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Vacation rentals in San Isidro

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in San Isidro

Guests agree: these stays are highly rated for location, cleanliness, and more.

Guest favorite

Cabin in San Ramón

4.94 out of 5 average rating, 17 reviews

Santa Isabel’s Mountain Lodge

Selected by Condé Nast Traveler as one of the best 12 Airbnbs in Nicaragua (2024) Santa Isabel’s mountain lodge is the perfect family getaway providing an amazing retreat from life's hectic pace. Relax and enjoy the splendor of the mountains, beautiful sunsets, walking through the coffee plantation, sightseeing of the valley, the singing of the Howler monkeys early in the morning to an exotic variety of birds. Enjoy waking up to a delicious freshly brewed, roasted coffee from Santa Isabel.

Jul 15 – 22

G$85,329 GYD per night
Superhost

Cabin in San Nicolás, Nicaragua

5.0 out of 5 average rating, 18 reviews

Green View

Experience the beautiful views of the forest at this spectacular cozy cabin with three beds, one bathroom, and a kitchen nestled in trees in the Garnacha, San Nicolás, Esteli. This lovely furnished chalet offers a fully equipped kitchen, a porch with outstanding views of the forest, and has electricity. A unique place you will not find anywhere else that you will always want to return to! This comfy cabin will provide an unforgettable experience and is perfect for families and friends! 🌲+Wifi

May 28 – Jun 4

G$16,794 GYD per night
Superhost

Cabin in Muy Muy

4.93 out of 5 average rating, 14 reviews

Tree house, Finca el Escondido.

Looking for jungle vibes and a lot of nature off the beaten track? You are at the right place at our organic coffee finca in Muy Muy, Nicaragua. We have a real treehouse built between 5 trees and lakeview and 3 spacious jungle cabins for you to stay in (see our other lisiting). Finca El Escondido is the place to be to relax peacefully. Watch monkeys swing by. Enjoy the more than 60 species of birds.Want to be active? Then hike one of the many hiking trails (for every level) around the finca.

Jan 28 – Feb 4

G$6,138 GYD per night

Popular amenities for San Isidro vacation rentals

Other great vacation rentals in San Isidro

Home in Matagalpa

4.84 out of 5 average rating, 32 reviews

Cute little house overlooks the mountains of Matagalpa

May 14 – 21

G$5,301 GYD per night

Home in Las Peñitas, Nicaragua

4.55 out of 5 average rating, 88 reviews

Coco Casa - Beach Front Home

Jul 21 – 28

G$32,052 GYD per night

Home in Matagalpa

4.5 out of 5 average rating, 16 reviews

Relax in this quiet and elegant space

Feb 21 – 28

G$13,863 GYD per night

Bungalow in Estelí, Nicaragua

5.0 out of 5 average rating, 6 reviews

Luxury 2Bungalow in privileged setting.

Apr 25 – May 2

G$12,907 GYD per night

Home in Las Peñitas

4.8 out of 5 average rating, 5 reviews

Casa Cielo Azul

May 31 – Jun 7

G$25,232 GYD per night

Cabin in Jinotega, Nicaragua

4.6 out of 5 average rating, 20 reviews

Cabana Apana

Jan 31 – Feb 7

G$22,168 GYD per night

Cottage in Buenos Aires, Santa Cruz, Esteli

4.67 out of 5 average rating, 3 reviews

Enchanting country jewel

Aug 22 – 29

G$38,411 GYD per night

Apartment in Matagalpa, Nicaragua

4.67 out of 5 average rating, 12 reviews

Private room in downtown Casa Agualí

Apr 23 – 30

G$5,053 GYD per night
Guest favorite

Home in Barrio Guadalupe

5.0 out of 5 average rating, 17 reviews

Casa Guadalupe - 4BR/4.5BA Two-Story In Leon

Sep 28 – Oct 5

G$31,050 GYD per night

Guest suite in Matagalpa, Nicaragua

4.72 out of 5 average rating, 18 reviews

House of the View

Aug 20 – 27

G$5,677 GYD per night

Home in León

4.72 out of 5 average rating, 18 reviews

Casa Coral / Renta Car

Jun 3 – 10

G$15,625 GYD per night

Farm stay in San Marcos de Colon, Honduras

4.65 out of 5 average rating, 26 reviews

Finca Escondida / Hidden Farm

Jul 23 – 30

G$10,306 GYD per night

Destinations to explore