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Vacation rentals in Cerro Santa Cruz

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Cerro Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
Home in Playa Costa Esmeralda
4.98 out of 5 average rating, 220 reviews

Beach House-Amazing Pool & Jacuzzi - Pet Friendly

Majestic Sands! Come relax with the whole family at this piece of paradise.located in a private beach community in Costa Esmeralda, San Carlos. Few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool and hot tub with hammocks with views of amazing palm trees.Uninterruptible power with Smart Home Energy Management Systems.

Guest favorite
Guesthouse in El Valle de Antón
4.91 out of 5 average rating, 115 reviews

The Retreat in El Valle - Casita de la Montaña

Welcome to your serene retreat in El Valle, Panama! Nestled amid lush nature, our two-bedroom casitas offer a peaceful escape with breathtaking views, exotic wildlife, and flora. Each casita features two rooms, including a queen bed, choice of king or twin beds, a small fridge, coffee station, Wi-Fi, and large terrace with comfy couch. Enjoy the shared pool, book meditation/ healing sessions, explore world-class hiking. Enjoy next door La Compania restaurants, El Valle’s famous artisan market!

Superhost
A modern living room features a spacious sectional sofa arranged around a circular coffee table. A large wall-mounted TV is centered within elegant wooden cabinetry, while planters holding lush greenery add a touch of nature. Natural light fills the room through large arched windows.
Home in El Valle
4.93 out of 5 average rating, 101 reviews

Casa Coco - Beautiful Mountain Villa With AC

Elegant and modern, our home strikes the perfect balance between luxury and warmth. With ample space to accommodate large groups and families, as well as cozy and inviting for smaller groups. The yard features a covered social area, ideal for relaxing or entertaining. A lush garden adorned with vibrant greenery includes a charming mango tree and mountain peak views. A 5 minute walk to restaurants and the open air market. If you have a group larger than 12- please reach out to us directly.

Top guest favorite
The exterior of the cabin is showcased amidst lush greenery, featuring a sloped roof and large glass windows. A wooden staircase leads up to the entrance, while a stone pathway meanders through the garden, enhancing the natural surroundings.
Cabin in Penonomé
4.98 out of 5 average rating, 139 reviews

Aqeel cabin in the nature

Relax at this unique and tranquil getaway surrounded by nature. If you're lucky, you may wake up to see white-faced capuchins from your bedroom window and spot an abundance of birds, such as the crested oropendola or a toucan. The property offers river access with a sandy, beach-like area, and there is a 1 km walking trail alongside the river. With satellite high-speed internet access, you'll stay connected, though the river and sandy area may not be accessible during rainy days.

Guest favorite
A spacious bedroom is depicted, featuring a large bed with white linens and two decorative pillows. Windows adorned with navy blue curtains allow natural light in. A desk with a chair and a television is positioned nearby, complemented by wall art in muted colors.
Home in Llano Marín
5.0 out of 5 average rating, 29 reviews

The trip house

Enjoy the simplicity of this accommodation with the technology you need. Advantages - Quiet and Safe area - Just 500 meters from the Inter-American highway. - Near to El Machetazo Supermarket (24 hours) - Near to the Splash Kindom Water Park - Restaurants near to the residence - Wifi (100 MB) - TV with Netflix available - Smart interior lights (voice control) - 1 large bedroom with air conditioning Reservation minimum 3 hours before Check-in: 3:00 p.m. Check out: 12:00 p.m.

Superhost
The modern house is set amidst lush greenery, featuring a sleek design with large glass windows. An infinity pool is positioned on a spacious patio that offers unobstructed views of the surrounding hills, creating an inviting outdoor space for relaxation.
Home in Altos del María
4.82 out of 5 average rating, 335 reviews

Modern House with Great Views and Heated Pool

Modern mountain house in Altos del Maria, Panama, a gated comunity at just 1 hour and 30 minutes away from Panama city. The comunity has rivers, bird watching trails, and is only 25 minutes away from the pacific beaches. Its a perfect place to take a break and relax. The house has a modern decor, infinity pool, 2 bedrooms with A/C, wifi, dishwashing machine, washer and dryer and great view of the mountains. Free late checkout is given for rentals checking out on Sundays.

