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Vacation rentals in Santa Ana

Find and book unique accommodations on Airbnb

Quick stats about vacation rentals in Santa Ana

  • Total vacation rentals

    Explore 90 vacation rentals in Santa Ana

  • Nightly prices starting at

    Santa Ana vacation rentals start at G$6,274 GYD per night before taxes and fees

  • Verified guest reviews

    Over 1,210 verified reviews to help you choose

  • Family-friendly vacation rentals

    50 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 50 rentals that welcome pets

  • Rentals with dedicated workspaces

    20 properties have a dedicated workspace

  • Wi-Fi availability

    40 of Santa Ana vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Santa Ana rentals

  • 4.7 Average rating

    Santa Ana stays receive an average rating of 4.7 out of 5 from guests

Top-rated vacation rentals in Santa Ana

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
Home in Pan de Azucar
5 out of 5 average rating, 34 reviews

"Arrayanes de las Ánimas" Chakra

Located in the heart of the Sierras de las Ánimas, this country house is perfect to disconnect and enjoy nature. It sleeps up to 7 people and features 3 bedrooms, 2 bathrooms (one en suite), a barbecue, an outdoor Nordic bath, a fire pit under the stars, and a pergola with dining and lounge space. It also has a kids’ outdoor play area. Surrounded by native plants and wildlife, it's ideal for hiking and relaxing with family or friends. Come experience the Uruguayan countryside like never before!

Top guest favorite
A vibrant sunset paints the sky in shades of orange and purple, reflected across the calm river surface. Silhouettes of trees line the horizon, while a small sailboat is anchored nearby. A wooden dock extends into the water, creating a serene focal point.
Home in Solís
5 out of 5 average rating, 36 reviews

Riverfront Home Near Beach in Solis

Relax with family at our peaceful paradise on the river. Our home sits on a huge garden right on the Arroyo Solís Grande. Especially tall trees provide ample shade and lots of pine cones for starting the BBQ or fireplace! With direct access to the river and a private dock, you can enjoy river activities, or walk 500m to the beach. Enjoy the sunset from the enclosed or outside terraces while you enjoy your Uruguayan BBQ! A modern kitchen and multiple living rooms make it perfect inside or out.

Guest favorite
A unique dome-shaped structure is set amidst natural greenery, featuring large glass windows that blend with the exterior. The minimalist design includes a black base that elevates the dome above the ground, offering an unobstructed view of the surrounding landscape and sky.
Dome in Nueva Carrara
5 out of 5 average rating, 5 reviews

Loft Dome in Piedra de las Ánimas

Domo Loft designed for comfort and connection with nature, equipped with a king size bed in a spacious space and an integrated living-dining room with kitchen and tatami. The windows offer stunning views of the mountains. The kitchen has an under-counter refrigerator, a stove, a dining table with chairs, and all the necessary equipment (dishes and utensils). It includes a full bathroom, wood-burning stove, outdoor grill and a deck with pergola, ideal for relaxing in the Paraguayan hammock.

Guest favorite
Home in Santa Ana
4.93 out of 5 average rating, 14 reviews

Beachfront house with a view of the hills

Beautiful house on the Rambla with a unique view of the ocean and the hills of Piriapolis. The location allows you to see the sunrise and sunset over the sea in summer. The main house has a living room with a large window facing the beach and a high-performance wood-burning stove. Semi-integrated kitchen with exit to the barbecue. The barbecue is spacious and covered and has a grill and a wood oven for pizza. 15 minutes from Piriapolis and 30 minutes from Punta del Este.

Top guest favorite
Tiny home in Sauce de Portezuelo
4.98 out of 5 average rating, 92 reviews

BondiHouse - Converted Bus

Welcome to BondiHouse! A space we built with lots of love and care. ** Adults-only accommodation ** Perfect for romantic getaways 😍 This tiny house is ideal for disconnecting, relaxing, and enjoying the peace of nature and all its comforts. We invite you to experience a stay full of unique details and amenities, thoughtfully designed with a boutique feel—where you won’t miss a thing. Every corner was crafted with love so you feel right at home… or even better. ✨

Top guest favorite
Cabin in El Edén
5 out of 5 average rating, 12 reviews

Spectacular cabin in the Edén mountains

Arrayán cabin in Finca María Justa, Pueblo Edén, 45 minutes from Punta del Este. On a 15-hectare property. Great for couples. It has 2 bedrooms. Designer retreat to experience the slow rhythm: silence, nature and peace. Open views of the mountain landscape and sunset. Access to the stream with natural pool, trails in the native forest and art gallery. Jacuzzi under the stars, surrounded by farm animals and birdsong. A well-kept experience, designed for rest.

Guest favorite
A sunshade is positioned over a deck area, providing a view of rolling hills and a serene body of water. Two lounge chairs are visible in the distance, and colorful cushions rest on the deck, creating a relaxed outdoor setting.
Cottage in Pan de Azucar
4.93 out of 5 average rating, 14 reviews

Casa Mara Sierra- 3

A unique place with style! The house has an area of 40 meters. It is located in a prime location high in the mountains, surrounded by beautiful scenery. It is part of a complex consisting of three houses in total. The house is for two people. It offers a spacious bedroom with an en-suite bathroom and a modern fully integrated kitchen. In addition, it has a high-performance wood-burning stove. Outside it has its private deck with a barbecue grill.

Top guest favorite
An open living area is presented with large windows allowing natural light to fill the space. A seating area features a wooden couch with orange cushions and a coffee table. A dining table with wicker chairs and a decorative bowl completes the inviting setting.
Home in Playa Verde
4.97 out of 5 average rating, 106 reviews

Playa Verde is 70 meters from the sea. Panoramic.

