House vacation rentals in Middlesex County

Find and book unique houses on Airbnb

Top-rated house rentals in Middlesex County

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Superhost

A dining area is highlighted by a glass table adorned with a decorative bowl and fresh flowers. Dark walls are complemented by elegant white trim, and a vintage mirror reflects soft light. An artwork of a woman grace the wall, adding a touch of sophistication.

Home in London

4.92 out of 5 average rating, 295 reviews

Elegant 3-Bdr House| DT| Parking | 1.5 Gbps WiFi

Welcome to your dream escape in downtown London! This 1200+ sqft, 3-bdr bungalow blends historic charm with modern luxury. Renovated and steps from Victoria Park, Budweiser Gardens, Covent Garden Market, and vibrant shops & cafes. Enjoy strolls to top attractions in London. With UH, UWO, and Fanshawe C nearby, convenience is at your doorstep. This cozy retreat feels like home with stylish elegance. Perfect for a weekend getaway or extended stay. Book now for an unforgettable London experience!

Top guest favorite

Two chairs are positioned on a stone patio overlooking a calm body of water. A small table sits between them, creating a cozy spot for relaxation. Lush greenery frames the view, enhancing the tranquil ambiance of the outdoor space.

Home in London

4.91 out of 5 average rating, 110 reviews

Cottage in the city

Welcome to your luxury oasis directly on the water and centrally located in the city! ☺️ short term includes Large backyard directly on the water. Easy access trails, including backyard access to the coves trail. 🌳 Private covered front porch 🌞 Fire pit along with fire wood 🪵 5 mins to downtown. 🏢 Work space, Self check in, Keyless entry, Free parking for 2 vehicles. 🚗 🚕 Infants stay in large wood crib, mattress, linens, and blankets 🍼 🚼 Long term please ask anything 🙂

Guest favorite

A well-lit living area featuring a cozy sofa and a small round table. A wall-mounted TV is visible, along with open shelves displaying decorative items. Windows with blinds allow natural light, while a desk and office chair provide a functional workspace.

Home in London

4.95 out of 5 average rating, 156 reviews

Welcome to your Serene Gateway!

A fully remodeled private basement unit. Your private Haven. Spacious, beautiful and clean studio in a quiet, beautiful, friendly and family oriented environment. minutes away from amenities like Tim Hortons, Bus stop, YMCA, masonville Shopping Mall and trails. 10 minutes drive to Western University, 11 minutes drive to Fanshawe College and 15 minutes drive to London ontario Downtown or Airport Need a hot drink, we offer a Keuring coffee maker with complimentary coffee pods, tea, suga etc

Top guest favorite

A spacious two-story brick house is presented, featuring a large driveway and a well-maintained front lawn. The entrance is accented by a covered porch and double glass-paned doors. Large windows allow natural light to illuminate the front façade.

Home in London

4.93 out of 5 average rating, 229 reviews

Spacious 4-bdr+Study/UWO/Masonville/YMCA/N. London

Please read the full description and notes before making reservations. Forget your worries in this spacious and serene space. Enjoy the quiet and safe location yet convenient to everything. Minutes drive to Masonville Place, the biggest mall in north Londn, SilverCity London Cinemas, YMCA, Public Libraries, UWO, University Hospital, shopping plazas, grocery stores, restaurants & more! High ranking Jack Chambers Public School is in walking distance. Laundry on site. Free parking on premises.

Guest favorite

The living room showcases a spacious gray sofa positioned around a round coffee table. A modern flat-screen TV is mounted on the wall, complemented by a sleek electric fireplace below. Large windows allow natural light to fill the space, revealing a peaceful outdoor view.

Home in London

4.92 out of 5 average rating, 169 reviews

4 Bedroom + 3.5 Bath + Close to Hwy/Dt/Boler Mt

Newly built and furnished designer home in the family neighborhood of Glendale with convenience and comfort in mind! Fully stocked kitchen, living room equipped with Samsung Smart TV (Netflix, Disney+, and more), super highspeed WiFi, and a modern designer bathroom ensures a comfortable and relaxing stay. Very close to the highway and just 10 minutes to Boler Mountain. 15-20 minutes to Western University and DT London. Easy access to city transportation makes this location a gem for anyone.

Top guest favorite

A cozy living room features a modern sectional sofa adorned with decorative pillows. A circular coffee table sits in front of the sofa, reflecting natural light from the large window with sheer curtains. Artwork is displayed on the light-colored walls, enhancing the serene ambiance.

Home in London

4.92 out of 5 average rating, 113 reviews

Chic home 5 min. from Downtown

Welcome to this chic prof. cleaned home with 3 bedrooms, two full baths, huge kitchen with everything you need to cook a meal. Large dinning room and a cozy living room with smart TV. Hi speed internet and a dedicated work station. All linens are luxurious hotel style. Fenced back yard oasis with a fire bowl for fun evenings and a bbq. 5 minutes walk to John Labatt Centre and all of downtown. Restaurants and shopping nearby. If you’re here for pleasure or business you’ll love our home!