Guest favorite
Home in Altos del María
4.76 out of 5 average rating, 165 reviews

Villa Acuario

Relaxation is guaranteed in this one-of-a-kind glass house nestled in the lush mountains of Altos del María. Surrounded by nature and designed with floor-to-ceiling glass walls on all sides— as if you’re living inside a crystal ball. With no direct neighbors, panoramic forest views, it is perfect for a family getaway, a quiet reset, or an extended stay. The home offers light-filled interiors during the day and unforgettable stargazing nights from the rooftop.

Superhost
Home in Penonomé
5.0 out of 5 average rating, 3 reviews

Villa Cecilia-Acogedor estudio en Penonomé Centro

Una casa auténtica del interior de Panamá, renovada con calidez y buen gusto. Esta habitación privada cuenta con una cama matrimonial cómoda, ideal para parejas, y espacio opcional para agregar una cama individual. Totalmente equipada: sala, cocina, comedor, escritorio para trabajar; ideal si buscas tranquilidad sin perder los espacios de una casa completa. Ideal para: parejas, familias pequeñas (2 adultos + 1 niño), viajeros solos que buscan privacidad.

Guest favorite
Home in Cañaveral
4.89 out of 5 average rating, 18 reviews

Guacamaya Hill View|3BR Country Home Near Penonomé

We want you to feel truly comfortable and at home. A home away from home. If you’re looking to spend quality time with family or friends, “Mi casa es su casa” at Villas de Santa María is the perfect place to relax, disconnect, and escape the noise of crowded cities. Enjoy our private garden and unwind on the terrace with stunning views of Guacamayas Hill, where you’ll experience peaceful surroundings and beautiful sunsets every afternoon.

Top guest favorite
A bright dining area features a round wooden table surrounded by six turquoise chairs. Large windows allow natural light to fill the space, showcasing a cozy atmosphere. A wooden dresser and potted plants add touches of comfort. Arched openings lead to other rooms.
Home in El Valle de Antón
4.96 out of 5 average rating, 198 reviews

Rustic family mountain home - 5 min walk to town!

Rustic family home with exquisitely landscaped garden complete with bridge over natural stream. Outdoor chill out space with barbecue and terrace under roof with hammocks on one side of the house, and a pergola with lounge area and gas grill on opposite side of the house. Centrally located to main attractions, only a 7 minute walk to the main market. Peaceful, relaxing refuge surrounded by views of nature and the cloud forest.

Guest favorite
A tranquil pool area is surrounded by tall palm trees, with wooden cabanas providing shaded seating. The clear blue water reflects the sunlight, creating a serene atmosphere. Lounge chairs line the sides, inviting relaxation in a lush tropical setting.
Home in Coclé
4.96 out of 5 average rating, 113 reviews

Panama del Mar

Panama del Mar, nestled in center of Buenaventura, is truly a tropical paradise with a variety of pools, cabanas, pristine beach, restaurants, spas, and everything that makes your vacation relaxing. This spacious home accommodates 12 guests and includes all the conveniences of home. Any further questions can directed to Sandra to 507-6980-1314.

Guest favorite
A comfortable porch area features two colorful hammocks suspended from the walls. The polished tile flooring reflects soft light, and a pair of large wooden doors stands closed in the background. A vehicle is parked nearby, adding to the casual ambiance.
Home in Penonomé
4.91 out of 5 average rating, 157 reviews

Comfortable, fenced and safe house.

Enjoy the simplicity of this spacious, quiet and centrally located place at Casa las Hamacas. You can enjoy the pleasant Penonomeño climate. A place close to everything, shopping malls, schools, hospital, mountains, rivers and beaches. Both rooms feature A/C to ensure your rest. A few minutes away from the Pan-American Highway.

Popular amenities for Cerro Santa Cruz vacation rentals