Vacation rentals in Mira Mesa, San Diego

Guest suite in Rancho Penasquitos

A private patio features two wicker chairs with plush cushions, positioned next to a small table. Sunlight filters through the trees, casting soft shadows on the wooden decking, with the entrance to the suite visible in the background.

5 out of 5 average rating, 15 reviews

Comfort Convenience and Beauty

This newly built two-story private suite is centrally located in San Diego: 12 min from the beach, great for families (World Famous San Diego Zoo/Safari, LegoLand, Disneyland), and close to business parks for work travel. Views are stunning and the property has wood/stone interior, natural lighting, & a gorgeous bathroom. The fully private suite shares a wall with the main property, has a private front & back entrance, private patio & rock garden, and is directly across from a large green space.

4.96 out of 5 average rating, 107 reviews

Private Suite w/ full Kitchen, Bath,Washer & Dryer

Newly-built 1 Bed/1 Bath Guest Suite with private entrance, private restroom, new air conditioning unit, new full-size kitchen and new washer/dryer inside the unit. It's a centrally-located place near Qualcomm, Sorrento Valley, UCSD, La Jolla beaches, etc...Easy access to I-15 and 805 freeways. Convenient travel to Legoland, SeaWorld, San Diego Zoo, USS Midway Museum,Balboa Park and many other attractions in San Diego. It offers everything you need for a nice stay. Check out our awesome reviews!

The kitchenette features a sleek countertop with a stylish black induction cooktop and a matching sink faucet. A small potted plant adds a touch of greenery, while the light-colored cabinetry provides a modern finish.

4.93 out of 5 average rating, 108 reviews

*Super cute* modern studio with private entrance!

☀️ Newly renovated, private guest suite with its own separate entrance; close to all the best parts of San Diego! 🖥️ It comes with AC/heat, a 60-inch TV with 85+ channels, high-speed internet, mini-fridge and freezer, kitchenette with induction cooktop and microwave. 💦 Guests LOVE the modern bathroom with a rainfall shower head. ✅ EASY, 24/7 self check-in with smart lock! 🏝️ Super close to freeways, Target, Starbucks and just 20 minutes from downtown, the airport, beaches and UCSD!

4.96 out of 5 average rating, 208 reviews

Guesthouse in Mira Mesa

Clean studio, private entrance & reserved parking

Newly remodelled studio with private entrance and one reserved drive way parking spot in an upscale neighborhood. Bright color designs will bring you all good moods and energy. Neighborhood is quiet and safe, near Sorrento valley, La Jolla and Del Mar beach. So many good restaurants and markets around. I'm an interior designer and really care about how my guests feel during their stays. When I designed and built this unit, I choose all unique materials that bring you the best experience.

Rolling green golf course overlooks the coastline, bordered by sandy shores and gentle waves. A vibrant sunset paints the sky in warm hues, reflecting off the water. The landscape features trees dotting the course and rocky cliffs in the distance.

4.91 out of 5 average rating, 130 reviews

Stunning Private Entrance 2bd/1ba Suite

Located in the heart of San Diego, guests are a short drive or bus ride to all the local hotspots. Shopping and restaurants are within walking distance. The space itself is large, exquisitely decorated, has a dedicated driveway parking space and its own private entrance in the front of the house. Also available are the washer/dryer for laundry, beach equipment, electric bikes (with signed waiver), cribs/toys/etc. for children. Short drive to SeaWorld, Zoo, Safari Park and beaches.

5 out of 5 average rating, 67 reviews

The open-concept living space features large windows allowing natural light to fill the room. A comfortable seating area includes a dark couch and an armchair facing a wall-mounted television. A modern kitchen counter with sleek cabinetry provides ample space for preparing meals.

Guesthouse in Mira Mesa

Modern and Spacious Guest House

About this place ☀️👨‍🍳 Newly Build, private guest suite with its own separate entrance, 600 sq ft space, additional 500 sq ft patio, close to all the best parts of San Diego! 🖥️👨‍🍳 It comes with AC/heat, a 65-inch TV, high-speed internet, Full Kitchen with smart appliances, washer dryer, a full length mirror, a huge closet with hangers 💦⛱️ Modern bathroom with push button rainfall shower, hair dryer, iron, and plenty of towels ✅ EASY, 24/7 self check-in with smart lock!

