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Guesthouse vacation rentals in Pima County

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in Pima County

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Top guest favorite
Guesthouse in Tucson
4.97 out of 5 average rating, 491 reviews

The Zendo Oasis. Your Private Resort in Tucson.

Discover the Zendo Oasis, your private resort in midtown Tucson. Don't settle for a sterile hotel room that can cost hundreds more. The Zendo offers a retreat atmosphere that will impress. Exercise in our full gym and luxuriate in a hot stone sauna! After, jump in the pool! Sip wine while enjoying evenings around a chiminea under starlit skies. Lounge by the pool in the sun or shade on the deck or under louvered patios. The Zendo is close to the UA and downtown. Book now and escape the ordinary!

Top guest favorite
A cozy living area features a light-colored sofa and two blue accent chairs. A round coffee table sits in the center, with a wooden TV stand showcasing a vibrant piece of art. Large windows provide natural light and overlook the landscaped outdoor space.
Guesthouse in Tucson
4.99 out of 5 average rating, 165 reviews

Peaceful Desert Oasis in Central Tucson Foothills

Newly renovated guest home located in a quiet central area in the Catalina Foothills. Trails and biking in our backyard, 10-15 min drive to hiking/parks, downtown and UofA! Away from everything and yet conveniently close to everything! Enjoy beautiful mountain views and professional landscaping. Well equipped kitchen with washer/dryer and a cozy fireplace and desk in the master bedroom. Lots of privacy from the main home. Stocked with all your amenities needed for a cozy and comfortable stay.

Top guest favorite
The guesthouse is set against a backdrop of desert landscape, showcasing a simple, earthy exterior. A wooden porch with railings invites guests to enjoy the outdoor space. Desert vegetation, including cacti and shrubs, enhances the natural surroundings, along with rocky pathways leading to the house.
Guesthouse in Tucson
4.99 out of 5 average rating, 368 reviews

West-side Trailhead Retreat in the Sonoran Desert

2017 guest house in Tucson Mountain foothills adjacent to Sweetwater Preserve (14+ mi.s of trails: mountain biking, horseback, running, & hiking)! Enjoy the giant soaking tub, BBQ grill, sunsets & patio. A full kitchen, sitting area, bath & BR are downstairs (550 sq. ft.). Up a 90-degree ladder to BR/retreat space, wonderful for getaway views. Our property is a 3-acre lot w/ desert flora/fauna, stars, & quietness, yet only 10 mi. from UA. Horses add to the ambiance with a taste of ranch life.

Top guest favorite
A saltwater pool is framed by wooden decking and two lounge chairs, offering a serene view of the evening sky painted in shades of orange and pink as the sun sets over the high desert landscape.
Guesthouse in Patagonia
4.99 out of 5 average rating, 128 reviews

HummingBird Casita at Birdsong Retreat

Your private studio casita at Birdsong Desert Retreat: thoughtfully curated eclectic furnishings & decor, full kitchen, private bath—opening to serene desert views. Welcome with homemade grain-free granola, pancake mix, syrup, coffee & teas. On 40 peaceful acres: 360° vistas of Patagonia, Atascosa Mtns, Coronado Forest, Mt Wrightson & Mexico. Lake 6 min away. Dark-sky compliant—profound starry nights, nature sounds, monsoon storms & rainbows (Jul-Sep) for renewing energy. More at birdsongaz

Top guest favorite
The exterior of the casita features a welcoming entrance with wrought iron French doors, flanked by two adirondack chairs. Large windows allow natural light to enter, while the rustic structure is covered by a gabled roof, creating an inviting front porch space.
Guesthouse in Patagonia
4.99 out of 5 average rating, 107 reviews

Dream House

Replenish * Re-calibrate * Reconnect.. Welcome to our little house of dreams! You have found the perfect leaping off point to explore all this region has to offer. Nestled snugly between the Patagonia and Santa Rita mountains, our casita sits at just under 5,000 ft, making it temperature perfect almost year round. Enjoy our 38 acres and private hiking trails right out the front door with endless possibilities for adventure. Recharge, Rejuvenate, and Revel in our cozy, clean, quite space.

Top guest favorite
The exterior of the Time Capsule is displayed, featuring a circular design with vibrant purple walls and a wooden deck. Two orange chairs are positioned on the deck, surrounded by desert vegetation. The minimalist structure is set against a clear blue sky.
Guesthouse in Tucson
4.99 out of 5 average rating, 428 reviews

Time Capsule in the Sonoran Desert

The Time Capsule is a unique experience in a space age module dropped in the middle of an 11 acres desert sanctuary and sculpture park, adjacent to the Saguaro National Park. Enjoy the quietness of the desert in a safe environment located at just 35 minutes from downtown Tucson. Because of the refinement of the interior design, we cannot accept any pets in the Time Capsule. However, service animals are welcome. Please note that check-in is in-person only and not later than 10:00 PM.

