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Vacation rentals in Santa Cruz Tlaxcala

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Cruz Tlaxcala

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
A spacious two-story house features a warm exterior and large glass doors that connect the indoor and outdoor areas. In the foreground, a patio set with six chairs surrounds a glass table, situated on a green lawn that extends to the house.
Home in Santa María Atlihuetzia
4.88 out of 5 average rating, 24 reviews

Beautiful house with a large garden

Less than two hours from Mexico City, spacious and cozy house very well lit with large garden, ideal for resting in a peaceful place, meeting and living with family or friends, appreciate the majesty of the Malinche, have breakfast or roast a meat outdoors, even play volleyball or basketball, or relax in the jacuzzi. Strategically located 20 minutes from downtown Tlaxcala and less than an hour from tourist attractions such as El Santuario de las Luciérnagas and Val'Quirico.

Guest favorite
Home in Ocotlán
4.95 out of 5 average rating, 22 reviews

Beautiful house with a garden. Close to downtown Tlax.

Comfortable and quiet stay with a large garden. Just 10 minutes from downtown Tlaxcala. The space: • Entire private house • Fully equipped kitchen area •Spacious garden (150 m2) • Private and secure parking. •Terrace with breakfast area • 1 full bathroom • Ambient lighting •Heaters and fan • Screen with Roku •High speed Wi-Fi • Clean, private street with surveillance •Quiet and safe area

Guest favorite
The open living area features a cozy green sofa and a marble coffee table. A small dining area is positioned beside the kitchen, which includes modern appliances. Natural light enters through large windows, while a spiral staircase leads to the upper level.
Loft in Santa Isabel Tetlatlauca
4.89 out of 5 average rating, 179 reviews

Piacere loft Val'Quirico. Bed, Jacuzzi & Coffee

Lotf Piacere features a unique design and a private Jacuzzi. In addition (we can rent you a car for 4 people) This space is located in the heart of Val' Quirico, in an excellent location—you can go out and find charming restaurants, cafes, shops, bars, etc., just a few steps away. In special cases, we can rent you a car for four people so you can explore the pre-Hispanic region, such as Cacaxtla, Xochitecalt and Tlaxcala City, which is 20–30 minutes away.

Superhost
Home in Santa Cruz Tlaxcala
4.77 out of 5 average rating, 13 reviews

House with pool and Jacuzzi for 6 · 1 hour from CDMX

House with pool and Jacuzzi for 6, 1 hour from CDMX. Immerse yourself in this private oasis: pool for the day, jacuzzi for the night, charcoal grill and bar to share with your loved ones. 3 bedrooms, 5 bathrooms, ideal for families, groups of friends or celebrations where you want to disconnect without driving for hours. Located in Santa Cruz Tlaxcala, 25-30 minutes from Puebla. The perfect place for laughter, good food, and nights under the stars.

Guest favorite
Home in San José Tetel
4.92 out of 5 average rating, 25 reviews

5 minutes from the High-Performance Deportiva de Alto Rendimiento (High Performance Sports Complex)

Stay in this spacious and cozy house, ideal for you or your family, in a quiet, safe, and private residential development in the heart of Apizaco. Central location to explore iconic places such as: Huamantla, La Trinidad, La Malinche volcano, Cacaxtla archaeological zone, Firefly Sanctuary, Barca de la Fe and more! 5 minutes from Plaza de Toros and Ciudad Deportiva, and 8 minutes from downtown Apizaco. “Book now and enjoy a most pleasant stay”

Guest favorite
A spacious sleeping area features a wooden four-poster bed with soft gray bedding. Natural light fills the room through large windows, framed by minimalistic light fixtures. A small table and chair are positioned beside the window, offering a serene view of the surrounding greenery.
Loft in Santa Agueda
4.98 out of 5 average rating, 141 reviews

Exclusive Penthouse, Val`Quirico

Perfect romantic escape for couples or solo travellers looking to unwind and relax. The private penthouse apartment is just a five minute walk away from the heart of Val’Quirico, includes free parking and a fully equipped kitchen. The private terrace is perfect for romantic dinners, star gazing and has amazing views of the Malinche mountain where the sunrises. An ideal space to recharge, celebrate love and enjoy an unforgettable experience.

Guest favorite
Cottage in Santa Cruz Tlaxcala
4.92 out of 5 average rating, 39 reviews

Spectacular Ranch 5 minutes from Trinidad IMSS

Bring the whole family to this fantastic place, enjoy the tranquility of nature, without leaving aside the fun both outside and inside, with the bar, pool table or movie night! Relax at this ranch located in the municipality of Santa Cruz Tlaxcala. Enjoy the views from the hillside, walk around the property, or visit the La Trinidad Holiday Center. At night, immerse yourself in the incredible views of the galaxy in the open field.

Guest favorite
A decorative stone fountain features a multi-tiered design, with flowing water cascading down. Surrounding the fountain are vibrant red poinsettias in black planters, creating a welcoming focal point in the outdoor space.
Home in Apizaco Centro
4.94 out of 5 average rating, 215 reviews

AMAZING "CASA CARMELA" in the center of Apizaco

THIS SPACE FOLLOWS AIRBNB'S ADVANCED CLEANING PROTOCOL. Cozy and wonderful 1-story house, located in downtown Apizaco. Excellent location a few blocks from restaurants, bars, convenience stores, cinema, among others. The house has excellent essential services (Internet, Netflix), as well as a garage (5.0 meters long) for a small or medium-sized sedan or SUV. We accept small or medium-sized pets; large pets with prior approval.

Guest favorite
A living area features comfortable black sofas arranged around a coffee table. Natural light fills the space, highlighting the minimalist decor. A doorway leads to a kitchen area, with cabinetry and an organized layout visible in the background.
Apartment in San Miguel Contla
4.8 out of 5 average rating, 50 reviews

Comfortable apartment with an excellent view

Cozy, quiet and luxurious apartment, ideal for family and friends who come to visit "located 3 minutes from the Trinidad Vacation Center, 5 minutes from Apizaco Centro, 15 minutes at the foot of Volcán la Malinche and 20 minutes from Huamantla" Excellent view and location ! Don't think about it and take advantage of your stay !

Guest favorite
Home in Santa María Atlihuetzian
5 out of 5 average rating, 13 reviews

Malintzi Garden House | Pet Friendly. We invoice

This beautiful accommodation is ideal for weekends with family, friends or as a couple, large garden with barbecue for gatherings and children's games, everyone will enjoy the beautiful view of the Malintzi, in addition to all the comforts of a charming, relaxing place full of harmony with nature.

Guest favorite
Home in San Juan Totolac
5 out of 5 average rating, 9 reviews

Bruma House. With garden, firepit for up to 8 gest

A retreat designed to disconnect and unwind. Casa Bruma blends spaciousness, design, and a peaceful setting—perfect for group getaways. The garden and fire pit create a warm space to relax and gather. Accommodating up to 8 guests, it offers comfort and privacy for families or friends.

Guest favorite
Apartment in Santa Ana Chiautempan
4.91 out of 5 average rating, 11 reviews

Apartment near downtown.

Comfortable apartment close to downtown and expressways. Enjoy a comfortable stay in this apartment. It's an ideal place for those looking for flexibility and a functional space.

Popular amenities for Santa Cruz Tlaxcala vacation rentals

  1. Airbnb
  2. Mexico
  3. Tlaxcala
  4. Santa Cruz Tlaxcala