
Places to stay near Museum of Life and Science
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Top-rated vacation rentals near Museum of Life and Science
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Modern Cottage With a Vintage Twist Near Downtown
Come stay at our modern vintage guesthouse in Historic Trinity Park. Our cottage has all modern appliances with vintage fixtures. Our cottage is a cozy, lived-in retreat with rustic charm. This 380 square foot cottage is located in a very lively and safe neighborhood just minutes from downtown Durham. Walk one mile on the Ellerbe creek trail to downtown! Walk 1.5 mile to 9th street restaurants and shops 1 mile to Central Park and farmers market <1 mile to bars and restaurants on geer street
4.96 out of 5 average rating, 401 reviews
Little House Old North Durham
Welcome to our little house in Old North Durham. The 380 square foot studio guest house (open concept) sits behind our Bungalow in a centrally located historic neighborhood.; a 15-20 minute walk to Durham's vibrant Central Park District and a little further to downtown. Close by restaurants, music, movies and shows. Sleeps 2 comfortably on queen bed, and 2 additional on convertible couch from IKEA. Living area joins kitchen and is open to bedroom (see photos). Vaulted ceilings create openness.
4.97 out of 5 average rating, 193 reviews
Cottage with Yard, Mins to Duke
Relax in our sunny 2-bedroom cottage on a lovely corner lot! Perfect for families or remote workers, this home comfortably fits 4-6 guests. Enjoy a private, fenced backyard with a deck, grill, and firepit. Inside, find a dedicated workspace, cozy fireplace, and smart TV. Located in a walkable, family-friendly neighborhood just blocks from Northgate Park. Features include reliable WiFi, a full kitchen, and amenities for children. Your perfect home away from home awaits!
4.88 out of 5 average rating, 169 reviews
Apartment in leafy Colonial Village, Durham
I turned my house into a duplex, by turning a very 70s addition into a private, cozy, and charming space. There's a kitchenette, a dining area, and a sitting area, a bedroom, and a bathroom. The location would be ideal for someone who needs quick access to Duke Regional Hospital (4 minutes away) or downtown (6 minutes), or someone who wants to keep up a running habit (the greenway is nearby). A taqueria, a grocery store, and a coffee shop are within walking distance.
4.83 out of 5 average rating, 162 reviews
Five & Dime Tiny House
Experience the charm of tiny living in this pet-friendly studio located in my serene yet urban backyard. It offers a peaceful escape while remaining convenient to the attractions & amenities that Durham has to offer. -only a mile east of downtown -1.5 miles to DPAC and Carolina Theatre -ten minutes to both Duke Hospital and Duke Regional -less than 20 minutes to RDU airport Let your dog run around the fully fenced yard while you sit on the deck and sip your coffee!
4.97 out of 5 average rating, 348 reviews
Cheerful 50s Cottage Near Duke
This charming 1950s two-bedroom 800-square-foot cottage is located just north of Duke’s East Campus in Durham’s Walltown neighborhood. The home sleeps up to four adults with two queen beds, offers keyless entry, and includes high-speed internet. Inside, you’ll find a bright, renovated space with a modern kitchen, colorful artwork, and a bathroom with a small soaking tub. Outside, a short set of steps leads to a large, fenced backyard shaded by mature oak trees.
4.9 out of 5 average rating, 395 reviews
Duke Forest Zen Treehouse - pool table, decks
Enjoy a unique japanese-inspired custom home just 2 miles from Duke. Ascend through the gated entrance up the winding driveway to your own Zen treehouse retreat perched on the edge of the forest. large custom kitchen with a gas range, striking stonework and fireplaces. Outside there is a built-in grill, dining area, and firepit. The downstairs rec room is perfect for families featuring a pool table, movie watching area, and huge enclosed exrerior porch
4.98 out of 5 average rating, 105 reviews
Duplex filled with natural light
A stylish, modern, and beautiful alley guesthouse that is located just 2 blocks from Duke's East Campus and 4 blocks from downtown Durham. The apartment is located in the historic Trinity Park Neighborhood in Durham. The apartment has a top of the line finish, hardwood floors, appliances, and furniture. The loft area is equipped with a standing desk and monitor and 2 Yoga matts, and it is ideal for working professionals visiting the area. Built: 2023
4.94 out of 5 average rating, 155 reviews
New Build |Trinity Park | 5 Min to Duke & Hospital
Spotless new-build in Trinity Park with 2 ensuite bedrooms, fast Wi-Fi, and TVs in every room. Guests love the thoughtful touches, plush bedding, and fully stocked kitchen. Driveway parking for 2 cars plus EV charger. Just a 5-minute drive to Duke University, Duke Hospital, Ninth Street dining, and downtown Durham. Quiet, safe neighborhood with washer/dryer, blackout curtains, and white noise machines for restful stays—your home away from home.
4.96 out of 5 average rating, 107 reviews
The Mural Suite, An Artsy One Bedroom in Durham
A mural filled one bedroom suite with a full bath and kitchenette attached to our house with its own separate entrance. Located less than 5 minutes by car to downtown Durham with easy access for those who prefer to travel by bicycle or foot to the Ellerbee Creek trail. Centrally located to Duke University and Duke Medical. Perfect for longer stays for visiting professionals as well as shorter stays to enjoy all Durham has to offer.
4.96 out of 5 average rating, 268 reviews
Garden Oasis in the heart of downtown Durham
Beautifully renovated must stay if visiting Durham downtown. Within walking distance of many restaurants and city sites. Close to Duke Medical and Campus, and a stone's throw from many of the great restaurants and activities downtown has to offer. Pearl mill (122) offers a secret garden courtyard, an oasis of serenity amongst the action of the city. Huge pool to enjoy, March through October, weather permitting.
4.94 out of 5 average rating, 141 reviews
Pet Friendly | Cozy Cottage in Bull City
In town for work? Fun? Catching a game? This lovely cottage is an 8 minute drive to Main Street, which means it’s convenient to the fun, but peaceful and quiet when you’re ready for the party to stop. Also less than 15 minutes to Duke Hospital, 20 minutes to Chapel Hill, and 30 minutes to Raleigh. We are also dog-friendly with a fenced in back yard!
4.97 out of 5 average rating, 177 reviewsPopular amenities for vacation rentals near Museum of Life and Science
Other top sights near Museum of Life and Science
Condo rentals with wifi

