Vacation rentals in Santa Cruz

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness, and more.

0 of 0 items showing

1 of 3 pages

Guest favorite

The image captures a serene sunset over calm waters, with two symmetrical volcanoes silhouetted against a vibrant orange sky. The sun descends slowly, reflecting golden hues across the water's surface, creating a tranquil atmosphere.

Guesthouse in San Fernando

4.96 out of 5 average rating, 52 reviews

Bungalow 3 guests-Casa Hernandez-Beach Access-Wi-Fi

Serene Beach Sunrises & Magical Tranquil Sunsets on Ometepe! Private Bungalow w/WiFi, clean bedroom & bathroom w/warm water showers! Patio w/hammock, table, seating - gardens - beach front property = longest stretch of sandy beach between 2 volcanoes on paved Main Road. Beautiful carved wood/glass door & windows - all screened w/metal bar protection plus ceiling fan. Natural wood ceiling & furniture with 1 dbl & 1 single bed. Ceramic tiled. Parking/Daily Housekeeping! Meals/laundry extra. Tours

Guest favorite

A cozy cottage is nestled among lush greenery, featuring a red-tiled roof and wooden shutters. A small outdoor seating area with two chairs is visible on the porch, surrounded by tropical plants. The natural setting provides a serene and inviting atmosphere.

Home in El Madroñal

4.91 out of 5 average rating, 33 reviews

Rustic AC Oasis on Ometepe Island

Escape to this cozy, air-conditioned hideaway on Ometepe Island. Surrounded by lush greenery, the house offers a peaceful retreat with a comfortable bedroom, a well-equipped kitchen, and a spacious bathroom. Relax in the cool, quiet atmosphere and enjoy the natural beauty outside your window. Just a 10-minute walk to El Pital and Bustavo, ideal for couples or solo travelers exploring the island's volcanoes, beaches, and local spots. Feel Ometepe's charm in this inviting, nature-inspired escape.

Guest favorite

A lush green landscape surrounds a red-roofed house, nestled among thriving tropical plants and trees. Various fruiting plants and flowering bushes populate the vibrant garden, indicating an organic environment. A hint of distant hills can be seen, complementing the serene natural setting.

Farm stay in Balgue

4.97 out of 5 average rating, 112 reviews

Finca Ometepe - The Hummingbird House

Wake up in Balgüe to fresh breezes, sweeping volcano views, and the sounds of farm life. The Butterfly House is a cozy, solar-powered hilltop retreat with A/C, fast Wi-Fi, and hammocks for lazy afternoons. Watch goats and donkeys graze just beyond your porch, pick fresh tropical fruit in season, and enjoy the outdoor shower under the open sky. This eco-friendly farm stay is perfect for nature lovers, families, and digital nomads seeking comfort, privacy, and a genuine Ometepe experience.

Top guest favorite

The image captures a tranquil lakeside scene at dusk, with a large volcano rising in the background. Soft sunlight filters through the clouds, illuminating the landscape and reflecting on the water surface. The shoreline is dotted with greenery, creating a serene atmosphere.

Cottage in Santa Cruz

4.99 out of 5 average rating, 80 reviews

Bella Beach Casita on Ometepe w/kitchen, warm H20!

Private clean comfy tranquil secure w/lots of screened windows w/security bars, kitchen, fast WiFi w/router, warm H20 shower, ceiling fan/wall fan, organic gardens surrounded by a volcanic rock wall w/a step to longest stretch of sandy beach. Central location on paved Main Road Santa Cruz - near produce stalls/shops/restaurants. Pre-travel info, tours, hikes, taxis, activities. Thank you for supporting our local beach clean-ups & donations to our community efforts. 3 night minimum stay.

Top guest favorite

A modern home is set within a lush green landscape, featuring well-maintained gardens. The exterior showcases a red-tiled roof, large windows, and a welcoming entrance adorned with two Madero Negro tree posts. A hammock is visible on the porch, inviting relaxation.

Home in Balgue

4.99 out of 5 average rating, 134 reviews

Casa Del Lago, Luxurious Beautiful Lakefront Home!

** MAXIMUM 6 GUESTS,THIS INCLUDES CHILDREN, NO EXCEPTIONS, STRICT POLICY* Style & comfort are evident in every aspect of our 2 bedroom,2 bathroom new luxurious home. Our waterfront location has stunning views of Concepcion & Maderas Volcanos. We are nestled in Maderas National Park, the surrounding lush areas add to the natural beauty. We offer modern amenities, free high speed internet/wifi (we cannot guarantee uninterrupted service), tv, hot water, air conditioning and ceiling fans.

Top guest favorite

A cozy interior showcases a spacious bed adorned with a colorful patterned blanket. A dining area with wooden chairs is visible, along with a fully equipped kitchen featuring a refrigerator. Soft natural light enters through bamboo windows, enhancing the warm ambiance.

