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Vacation rentals in Cerro Santa Cruz

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Cerro Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
Guesthouse in El Valle de Antón
4.92 out of 5 average rating, 106 reviews

The Retreat in El Valle - Casita de la Montaña

Welcome to your serene retreat in El Valle, Panama! Nestled amid lush nature, our two-bedroom casitas offer a peaceful escape with breathtaking views, exotic wildlife, and flora. Each casita features two rooms, including a queen bed, choice of king or twin beds, a small fridge, coffee station, Wi-Fi, and large terrace with comfy couch. Enjoy the shared pool, book meditation/ healing sessions, explore world-class hiking. Enjoy next door La Compania restaurants, El Valle’s famous artisan market!

Guest favorite
A private pool is surrounded by a smooth concrete deck, with gentle steps leading into the water. The adjacent open-air area features large glass doors that highlight the indoor living space, while the softly lit evening sky adds a serene ambiance.
Home in El Higo
4.97 out of 5 average rating, 33 reviews

CasAna

Fantastic place with open spaces, natural light and fresh air, 2 bedrooms with internal bathroom, terrace to receive the sunrise and sunset, private pool that makes you feel like you are flying, while you can share with friends and family in a group area provided by a spacious deck, enjoy your barbecues on the terrace and kitchen equipped with everything you need Located 10 meters from Playa La Ermita and 12 meters from the entrance to the Valley, and a hop from the Los Camisones Restaurant.

Superhost
A modern house features a prominent roof and large glass walls surrounded by lush greenery. The structure is set within a hillside landscape, with plants and stones leading to the entrance. Evening light enhances the natural beauty of the surroundings.
Home in El Valle
4.92 out of 5 average rating, 65 reviews

Entre Montañas 1 - Anton Valley

Discover the ultimate retreat in Anton Valley, where breathtaking views meet modern comforts. Relax by the fire pit under starry skies, marvel at the colorful aquarium, and soak in panoramic mountain scenery. This home is designed for unforgettable moments, offering cozy spaces, outdoor lounging areas, is a perfect stay. Whether you’re here to explore or unwind, this is your ideal escape. We are a conservative family that wants their home to be a pleasant experience for other families.

Top guest favorite
The exterior of the cabin is showcased amidst lush greenery, featuring a sloped roof and large glass windows. A wooden staircase leads up to the entrance, while a stone pathway meanders through the garden, enhancing the natural surroundings.
Cabin in Penonomé
4.98 out of 5 average rating, 136 reviews

Aqeel cabin in the nature

Relax at this unique and tranquil getaway surrounded by nature. If you're lucky, you may wake up to see white-faced capuchins from your bedroom window and spot an abundance of birds, such as the crested oropendola or a toucan. The property offers river access with a sandy, beach-like area, and there is a 1 km walking trail alongside the river. With satellite high-speed internet access, you'll stay connected, though the river and sandy area may not be accessible during rainy days.

Guest favorite
A spacious bedroom is depicted, featuring a large bed with white linens and two decorative pillows. Windows adorned with navy blue curtains allow natural light in. A desk with a chair and a television is positioned nearby, complemented by wall art in muted colors.
Home in Llano Marín
5.0 out of 5 average rating, 29 reviews

The trip house

Enjoy the simplicity of this accommodation with the technology you need. Advantages - Quiet and Safe area - Just 500 meters from the Inter-American highway. - Near to El Machetazo Supermarket (24 hours) - Near to the Splash Kindom Water Park - Restaurants near to the residence - Wifi (100 MB) - TV with Netflix available - Smart interior lights (voice control) - 1 large bedroom with air conditioning Reservation minimum 3 hours before Check-in: 3:00 p.m. Check out: 12:00 p.m.

Guest favorite
The modern house is set amidst lush greenery, featuring a sleek design with large glass windows. An infinity pool is positioned on a spacious patio that offers unobstructed views of the surrounding hills, creating an inviting outdoor space for relaxation.
Home in Altos del María
4.82 out of 5 average rating, 327 reviews

Modern House with Great Views and Heated Pool

Modern mountain house in Altos del Maria, Panama, a gated comunity at just 1 hour and 30 minutes away from Panama city. The comunity has rivers, bird watching trails, and is only 25 minutes away from the pacific beaches. Its a perfect place to take a break and relax. The house has a modern decor, infinity pool, 2 bedrooms with A/C, wifi, dishwashing machine, washer and dryer and great view of the mountains. Free late checkout is given for rentals checking out on Sundays.

