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Vacation rentals in Santa Ana

Find and book unique accommodations on Airbnb

Quick stats about vacation rentals in Santa Ana

  • Total vacation rentals

    Explore 90 vacation rentals in Santa Ana

  • Nightly prices starting at

    Santa Ana vacation rentals start at G$6,249 GYD per night before taxes and fees

  • Verified guest reviews

    Over 1,190 verified reviews to help you choose

  • Family-friendly vacation rentals

    50 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 50 rentals that welcome pets

  • Rentals with dedicated workspaces

    20 properties have a dedicated workspace

  • Wi-Fi availability

    40 of Santa Ana vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Santa Ana rentals

  • 4.7 Average rating

    Santa Ana stays receive an average rating of 4.7 out of 5 from guests

Top-rated vacation rentals in Santa Ana

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
Home in Pan de Azucar
5 out of 5 average rating, 34 reviews

"Arrayanes de las Ánimas" Chakra

Located in the heart of the Sierras de las Ánimas, this country house is perfect to disconnect and enjoy nature. It sleeps up to 7 people and features 3 bedrooms, 2 bathrooms (one en suite), a barbecue, an outdoor Nordic bath, a fire pit under the stars, and a pergola with dining and lounge space. It also has a kids’ outdoor play area. Surrounded by native plants and wildlife, it's ideal for hiking and relaxing with family or friends. Come experience the Uruguayan countryside like never before!

Top guest favorite
A vibrant sunset paints the sky in shades of orange and purple, reflected across the calm river surface. Silhouettes of trees line the horizon, while a small sailboat is anchored nearby. A wooden dock extends into the water, creating a serene focal point.
Home in Solís
5 out of 5 average rating, 36 reviews

Riverfront Home Near Beach in Solis

Relax with family at our peaceful paradise on the river. Our home sits on a huge garden right on the Arroyo Solís Grande. Especially tall trees provide ample shade and lots of pine cones for starting the BBQ or fireplace! With direct access to the river and a private dock, you can enjoy river activities, or walk 500m to the beach. Enjoy the sunset from the enclosed or outside terraces while you enjoy your Uruguayan BBQ! A modern kitchen and multiple living rooms make it perfect inside or out.

Guest favorite
A unique dome-shaped structure is set amidst natural greenery, featuring large glass windows that blend with the exterior. The minimalist design includes a black base that elevates the dome above the ground, offering an unobstructed view of the surrounding landscape and sky.
Dome in Nueva Carrara
5 out of 5 average rating, 5 reviews

Loft Dome in Piedra de las Ánimas

Domo Loft designed for comfort and connection with nature, equipped with a king size bed in a spacious space and an integrated living-dining room with kitchen and tatami. The windows offer stunning views of the mountains. The kitchen has an under-counter refrigerator, a stove, a dining table with chairs, and all the necessary equipment (dishes and utensils). It includes a full bathroom, wood-burning stove, outdoor grill and a deck with pergola, ideal for relaxing in the Paraguayan hammock.

Guest favorite
Home in Santa Ana
4.93 out of 5 average rating, 14 reviews

Beachfront house with a view of the hills

Beautiful house on the Rambla with a unique view of the ocean and the hills of Piriapolis. The location allows you to see the sunrise and sunset over the sea in summer. The main house has a living room with a large window facing the beach and a high-performance wood-burning stove. Semi-integrated kitchen with exit to the barbecue. The barbecue is spacious and covered and has a grill and a wood oven for pizza. 15 minutes from Piriapolis and 30 minutes from Punta del Este.

Top guest favorite
Tiny home in Sauce de Portezuelo
4.98 out of 5 average rating, 93 reviews

BondiHouse - Converted Bus

Welcome to BondiHouse! A space we built with lots of love and care. ** Adults-only accommodation ** Perfect for romantic getaways 😍 This tiny house is ideal for disconnecting, relaxing, and enjoying the peace of nature and all its comforts. We invite you to experience a stay full of unique details and amenities, thoughtfully designed with a boutique feel—where you won’t miss a thing. Every corner was crafted with love so you feel right at home… or even better. ✨

Top guest favorite
Cabin in El Edén
5 out of 5 average rating, 12 reviews

Spectacular cabin in the Edén mountains

Arrayán cabin in Finca María Justa, Pueblo Edén, 45 minutes from Punta del Este. On a 15-hectare property. Great for couples. It has 2 bedrooms. Designer retreat to experience the slow rhythm: silence, nature and peace. Open views of the mountain landscape and sunset. Access to the stream with natural pool, trails in the native forest and art gallery. Jacuzzi under the stars, surrounded by farm animals and birdsong. A well-kept experience, designed for rest.

Top guest favorite
An open living area is presented with large windows allowing natural light to fill the space. A seating area features a wooden couch with orange cushions and a coffee table. A dining table with wicker chairs and a decorative bowl completes the inviting setting.
Home in Playa Verde
4.97 out of 5 average rating, 106 reviews

Playa Verde is 70 meters from the sea. Panoramic.

House 70 meters from the beach, on a street with access to the beach. Bright, spacious, airy, with ocean views, sunset and sunrise to enjoy every day. Two bedrooms and a bathroom on the ground floor. Upstairs, integrated kitchen, dining room and living room plus roofed terrace. Air conditioning in all rooms. Outdoor shower with hot water. More roofed space with grill. Located on 300 meters of land, with several floors and native trees growing.