House 70 meters from the beach, on a street with access to the beach. Bright, spacious, airy, with ocean views, sunset and sunrise to enjoy every day. Two bedrooms and a bathroom on the ground floor. Upstairs, integrated kitchen, dining room and living room plus roofed terrace. Air conditioning in all rooms. Outdoor shower with hot water. More roofed space with grill. Located on 300 meters of land, with several floors and native trees growing.

Guest favorite
A charming house features a sunlit exterior painted in warm yellow, complemented by brown stone accents. A tiled roof adds character, while a wooden fence encloses a lush garden area. Nearby greenery and flowers enhance the inviting atmosphere of this peaceful retreat.
Home in Santa Ana
4.87 out of 5 average rating, 30 reviews

I WANT IT, I CAN DO IT, AND I DESERVE IT!!

Our house is brand new and meets disinfection requirements for an excellent stay. Welcome to MARCOR, located in a strategic area, a minute from the splendor of Piriápolis and about 50 km from Punta Del Este. We have natural waters that make it extremely unique and unparalleled. Santa Ana links the rustic with the harmonious where native animals of the fauna coexist. We also have OSE and UTE connections, which is no small thing.

Superhost
Home in Balneario Argentino
4.86 out of 5 average rating, 29 reviews

House with enclosed jacuzzi, pool and barbecue grill

Private ✨ Heated Salt Water Pool October-May ♨️ Private Jacuzzi to enjoy and relax in Roofed 🍽️ grill and outdoor furniture 🚗 Parking 📶 WiFi 📺 -Smart TV 40” with Netflix, Disney+ Full 👩‍🍳 kitchen microwave, coffee maker, toaster, blender, blender and electric jug ❄️ A/C 🛏️ Bed linens and towels included 🏐 Volleyball Court 🧺 Washing machine 🚿 Outdoor shower. 💇‍♀️ Hair dryer 👕 Iron 🧴shampoo, rinse cream

Top guest favorite
A sunlit outdoor area features a calming pool surrounded by wooden lounge chairs, positioned on a deck of pale wood. Lush greenery and swaying palm-like plants add a touch of nature, with a clear blue sky in the background.
Cabin in Punta Negra
4.97 out of 5 average rating, 139 reviews

House with pool near the sea.

House with a private heated pool, just 30 meters from the sea in Barra de Portezuelo. Ideal for relaxing all year round, with a fenced-in garden, barbecue, and a quiet setting. It features Wi-Fi, air conditioning in the living room, a wood-burning stove, and parking. Perfect for couples or families seeking privacy, comfort, and proximity to the beach. *We accept pets. *Heated pool available from September to mid-April.

Guest favorite
The exterior of a colonial-style house is illuminated by warm lighting, set against a night sky with visible stars. Surrounding greenery and flowers add to the natural ambiance, while a car is parked nearby and a dog sits on the path.
Home in Guazuvirá Nuevo
4.85 out of 5 average rating, 197 reviews

Colonial style house ❀ ideal for your rest

Looking for peace and quiet? You've come to the right place. 🌿 Two-bedroom house in Guazuvirá Nuevo, surrounded by nature and with a perimeter fence, ideal for protecting children and pets. It features a wood-burning stove, perfect for enjoying a glass of wine or simply watching the fire in a warm and cozy atmosphere. A place to disconnect and relax. If you have any questions, please don't hesitate to let me know.

Popular amenities for Santa Ana vacation rentals

When is the best time to visit Santa Ana?

MonthJanFebMarAprMayJunJulAugSepOctNovDec
Avg. priceG$15,058 GYDG$14,640 GYDG$13,385 GYDG$12,758 GYDG$10,666 GYDG$12,758 GYDG$12,758 GYDG$12,967 GYDG$12,967 GYDG$12,967 GYDG$12,967 GYDG$14,221 GYD
Avg. temp23°C22°C21°C18°C14°C11°C11°C12°C13°C16°C19°C21°C

Frequently Asked Questions

  • Are there family-friendly vacation rentals in Santa Ana?

    Santa Ana has more than 50 family-friendly stays. Amenities on the property may include high chairs, travel cribs, or strollers.

  • How much does it cost to stay in house rentals in Santa Ana?

    Experience the best of Santa Ana with our house rentals, starting at about $30 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.

  • Are there pet-friendly vacation rentals in Santa Ana?

    Four-legged friends are welcome in Santa Ana. Choose from more than 50 vacation rentals for guests traveling with pets.

  • Are there vacation rentals with a dedicated workspace in Santa Ana?

    Yes! Work meets play with ease at over 20 vacation rentals in Santa Ana featuring dedicated workspaces. Stay connected and productive in your home away from home.

  • Do house rentals in Santa Ana have air conditioning?

    Absolutely! We offer over 30 house rentals with air conditioning in Santa Ana. Enjoy a tailored experience with all the comforts you desire.

  • Do house rentals in Santa Ana have a kitchen?

    Absolutely! We offer over 60 house rentals with a kitchen in Santa Ana. Enjoy a tailored experience with all the comforts you desire.

  • Do house rentals in Santa Ana have wifi?

    Absolutely! We offer over 30 house rentals with wifi in Santa Ana. Enjoy a tailored experience with all the comforts you desire.

  • Do house rentals in Santa Ana have free parking?

    Absolutely! We offer over 50 house rentals with free parking in Santa Ana. Enjoy a tailored experience with all the comforts you desire.

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