A modern living area features a neutral-toned sofa with navy blue decorative pillows. A round table sits in the center, displaying a circular platter. An open kitchen area with white cabinetry and stainless steel appliances can be seen in the background, complemented by warm lighting.

5 out of 5 average rating, 37 reviews

Brand New Suite in Mira Mesa

Free Parking / Patio / Welcome to our brand new guest suite. This is a newly built place and I hope you enjoy it! It is located on left side of the main house. It’s a great and cozy place and a good spot for you to rest during your trip of enjoying San Diego. This manual will tell you the house rules for the stay, general information about the place, and even recommendations for places to visit and stay in the city. We hope you enjoy your stay!

Superhost

A compact sink is positioned below a wooden-framed mirror, reflecting the bright bathroom space. A soap dispenser is placed beside the faucet, and a towel bar is mounted on the wall above. Light streams through a nearby window, enhancing the clean, airy atmosphere.

Tiny home in Rancho Penasquitos

4.88 out of 5 average rating, 187 reviews

WOW! Private Studio Minutes To Shopping& Freeways.

Entire Private Studio Suite. Brand new up dated entire suite with 1 Queen Bed & 1 bath. Ideal for couples, solo adventurers, and business travelers. Studio is fully equipped with 1 queen bed, 1 working desk, kitchenette meant for light food warm, mini size refrigerator, single sink meant for light cup and dish wash. All new furniture, mattress, beddings. All shops, restaurants, cinema, hiking trails within minus drive about 1-5 miles away!

5 out of 5 average rating, 28 reviews

An outdoor dining table is set with beige dinnerware and natural woven placemats. A centerpiece of fresh flowers rests in a woven basket, adding a touch of greenery. Comfortable seating is visible in the background, complemented by ample sunlight.

Home in Mira Mesa

Charming Family 3BR w/ Game Room

Experience San Diego living in this welcoming 3-bed, 2-bath Mira Mesa home. Perfect for families with a fun game room for entertainment and a spacious backyard featuring covered patio seating and grill for outdoor dining. Minutes from scenic hiking trails, family-friendly parks, and beautiful beaches. Easy access to diverse local restaurants. Your ideal Southern California base with space for both lively gatherings and relaxing downtime.

A modern bathroom features a round mirror above a sleek vanity with a single faucet. Soft, ambient light is provided by a wall-mounted fixture. A glass shower enclosure is visible in the background, complemented by light-colored tiles and a towel hanging from a stylish holder.

4.85 out of 5 average rating, 172 reviews

STUDIO 56

Entire Private Studio Suite. The entire suite is brand new and updated with 1 queen bed, 1 double bed, and 1 full bath. Quiet midtown of Mira Mesa central drive in San Diego. Studio fully equipped with 2 beds, a leather sofa, working desk, kitchenette meant for light food warm, full size refrigerator, single sink meant for light cup and dish wash All shops, restaurants, a cinema within minus drive about 2 miles away.

Superhost

Home in Mira Mesa

4.78 out of 5 average rating, 36 reviews

Charming & Spotless Studio with Own Entry

Entire Private Studio Suite. Brand new updated entire suite with 1 Queen Bed & 1 Full bathroom. Ideal for couples, solo adventurers, and business travelers. Just minutes from central of shopping and food like Asian restaurants, markets as well as 24h stores, Edward Cinema, etc... Less than 20 mins to Balboa Park, La Jolla Shores Park, Solana Beach, Moonlight Beach, San Diego Zoo, San Diego Sea World.

5 out of 5 average rating, 11 reviews

A modern kitchen features warm wood cabinetry and a sleek countertop. Natural light fills the space through a large window, framing views of a private outdoor area. Stainless steel appliances, including a gas range and microwave, offer functional elegance alongside practical accessories.

