternoon nap. Washer/dryer in the casita. Hot water throughout. Kitchen has a 2 burner cooktop, countertop oven, microwave, instant pot, electric skillet, blender and coffee maker. 2 Internet providers and a small workspace available. * No television set * Non smoking property

Guest favorite
Apartment in San Carlos
4.88 out of 5 average rating, 17 reviews

Beachfront 1BR Corner Condo

Corner units are ideal for those seeking privacy and natural light. This condo offers ocean and green views, and a wrap-around balcony. The fully equipped kitchen includes everything you need to cook and dine at home. The master bedroom features a king-size bed, a built-in closet, a TV, and direct access to the balcony with its signature ocean view. The living room and bedroom come with air conditioning for added comfort. You’ll also enjoy the side balcony—perfect for quiet dinners outdoors.

Top guest favorite
A serene evening scene features the bohío cottage with its thatched roof, surrounded by lush greenery and potted plants. The moon is visible in the sky above, casting a gentle glow on the outdoor area, near the tranquil pool reflecting the soft outdoor lighting.
Place to stay in Rio Hato
5 out of 5 average rating, 25 reviews

Paradise from ocean to jungle. Bohío cottage

Welcome to our beach house 850meters to beautiful pacific beach & 3 beach restaurants . Our house is gated and in a safe area .Many areas to visit nearby from surf areas to crater town in the mountains ! Hikes , Canyons , waterfalls ! Coronado is a 35 min drive with all conveniences .New mall is 10 min drive to grocery store , large drugstore. Fish market is 5 min . Seasonal riohato airport 5 min. . Our 1/4 acre property & house is on a country lane with some lovely estates surrounding it.

Top guest favorite
A serene outdoor space features a large saltwater pool surrounded by multiple lounge chairs and red umbrellas. Lush greenery is visible in the background, providing a tropical setting under a bright blue sky. A hand holds a beverage in the foreground, adding depth to the scene.
Home in Costa Esmeralda
4.98 out of 5 average rating, 203 reviews

Beach House-Amazing Pool & Jacuzzi - Pet Friendly

Majestic Sands! Come relax with the whole family at this piece of paradise.located in a private beach community in Costa Esmeralda, San Carlos. Few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool and hot tub with hammocks with views of amazing palm trees.Uninterruptible power with Smart Home Energy Management Systems.

Top guest favorite
An open living space features a wooden dining table surrounded by six wicker chairs. Two hanging hammocks are displayed on the covered terrace, offering views of the lush hills. Large glass doors reflect the greenery, blending indoor and outdoor spaces harmoniously.
Cabin in Torio
4.97 out of 5 average rating, 172 reviews

Cozy open space, unique jungle views, river access

An open-style jungle home with mesmerizing treetop and mountain views. Located 10 minute walk to the beach, with a trail that leads to the River. The house is not childproof! It has three individual bedrooms, each with its own key. The price is based on the number of guests. The entire house is always yours. The house offers fiber optic WiFi and two dedicated workspaces. The property is surrounded by large trees, naturally keep the house cool and provide shelter for birds and wildlife.

Top guest favorite
An inviting infinity pool overlooks a stunning coastal view. A spacious seating area, featuring colorful cushions, complements the serene atmosphere. Natural light fills the space, enhancing the connection to the outdoors, while the blue waters of the pool blend seamlessly with the distant ocean.
Villa in Cacique
4.98 out of 5 average rating, 52 reviews

FACING THE SEA Cacique (Portobello Park)

A house! A real glass island in the heart of the jungle! In the middle of the Portobello National Park (access only by 4x4 AWD) nestled at the top of the hill, between sky/sea, away from all eyes, a transparent house where glass embraces nature on all sides creating a unique connection between the inside and the outside, ideal for resting, disconnecting, comfortable, spacious, cool (central air conditioning), exclusive. It is the witness of a grandiose spectacle that awaits you!

Guest favorite
A modern living area is illuminated by natural light, featuring a comfortable gray sofa and an orange accent chair. A sleek coffee table sits in front, complemented by a stylish entertainment unit with a television. Floor-to-ceiling windows offer panoramic ocean views.
Apartment in San Carlos
4.91 out of 5 average rating, 47 reviews

Experience Rio Mar Penthouse

Experience unparalleled luxury in Rio Mar, San Carlos’ premier beachfront community near Coronado. This top-floor penthouse offers breathtaking ocean and mountain views from every room. Enjoy world-class amenities, including a surfing beach, sparkling pools, a spa, gym, and on-site restaurant. Relax in the elegant, open-concept living space with high-end finishes. Perfectly located near shops and attractions, this is the ultimate getaway for relaxation and adventure.

Guest favorite
A modern living area features a light-colored sofa and a wooden coffee table. Large glass sliding doors provide a clear view of the ocean and greenery outside. A decorative plant adds a touch of nature, while soft light fills the space.
Apartment in Rio Hato
4.94 out of 5 average rating, 86 reviews

Ocean View Marina Stay in Buenaventura | By Alura

Enjoy an exceptional stay in this elegant and modern apartment, located on the top floor in the marina in Buenaventura, Panama’s most exclusive beach resort. It offers panoramic views of the Pacific Ocean and the Marina. The apartment is fully equipped with high-quality furniture and finishes, thoughtfully designed to provide both comfort and style. You’ll also have access to beach clubs, restaurants, and more, for a truly unforgettable resort experience.

Top guest favorite
Loft in Panama City
5 out of 5 average rating, 17 reviews

Casco Viejo Dream Loft – Cozy & Central 1BR Apt

Enjoy a unique experience, in this elegant and centrally-located loft. Fully remodeled 1 bedroom apartment, in a central location in Casco Viejo (the old city). You will be just steps away from many restaurants, cafes, museums, and the existing night life casco has to offer. Located in “Casa Neuman",” this restored- colonial building and features unique crafted wall décor, as well as some of the original "calicanto" walls.

Top guest favorite
An infinity pool blends seamlessly into the ocean view, with a person standing at the edge. A lounge chair is positioned nearby, providing a relaxing spot to enjoy the scenery under a clear blue sky.
Condo in San Carlos
4.96 out of 5 average rating, 142 reviews

New ocean apartment in beautiful beach complex

Modern new condo with breath taking views of the Pacific Ocean. We are in a beautiful new beach complex, Punta Caelo, with direct beach access, a beach club, and several large swimming pools. The Social Area is resort quality with deck chairs, infinity pools, billiards, children’s pools and pool beds. The apartment is open and spacious with a fully stocked kitchen and large terrace directly looking out over the ocean.

Guest favorite
Apartment in Panamá
4.99 out of 5 average rating, 138 reviews

Full apartment in Panama

This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.

Top guest favorite
A spacious exterior view of the loft @ Londolozi showcases a two-story structure with a red-tiled roof. Large glass doors open to a patio area with lounge chairs and a hammock, surrounded by lush greenery and mountains in the background.
Cottage in Sorá
4.95 out of 5 average rating, 118 reviews

Luxury Private Cottage in Altos del Maria

This property is situated within the gated community of Altos del Maria. Surrounded by lush forest and rivers, the loft @ Londolozi is for guests who appreciate a sense of luxury while being close to nature. While Altos del Maria enjoys a warm tropical climate, there is a cooling breeze in the mountains that is not often present in the coastal areas.

Popular amenities for Isthmus of Panama vacation rentals