Top guest favorite
A dining area is presented with a wooden table set for a meal, surrounded by woven chairs. Large arched windows provide views of the garden, allowing natural light to fill the space. Decorative plants and vibrant table settings add a touch of warmth.
Guesthouse in Tucson
5 out of 5 average rating, 117 reviews

Attractive Casita In Tucson

A charming getaway casita with stunning views of the majestic Saguaro National Park and the Picture Rock Mountains for spectacular sunsets. The 5-acre site is home to many varieties of cacti, including giant saguaros and other native plants and trees. Through the casita's panoramic windows, you can observe desert vegetation, birds, rabbits, coyotes, bobcats, javelinas, and deer. An evening bath in the jacuzzi under the starry sky will certainly remain in your memory for a long time.

Top guest favorite
A modern kitchen is showcased with wooden cabinetry and dark appliances. A spacious white countertop extends into a breakfast bar with two wooden stools. A door leading to the outside is visible, framed by natural light, creating an open and inviting atmosphere.
Guesthouse in Tucson
4.97 out of 5 average rating, 231 reviews

The Coop- Luxury guest house with ideal location

This luxury guest home was originally a chicken coop for a farmer over 60 years who owned the majority of the land in the area. With an addition and a complete renovation, we have designed this for the perfect vacation rental ideally located in Tucson. 15 minutes to Banner and the U of A. 10 minutes to Oro Valley or the freeway. The stylish guest home is separated from our home and designed with privacy in mind. Enjoy this brand new house for your stay with experienced hosts.

Guest favorite
Guesthouse in Tucson
4.89 out of 5 average rating, 125 reviews

Guest House with private courtyard, Saguaro Park

✷ Scenic Location ✷ Fastest WiFi ✷ Huge Outdoor Fully Fence Living Space ✷ Low cleaning fees ✷ Pet Friendly ✷ For more pictures and videos, find us on social media! Follow @casajaguartucson We believe that true peace is found through a connection to nature, in a home where every detail has been carefully considered. Welcome to Casa Jaguar, the ideal desert getaway located in Saguaro National Park for those seeking to reconnect with nature and revitalize their spirit.

Top guest favorite
A spacious studio features a queen-sized bed adorned with a soft coverlet. A curved red lounge chair complements the warm adobe walls and wooden ceiling beams. Natural light filters through large windows, illuminating the cozy corner with a beehive fireplace, enhancing the tranquil atmosphere.
Guesthouse in Tucson
4.96 out of 5 average rating, 907 reviews

Tucson Poet's Studio

Tucson Poet's Studio was featured in Architectural Digest (10-1-2025) “50 Best Airbnbs Across the United States", New York Magazine (6-19-2015) “Taste the Flavors of Tucson” and LivAbility (7-6-2018) “Accessible Airbnb” *NEW* EV Charger! The studio shares the private, walled courtyard and pool with the main house where my husband and I live. Located in the Peter Howell neighborhood, a convenient midtown area close to everything (2.5 mi to UA, 5 mi to downtown).

Top guest favorite
An outdoor patio area is highlighted by vibrant tiled tables surrounded by metal chairs. A stone countertop with a built-in grill is located under a shaded roof, while a pool with steps leads to a landscaped area featuring various cacti and plants, creating a relaxing atmosphere.
Guesthouse in Tucson
4.99 out of 5 average rating, 271 reviews

Saguaro Oasis Retreat near National Park

If you love nature this casita is just for you. Located 15 minutes from downtown and only a few minutes from stunning hiking and mountain biking trails in the National Park. The property is very much like a botanical garden with fruit trees filling up the back and a wide variety of succulents filling the front. The casita has its own private porch while the property shares two large communal patios with outdoor dining and a fire pit.

Guest favorite
Guesthouse in Tucson
4.95 out of 5 average rating, 101 reviews

Horse house

Welcome to your perfect getaway! This house is located in the heart of the city, giving you easy access to the best restaurants, shops, and local attractions. Enjoy the comfort of modern design with all the amenities you need for an unforgettable stay. The property has private parking, ideal for peace of mind, and a large outdoor space where you can relax, organize meetings, or simply enjoy the outdoors.

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