Home in Mira Mesa

Urban Oasis - Just Remodeled

**Brand New Listing** Located in the heart of Mira Mesa and just minutes from the 15 Freeway, this beautifully remodeled home offers the perfect combination of style, comfort, and convenience. Whether you're visiting for business, pleasure, or a bit of both, you'll love the thoughtful upgrades and luxurious touches throughout. The home offers plenty of parking, in a safe neighborhood.

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Popular amenities for Mira Mesa, San Diego vacation rentals

Self check-in

Gym

BBQ grill

Laptop-friendly workspace

Wifi

Other great vacation rentals in Mira Mesa, San Diego

5 out of 5 average rating, 3 reviews

Alice’s House Champagne Room

BenoitRating, 5 stars1 month ago

I had a great stay! Street parking was easy, which was super convenient. The self check-in was smooth and very easy. The host was kind and very responsive to my questions. The house was clean, in a safe neighborhood, and perfectly located near restaurants and shops. The room was comfortable, and I especially loved the water pressure in the shower — such a nice touch! I definitely recommend this place.

A two-story home with a tiled roof and a welcoming façade is shown. A car is parked in the driveway beside a small garden featuring green shrubs and decorative plants. A balcony is visible above the entrance, with large windows offering natural light.

4.94 out of 5 average rating, 251 reviews

A Private Hideout (With Massage Chair!)

ShelleyRating, 5 stars1 week ago

The guest suite was absolutely perfect! Quiet, private, and super comfortable. Vince and his Mom were great hosts and we're very kind to my service dog Axl. The bed was SO comfy and that massage chair was WONDERFUL. I highly recommend staying with Vince!

An outdoor patio area is presented under a covered space with overhead string lights providing soft illumination. A central round rug anchors the space, which is surrounded by several woven chairs and a wooden table. A fence encloses the area, creating a sense of privacy.

4.99 out of 5 average rating, 80 reviews

Boho Room in a Convenient Area w/AC。Washer。Kitchen

AlexRating, 5 stars2 weeks ago

Alan’s hospitality was incredibly welcoming and kind! We felt right at home. The stay was super comfortable with a luxurious memory foam bed and pillows. He even went above and beyond by allowing us to do some laundry during our stay. He recommended so many great places to visit as well. I highly recommend Alan to anyone seeking a comfortable night’s stay!

Private room in Scripps Miramar Ranch

A well-organized closet displays multiple shelves, featuring neatly stacked linens and a blanket. A green hanger is visible along with additional hooks on the wall, providing convenient storage options. The light-colored walls enhance the clean and tidy appearance of the space.

4.97 out of 5 average rating, 70 reviews

New Modern Suite with Private Entrance in SD

DeeapkRating, 5 stars2 weeks ago

Perfect for couple and single person stay, not suited for friends as bathroom there is no door. If you compromise this then it is a good place to stay close to all attractions.

A spacious backyard is displayed, featuring a well-maintained lawn and colorful plants. A patio dining set with multiple chairs is visible, along with a gas barbecue grill. A large umbrella provides shade, enhancing the outdoor setting for relaxation and dining.

4.92 out of 5 average rating, 48 reviews

#1 Private Master Room ,Center of San Diego County

TanishRating, 5 stars1 month ago

nice place

4.88 out of 5 average rating, 24 reviews

Cozy guest suite in Mira Mesa w private entrance

AyianaRating, 5 stars1 week ago

Great with communication. Cute area and a very clean and well decorated place. 10/10 stay!

The private room features a spacious bed adorned with soft linens, complemented by two large windows allowing natural light. A mirrored closet reflects the calming decor, while a chair is visible in the adjacent area. The flooring is a rich wood tone, enhancing the room's serene atmosphere.

Private room in Scripps Miramar Ranch

5 out of 5 average rating, 5 reviews

Zen Haven San Diego.

MRating, 5 stars2 days ago

This is such a great little place to stay. The house and the room were incredibly clean. Flor was amazing at communicating during my stay. I highly recommend this home.