Vacation rentals in Cerro Santa Cruz

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Cerro Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness, and more.

0 of 0 items showing

1 of 3 pages

Top guest favorite

The living area features large glass doors that invite natural light and views of the garden. Indoor plants enhance the space, and a cozy seating arrangement includes a sofa and eclectic chairs. A workspace with a desk and lamp is positioned to the side.

Guesthouse in El Valle de Antón

4.99 out of 5 average rating, 102 reviews

Spacious Casita with Bamboo View

Walk 20 minutes to the artisan mercado and restaurants on Ruta 71. Cerro Cara Iguana trailhead is walking distance from the casita. High insulated ceilings and 2 ceiling fans for comfort. Private hammock patio for an afternoon nap. Washer/dryer in the casita. Hot water throughout. Kitchen has a 2 burner cooktop, countertop oven, microwave, instant pot, electric skillet, blender and coffee maker. 2 Internet providers and a small workspace available. * No television set * Non smoking property

Top guest favorite

Lush greenery surrounds the charming casitas, with vibrant tropical plants in various colors dotting the landscaped garden. Mountains rise in the background under a partly cloudy sky, creating a serene backdrop for this tranquil retreat.

Guesthouse in El Valle de Antón

5 out of 5 average rating, 41 reviews

The Retreat in El Valle - Mountain House

Welcome to your serene retreat in El Valle, Panama! Nestled amid lush nature, our two-bedroom casitas offer a peaceful escape with breathtaking views, exotic wildlife, and flora. Each casita features a queen bed, choice of king or twin beds in the second room, a small fridge, coffee station, Wi-Fi, and large terrace. Enjoy the shared pool, meditation and healing sessions by appointment, and explore world-class hiking nearby. Just a short walk to restaurants and El Valle’s famous artisan market!

Top guest favorite

An aerial view of the property showcases a spacious layout surrounded by lush greenery. A large saltwater pool and a hot tub are visible alongside a well-maintained outdoor area with red umbrellas providing shade. The roof of the main structure features a brown tone, blending with the natural surroundings.

Home in Costa Esmeralda

4.98 out of 5 average rating, 178 reviews

Beach House-Amazing Pool, Surf & Pet Friendly

Majestic Sands! Come relax with the whole family at this piece of paradise.located in a private beach community in Costa Esmeralda, San Carlos. Few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool and hot tub with hammocks with views of amazing palm trees.Uninterruptible power with solar and battery backup systems.

Top guest favorite

The exterior of the cabin is showcased amidst lush greenery, featuring a sloped roof and large glass windows. A wooden staircase leads up to the entrance, while a stone pathway meanders through the garden, enhancing the natural surroundings.

Cabin in Penonome

4.97 out of 5 average rating, 111 reviews

Aqeel cabin in the nature

Relax at this unique and tranquil getaway surrounded by nature. If you're lucky, you may wake up to see white-faced capuchins from your bedroom window and spot an abundance of birds, such as the crested oropendola or a toucan. The property offers river access with a sandy, beach-like area, and there is a 1 km walking trail alongside the river. With satellite high-speed internet access, you'll stay connected, though the river and sandy area may not be accessible during rainy days.

Guest favorite

A spacious bedroom is depicted, featuring a large bed with white linens and two decorative pillows. Windows adorned with navy blue curtains allow natural light in. A desk with a chair and a television is positioned nearby, complemented by wall art in muted colors.

Home in Llano Marín

5 out of 5 average rating, 23 reviews

The trip house

Enjoy the simplicity of this accommodation with the technology you need. Advantages - Quiet and Safe area - Just 500 meters from the Inter-American highway. - Near to El Machetazo Supermarket (24 hours) - Near to the Splash Kindom Water Park - Restaurants near to the residence - Wifi (100 MB) - TV with Netflix available - Smart interior lights (voice control) - 1 large bedroom with air conditioning Reservation minimum 3 hours before Check-in: 3:00 p.m. Check out: 12:00 p.m.

Guest favorite

A small wooden deck features two chairs and a table, positioned against a maroon wooden exterior. Natural surroundings are visible in the background, with trees enhancing the outdoor space's appeal. A subtle decorative sign hangs near the window.

Cabin in El Valle de Antón

4.86 out of 5 average rating, 122 reviews

5 min from Valle I Incredible View Cabin 2

This cabin is modern and full of nature. The cabin is 5 minutes before arriving at Valle de Anton, it has a single space where the beds, kitchen and breakfast bar are located. Outside there is a small terrace with a nice view to enjoy. It has a TV with HBOMax, a coffee maker, and an electric stove without an oven. The last 3 minutes of the road there is a stone street, but a Picanto passes without problems. Up to two small dogs are allowed. Check-in 3 pm and Check-out 12 noon.