Top guest favorite

A modern kitchen features sleek white cabinetry and stainless-steel appliances, including a refrigerator and oven. A spacious dark countertop extends to an island with seating for four. Recessed lighting illuminates the area, enhancing the contemporary design.

Home in St. Thomas

4.93 out of 5 average rating, 105 reviews

Luxurious Four Bedroom Home

Luxurious four bedroom home in the heart of St. Thomas. Located minutes from shopping, grocery stores, restaurants, Cineplex, Fit4Less, Tim Hortons and St. Thomas/Elgin Fanshawe College. You’ll immediately fall in love with my place because of the beautiful open concept living space fully loaded with brand new appliances for you and your group to use during your stay. My space features 4 comfortable queen beds, 2.5 washrooms, cable TV, fast Wi-Fi and parking for 4 vehicles.

Top guest favorite

The charming exterior of the cottage features a covered wraparound porch adorned with hanging flower baskets. A well-kept lawn and garden enhance its appeal, while visible steps lead to the porch entrance. The roof is structured with a gable design, complemented by large windows for natural light.

Home in Port Stanley

4.99 out of 5 average rating, 174 reviews

Orchard Beach Boutique Cottage

**See note on guest maximum** Your family will be close to shopping, dining and fun when you stay at this home that’s hidden away, while in the center of everything. **Guest maximum of 4 does not include children under the age of 12, as per local municipal license approval** please help us adhere to our license rules, ask if you aren’t sure. Pet-friendly, well-appointed cozy cottage steps from the beach, shops and restaurants, with plenty of parking in the driveway.

Guest favorite

The modern exterior of the detached house features a mix of textured stone and smooth stucco. Large windows allow for natural light, while the spacious driveway provides access to the attached garage. The elevated entrance is marked by steps leading to the front door.

Home in London

4.83 out of 5 average rating, 116 reviews

Amazing 6BR in London - Spacious Family Stay

Introducing our brand new 5BR, 5 full bath detached house in London. Enjoy its modern open-concept design flooded with natural light. The fully equipped kitchen, cozy family room with a large flat-screen TV, and high-speed internet ensure comfort and convenience. Located in a safe neighborhood with easy access to major highways, this home boasts comfortable bedrooms with high-quality linens and free parking. Your perfect haven awaits!

Top guest favorite

A hot tub is situated on a spacious deck surrounded by lush green trees, providing a serene forest backdrop. Nearby, a glass-top table with several chairs offers an inviting space for outdoor dining. Sunlight filters through the leaves, creating a calming atmosphere.

Home in Southwold

4.97 out of 5 average rating, 209 reviews

Nature Lover's Luxury Paradise

Nature Lover's Luxury Home in the woods. Creek's Edge Estate is a beautifully decorated home that is nestled on 10 acres of private woods. Minutes from London, ON this 4BDRM+3.5 BATH home sits next to some private hiking trails. Enjoy the sounds & sights of nature while relaxing in the hot tub. A beautiful escape for couples, families or groups looking to relax and recharge. Too many amazing amenities to list!

Top guest favorite

A wooden patio area is presented, featuring a gazebo and various seating arrangements. A round table is surrounded by four chairs, and colorful flowers are placed in pots nearby. Lush greenery provides a natural backdrop, complementing the outdoor space under clear blue skies.

Home in London

4.88 out of 5 average rating, 312 reviews

*New Renovated+Spacious+Cozy* 4 BR Near UWO

Located in a quiet and safe neighborhood close to Downtown and a number of amenities including: Walmart supperstore, Masonville Place, Canada Games Aquatic Center and Western University. Complete with four bedrooms, two bathrooms, hardwood floors throughout, a spacious backyard with a beautiful patio, and five free parking spaces. This house is sure to make you feel comfortable during your stay.

Guest favorite

A well-lit bedroom features a spacious bed adorned with neutral bedding and a colorful throw. A comfortable chair sits beside a window with wooden blinds, allowing natural light to filter in. Light hardwood flooring gives a warm feel to the room.

Home in London

4.91 out of 5 average rating, 178 reviews

Centrally Located - 2 bdrm & 2 Free Parking Spots

Welcome to Your Modern Retreat! Enjoy our 2-Bedroom Space with a Stylish Kitchen for cooking up great meals. Relax in the spa-like bathroom for your ultimate chill-out time. Just 2 kilometers from Downtown, explore the city's hotspots easily. Have fun with our collection of board games for cozy evenings. Your perfect modern getaway is here, mixing comfort and urban vibes!