Downtown "Bull Durham" Condo
4.8 out of 5 average rating, 349 reviews
Pet Friendly, Brand New Condo, Quiet, Green Space
4.93 out of 5 average rating, 107 reviews
Carrboro/Chapel Hill/UNC bright contemporary condo
4.96 out of 5 average rating, 134 reviews
Lovely condo on the Greenway—near Raleigh
4.98 out of 5 average rating, 135 reviews
Bull City Shangri-la
5.0 out of 5 average rating, 15 reviews
Comfy Home In Durham
4.94 out of 5 average rating, 49 reviews
Charming Historic Downtown Retreat 3
5.0 out of 5 average rating, 32 reviews
Stylish Retreat Steps from Duke East Campus
5.0 out of 5 average rating, 15 reviewsFamily-friendly house rentals

Warm and Welcoming 3-Bedroom Cottage
4.98 out of 5 average rating, 147 reviews
3BR Durham Haven: Perfect for Visiting Duke & DTWN
4.92 out of 5 average rating, 143 reviews
Stylish historic home—walk to Duke & 9th Street!
5.0 out of 5 average rating, 104 reviews
HistoricallyHip on Hale/Walkable, 3 min to Duke
4.89 out of 5 average rating, 101 reviews
Luxe 5* Home 4 Mins Duke/DPAC, King Beds, Fire Pit
5.0 out of 5 average rating, 137 reviews
Spacious Newly Renovated Home in great location
4.88 out of 5 average rating, 121 reviews
Clean Quiet Medical&Work Stay, Fenced Yard, Pets
4.91 out of 5 average rating, 244 reviews
Guest house With Private Gate Near downtown
4.88 out of 5 average rating, 60 reviewsApartment rentals with air conditioning

Clean Apartment Downtown Durham
4.91 out of 5 average rating, 109 reviews
The Classic @ Casa Azul - Warm & Cozy 1 BR Unit
4.88 out of 5 average rating, 150 reviews
Walk to Duke Campus! 1 Bedroom in Trinity Park!
4.85 out of 5 average rating, 167 reviews
Entertainment Central Park, Downtown, Unit B
4.96 out of 5 average rating, 101 reviews
Walk to Downtown & Duke- King bed
4.93 out of 5 average rating, 188 reviews
Downtown Durham Retreat
5.0 out of 5 average rating, 125 reviews
2-BR apt/garden near downtown Durham arts & eats
4.98 out of 5 average rating, 1187 reviews
Dollar Avenue Treehouse near Duke
4.94 out of 5 average rating, 144 reviewsOther great vacation rentals near Museum of Life and Science

Midcentury Modern, Near Duke
4.98 out of 5 average rating, 140 reviews
Rivers Edge Farm Silo Suite
4.99 out of 5 average rating, 140 reviews
VIP Loft on Main St. - Center of downtown Durham!
4.94 out of 5 average rating, 350 reviews
Luxurious Modernist Tree House
4.96 out of 5 average rating, 207 reviews
Downtown Durham Area
4.99 out of 5 average rating, 162 reviews
Sleeps 5| Fenced Yard| Dogs OK| Near Duke & DPAC
4.99 out of 5 average rating, 90 reviews
Luxury Hot Tub | 3BR Suites near Duke
5.0 out of 5 average rating, 33 reviews
Central Durham Cottage - Spa Bath
4.98 out of 5 average rating, 46 reviewsDestinations to explore
- Duke University
- North Carolina State University
- Raleigh Convention Center
- University of North Carolina at Chapel Hill
- Raven Rock State Park
- Virginia International Raceway
- Crabtree Valley Mall
- William B. Umstead State Park
- Sarah P. Duke Gardens
- North Carolina Museum of Art
- Lake Johnson Park
- North Carolina Museum of Natural Sciences
- Dorothea Dix Park
- Durham Bulls Athletic Park
- Duke Chapel
- Eno River State Park
- Koka Booth Amphitheatre
- Red Hat Amphitheater
- Durham Farmers' Market
- American Tobacco Campus
- North Carolina Museum of History
- Carolina Theatre
- International Civil Rights Center & Museum
- American Tobacco Trail