Guest favorite
A charming house features a sunlit exterior painted in warm yellow, complemented by brown stone accents. A tiled roof adds character, while a wooden fence encloses a lush garden area. Nearby greenery and flowers enhance the inviting atmosphere of this peaceful retreat.
Home in Santa Ana
4.87 out of 5 average rating, 30 reviews

I WANT IT, I CAN DO IT, AND I DESERVE IT!!

Our house is brand new and meets disinfection requirements for an excellent stay. Welcome to MARCOR, located in a strategic area, a minute from the splendor of Piriápolis and about 50 km from Punta Del Este. We have natural waters that make it extremely unique and unparalleled. Santa Ana links the rustic with the harmonious where native animals of the fauna coexist. We also have OSE and UTE connections, which is no small thing.

Guest favorite
Home in Balneario Argentino
4.87 out of 5 average rating, 31 reviews

House with enclosed jacuzzi, pool and barbecue grill

Private ✨ Heated Salt Water Pool October-May ♨️ Private Jacuzzi to enjoy and relax in Roofed 🍽️ grill and outdoor furniture 🚗 Parking 📶 WiFi 📺 -Smart TV 40” with Netflix, Disney+ Full 👩‍🍳 kitchen microwave, coffee maker, toaster, blender, blender and electric jug ❄️ A/C 🛏️ Bed linens and towels included 🏐 Volleyball Court 🧺 Washing machine 🚿 Outdoor shower. 💇‍♀️ Hair dryer 👕 Iron 🧴shampoo, rinse cream

Guest favorite
An illuminated restored train car is set against a star-filled night sky. The spacious interior is visible through the open doorway, showcasing a cozy living space. The surrounding landscape is dark, emphasizing the vibrant celestial display above.
Cottage in Sierra de las Ánimas
4.92 out of 5 average rating, 119 reviews

"Sierras de Leskem", - Sierras de Maldonado (Maldonado Mountains)

Sierras de Leskem is a nature reserve, located in the Department of Maldonado, 30 minutes from Piriapolis and 20 minutes from Minas. Our accommodation consists of an old AFE train car, restored with all amenities, to enjoy tranquility with a spectacular 360-degree view of the mountains. We also have other lodging options that you can visit through networks. Comfortable place, surrounded by lots of peace and quiet.

Top guest favorite
A bright living area is highlighted by large windows offering views of lush greenery and the ocean. Two comfortable armchairs and a sofa are arranged around a coffee table, while a dining table for four sits nearby. Floral decor adds a touch of elegance.
Home in Araminda
4.94 out of 5 average rating, 97 reviews

Beautiful house with ocean views

Relax in this unique and quiet getaway. Fall in love with this place like we did. Enjoyable in summer for its beaches and also in winter for its tranquility, incredible views and its bio diversity that surprises you when you see hares, apereases, birds of all kinds including vultures and eagles. We think about enjoying it year-round. Accommodation for adults (except for teenagers 13 years of age and older)

Guest favorite
A modern cabin is positioned on a wooden deck, surrounded by lush greenery. The structure features large windows that invite natural light, showcasing a minimalistic interior. Two outdoor chairs and a small table are arranged on the deck, completing a serene outdoor space.
Place to stay in Piriápolis
4.95 out of 5 average rating, 111 reviews

Las Quicas - Terraces by the sea

Our location between hills and ocean views creates a feeling of peace and incomparable natural charm We are 5 minutes away from Piriapolis and 20 minutes away from Punta del Este, passing through beautiful beaches such as Punta Colorada and Punta Negra With an increasingly interesting gastronomic and entertainment offer ready to be discovered!

Popular amenities for Santa Ana vacation rentals

When is the best time to visit Santa Ana?

MonthJanFebMarAprMayJunJulAugSepOctNovDec
Avg. priceG$14,997 GYDG$14,580 GYDG$13,330 GYDG$12,706 GYDG$10,623 GYDG$12,706 GYDG$12,706 GYDG$12,914 GYDG$12,914 GYDG$12,914 GYDG$12,914 GYDG$14,164 GYD
Avg. temp23°C22°C21°C18°C14°C11°C11°C12°C13°C16°C19°C21°C

Frequently Asked Questions

  • Are there family-friendly vacation rentals in Santa Ana?

    Santa Ana has more than 50 family-friendly stays. Amenities on the property may include high chairs, travel cribs, or strollers.

  • How much does it cost to stay in house rentals in Santa Ana?

    Experience the best of Santa Ana with our house rentals, starting at about $30 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.

  • Are there pet-friendly vacation rentals in Santa Ana?

    Four-legged friends are welcome in Santa Ana. Choose from more than 50 vacation rentals for guests traveling with pets.

  • Are there vacation rentals with a dedicated workspace in Santa Ana?

    Yes! Work meets play with ease at over 20 vacation rentals in Santa Ana featuring dedicated workspaces. Stay connected and productive in your home away from home.

  • Do house rentals in Santa Ana have air conditioning?

    Absolutely! We offer over 30 house rentals with air conditioning in Santa Ana. Enjoy a tailored experience with all the comforts you desire.

  • Do house rentals in Santa Ana have a kitchen?

    Absolutely! We offer over 60 house rentals with a kitchen in Santa Ana. Enjoy a tailored experience with all the comforts you desire.

  • Do house rentals in Santa Ana have wifi?

    Absolutely! We offer over 30 house rentals with wifi in Santa Ana. Enjoy a tailored experience with all the comforts you desire.

  • Do house rentals in Santa Ana have free parking?

    Absolutely! We offer over 50 house rentals with free parking in Santa Ana. Enjoy a tailored experience with all the comforts you desire.

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