Guesthouse vacation rentals in Charleston Harbor

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in Charleston Harbor

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Top guest favorite

A bright bedroom is highlighted by a spacious bed with white linens and decorative pillows. Natural light floods in through two windows adorned with bamboo shades. Green plants add a refreshing touch on bedside tables. A light blue throw blanket is casually draped over the foot of the bed.

Guesthouse in James Island

4.98 out of 5 average rating, 124 reviews

Walk to restaurants! New, beautiful & clean home

Welcome to Curlew Corner! A new, private upstairs guesthouse in one of Charleston’s most desirable neighborhoods. With a king bed+sofa bed, this is an ideal spot for couples, friends, or small families looking for a getaway in a beautiful city! Location! The guesthouse is within walking distance to many eateries, bars, a music venue, cinema, farmer’s market, yoga studio, playground, boat landing, and beautiful water views. Close to downtown Charleston and Folly Beach, you can’t beat this spot!

LocationFamilyComfort

Top guest favorite

A bright living area features a white sofa adorned with blue and white decorative pillows, alongside a leather recliner. Two woven tables sit in front of the couch on a textured rug. A flat-screen TV and kitchen are visible in the background.

Guesthouse in Mount Pleasant

4.97 out of 5 average rating, 354 reviews

Upscale Couple's Escape | Beach & Downtown CHS

Perfect getaway for anyone looking to relax and enjoy the beautiful Charleston beaches. We maintain the highest standards for luxury - including curated interior design touches to make you forget reality and enjoy some much needed R&R time. The Pump House is the ideal place to escape to and enjoy the outdoors, local restaurants, breweries, parks, and, of course, beaches! Our reviews speak for themselves - Always 5 stars and many return guests! Permit #ST260062 | Business License #BL-24-002140

ValueFamilyWalkability

Top guest favorite

An airy loft space features a suspended wooden swing, inviting relaxation under the high, timbered ceilings. Natural light streams through large windows, illuminating cozy furnishings including a bed and a dining area with a wooden table. Unique decor elements enhance the overall character.

Guesthouse in Summerville

4.98 out of 5 average rating, 776 reviews

★Delightful guest house near historic plantations★

Nestled in the Historic Plantation District between Summerville & Charleston, our timberframe "bunkhouse" offers privacy, comfort & convenience. This 850+ sq ft retreat includes full kitchen & bath, 2 dbl beds, twin bed & plenty of living space. There's a private entrance, so come & go as you please (we're right next door if you need us). Minutes from Middleton Place, Drayton Hall & Magnolia Gardens, an easy drive to dntn Charleston, historic S'ville, beaches & golf courses. *Now with WiFi*

LocationValueAccess

Guest favorite

A well-lit living area features a dark sofa, a small round table with a plant, and a workspace equipped with a desk and chair. A television is positioned on a wooden stand. Light-colored walls and large windows contribute to the welcoming ambiance.

Guesthouse in Mount Pleasant

4.92 out of 5 average rating, 112 reviews

Spacious Guest House in Mt Pleasant *10 min to dtn

The apartment has a perfect location! Just over the bridge, you are minutes to all Mt. Pleasant and Downtown Charleston has to offer! The space has lots of natural light and charm. Plenty of space to cook in the full kitchen. Great sized bedroom with king size bed. Tons of storage. Couch is a pull-out in case someone snores! Laundry is hidden in the closet. Boat ramp is a few blocks away. If you do need to park your boat on property there will be a $25 per night charge. ST260308, BL20135246

FamilyValueTV

Top guest favorite

A spacious sleeping area features a king bed with a simple wooden frame and high-quality linens. Two white dogs sit on the floor, with a neon sign hanging above the bed, stating 'the Folly Beach swell and a Charleston lake.' The room is adorned with tropical-themed decor.

Guesthouse in James Island

4.98 out of 5 average rating, 268 reviews

The James: “Tiny” Home b/w Downtown & Folly

The James is a unique 530 sq ft retro coastal tiny home located in a gorgeous neighborhood on James Island ◡̈ 10 mins to downtown Charleston 12 minutes to Folly Beach Walking distance to restaurants The James sleeps up to 6 people and 2 dogs (NO PET FEE) & boasts a private fenced yard & patio with an outdoor shower and Clawfoot tub! The James is ideal for solo travelers, couples, families, those traveling w/ their dog(s), those w/ limited mobility and groups of friends. #BNB-2023-02

FamilyValueGrill

Top guest favorite

A spacious bedroom features a wooden bed frame adorned with a floral-patterned comforter. Two bedside tables with lamps are positioned on either side of the bed. Bright light filters in through a window, complemented by soft neutral walls and warm wood flooring.

Guesthouse in Mount Pleasant

4.98 out of 5 average rating, 180 reviews

5 STAR 1bd/1ba Shem Creek Retreat in #1 MtP area!

The Treehouse is a private, cozy, modern retreat in the hippest area of Mt. Pleasant - right between downtown & the beaches for easy access to both. Located less than 5 mi. from Sullivan's Island, less than 2 mi. from the Cooper River Bridge (to downtown Charleston), and just a short walk from Shem Creek, you won't find a better place to stay in the Holy City. *Minimum age required to rent: 21 years old. Children welcome with adult accompaniment.*STR PERMIT #: ST250220 SC BUS. LIC #: 20135380

LocationValueHospitality

Top guest favorite

The exterior of the bungalow features a white-painted facade and a welcoming entrance, framed by lush landscaping with flowering shrubs. Two windows provide natural light, accompanied by a small porch covered by an awning. Nearby trees contribute to the serene atmosphere.

