
Vacation rentals in Santa Cruz Mixtepec
Find and book unique accommodations on Airbnb
Top-rated vacation rentals in Santa Cruz Mixtepec
Guests agree: these stays are highly rated for location, cleanliness, and more.

Apartment with terrace and view – Xochimilco neighborhood
Bienvenidos a su hogar en el barrio más antiguo y pintoresco de Oaxaca, nuestro departamento de 2 habitaciones combina la tranquilidad de Xochimilco con todas las comodidades para que solo se preocupen por disfrutar. *Detalles que importan: cocina equipada, café local de cortesía, agua purificada, Wi-Fi de alta velocidad. *Terraza privada para relajarte tras un día intenso. *Ubicación premium, camina entre las calles empedradas, acueductos, talleres. Estamos a 12 minutos a pie de Santo Domingo.

Casa Besos loft 1, tub and garden, St Domingo area
Discover your refuge in the heart of Oaxaca. Casa Besos offers lofts and villas with vernacular design, steps from the Santo Domingo Temple, with the comfort of a boutique hotel and the authentic charm of the city. Want to relax? Enjoy your outdoor tub under the stars. Would you rather explore? All the folklore, gastronomy, art and culture are just a few steps away.” "DON'T FORGET TO SEE MY OTHER BOUTIQUE ACCOMMODATIONS IN MY PROFILE, (LOFTS and VILLAS) steps from the Santo Domingo temple".

Alebrije Loft, Center of the City, "Merced house"
Bonito Mini Loft, ubicado a cuatro calles de la plaza principal de la ciudad. En la zona mas tranquila del centro histórico. Disfruta de la comida tradicional de la ciudad, de los lugares mas emblemáticos del centro, Santo Domingo, catedral, mercados tradicionales, museos, comida tradicional, a solo unas calles del alojamiento. En la casa observaras otros alojamientos y viajeros que al igual que tu disfrutan de la tranquilidad de la casa. Disfruta la hermosa decoración con artistas locales.

Casa MaryFer
Casa MaryFer is located 1.5 km from Oaxaca City's International Airport and 10.3 km from the city's Zócalo and Santo Domingo church. What sets it apart is that it is located in the tranquility of a picturesque village, as well as the friendliness of its people and their traditions. The Mexican-style decoration offers its guests the comfort and friendliness of "being at home", in addition to having a temazcal bath for 6 people and therapeutic massages (at an extra cost and by appointment).

Magical Restored house, KS Bed/AC in Oaxaca heart
Step into CASA Espíritu Fuego, where the spirit of Oaxaca is reimagined through thoughtful design and handcrafted beauty. Earthy textures, native clay, and woven textiles tell stories in every corner. Located just 3 blocks from Santo Domingo, the city’s best galleries, fine dining, and cultural gems unfold at your doorstep. You’ll be immersed in the city soul where art, cuisine, and vibrant culture await. A curated stay for the discerning traveler seeking authenticity and beauty. .

Cabin 1 on the mezcal route
Cabin with sleeping platform and terrace viewpoint located on the mezcal route. While you rest, enjoy the scenery of the agave fields, mountains, and stars. Outside there is a shared kitchen that you can use to prepare your own food. The cabin is located on the international highway that connects the capital with tourist places such as Tlacolula de Matamoros, Mitla or Hierve el Agua. All kinds of public transportation pass by on the road: bus, van, or taxi.

Casa Zá - Modern home, Gardens, A/C
Architect-designed home, a collaboration with architect Daniel Lopez Salgado. The thoughtfully planned layout, soaring ceilings and abundant light create a calming atmosphere, perfect for unwinding after a day of exploring. 15-minute taxi/car ride from Oaxaca Centro, our home offers a perfect balance of tranquility and accessibility. While you won't find tourist spots nearby, you'll be able to find flavors of Oaxaca at local family owned restaurants nearby.

The House of Don Mario /November 20. Downtown
Located on one of Oaxaca's main streets, "La casa de don Mario" is close to everything Oaxaca is a walkable city, and having a lodging space downtown is a great plus. Staying in an old house that is part of the city's history is a privilege. Decorated with furniture made from parts of the old oil factory and rebuilt while bearing in mind the idea of a vintage atmosphere, the house has many features to enjoy Oaxaca and its heart full of flavor and color.

Perfect Peacefull Bungalow
Beautifully decorated rustic bungalow nested in a quiet location 20 minutes drive from downtown Oaxaca. In this peaceful location you will be able to enjoy spectacular views while finding everything you need within walking distance: local restaurants, nature hikes and abarrotes. Our bungalow is the perfect place for those seeking to spend a few days in the Oaxaca Valley, getting to know all the beautiful pueblos while staying away from tourist crowds.

Sweet Studio downtown
Nice little studio with air conditioning two blocks from the Zócalo of the city. Walk to all attractions in 10 minutes. The place is nicely furnished with simple Oaxacan charm. Everything is provided. Please note that since it is in a restaurant area there might be some noise at night... We do have double glazed windows, however it is not recommended for light sleepers (hence we kept the reasonable price for this list)...

Apartment with balcony and breakfast included
An authentic home where you'll feel like family. Wake up to homemade breakfasts on our terrace overlooking the mountains and let yourself be guided by local tips. Ideal location: a quiet neighborhood just a 10-minute walk from the city center. Enjoy comfortable beds, fast Wi-Fi, and unparalleled warmth. A space full of color, light, and peace, designed for experiencing Oaxaca like a local.

From Marijo
Located on the rooftop of our home, this charming apartment is the ideal retreat for one couple or up to three people looking for rest and privacy in Oaxaca. Enjoy wonderful views of the Cerro de Oaxaca, unforgettable sunsets and an atmosphere full of calm. Every detail is designed for you to live a comfortable and special stay. A loft for perfect rest and relaxation
Popular amenities for Santa Cruz Mixtepec vacation rentals
Other great vacation rentals in Santa Cruz Mixtepec

Casa Rufina in the historic center of Oaxaca

Casa Matus Oaxaca. Beautiful house

Zócalo apartment 4 blocks away, patio, garden, fast Wi-Fi

Wonderful King Suite Great Location| Free mini bar

Mid Century Studio

Cantarranas Ranch

Rooftop Glass House in Old Town/Jalatlaco

Casa Chole
Destinations to explore
- Mexico City Vacation rentals
- Puerto Escondido Vacation rentals
- Acapulco Vacation rentals
- Oaxaca Vacation rentals
- Puebla Vacation rentals
- Valle de Bravo Vacation rentals
- Tepoztlán Vacation rentals
- Cuernavaca Vacation rentals
- Santa María Huatulco Vacation rentals
- San Cristóbal de las Casas Vacation rentals
- Veracruz Vacation rentals
- Veracruz Centro Vacation rentals
- Hierve el Agua
- El Llano
- Oaxaca Artisan Market
- Museo Textil de Oaxaca
- Basilica De Nuestra Senora De La Soledad
- Instituto de Artes Gráficas de Oaxaca
- Zona Arqueológica Mitla
- Teatro Macedonia Alcala
- Templo Santo Domingo de Guzman
- Museo de Filatelía
- Centro Cultural San Pablo
- Jardin Etnobotanico
- Mercado Sanchez Pascuas
- 20th November Market
- Museum of the Cultures of Oaxaca
- The Plaza de la Constitución
- Museo de los Pintores Oaxaqueños
- Tree Of Tule
- Mercado Benito Juarez
- Auditorio Guelaguetza
- Catedral de Oaxaca
- Jacobo And María Ángeles
- Zona Arqueológica Monte Albán
- Mercado Municipal Martín González