Superhost
Home in Altos del María
4.76 out of 5 average rating, 157 reviews

Villa Acuario

Relaxation is guaranteed in this one-of-a-kind glass house nestled in the lush mountains of Altos del María. Surrounded by nature and designed with floor-to-ceiling glass walls on all sides— as if you’re living inside a crystal ball. With no direct neighbors, panoramic forest views, it is perfect for a family getaway, a quiet reset, or an extended stay. The home offers light-filled interiors during the day and unforgettable stargazing nights from the rooftop.

Guest favorite
A small pool sits within a wooden deck area, surrounded by lush greenery. Steps lead from the deck to the pool, where a gentle waterfall feature adds a soothing element. Lounge chairs are positioned nearby for relaxation in a tranquil setting.
Guesthouse in Panamá Oeste
4.84 out of 5 average rating, 152 reviews

Mountain cabin with private pool

Enjoy peace and nature in this cozy and equipped cabin, perfect for disconnecting and relaxing. Surrounded by forests and spectacular views, here you can breathe fresh air and gaze at the stars. ✔️ Ideal for couples, families or adventurers. ✔️ Trails, rivers and viewpoints nearby. ✔️ Comfortable and equipped spaces for your comfort. - Sleeps 4 people. - Possibility of having 1 double bed and 2 single beds or 4 single beds. - Discount for two nights or more.

Top guest favorite
Home in Cañaveral
5.0 out of 5 average rating, 15 reviews

Peaceful Garden Home |3BR| Fast WiFi|Near Penonomé

We want you to feel truly comfortable and at home. A home away from home. If you’re looking to spend quality time with family or friends, “Mi casa es su casa” at Villas de Santa María is the perfect place to relax, disconnect, and escape the noise of crowded cities. Enjoy our private garden and unwind on the terrace with stunning views of Guacamayas Hill, where you’ll experience peaceful surroundings and beautiful sunsets every afternoon.

Guest favorite
A cozy sleeping area features a spacious bed with neutral bedding. Soft lighting is provided by bedside lamps, and a ceiling fixture adds warmth. Two framed art pieces adorn the walls, offering a subtle contrast to the light decor.
Tiny home in Penonomé
4.84 out of 5 average rating, 76 reviews

Fenced and Pet-Friendly Cottage in Penonomé

Cozy private cottage, fully fenced — perfect for relaxing, remote work, or traveling with your pet. Enjoy the garden surrounded by greenery, rest in the covered hammocks, or do some birdwatching. Equipped kitchen, air conditioning, high-speed WiFi, and secure on-site parking. Just minutes from the Interamerican Highway, with easy access to cafés, shops, and more. Ideal for a peaceful getaway or productive stay.

Guest favorite
A welcoming porch area is furnished with comfortable seating and vibrant hammocks, surrounded by lush greenery and flowering plants. The structure is set against a backdrop of a clear blue sky, with sunlit grass creating an inviting outdoor space.
Home in El Valle de Antón
4.91 out of 5 average rating, 77 reviews

La Florecita - Country house in Valle de Antón

Cozy getaway in the heart of the Anton Valley Enjoy an unforgettable stay in our warm and cozy house, ideal for families and groups of friends. Located in the center of the Anton Valley, you'll be minutes away from markets, restaurants, and major natural attractions. Our house combines comfort and charm, with spacious spaces perfect for relaxing and enjoying the cool mountain climate.

Top guest favorite
A comfortable porch area features two colorful hammocks suspended from the walls. The polished tile flooring reflects soft light, and a pair of large wooden doors stands closed in the background. A vehicle is parked nearby, adding to the casual ambiance.
Home in Penonomé
4.92 out of 5 average rating, 152 reviews

Comfortable, fenced and safe house.

Enjoy the simplicity of this spacious, quiet and centrally located place at Casa las Hamacas. You can enjoy the pleasant Penonomeño climate. A place close to everything, shopping malls, schools, hospital, mountains, rivers and beaches. Both rooms feature A/C to ensure your rest. A few minutes away from the Pan-American Highway.

Popular amenities for Cerro Santa Cruz vacation rentals