Vacation rentals in Santa Ana

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Top-rated vacation rentals in Santa Ana

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite

A captivating view of the Apoyo Lagoon is displayed, framed by lush greenery and vibrant flowers. The water reflects a clear blue sky dotted with clouds, while the surrounding mountains create a serene backdrop. A hint of the infinity pool's edge can be seen in the foreground.

Home in Apoyo Lagoon

4.9 out of 5 average rating, 105 reviews

Casa Castillo: Million Dollar View Of Lake Apoyo

This property is truly one of a kind. We’d love for you to experience both the breath taking view outside and the Spanish revival elements of the house inside. Located on the northwest rim of an extinct volcano in the Apoyo Lagoon Natural Reserve, the view is...spectacular! Looking out from the Castillo terrace, in front of you lies the ancient volcanic Apoyo lake. In the distance, you can see the Mombacho volcano, Lake Nicaragua, the city of Granada and the Isletas ,and sometimes Concepcion.

ValueFamilyBathroom

Top guest favorite

A spacious terrace features two comfortable lounge areas, framed by floor-to-ceiling glass doors that open to reveal serene lake views. The infinity pool reflects the sky, surrounded by lush greenery, creating a seamless transition between indoor and outdoor living.

Island in Isletas de Granada

4.95 out of 5 average rating, 62 reviews

A Private Island on Lake Nicaragua — Just For You

The Whole Island is Yours to Enjoy Just 10 minutes by boat from the UNESCO World Heritage city of Granada, this breathtaking private island villa on Lake Nicaragua is yours to enjoy exclusively. Completely secluded and surrounded by tropical beauty, it’s a luxurious retreat for up to 8 guests— perfect for couples, friends or family. Relax, reconnect and create unforgettable moments together. Our team handles everything for you. - Infinity Pool - Lakeside Yoga - Hanging Bed - Massages

LocationFamilyLong stay

Guest favorite

A bamboo-roofed pavilion rests on a wooden deck overlooking the tranquil waters of Laguna de Apoyo. Vibrant flowering plants surround the area, blending with the natural landscape, and hills can be seen in the distance beneath a soft morning light.

Villa in La Laguna Número 1

5 out of 5 average rating, 28 reviews

Casa del Alma – Private Oasis on Laguna de Apoyo (Support Lagoon)

Casa del Alma is a 4-bedroom Laguna front sanctuary crafted by Driftwood Homes & Rentals. Designed for soul-deep rest and reconnection, it offers open-air living, an infinity pool, yoga deck, beach volleyball court, dock, and panoramic views of Laguna de Apoyo. Grounded in nature, elevated by design—this space invites you to slow down, stretch out, and settle into the rhythm of Laguna life. Ideal for families or friends. Please note: retreats, events, or group hosting are not permitted.

FamilyLocationOutdoor spaces

Top guest favorite

Aerial view of Isla Mirabel, surrounded by the serene waters of the lake, with lush greenery and fruit trees visible. The imposing Mombacho volcano stands majestically in the background, and a variety of boats can be seen dotting the water, enhancing the natural beauty of the area.

Island in El Encanto

5 out of 5 average rating, 69 reviews

Unique private island experience close to center!

Isla Mirabel is located less than 5 minutes from Marina Cocibolca and 10 min from the colonial Granada. The island is full of exuberant flowers and fruit trees and has and a beautiful view of the Mombacho volcano. The glass house blends in with the trees, providing privacy for your stay. Swim, kayak, or simply enjoy the beautiful surroundings. Transportation at check in and out is included. Extra transportation is $6 round trip. There are 3 restaurants right there at the port.

ValueFamilyView

Superhost

The image features a serene courtyard with a bright swimming pool surrounded by vibrant greenery. Majestic palm trees and lush plants are seen, complemented by decorative tiles. Comfortable seating areas are arranged nearby under archways, inviting relaxation and leisure.

Home in Granada

4.86 out of 5 average rating, 164 reviews

Casa La Sultana - Your luxury home away from home.

Casa La Sultana is your luxury home in the heart of the beautiful colonial city of Granada, Nicaragua. The villa has four spacious air-conditioned bedrooms with ensuite bathrooms, a fully equipped kitchen and a beautiful swimming pool. It's located just a short stroll away from the main city square and numerous restaurants. The open-living concept creates a wonderful, intimate atmosphere, connecting all guests both inside and outside, which is especially appreciated by families.

ValueFamilyTV

Guest favorite

An aerial view of the property showcases a spacious infinity pool surrounded by tiled patio areas. The main house, featuring a rustic tile roof, is visible alongside landscaped gardens with vibrant flowering plants. A shaded outdoor dining area is positioned next to the pool.