Cabin in Balgue

5 out of 5 average rating, 13 reviews

The Bamboo Lake Cabin

Offering edible gardens and lake views, Bamboo Cabins is located in Balgue, 1.5 km from Maderas Volcano. This beachfront property offers access to a patio, free private parking and free WiFi. Guests can use the sun terrace or enjoy mountain and lake views. The units have a fully equipped kitchen with a dining area, refrigerator, blender, coffee maker and kitchenware. The rooms have a private bathroom with a hot shower and a living room. The cabin is equipped with bed linen and towels.

Guest favorite

A unique cabin structure with a triangular roof sits amidst lush greenery. Large windows enhance natural light inside, and a stone path leads up to the entrance. Surrounding foliage includes vibrant plants and trees, providing a peaceful natural ambiance.

Dome in Ometepe

4.96 out of 5 average rating, 26 reviews

Magical cabin on Ometepe

A cute little cabin set in the wild lush nature of Ometepe Island. Located on a family organic homestead, with peaceful views of Conception volcano and the sunset on the lake. Enjoy your own private and quiet space, with a comfortable king size bed, outdoor shower with hot water and stunning view and your own compost toilets. Cook your meals in the farm kitchen. Seasonal greens, herbs and local organic farm products such as honey and yogurt are available to purchase for your meals.

Top guest favorite

A spacious sleeping area features a minimalist design with light-colored walls and a built-in bed frame. Natural light enters through a nearby window, complemented by a ceiling fan. A simple art piece hangs above the bed, while a adjoining bathroom is visible in the background.

Tiny home in Rivas

4.96 out of 5 average rating, 137 reviews

Casita # 3 With Kitchen on Lakefront Property

Ometepe Casitas - Cabin with private Kitchen on peaceful and beautiful lakefront property in El Peru, Ometepe. Guest can swim at the calm beach and enjoy stunning views of both the Maderas and Concepcion Volcanoes, rent a kayak and paddle up to the Istian river, Rent a scooter and explore the rest of the island or just sit back and relax at the beach or terrace and see the sunset while watching monkeys and hundreds of birds and parrots flying back home to our neighboring trees.

Guest favorite

A cozy sleeping area features a wooden bed draped with a mosquito net. The walls are painted in earthy tones, complemented by colorful wall art. Natural light streams through windows adorned with vibrant curtains. A standing fan and a mirror are also visible in the space.

Tiny home in Santa Cruz

4.92 out of 5 average rating, 12 reviews

Finca Aisa: boutique bungalow in Ometepe island

A charming bungalow retreat nestled between two of the island’s most popular beaches, Playa Santo Domingo and Playa Mangos. Enjoy a fully equipped kitchen, a cozy double bed with a mosquito net, and a private bathroom with hot water. Relax on the spacious patio with hammock and volcano views, ideal for unwinding. With high-speed internet, ample outlets, solar lighting, on-site parking, and optional scooter rentals, we offer convenience and tranquility for an unforgettable stay.

Guest favorite

A rustic wooden cabin features a charming porch with two wooden chairs and a small table. Natural light filters through the windows, and lush greenery surrounds the structure. Decorative string lights hang above, enhancing the inviting outdoor space.

Cabin in Escamequita

4.95 out of 5 average rating, 19 reviews

Surfers Paradise - Las Planadas Cabin Yankee Beach

in the heart of the village of Escamequita, our rustic cabin offers a unique escape surrounded by nature. This cozy cabin is where you can disconnect from the city life and reconnect with the beauty of the natural world. Our rustic wooden cabin is designed to harmonize seamlessly with the lush surroundings. Inside, you'll find a comfortable sleeping area and a well-equipped kitchen. Check our project and the beauty of the complex through youtube at Las Planadas de Escamequita.

Top guest favorite

The eco cabin is surrounded by tropical greenery, with woven palm fronds covering the exterior. Large windows allow natural light to enter, while vibrant plants and flowers are visible in the foreground, creating a harmonious connection with nature.

Cabin in Rivas

4.96 out of 5 average rating, 98 reviews

Ometepe cozy lakefront cabin

Disconnect from your worries in this spacious, magical place full of peace, right on the shores of Lake Cocibolca 🌊🌿. Breathe fresh air, listen to the waves from your eco-cabin, and let your body, mind, and heart deeply relax 😌🛏️. Breakfast included 🥣☕, with lunch and dinner options available 🍽️. Excellent WiFi 🛜. Get all the info you need about the island 📍. Located on the beautiful and unique Ometepe Island 🏝️. We welcome you with an open heart! ❤️ — Toño & Ledis

Top guest favorite

A person is seen relaxing in an infinity pool, gazing over a coastal landscape featuring rocky cliffs and a distant island. The tranquil water reflects the soft colors of the sky at dusk, surrounded by lush greenery and trees framing the serene view.

Home in Rivas

4.86 out of 5 average rating, 249 reviews

Shankton Harbour 3BR/4Bed/4BA w Private SEA path

This amazing house is truly one of a kind. Modern luxury with your own PRIVATE sea shelf! Modern designed house with full amenities package including pool, private beach, yoga platform access, sea shelf fishing and more! A spectacular location near many famous surfing breaks (Colorado, Amarillo, San Juan, Popoyo, etc). The house also includes options for private yoga, massage, surf lessons, deep sea fishing excursions, and even private transportation by land or sea!