Guest favorite

The modern house is set amidst lush greenery, featuring a sleek design with large glass windows. An infinity pool is positioned on a spacious patio that offers unobstructed views of the surrounding hills, creating an inviting outdoor space for relaxation.

Home in Altos del Maria

4.8 out of 5 average rating, 296 reviews

Modern House with Great Views and Heated Pool

Modern mountain house in Altos del Maria, Panama, a gated comunity at just 1 hour and 30 minutes away from Panama city. The comunity has rivers, bird watching trails, and is only 25 minutes away from the pacific beaches. Its a perfect place to take a break and relax. The house has a modern decor, infinity pool, 2 bedrooms with A/C, wifi, dishwashing machine, washer and dryer and great view of the mountains. Free late checkout is given for rentals checking out on Sundays.

Guest favorite

An outdoor terrace is showcased, featuring a cozy hammock draped with red fabric. The space is illuminated by subtle lighting along the edge, enhancing the serene atmosphere. Lush greenery and distant mountains are visible, creating a peaceful setting as the evening approaches.

Cabin in Cerro Santa Cruz

4.89 out of 5 average rating, 44 reviews

Magical getaway in nature

Sunrise Glamping is a charming retreat where nature and comfort intertwine. A container transformed into a cabin welcomes you with its private bathroom, hot water, and a fully-equipped kitchenette. Relax on its terrace or on the catamaran net while enjoying panoramic views of spectacular sunrises. The small swimming pool and barbecue complete this magical space, ideal for disconnecting, exploring and experiencing unforgettable moments in a unique and peaceful environment.

Guest favorite

A spacious outdoor deck features modern furniture arranged for relaxation, overlooking a lush mountainous landscape. Verdant hills and a colorful sky at dawn create a tranquil environment, inviting guests to enjoy the natural beauty and serenity of the surroundings.

Villa in El Cope, Penonome

4.92 out of 5 average rating, 182 reviews

Mountain retreat

Our beautiful, modern, comfortable house is designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and also a base to explore the area which is in a beautiful part of Panama near a cloud forest national park with amazing hiking to waterfalls and local communities. The house is large, sleeping 12, within 17 acres of forest with rivers for swimming. We can arrange tours and hosted retreats for yoga, cooking and more.

Top guest favorite

A compact dining area features a foldable table surrounded by two upholstered chairs in a bold shade of purple. Natural light filters through a nearby window, illuminating the well-organized kitchenette, where shelves contain various glassware and utensils.

Camper/RV in El Valle de Antón

4.99 out of 5 average rating, 228 reviews

Armadillo Shelter & Garden Valle de Anton

It is a unique and special accommodation that we have designed for you to experience the Anton Valley in a more conscious and natural way. It's a remodeled RV or trailer, to make it cozy>functional and comfortable>tiny house style. The space has a small and complete kitchen, hot water, Wi-Fi, coffee and tea. It is surrounded by a nice garden. With a separate entrance and an area to park the car. Ideal for 1-2 people.

Guest favorite

A cozy sleeping area features a spacious bed with neutral bedding. Soft lighting is provided by bedside lamps, and a ceiling fixture adds warmth. Two framed art pieces adorn the walls, offering a subtle contrast to the light decor.

Tiny home in Penonome

4.87 out of 5 average rating, 46 reviews

Cumbrera Deal

Enjoy the best of both worlds in this cozy and charming tiny home. Surrounded by nature, you can relax in the garden, rest in the hammocks, or admire the trees. You are also just minutes away from the highway, where you can find coffee shops, shopping malls, and everything you need. Whether you are looking for a peaceful getaway or a convenient base, this is the perfect place for you in Penonomé, Coclé.

Top guest favorite

A covered patio area is presented, featuring sturdy wooden posts and stone accents. Potted plants line the edges, showcasing vibrant flowers. The sky is partly cloudy, and a grassy area is visible beyond the patio, enhancing the outdoor experience.

Home in Cañaveral

5 out of 5 average rating, 10 reviews

Entire stylish Country Home in Penonomé

We want you to be comfortable and feel at home away from home. If you are looking to spend quality time with friends or family, “Mi casa es su casa” at Villas de Santa Maria is the ideal place to stay and disconnect from the routine and crowded cities. Here you can enjoy our garden and the stunning view of “Guacamayas Hill” and its beautiful sunsets from our terrace.