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Vacation rentals in Santa Cruz Tlaxcala

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Cruz Tlaxcala

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
A spacious two-story house features a warm exterior and large glass doors that connect the indoor and outdoor areas. In the foreground, a patio set with six chairs surrounds a glass table, situated on a green lawn that extends to the house.
Home in Santa María Atlihuetzia
4.88 out of 5 average rating, 24 reviews

Beautiful house with a large garden

Less than two hours from Mexico City, spacious and cozy house very well lit with large garden, ideal for resting in a peaceful place, meeting and living with family or friends, appreciate the majesty of the Malinche, have breakfast or roast a meat outdoors, even play volleyball or basketball, or relax in the jacuzzi. Strategically located 20 minutes from downtown Tlaxcala and less than an hour from tourist attractions such as El Santuario de las Luciérnagas and Val'Quirico.

Guest favorite
Home in Ocotlán
4.96 out of 5 average rating, 24 reviews

Beautiful house with a garden. Close to downtown Tlax.

Comfortable and peaceful stay with a large garden. Just 10 minutes from downtown Tlaxcala. The space: •Entire private house • Fully equipped kitchen area •Spacious garden (150 m2) • Private and secure parking. •Terrace with breakfast bar •1 Full bathroom • Ambient lighting •Heaters and fan • Screen with Roku • High Speed WiFi • Street with surveillance, clean and private • No invoicing at this time

Guest favorite
The open living area features a cozy green sofa and a marble coffee table. A small dining area is positioned beside the kitchen, which includes modern appliances. Natural light enters through large windows, while a spiral staircase leads to the upper level.
Loft in Santa Isabel Tetlatlauca
4.89 out of 5 average rating, 179 reviews

Piacere loft Val'Quirico. Bed, Jacuzzi & Coffee

Lotf Piacere features a unique design and a private Jacuzzi. In addition (we can rent you a car for 4 people) This space is located in the heart of Val' Quirico, in an excellent location—you can go out and find charming restaurants, cafes, shops, bars, etc., just a few steps away. In special cases, we can rent you a car for four people so you can explore the pre-Hispanic region, such as Cacaxtla, Xochitecalt and Tlaxcala City, which is 20–30 minutes away.

Superhost
Home in Santa Cruz Tlaxcala
4.77 out of 5 average rating, 13 reviews

House with pool and Jacuzzi for 6 · 1 hour from CDMX

House with pool and Jacuzzi for 6, 1 hour from CDMX. Immerse yourself in this private oasis: pool for the day, jacuzzi for the night, charcoal grill and bar to share with your loved ones. 3 bedrooms, 5 bathrooms, ideal for families, groups of friends or celebrations where you want to disconnect without driving for hours. Located in Santa Cruz Tlaxcala, 25-30 minutes from Puebla. The perfect place for laughter, good food, and nights under the stars.

Guest favorite
A spacious sleeping area features a wooden four-poster bed with soft gray bedding. Natural light fills the room through large windows, framed by minimalistic light fixtures. A small table and chair are positioned beside the window, offering a serene view of the surrounding greenery.
Loft in Santa Agueda
4.98 out of 5 average rating, 142 reviews

Exclusive Penthouse, Val`Quirico

Perfect romantic escape for couples or solo travellers looking to unwind and relax. The private penthouse apartment is just a five minute walk away from the heart of Val’Quirico, includes free parking and a fully equipped kitchen. The private terrace is perfect for romantic dinners, star gazing and has amazing views of the Malinche mountain where the sunrises. An ideal space to recharge, celebrate love and enjoy an unforgettable experience.