Guesthouse in Mount Pleasant

4.97 out of 5 average rating, 624 reviews

Private 1/1 Old Mt Pleasant/Shem Creek Bungalow

Nestled in desirable Old Mt. Pleasant off Coleman Blvd, this quaint 1 bed/1 bath bungalow offers location and convenience. Minutes to Shem Creek and waterfront dining, just 3 miles from Sullivan's Island Beach. Enjoy sunsets from the nearby Pitt Street Bridge, or stroll just one block to bustling Coleman Blvd with restaurants, shops, and fitness. Three major grocery stores are <1 mile. Quiet, clean, and situated minutes to Downtown Charleston. STR Permit #ST260001 MP Bus Lic #BL-24-000053

LocationValueCheckout

Top guest favorite

A modern living area features a light grey sofa with pink accent pillows, arranged around a wooden coffee table. A colorful artwork adorns the wall, while a kitchen with wooden cabinetry and a breakfast bar with four stools is visible in the background.

Guesthouse in Mount Pleasant

4.96 out of 5 average rating, 153 reviews

Shem Creek Cottage!

Your own newly renovated cottage in a phenomenal location! Walk or ride bikes to Shem Creek and hundreds of restaurants and bars. 3 minute drive or 10 minute bike ride to downtown Charleston. Private neighborhood path through the marsh to Shem Creek and Shrimpboats. Cottage equipped with king bed, pullout king bed couch, full kitchen, bath, two large TV’s, washer & dryer, counter with barstools and private patio. 50 paces to neighborhood park! Permit #ST260119 - License #BL-24-035115

ValueLocationGetting around

Top guest favorite

Two high-backed wicker chairs are positioned on a wooden deck, overlooking a calm saltwater pond. Sunlight casts a warm glow on the scene, highlighting the surrounding trees and nature. The peaceful water reflects the clear blue sky.

Guesthouse in James Island

4.99 out of 5 average rating, 108 reviews

Island Life

Take it easy at this cozy & tranquil getaway, located on a saltwater pond. Share our backyard with us to relax in a hammock, enjoy catch & release fishing & chill by the fire 🔥 pit. No cleaning fee! Fragrance free detergent used for bedding & towels. No smoking or vaping anywhere on the property. No animals of any kind allowed. We would love to adhere to Airbnb's guidelines for service or emotional support animals, unfortunately we cannot due to health issues of the owner.

LocationValueKitchen

Top guest favorite

A modern two-story guest house is depicted, featuring a combination of white and light brown exteriors. A covered entryway with pergola extends over the front door. A tranquil pool is visible in the foreground, surrounded by landscaped greenery and stone paving.

Guesthouse in Mount Pleasant

4.96 out of 5 average rating, 196 reviews

*Old Village/Shem Creek Charmer*NEW 2BR Guesthouse

LOCATION, LOCATION, LOCATION! Welcome to Persimmon Place, a new guesthouse in the heart of Old Village in Mt. Pleasant. Historic Old Village is one of Charleston's most beautiful neighborhoods, central to all Charleston has to offer. This 2BR 1 BA is the perfect spot for your Lowcountry visit. -Walk to Shem Creek with bars, restaurants, & water activities -Less than 4 miles(8 min drive)to Sullivan's Island Beach -5 miles(9 min drive)to downtown Charleston ST260213 BL20137971

LocationValueComfort

Guest favorite

A light and airy living space features a comfortable white sofa adorned with decorative pillows. An area rug enhances the room's warmth, while a kitchen area with modern appliances is visible in the background. Natural light enters through a nearby window, illuminating the open layout.

Guesthouse in Mount Pleasant

4.96 out of 5 average rating, 193 reviews

Beach, downtown, Alhambra Hall weddings so close!

Quiet location close to everything Charleston has to offer! Located in historic Old Village we are less than 2 blocks from Alhambra hall (with playground) and 10 minutes walking to Pitt street bridge recreational area. Sullivan's Island beach is 3 miles away, with a bike path or sidewalk the entire way! After a day of exploring, relax for a few then go downtown Charleston (10 minutes away) or to the Shem Creek district (minutes away)! Cable/Wi-Fi are provided.

FamilyLocationCheck-in

Guest favorite

A newly-built guest cottage is depicted, elevated on pilings and surrounded by lush greenery. Light-colored siding is complemented by green shutters. Steps lead up to a welcoming porch with a railing, providing access to the spacious entry and large windows that invite natural light.

Guesthouse in Mount Pleasant

4.98 out of 5 average rating, 287 reviews

Stunning Couples Cottage with Creek Dock!

You will fall in love with this stunning, newly-built guest cottage nestled under the canopy of a majestic 400-year-old live oak tree! Providing ultimate comfort, convenience and serenity, this is the perfect place to launch your Charleston adventure – 10 minutes to Shem Creek, & 15 minutes to Sullivan's Island or Downtown Charleston. PLUS, come enjoy our brand new dock on the creek! A picture-perfect spot to relax and enjoy the stunning Lowcountry scenery!

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