Home in Apoyo Lagoon

4.93 out of 5 average rating, 123 reviews

Luxury Waterfront @ Laguna de Apoyo

Waterfront property located at Laguna de Apoyo. Relax in the infinity pool or take a swim in the lake where you will find hot thermals nearby. 2 kayaks & 24 hour security. High speed wireless network and cable TV. Separate A/C units are in each bedroom. Due to extremly high cost of electricity, the price includes A/C from 10pm to 7am. Additional A/C service is $20/day. There is a casita also located on the property that is occupied at times with shared driveway access.

LocationValueWifi

Guest favorite

A serene courtyard features a custom-tiled pool, surrounded by lush tropical greenery. Two lounge areas with striped cushions are positioned beside the pool, complemented by vibrant plants adding depth to the tranquil setting.

Home in Granada

4.94 out of 5 average rating, 175 reviews

Casa Violeta: Private Retreat in Colonial Granada

As seen in Architectural Digest, Condé Nast Traveler and Domino Magazine, Casa Violeta provides escape, peace, and tranquility in Granada's tropical, Spanish-Colonial town. Every booking includes access to highly curated travel tips and recs provided by the founder of El Camino Travel, Katalina Mayorga. Armed with her knowledge, you'll have direct access to one-of-a-kind experiences not available anywhere else and discover hidden gems to visit in this stunning country.

LocationFamilyCheck-in

Guest favorite

An aerial view captures the serene waters of Laguna de Apoyo, bordered by lush green forests. A small section of the secluded coastline is visible, with gentle waves caressing the shore. The vibrant foliage encompasses the villa, blending harmoniously into the natural landscape.

Villa in Apoyo Lagoon

4.95 out of 5 average rating, 100 reviews

Large Villa for Families or Groups Laguna de Apoyo

Villa Laguna is an exclusive private villa located in a secluded area of the Laguna de Apoyo Natural Reserve, offering families and groups of up to 22 people the opportunity to relax and enjoy one of the most beautiful parts of the lagoon. We specialize in retreat and group experiences, so if you are interested in that kind of stay, we can also offer meals, transport and tours services for an additional cost. Let us know, thank you!

ValueLocationKitchen

Guest favorite

A tranquil pool reflects clear blue water, framed by lush green tropical plants. Arched entryways lead to a seating area with minimalist furniture, enhancing the serene atmosphere created by the light-colored walls and natural stone flooring.

Home in Granada

4.97 out of 5 average rating, 112 reviews

Bao Bei : Wabi Sabi Colonial Villa

Welcome to Bao Bei, a 1930's colonial villa, meticulously restored with a minimalist, wabi sabi aesthetic. Located in the historic centre of Granada, Bao Bei is short walk away from all of Granada's attractions. Lose your sense of time exploring the colonial streets of Granada, or just lay back in your own private oasis. Bao Bei allows you to immerse yourself in Nicaraguan culture while experiencing unparalleled style and luxury.

FamilyLocationQuiet

Superhost

Cabin in Catarina

5 out of 5 average rating, 3 reviews

Villa Laguna Azul facing the Apoyo Lagoon

Welcome to Villa Laguna Azul Nicaragua, a retreat facing the beautiful Laguna de Apoyo. Our private cabins are designed for those seeking tranquility, nature and comfort. Enjoy direct access to the lagoon, kayak use, Wi-Fi, parking and a delicious Creole breakfast. Wake up to spectacular views, relax in a unique natural setting, and enjoy an unforgettable experience in one of the most beautiful destinations in Nicaragua.

Indoor spacesHospitalityAmenities

Superhost

A private pool is surrounded by lush greenery and vibrant flowers, creating a serene outdoor space. The swimming area is framed by yellow walls, complementing the traditional clay tile roof. Nearby, a covered patio area offers additional seating and relaxation opportunities.

Villa in Granada

4.8 out of 5 average rating, 125 reviews

Colonial Home Private Pool, Best Location, and AC

Your private oasis in the heart of Granada awaits! Stay in our historic colonial home, completely independent with fully private spaces. Relax in your private pool, enjoy the best location in town, and unwind with air conditioning in every room. Benefit from on-demand cleaning, night security, and personalized attention with direct contact. Book now and experience the charm of Granada like never before!

FamilyLocationTV

Superhost

Island in Las Isletas de Granada

4.91 out of 5 average rating, 11 reviews

Private Island in Granada | Kayak + Nature

Discover a charming island retreat that welcomes everyone. Our accommodation offers relaxing activities for families to have fun and enjoy a healthy environment for couples, exciting water sports for adventurers and immersive cultural experiences for curious minds. Whether you're looking for relaxation, adventure, or connection to nature, our island paradise has it all. Your dream getaway is here!

LocationFamilyAir conditioning