Top guest favorite
A bright living area is showcased with large windows covered by sheer curtains, allowing natural light to fill the space. A circular marble coffee table sits atop a soft area rug, accompanied by two chocolate brown armchairs and a dark sectional sofa. A television is positioned on a wooden stand.
Apartment in Apizaco
4.98 out of 5 average rating, 51 reviews

A complete and centrally located apartment

Excellent full apartment with privileged location in Apizaco Tlax. Ideal for short and long stays, located on the second floor of a building, in front of the only Soriana in the center, 5 minutes from the city's main park and with a fast route to the main roads. It has two full bedrooms, a full kitchen, a full bathroom and a living room with all amenities. Free street parking or a boarding service a block and a half away at no extra cost.

Guest favorite
Cottage in Santa Cruz Tlaxcala
4.92 out of 5 average rating, 39 reviews

Spectacular Ranch 5 minutes from Trinidad IMSS

Bring the whole family to this fantastic place, enjoy the tranquility of nature, without leaving aside the fun both outside and inside, with the bar, pool table or movie night! Relax at this ranch located in the municipality of Santa Cruz Tlaxcala. Enjoy the views from the hillside, walk around the property, or visit the La Trinidad Holiday Center. At night, immerse yourself in the incredible views of the galaxy in the open field.

Guest favorite
A decorative stone fountain features a multi-tiered design, with flowing water cascading down. Surrounding the fountain are vibrant red poinsettias in black planters, creating a welcoming focal point in the outdoor space.
Home in Apizaco Centro
4.94 out of 5 average rating, 215 reviews

AMAZING "CASA CARMELA" in the center of Apizaco

THIS SPACE FOLLOWS AIRBNB'S ADVANCED CLEANING PROTOCOL. Cozy and wonderful 1-story house, located in downtown Apizaco. Excellent location a few blocks from restaurants, bars, convenience stores, cinema, among others. The house has excellent essential services (Internet, Netflix), as well as a garage (5.0 meters long) for a small or medium-sized sedan or SUV. We accept small or medium-sized pets; large pets with prior approval.

Guest favorite
Home in San Juan Totolac
5 out of 5 average rating, 10 reviews

Bruma House. With garden, firepit and pet friendly

Welcome to Casa Bruma, a spacious and cozy home perfect for families, friends, and travelers with pets. Relax in the garden, gather around the fire pit, or enjoy the BBQ area. The house comfortably accommodates 6 guests in beds and can host up to 8 guests. For groups of 7 or 8, two guests will sleep on the sofa bed located in the fourth bedroom. Just 10 minutes from downtown Tlaxcala.

Guest favorite
A living area features comfortable black sofas arranged around a coffee table. Natural light fills the space, highlighting the minimalist decor. A doorway leads to a kitchen area, with cabinetry and an organized layout visible in the background.
Apartment in San Miguel Contla
4.8 out of 5 average rating, 50 reviews

Comfortable apartment with an excellent view

Cozy, quiet and luxurious apartment, ideal for family and friends who come to visit "located 3 minutes from the Trinidad Vacation Center, 5 minutes from Apizaco Centro, 15 minutes at the foot of Volcán la Malinche and 20 minutes from Huamantla" Excellent view and location ! Don't think about it and take advantage of your stay !

Guest favorite
Apartment in Santa Ana Chiautempan
4.91 out of 5 average rating, 11 reviews

Apartment near downtown.

Comfortable apartment close to downtown and expressways. Enjoy a comfortable stay in this apartment. It's an ideal place for those looking for flexibility and a functional space.

Guest favorite
A cozy living area is featured with a maroon-covered sectional sofa, positioned against a light pink wall. A glimpse of the kitchen area is visible in the background, showcasing an organized space with appliances and utensils arranged on the counter.
Apartment in San Miguel Contla
4.93 out of 5 average rating, 44 reviews

Comfortable apartment (Netflix included)

Comfortable, cozy and quiet apartment (Netflix included), 5 min from La Trinidad Vacation Center and 15 min from Apizaco's Zócalo.

Popular amenities for Santa Cruz Tlaxcala vacation rentals

  1. Airbnb
  2. Mexico
  3. Tlaxcala
  4. Santa Cruz Tlaxcala